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Effect of the Nanoparticle Functionalization on the Cavitation and Crazing Process in the Polymer Nanocomposites

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Chinese Journal of Polymer Science 2021年第2期39卷 249-257,I0008页

作者： yan-long luo Tian-Tian Li Bin Li Xian-Ling Chen Zhen-yang luo yang-yang Gao Li-Qun Zhang College of Science Nanjing Forestry UniversityNanjing 210037China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing 100029China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The nanoparticle(NP) functionalization is an effective method for enhancing their compatibility with polymer which can influence the fracture property of the polymer nanocomposites(PNCs). This work aims to further understand the cavitation and crazing process, hoping to uncover the fracture mechanism on the molecular level. By adopting a coarse-grained molecular dynamics simulation, the fracture energy of PNCs first increases and then decreases with increasing the NP functionalization degree α while it shows a continuous increase with increasing the interaction εpA between polymer and modified beads. The bond orientation degree is first characterized which is referred to as the elongation. Meanwhile, the stress by polymer chains is gradually reduced with increasing the α or the εpA while that by NPs is ***, the percentage of stress by polymer chains first increases and then decreases with increasing the strain while that by NPs shows a contrast trend. Moreover, the number of voids is quantified which first increases and then decreases with increasing the strain which reflects their nucleation and coalescence process. The voids prefer to generate from the polymer-NP interface to the polymer matrix with increasing α o r ε*** a result, the number of voids first increases and then decreases with increasing α while it continuously declines with the εpA. In summary, our work provides a clear understanding on how the NP functionalization influences the cavitation and crazing process during the fracture process.

关键词： Nanoparticle functionalization Cavitation and crazing Polymer nanocomposites Molecular dynamics simulation

Tuning the Electrically Conductive Network of Grafted Nanoparticles in Polymer Nanocomposites by the Shear Field

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Chinese Journal of Polymer Science 2020年第12期38卷 1426-1434页

作者： yan-long luo Xiao Hui Duan Bin Li Xin-Ling Chen yang yang Gao Li-Qun Zhang Cllege of Science Nanjing Forestry UniversityNanjing 210037 China KeyLaboratoryof Bejing Ciy on Preparation and Pocessing of Novel Polmer Materials Bejing University ofChemical TechnologyBejing 100029China State Key Laboratory of Organic-lnorganic Composites Bejing Universityof Chemical Technology Bejing 10029China School of Chemical Engneering and Technology.Sun Yat sen University Zhuhai 519082 China

Contolling the formation of the conductive network in the polymer nanocomposites(PNCs)is very meaningful to enhance their electrical *** this work,we investigated the effect of grafted nanoparticles(NPs)on the conductive probability of PNCs in the quiescent state as well as under the shear field via a coarse grained molecular dynamics *** is found that the smallest percolation threshold is realized at the moderate grafting density,the moderate length of grafted chains or the moderate interaction between grafted chains and free *** to it,the dispersion state of NPs varies from the contact aggregation to the uniform *** analyzing the connection mode among NPs,the probabilty of NPs which connect three other ones reaches the maximum value at their moderate dispersion state which is responsible for the optimal conductive *** addition,the main cluster size is characterized to better understand the conductive network which is consistent with the percolation *** is interesting to find that the percolation threshold is smaller under the shear field than under the quiescent *** shear field induces more NPs which connect three other *** benefits the formation of the new conductive ***,the anisotropy of the conductive probability is reduced with increasing the grafting *** summary,this work provides a clear picture on how the conductive network of grafted NPs evolves under the shear field.

关键词： Conductive network Grafted nanoparticles Molecular dynamics simulation

Lithium Diisopropylamide (LDA) Mediated Benzylic Benzoylation of Toluenes with Benzamides

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Lithium Diisopropylamide (LDA) Mediated Benzylic Benzoylatio...

Exploring practical methods for detecting k-nonseparability in multipartite quantum states

中国化学会·第十六届全国有机合成化学学术研讨会

作者： Can-Can Bao yan-long luo Yu-Feng Liu 关冰涛 State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University 南开大学

In the past decades,various synthetic methods including Friedel-Crafts acylation reactions(Scheme 1 A),α-arylation reactions(Scheme 1 B),had been developed for the synthesis of deoxybenzoin *** them,the addition of an organometallic reagent to carboxylic acid derivatives is the most feasible and most popular approach(Scheme 1 C).However,for the nice reactivity between the ketone products and organometallic reagents,the side reactions of reduction and over addition usually readily take *** overcome these side reactions,various chelating amides,chelating esters and thioesters had been developed as more reactive ***,with the amide activation strategy,the direct transformation of secondary and tertiary amides with Grignard reagent were achieved recently. Besides,the less reactive organometallic reagents,such as organozinc or organoboron ones,are conductive to avoid the side reactions of ***,transition metal catalysts were always necessary. Based on our studies about s-block catalysts,we proposed that a weak base could possibly inhibit the side reactions of the reactive intermediate.3 Herein,we reported a direct deoxybenzoin synthesis via a LDA-promoted benzylic benzoylation of toluenes with tertiary amides(Scheme 1D).

关键词： Lithium Diisopropylamide(LDA) Benzylic Benzoylation of Toluenes Benzamides

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 255-256页

作者： Shunlong luo Academy of Mathematics and Systems Science Chinese Academy of Sciences

Quantum entanglement, referred to as “spooky action at a distance” by Einstein, is not only an intriguing and fascinating feature of quantum theory challenging our classical intuitions about locality and correlations, but also has practical and profound implications for quantum technologies. Initially described by Einstein, Podolsky and Rosen, as well as by Schro¨dinger, entanglement now has become a basic and crucial ingredient for both foundational and experimental investigations of the quantum world.

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues Yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

硬枝碱蓬对卡拉库尔羊血清中谷胱甘肽及其相关酶活性的影响

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新疆农业大学学报 2017年第1期40卷 20-24页

作者：郝海燕沙爱龙骆春敏西南医科大学药物与功能性食品研究中心泸州646000 西南医科大学基础医学院生理学教研室泸州646000 新疆温泉县畜牧兽医站温泉833500

为了探讨硬枝碱蓬(Suaeda rigida Kung et ***)对卡拉库尔羊抗氧化能力及肝脏功能的影响,选择18只健康卡拉库尔羊,随机分为对照组和试验组,试验组羊日粮粗粮中添加硬枝碱蓬,分别在试验期第10天、第20天和第30天测定卡拉库尔羊血清中还... 详细信息

为了探讨硬枝碱蓬(Suaeda rigida Kung et ***)对卡拉库尔羊抗氧化能力及肝脏功能的影响,选择18只健康卡拉库尔羊,随机分为对照组和试验组,试验组羊日粮粗粮中添加硬枝碱蓬,分别在试验期第10天、第20天和第30天测定卡拉库尔羊血清中还原型谷胱甘肽(GSH)含量及谷胱甘肽-S转移酶(GST)、谷胱甘肽过氧化物酶(GSH-Px)、谷氨酰氨转移酶(GGT)、谷丙转氨酶(GPT)、谷草转氨酶(GOT)和碱性磷酸酶(AKP)活性。结果表明:硬枝碱蓬对卡拉库尔羊血清中GSH含量及GSH-Px、GST活性均有促进作用,第10天时促进显著(P0.05)。说明日粮添加适量的硬枝碱蓬可显著提高卡拉库尔羊机体的抗氧化能力,延长其寿命,且可以保护卡拉库尔羊肝脏。

关键词：硬枝碱蓬卡拉库尔羊还原型谷胱甘肽谷胱甘肽过氧化物酶谷胱甘肽S-转移酶

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： Shan luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin Li Jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation