检索结果-南通市图书馆

A novel deep quality-supervised regularized autoencoder model for quality-relevant fault detection

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第5期65卷 280-282页

作者： Zhichao LI Li TIAN xuefeng yan Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and Technology

Dear editor,In the industrial processes, timely detection of key quality variables is very important for tracking the product quality, monitoring the process status, and achieving stable and reliable control. However,... 详细信息

关键词： supervised learning deep learning regularized autoencoder process monitoring quality-relevant fault detection

Bidirectional Feedback Dynamic Particle Filter with Big Data for the Particle Degeneracy Problem

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2018年第4期23卷 463-478页

作者： xuefeng yan Xiangwen Feng Chengbo Song Xiaolin Hu College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Department of Computer Science Georgia State University

Particle Filter （PF） is a data assimilation method to solve recursive state estimation problem which does not depend on the assumption of Gaussian noise, and is able to be applied for various systems even with non-linear and non-Gaussian noise. However, while applying PF in dynamic systems, PF undergoes particle degeneracy, sample impoverishment, and problems of high computational complexity. Rapidly developing sensing technologies are providing highly convenient availability of real-time big traffic data from the system under study like never before. Moreover, some sensors can even receive control commands to adjust their monitoring parameters. To address these problems, a bidirectional dynamic data-driven improvement framework for PF （B3DPF） is proposed. The B3DPF enhances feedback between the simulation model and the big traffic data collected by the sensors, which means the execution strategies （sensor data management, parameters used in the weight computation, resampling） of B3DPF can be optimized based on the simulation results and the types and dimensions of traffic data injected into B3DPF can be adjusted dynamically. The first experiment indicates that the B3DPF overcomes particle degeneracy and sample impoverishment problems and accurately estimates the state at a faster speed than the normal PF. More importantly, the new method has higher accuracy for multidimensional random systems. In the rest of experiments, the proposed framework is applied to estimate the traffic state on a real road network and obtains satisfactory results. More experiments can be designed to validate the universal properties of B3DPF.

关键词： big traffic data dynamic particle filter particle degeneracy particle impoverishment Dynamic Data-Driven Application System (DDDAS)

Zoning search using a hyper-heuristic algorithm

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2019年第9期62卷 193-195页

作者： Qinqin FAN Ning LI Yilian ZHANG xuefeng yan Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai Jiao Tong University Logistics Research Center Shanghai Maritime University Key Laboratory of Marine Technology and Control Engineering Ministry of CommunicationsShanghai Maritime University Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and Technology

Dear editor,With the development of high-performance computing techniques, run time of meta-heuristic algorithms can be reduced effectively. However, improved computation power has not been indirectly converted into search capability in most of previous studies [1]. Moreover, the solution precision of an optimization problem is directly determined

关键词： pro CEC Zoning search using a hyper-heuristic algorithm

EBV miR-BART17-3p对原发免疫性血小板减少症患儿Treg/Th17平衡的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国药业 2024年第18期33卷 51-57页

作者：张雅丽闫雪峰冯茹清河北省张家口市妇幼保健院河北张家口075000

目的探讨EBV mi R-BART17-3p影响原发免疫性血小板减少症(ITP)患儿Treg/Th17平衡的机制。方法收集ITP患儿(ITP组,20例)和健康儿童(对照组,20例)外周血并分离CD_(4)^(+)T细胞。采用实时荧光定量聚合酶链式反应法、Western blot法、酶联... 详细信息

目的探讨EBV mi R-BART17-3p影响原发免疫性血小板减少症(ITP)患儿Treg/Th17平衡的机制。方法收集ITP患儿(ITP组,20例)和健康儿童(对照组,20例)外周血并分离CD_(4)^(+)T细胞。采用实时荧光定量聚合酶链式反应法、Western blot法、酶联免疫吸附法检测EBV mi R-BART17-3p、T细胞免疫球蛋白黏蛋白3(Tim-3)、叉头框蛋白P3(Fox P3)、白细胞介素17A(IL-17A)和转化生长因子-β(TGF-β)的m RNA、蛋白表达水平及含量。采用双荧光素酶报告基因实验考察EBV mi R-BART17-3p对Tim-3表达水平的影响。将15只BALB/C小鼠随机分为空白对照组、模型组、观察组,各5只。腹腔注射抗血小板抗体MWReg30以复制ITP小鼠模型,建模4 d后观察组小鼠予尾静脉注射携带EBV mi R-BART17-3p inhibitor的腺病毒载体。细胞染色并观察形态,检测外周血中TGF-β、IL-17A含量及血小板计数,采用流式细胞仪分别检测CD_(4)^(+)T细胞中Th17和Treg水平,并计算二者百分比。结果与对照组比较,ITP组患儿外周血EBV mi R-BART17-3p表达水平显著升高,Tim-3和TGF-βm RNA表达水平显著降低(P<0.05);Tim-3 m RNA表达水平与EBV mi R-BART17-3p表达水平呈显著负相关(r=-0.732,P<0.001)。Tim-3慢病毒载体p LKO.1-sh-Tim-3(sh-Tim-3)可显著降低Tim-3、Fox P3、TGF-β水平(P<0.05)。mi R-BART17-3p mimic显著升高了CD_(4)^(+)T细胞中mi R-BART17-3p的表达水平,并显著降低了Tim-3、Fox P3、TGF-βm RNA和蛋白表达水平(P<0.05);mi R-BART17-3p mimic可显著降低TGF-β含量,Tim-3+mi R-BART17-3p过表达逆转了mi R-BART17-3p mimic对TGF-β的抑制作用。动物实验结果显示,沉默EBV mi R-BART17-3p可促进Treg分化,减少脾脏和骨髓组织中的巨核细胞计数,并显著增加外周血中血小板计数。结论EBV mi R-BART17-3p可通过Fox P3/Tim-3途径调节ITP患儿Treg/Th17的免疫失衡。

关键词： EBV mi R-BART17-3p T细胞免疫球蛋白黏蛋白3 叉头框蛋白P3 辅助性T细胞17 原发性血小板减少症

重组促红细胞生成素联合布地奈德对早产儿BPD动脉血气指标、炎性反应的影响

在线全文

学校读者我要写书评

暂无评论

河北医药 2024年第8期46卷 1221-1223,1227页

作者：闫雪峰王晓娇冶斐然河北省张家口市妇幼保健院新生儿科 075000

目的研究重组促红细胞生成素结合布地奈德对早产儿支气管肺发育不良(BPD)动脉血气指标、炎性反应、呼吸机应用及吸氧时间的影响。方法选取2021年11月至2022年10月治疗的116例早产儿,根据信封法把患儿分为观察组与对照组,对照组57例给予... 详细信息

目的研究重组促红细胞生成素结合布地奈德对早产儿支气管肺发育不良(BPD)动脉血气指标、炎性反应、呼吸机应用及吸氧时间的影响。方法选取2021年11月至2022年10月治疗的116例早产儿,根据信封法把患儿分为观察组与对照组,对照组57例给予布地奈德进行治疗,观察组59例给予重组促红细胞生成素联合布地奈德进行治疗。比较2组患儿动脉血气指标、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)等炎性因子以及撤机时间、有创通气时间、住院时间、总吸氧时间,统计并发症发生情况。结果治疗前2组氧分压(PO_(2))、二氧化碳分压(PCO_(2))、IL-8、TNF-α、IL-4水平、治疗后颅内出血、早产儿视网膜病、感染比例比较,差异无统计学意义(P>0.05);2组治疗后PO_(2)高于治疗前且观察组患儿更高(P<0.05),治疗后2组患儿TNF-α、PCO_(2)、IL-8以及IL-4较治疗前下降且观察组更低(P<0.05);观察组患儿总吸氧时间、有创通气时间、住院时间及撤机时间较比照组短(P<0.05);治疗后观察组患儿早产儿贫血及BPD发生比例较对照组低(P<0.05)。结论重组促红细胞生成素联合布地奈德可显著改善早产儿氧合,降低炎性反应,明显缩短吸氧时间及呼吸机使用时间,降低早产儿BPD发生率。

关键词：重组促红细胞生成素布地奈德早产儿支气管肺发育不良动脉血气指标炎症反应

人重组促红细胞生成素联合布地奈德对支气管肺发育不良早产儿炎性因子及肺功能的影响

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

河北医药 2024年第2期46卷 235-238页

作者：王晓娇闫雪峰冶斐然河北省张家口市妇幼保健院新生儿科 075000

目的探讨人重组促红细胞生成素联合布地奈德对支气管肺发育不良早产儿炎性因子及肺功能改善的影响。方法选择2021年11月至2022年10月收治116例支气管肺发育不良早产儿,随机数字表法为对照组和观察组,每组58例,对照组给予布地奈德治疗,... 详细信息

目的探讨人重组促红细胞生成素联合布地奈德对支气管肺发育不良早产儿炎性因子及肺功能改善的影响。方法选择2021年11月至2022年10月收治116例支气管肺发育不良早产儿,随机数字表法为对照组和观察组,每组58例,对照组给予布地奈德治疗,观察组在此基础上再给予人重组促红细胞生成素治疗,比较治疗前后2组炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]情况;比较治疗前后2组肺功能[吸频率(RR)、吸气峰压(PIP)、潮气量(VT)]情况;比较治疗前后2组血气指标[氧分压(PO_(2))、氧饱和度(SpO_(2))及二氧化碳分压(PCO_(2))]变化情况;观察2组疗效况及并发症情况。结果治疗前,2组血清TNF-α、IL-6、IL-8水平比较,差异无统计学意义(P>0.05);治疗后,2组血清TNF-α、IL-6、IL-8水平降低,观察组更明显(P0.05);治疗后,2组RR、PIP、VT指标明显改善,观察组更明显(P0.05);治疗后,2组PO_(2)、SpO_(2)、PCO_(2)指标明显改善,观察组更明显(P<0.05);观察组疗效优于对照组,并发症发生率低于对照组(P<0.05)。结论对支气管肺发育不良早产儿给予人重组促红细胞生成素联合布地奈德治疗,可改善其气血指标,减低炎症水平,改善肺功能。

关键词：人重组促红细胞生成素布地奈德支气管肺发育不良早产儿炎症因子肺功能

Statistical Monitoring of Chemical Processes Based on Sensitive Kernel Principal Components

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2013年第6期21卷 633-643页

作者： JIANG Qingchao yan xuefeng Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education EastChina University of Science and Technology Shanghai 200237 China

The kernel principal component analysis （KPCA） method employs the first several kernel principal components （KPCs）, which indicate the most variance information of normal observations for process monitoring, but may not reflect the fault information. In this study, sensitive kernel principal component analysis （SKPCA） is proposed to improve process monitoring performance, i.e., to deal with the discordance of T2 statistic and squared prediction error SVE statistic and reduce missed detection rates. T2 statistic can be used to measure the variation di rectly along each KPC and analyze the detection performance as well as capture the most useful information in a process. With the calculation of the change rate of T2 statistic along each KPC, SKPCA selects the sensitive kernel principal components for process monitoring. A simulated simple system and Tennessee Eastman process are employed to demonstrate the efficiency of SKPCA on online monitoring. The results indicate that the monitoring performance is improved significantly.

关键词： statistical process monitoring kernel principal component analysis sensitive kernel principal compo-nent Tennessee Eastman process

Nanomaterial-based strategies in antimicrobial applications:Progress and perspectives

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第12期14卷 4417-4441页

作者： Yi Zhao Long Chen yanan Wang Xinyu Song Keyang Li xuefeng yan Liangmin Yu Zhiyu He Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao266100China Department of Orthopedics Guizhou Provincial People’s HospitalGuiyang550000China

The dramatic increase of microbial resistances against conventional available antibiotics is a huge challenge to the effective treatment of infectious disease and thus becoming a daunting global threat of major concern,which necessitates the development of innovative ***-based antimicrobial strategies have emerged as novel and promising tools to combat lethal bacteria and recalcitrant biofilm,featuring the abilities to evade existing drug resistance-related *** this review,recent advances in“state-of-the-art”nanosystems which acting either as inherent therapeutics or nanocarriers for the precise delivery of antibiotics,are comprehensively *** nanosystems can effectively accumulate at the infectious sites,achieve multifunctional synergistic antibacterial efficacy,and provide controlled release of antibiotics in response to endogenous or exogenous stimulus(e.g.,low pH,enzymes,or illumination).Especially,the nanoplatform that integrated with photothermal/photodynamic therapy(PTT/PDT)can enhance the bacterial destruction and biofilm penetration or *** addition,nanoparticle-based approaches with enzymatically promoting bacterial killing,anti-virulence,and other mechanisms were also ***,this review provides crucial insights into the recent progress and remaining limitations of various antimicrobial nanotherapeutic strategies,and enlightens the further developments in this field simultaneously,which eventually benefiting public health.

关键词： multi-drug resistance bacteria nanoparticles anti-biofilm antibiotic delivery photothermal/photodynamic therapy

Research on the Marine Antifouling Ability and Mechanism of Acrylate Copolymers and Marine Coatings Based on a Synergistic Effect

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2023年第3期22卷 717-727页

作者： ZHOU Wenjun ZHOU Yu NI Chunhua YU Liangmin YUAN Zhengjun LI Changcheng yan xuefeng Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Sanya Oceanographic Institution Ocean University of ChinaSanya 572024China

Marine biofouling is an urgent global problem in the process of ocean exploitation and *** our work,a series of zinc-based acrylate copolymers(ACZn-x)were designed and synthesized using benzoic acid,zinc oxide(ZnO)and a random quaternion copolymer consisting of ethyl acrylate(EA),butyl acrylate(BA),acrylic acid(AA)and methacrylic acid(MAA)by free radical polymerization and dehydration *** ACZn-x with a zinc benzoate side chain is able to hydrolyze in natural seawater under static conditions,resulting in the formation of a smooth *** investigated and confirmed the antifouling(AF)behavior of ACZn-x in the laboratory and revealed that they have better antibacterial(86%for *** and 72%for ***)and anti-algal(≥60.1%for *** and≥67.5%for ***)*** also assessed the marine AF properties of ACZn-x and corresponding coatings in Qingdao,China;the ACZn-x exhibited ideal AF properties with little silt and biological mucosa adhered to the ACZn-x surface after 6 months,and corresponding coatings exhibited little biofouling after 16 months in the ***,possible AF mechanisms were further proposed at the cellular *** results could be helpful for the development and application of effective AF coatings.

关键词： zinc-based acrylate copolymer self-polishing marine antifouling mechanism