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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu yan-chang gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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A Sustainable Dual Cross‑Linked Cellulose Hydrogel Electrolyte for High‑Performance Zinc‑Metal Batteries

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Nano-Micro Letters 2024年第6期16卷 63-75页

作者： Haodong Zhang Xiaotang gan Yuyang yan Jinping Zhou Hubei Engineering Center of Natural Polymers‑Based Medical Materials Key Laboratory of Biomedical Polymers of Ministry of EducationCollege of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072People’s Republic of China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityWuhan 430072People’s Republic of China

Aqueous rechargeable Zn-metal batteries(ARZBs)are considered one of the most promising candidates for grid-scale energy ***,their widespread commercial application is largely plagued by three major challenges:The uncontrollable Zn dendrites,notorious parasitic side reactions,and sluggish Zn^(2+) ion *** address these issues,we design a sustainable dual crosslinked cellulose hydrogel electrolyte,which has excellent mechanical strength to inhibit dendrite formation,high Zn^(2+) ions binding capacity to suppress side reaction,and abundant porous structure to facilitate Zn^(2+) ions ***,the Zn||Zn cell with the hydrogel electrolyte can cycle stably for more than 400 h under a high current density of 10 mA cm^(−2).Moreover,the hydrogel electrolyte also enables the Zn||polyaniline cell to achieve high-rate and long-term cycling performance(>2000 cycles at 2000 mA g^(−1)).Remarkably,the hydrogel electrolyte is easily accessible and biodegradable,making the ARZBs attractive in terms of scalability and sustainability.

关键词： Cellulose Dual cross-linked Aqueous rechargeable Zn-metal batteries Hydrogel electrolyte

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Research of simulation and experiment on arc characteristics of gas mechanical switch

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High Voltage 2024年第3期9卷 626-635页

作者： Cheng Jiang Lu Qu Zhangqing Yu Zhizheng gan Xin yan Rong Zeng Yulong Huang Shaofu Li Department of Electrical Engineering Tsinghua UniversityBeijingChina School of Information Engineering Southwest University of Science and TechnologyMianyangChina Sichuan Energy Internet Research Institute Tsinghua UniversityChengduChina

An arc is the high-temperature discharge plasma produced in the opening process of mechanical switches,which directly affects the breaking capability of a hybrid DC circuit *** to the physical mechanism of an electric arc,the construction of an arc model for simulation analysis is an important technical means in the electrical *** this study,based on the theory of magneto hydrodynamics(MHD),a gas mechanical switch model of a natural commutation DC circuit breaker with a compound gap is *** arc motion process under different conditions is simulated and *** influence of different initial pressures,different opening speeds,and different striking currents on the arc voltage characteristics is *** results show that the larger the gas pressure,the smaller the arc volume and the higher the arc *** faster the opening speed,the longer the arc and the higher the arc voltage;with the increase of the current,the arc voltage increases rapidly at a low current,while the arc voltage increases slowly at a high current.

关键词： characteristics striking slowly

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Predictive value of angiopoietin-like protein 8 in metabolic dysfunction-associated fatty liver disease and its progression:A case-control study

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World Journal of Diabetes 2024年第3期15卷 418-428页

作者： Lu-Lu gan Can Xia Xuan Zhu Yue Gao Wen-chang Wu Qi Li Ling Li Zhe Dai Yi-Min yan Medical College Wuhan University of Science and TechnologyWuhan 430071Hubei ProvinceChina Department of Endocrinology Xiaogan Hospital Affiliated with Wuhan University of Science and TechnologyThe Central Hospital of XiaoganXiaogan 432000Hubei ProvinceChina Department of Endocrinology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND The prevalence of metabolic dysfunction-associated fatty liver disease(MAFLD)is rapidly increasing,currently affecting approximately 25%of the global *** fibrosis represents a crucial stage in the development of MAFLD,with advanced liver fibrosis elevating the risks of cirrhosis and hepatocellular *** serum markers are less effective in diagnosing liver fibrosis compared to more complex ***,imaging techniques like transient elastography face limitations in clinical application due to equipment and technical ***,it is imperative to identify a straightforward yet effective method for assessing MAFLD-associated liver *** To investigate the predictive value of angiopoietin-like protein 8(ANGPTL8)in MAFLD and its *** We analyzed 160 patients who underwent abdominal ultrasonography in the Endocrinology Department,Xiaogan Central Hospital affiliated to Wuhan University of Science and Technology,during September 2021-July *** abdominal ultrasonography and MAFLD diagnostic criteria,among the 160 patients,80 patients(50%)were diagnosed with *** MAFLD group was divided into the liver fibrosis group(n=23)and non-liver fibrosis group(n=57)by using a cut-off fibrosis-4 index≥*** regression was used to analyze the risk of MAFLD and the risk factors for its *** operating characteristic curves were used to evaluate the predictive value of serum ANGPTL8 in MAFLD and its *** Compared with non-MAFLD patients,MAFLD patients had higher serum ANGPTL8 and triglyceride-glucose(TyG)index(both P<0.05).Serum ANGPTL8(r=0.576,P<0.001)and TyG index(r=0.473,P<0.001)were positively correlated with *** ANGPTL8 was a risk factor for MAFLD[odds ratio(OR):1.123,95%confidence interval(CI):1.066-1.184,P<0.001).Serum ANGPTL8 and ANGPTL8+TyG index predicted MAFLD[area under the curve(AUC):0.832 and 0.886,respectively;both P<0.05].Compared with MAFL

关键词： Angiopoietin-like protein 8 Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index Liver fibrosis

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Network Meta-analysis of the Clinical Efficacy and Safety of Kidney-Tonifying and Bone-Strengthening Therapies for the Treatment of Rheumatoid Arthritis with Kidney Deficiency Type

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Journal of Traditional Chinese Medicine 2024年

作者： gan chang TAO Qingwen YI Haoying BIAN Yuting WANG Jianming School of Traditional Chinese Medicine， Beijing University of Chinese Medicine Department of Traditional Chinese Medicine Rheumatology， China-Japan Friendship Hospital Beijing Key Lab for Immune-Mediated Inflammatory Diseases， China-Japan Friendship Hospital

OBJECTIVE: To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).METHODS: The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were ***: A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction (顽痹汤); Bushen Quhan Zhiwang decoction (补肾祛寒治尪汤) was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid (七味通痹口服液) effectively reduced C-reactive protein and erythrocyte sedimentation rate ***: Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments， reduce inflammatory indexes， and result in a higher safety profile. However， this conclusion needs to be verified by more high-quality randomized controlled trials.

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Elaborating strengthen mechanism of Pt-Ir solid solution superalloy at finite temperature

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Rare Metals 2024年第3期43卷 1243-1256页

作者： Wei Yu Xiao-Yu Chong Yun-Xuan Zhou Meng-Di gan Ying-Xue Liang yan Wei Ai-Min Zhang chang-Yi Hu Xing-Yu Gao Li Chen Hai-Feng Song Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Precious Metals Laboratory Co.LTD Kunming650106China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing100088China

Pt-Ir alloy is potential superalloys used above 1300℃because of their high strength and creep ***,the ductility of Pt-Ir alloy has rapidly deteriorated with the increase of Ir,resulting in poor *** work quantitatively evaluated the solid solution strengthening(SSS)and grain refinement strengthening(GRS)of Pt-Ir alloy using first-principles calculations combined with experimental ***,the stretching force constants in the second nearest neighbor region(SFC^(2nd))of pure Ir(193.7 eV·nm^(-2))are 3.40 times that of pure Pt(57.0 eV·nm^(-2)),i.e.,the interatomic interaction is greatly enhanced with the increase of Ir content,which leads to the decrease of ductility,and modulus misfit plays a dominant role in ***,the physical mechanisms responsible for the hardness(H_(V))of Pt-Ir alloy,using the power-law-scaled function of electron work function coupled SSS and GRS,are attributed to the electron redistribution caused by different Ir ***,a thorough assessment of the thermodynamic characteristics of Pt-Ir binary alloy was conducted,culminating in development of a mapping model that effectively relates enmposition,temperature and *** results revealed that the compressive strength incrcases with the Ir content,and the highest strength was observed in Pt_(0.25)Ir_(0.75).This study provides valuable insights into the Pt-Ir alloy system.

关键词： Elastic properties Phonon Solid solution strengthen Force constants CALPHAD

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Effect of Oxygen-Rich Combustion on Flame Propagation of Syngas in a Half-Open Pipe at Elevated Temperatures

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Journal of Thermal Science 2024年第5期33卷 1920-1934页

作者： LI Ningning DENG Haoxin XU Zhuangzhuang yan Mengmeng WEI Shengnan SUN Guangzhen WEN Xiaoping gan Haowen WANG Fahui School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454003China

The investigation of syngas flame propagation has great benefits for the effective use of gas *** essay sets out to study the flame propagation of premixed oxygen-rich combustion(oxygen enrichment coefficient in volumeΩ:0.21,0.27,0.32,0.37)of syngas(H_(2):CO=2:8)in half-closed rectangular ducts at elevated temperatures(T:300 K,400 K,500 K)and evaluate the effects of initial temperature and oxygen enrichment coefficient on the LBV from sensitivity analysis and kinetic *** paper presents the effect of the expansion effect on laminar burning velocity for the first time,and separates the effect of the expansion effect on laminar burning velocity by a new *** shows that as the initial temperature goes up,the faster the exponential growth phase of the flame front velocity,the slower the slow growth *** smaller and earlier the maximum flame front velocity arrives,the slower the average flame speed *** the oxygen enrichment coefficient goes up,the peak value of the flame front velocity gradually ***-rich combustion and increasing initial temperature inhibit flame propagation in a half-open tube,but promote laminar burning velocity,which increases the key chemical bond and adiabatic flame *** net reaction rate shows that oxygen-rich combustion mainly promotes the combustion reaction of H_(2)(R2).However,increasing the initial temperature mainly promoted the oxidation of CO(R29).Analysis of the reaction path showed that oxygen-rich combustion and increased initial temperature promoted the reaction of H_(2)and CO with key chemical bonds,increased OH concentration,and inhibited OH cracking reaction.

关键词： gas turbines oxyfuel combustion numerical simulation combustion kinetics fire and flame

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Preoperative blood markers and intra-abdominal infection after colorectal cancer resection

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 451-462页

作者： chang-Qing Liu Zhong-Bei Yu Jin-Xian gan Tian-Ming Mei Department of Gastrointestinal Anorectal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)has one of the highest morbidity and mortality rates among digestive tract ***-abdominal infection(IAI)is a common postoperative complication that affects the clinical outcomes of patients with CRC and hinders their rehabilitation ***,the factors influencing abdominal infection after CRC surgery remain unclear;further,prediction models are rarely used to analyze preoperative laboratory indicators and postoperative *** To explore the predictive value of preoperative blood markers for IAI after radical resection of *** The data of 80 patients who underwent radical resection of CRC in the Anorectal Surgery Department of Suzhou Hospital affiliated with Anhui Medical University were *** patients were categorized into IAI(n=15)and non-IAI groups(n=65)based on whether IAI *** factors were compared;general data and laboratory indices of both groups were *** relationship between the indicators was ***,a nomogram prediction model was developed and evaluated;its utility and clinical applic-ability were *** The risk factors for IAI after radical resection of CRC were neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),systemic immune-inflammation index(SII),and carcinoembryonic antigen(CEA)*** was correlated with PLR and SII(r=0.604,0.925,and 0.305,respectively),while PLR was correlated with SII(r=0.787).The nomogram prediction model demonstrated an area under the curve of 0.968[95%confidence interval(CI):0.948-0.988]in the training set(n=60)and 0.926(95%CI:0.906-0.980)in the validation set(n=20).The average absolute errors of the calibration curves for the training and validation sets were 0.032 and 0.048,respectively,indicating a good model *** decision curve analysis curves demonstrated high net income above the 5%threshold,indicating the clinical practicality of the *** The nomogram model constructed

关键词： Radical resection of colorectal cancer Inflammatory factors Intra-abdominal infection Predictive model Blood markers

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Comprehensive prognostic and immune analysis of sterol Oacyltransferase 1 in patients with hepatocellular carcinoma

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World Journal of Hepatology 2024年第3期16卷 439-451页

作者： chang-Jiao gan Yue Zheng Bin yang Li-Min Cao Development Research Department National Medical Products Administration Institute of Executive DevelopmentBeijing 100071China School of Medicine Nankai University Affiliated Third Center HospitalTianjin 300070China Tianjin Institute of Hepatobiliary Disease The Third Central Hospital of TianjinTianjin 300170China Department of Science and Technology Tianjin Third Central HospitalTianjin 300170China

BACKGROUND Sterol O-acyltransferase 1(SOAT1)is an important target in the diagnosis and treatment of liver ***,the prognostic value of SOAT1 in patients with hepatocellular carcinoma(HCC)is still not *** To investigate the correlation of SOAT1 expression with HCC,using RNA-seq and gene expression data of The Cancer Genome Atlas(TCGA)-liver hepatocellular carcinoma(LIHC)and *** The correlation between SOAT1 expression and HCC was *** hazard regression models were conducted to investigate the prognostic value of SOAT1 in *** survival and disease-specific survival were explored based on TCGA-LIHC *** processes and functional pathways mediated by SOAT1 were characterized by gene ontology(GO)analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of differentially expressed *** addition,the protein-protein interaction network and co-expression analyses of SOAT1 in HCC were performed to better understand the regulatory mechanisms of SOAT1 in this *** SOAT1 and SOAT2 were highly expressed in unpaired samples,while only SOAT1 was highly expressed in paired *** area under the receiver operating characteristic curve of SOAT1 expression in tumor samples from LIHC patients compared with para-carcinoma tissues was 0.748,while the area under the curve of SOAT1 expression in tumor samples from LIHC patients compared with GTEx was *** with higher SOAT1 expression had lower survival *** from GO/KEGG and gene set enrichment analyses suggested that the PI3K/AKT signaling pathway,the IL-18 signaling pathway,the calcium signaling pathway,secreted factors,the Wnt signaling pathway,the Jak/STAT signaling pathway,the MAPK family signaling pathway,and cell–cell communication were involved in such ***1 expression was positively associated with the abundance of macrophages,Th2 cells,T helper cells,CD56bright natural killer cells,and Th1 cells,and negatively

关键词： Sterol O-acyltransferase 1 Hepatocellular carcinoma Prognostic Immune

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A buffer overflow detection and defense method based on RiSC-V instruction set extension

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Cybersecurity 2024年第2期7卷 28-43页

作者： chang Liu yan-Jun Wu Jing-Zheng Wu Chen Zhao Intelligent Software Research Center Institute of SoftwareChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijingChina

Buffer overflow poses a serious threat to the memory security of modern operating *** overwrites the con-tents of other memory areas by breaking through the buffer capacity limit,destroys the system execution environ-ment,and provides implementation space for various system attacks such as program control flow *** makes it a wide range of harms.A variety of security technologies have been proposed to deal with system security problems including buffer *** example,No eXecute(NX for short)is a memory management technology commonly used in Harvard *** can refuse the execution of code which residing in a specific memory,and can effectively suppress the abnormal impact of buffer overflow on control ***,in recent years,it has also been used in the field of system security,deriving a series of solutions based on NX technology,such as ExecShield,DEP,StackGuard,***,these security solutions often rely too much on the processor archi-tecture so that the protection coverage is insufficient and the accuracy is *** in the emerging system architecture field represented by RiSC-V,there is still a lack of effective solutions for buffer overflow *** the continuous rapid development of the system architecture,it is urgent to develop defense methods that are applicable to different system application environments and oriented to all executable memory spaces to meet the needs of system security ***,we propose BOP,A new system memory security design method based on RISC-V extended instructions,to build a RISC-V buffer overflow detection and defense system and deal with the buffer overflow threat in *** to this method,NX technology can be combined with program control flow analysis,and Nx bit mechanism can be used to manage the executability of memory space,so as to achieve a more granular detection and defense of buffer overflow attacks that may occur in RISC-V system

关键词： RISc-V Operating system security Buffer overflow Control flow hijacking Nx bit Xibop

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