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Methodology of the Global Adult Tobacco Survey in China, 2010

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Biomedical and Environmental Sciences 2010年第6期23卷 445-450页

作者： JASON HSIA GONG-HUAN yanG QIANG LI LIN XIAO VAN yanG yan-WEI wo SAMIRAASMA Office On Smoking And Health Centers For Disease Control And Prevention Atlanta Ga USA National Tobacco Control Office Chinese Center For Disease Control And Prevention Beijing 100050 China University Of Waterloo Waterloo Ontario Canada world Health Organization Country Office Beijing China

INTRODUCTION The Global Adult Tobacco Survey （GATS） is a component of Global Tobacco Surveillance System （GTSS） under auspices of the Bloomberg philanthropy and the Bill and Melinda Gates Foundation. GATS is a household survey with a standard protocol and its goals are to measure tobacco use, to assess changes due to policy and to facilitate cross country comparison. China is the largest consumer and producer of tobacco in the world. China was selected as one of 14 countries of high burden of tobacco use, large population, and mostly low income, to conduct the GATS.

关键词： GATS Methodology of the Global Adult Tobacco Survey in China 2010

Downregulated cytotoxic CD8^(+)T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids

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Cellular & Molecular Immunology 2022年第4期19卷 527-539页

作者： Heng Xu Zhu Zhu Jian Hu Jiawei Sun yan wo Xianshu Wang Hongzhi Zou Bin Li Yixin Zhang Department of Plastic and Reconstructive Surgery Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Biostatistics Epidemiology and InformaticsUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Genekinder Medicaltech(Shanghai)Co. LtdShanghaiChina Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghaiChina Creative Biosciences(Guangzhou)Co. Ltd.GuangzhouGuangdongChina Department of Colorectal Surgery Guangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-Sen UniversityGuangdongChina Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghaiChina

Keloids are an abnormal fibroproliferative wound-healing disease with a poorly understood pathogenesis,making it difficult to predict and prevent this disease in clinical *** disease-specific signatures at the molecular and cellular levels in both the blood circulation and primary lesions is urgently needed to develop novel biomarkers for risk assessment and therapeutic targets for recurrence-free *** is mounting evidence of immune cell dysregulation in keloid *** this study,we aimed to profile keloid scar tissues and blood cells and found that downregulation of cytotoxic CD8^(+)T cells is a keloid signature in the peripheral blood and keloid ***-cell RNA sequencing revealed that the NKG2A/CD94 complex was specifically upregulated,which might contribute to the significant reduction in CTLs within the scar tissue *** addition,the NKG2A/CD94 complex was associated with high serum levels of soluble human leukocyte antigen-E(sHLA-E).We subsequently measured sHLA-E in our hospital-based study cohort,consisting of 104 keloid patients,512 healthy donors,and 100 patients with an interfering *** sensitivity and specificity of sHLA-E were 83.69%(87/104)and 92.16%(564/612),respectively,and hypertrophic scars and other unrelated diseases exhibited minimal interference with the test ***,intralesional therapy with triamcinolone combined with 5-fluorouracil drastically decreased the sHLA-E levels in keloid patients with better prognostic outcomes,while an incomplete reduction in the sHLA-E levels in patient serum was associated with higher ***-E may effectively serve as a diagnostic marker for assessing the risk of keloid formation and a prognostic marker for the clinical outcomes of intralesional treatment.

关键词： Keloid Biomarker T cell immunology

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一种基于图的彩色图像分割算法

华南理工大学学报（自然科学版） 2016年第9期44卷 1-8页

作者：沃焱金璇华南理工大学计算机科学与工程学院广东广州510006

为了解决图像分割中容易出现的过分割问题,提出了一种基于图的彩色图像分割算法.该算法在区域合并的基础上,首先用Mean shift方法进行预处理,得到初始过分割区域后对其构造邻接图,然后计算邻接区域的颜色、纹理及边缘特征相似性以判断... 详细信息

为了解决图像分割中容易出现的过分割问题,提出了一种基于图的彩色图像分割算法.该算法在区域合并的基础上,首先用Mean shift方法进行预处理,得到初始过分割区域后对其构造邻接图,然后计算邻接区域的颜色、纹理及边缘特征相似性以判断区域是否需要合并直到所有满足条件的区域都被合并.为了保持图像的全局属性,文中通过查找最优合并成本的方式进行区域合并.实验结果表明:即使在图像目标和背景区域颜色比较相似时,文中算法也能较好地实现对目标区域的完整分割;与其他4种算法相比,文中算法具有更好的分割性能.

关键词：图像分割 Gabor滤波器纹理边缘区域相似性

Vascularized lymph node flaps can survive on venous blood without an arterial inflow:an experimental model describing the dynamics of venous flow using indocyanine green angiography(With video)

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Burns & Trauma 2023年第1期11卷 470-478页

作者： Ke Li Fabio Nicoli Chunxiao Cui yan wo Ning Fei Liu Shaoqing Feng Wenjing Xi Peiru Min Yixin Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200000China Translational and Clinical Research Institute Newcastle UniversityNewcastle upon Tyne NE11ADUK Department of Plastic and Reconstructive Surgery University of Rome“Tor Vergata”999016Italy Department of Plastic and Reconstructive Surgery Northumbria NHS TrustNewcastle upon Tyne NE11ADUK Department of Facial Plastic and Reconstructive Surgery ENT InstituteEye and ENT HospitalFudan UniversityShanghai 200000China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200000P.R.China

Background:Several surgeons have described studies of free-tissue transfers using veins instead of *** innovative microsurgical techniques can offer several advantages,such as an easier dissection during flap harvesting,and represent an alternative during an accidental surgical mistake or development of new surgical *** purpose of this study was to describe and explore different constructs of vascularized lymph node transfer(VLNT)only based on venous blood flow in a mouse model,evaluate their blood flow microcirculation through indocyanine green(ICG)angiography and investigate the lymphatic drainage function and the lymph nodes’***:Five types of venous lymph node flaps(LNF)were created and investigated:Types IA,IB,IC,IIA and IIB were developed by ICG intraoperatively(with videos in the article).Seven weeks later,by applying methylene blue,the recanalization of the lymphatic vessels between the LNF and the recipient site was *** nodes were collected at the same time and their structures were analyzed by hematoxylin and eosin staining ***:All of the venous LNFs developed except Type *** weeks later,methylene blue flowed into Types IA,IB,IIA and IIB from recipient *** comparing with arteriovenous lymph node,the medullary sinus was diffusely distributed in venous lymph *** proportion of cells was significantly reduced(p<0.05).The artery diameters were significantly smaller(p<0.05).The veins diameters and lymphatic vessels output in Types IA,IB,IIA and IIB were more dilated(p<0.05).Conclusions:This research demonstrated that Type IA,IB,IIA and IIB venous LNFs can retrogradely receive venous blood supply;they can survive,produce a lymphatic recanalization and integrate with the surrounding tissue,despite lymph node structural *** results will improve the understanding of the survival mechanism of venous LNFs and will help researchers to design new studies or lymphatic models and eventua

关键词： Vein circulation Venous Lymph node Flap Vascularized lymph node flap Lymphedema Indocyanine green

In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window

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Nano Research 2019年第12期12卷 3059-3068页

作者： Zhujun Feng Yimeng yang Jian Zhang Kan Wang Yunxia Li Heng Xu Zhen Wang Ewelina Biskup Shixian Dong Xing yang Yuefeng Hao Jun Chen yan wo Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Sports Medicine Institute ofFudan University Department of Orthopedic Sports MedicineHuashan HospitalFudan UniversityShanghaiChina Department of Instrument Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao long UniversityShanghai Engineering Research Center for Intelligent diagnosis and treatment instrumentKey Laboratory of Thin Film and Microfabrication(Ministry of Education)Shanghai 200240China Department of Plastic Surgery Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department cf physical education Fudan UniversityShanghai 200040China Department of Internal Medicine University Hospital of BaselPetersgraben 44051 BaselSwitzerland Department of orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China

The peripheral nervous system(PNS)is essential for performing and maintaining various motor and sensory *** can lead to a series of peripheral neurological conditions,such as paraesthesia,pain,or spasms,which are debilitating and lowering the quality of *** guidelines for diagnosis rely predominantly on clinical symptoms resulting from PNS dysfunction,which occur already at an *** are currently no effective methods that visually reflect the extent of peripheral *** our study,we present a novel in vivoand in situ real-time imaging of peripheral nerves based on the second near-infrared window(NIR-II)fluoresce *** NIR-II system,lead sulfidequa ntum dots(PbS Qds)with NIR-II fluoresce nee specifically bound to motor neuro rvspecific protein agrin,acting as image con *** micemodel,peripheral nerves were visible as soon as after 2 h post *** provide evidenee for the efficacy of this approach,which allows todirectly dem on strate peripheral nerves,their structure,and pote ntial damagesites and ***,our products were of goodbiocompatibility,while the n eural fluoresce nee signal was solid,bright and stable for 4 h in ***,overall,our results suggest that NIR-II isan effective new method for direct imaging of peripheral nerves in vivo,opening new horizons on early,improved and more precise,targeteddiag no sis.A resulti ng more rapid installatio n of perso nalized therapy facilitates a better prognosis of clinical peripheral neuropathy.

关键词： peripheral nerve the second near-infrared window(NIR-II) fluorescent imaging Agrin@PbS Qds biocompatibility

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精确的快速极坐标谐波变换

华南理工大学学报（自然科学版） 2012年第4期40卷 23-29页

作者：沃焱徐角华南理工大学计算机科学与工程学院广东广州510006

将极坐标下计算Zernike矩的方法推广到笛卡尔坐标下PHT矩的计算中.对极坐标进行设计和规划,以消除笛卡尔坐标下PHT矩计算中存在的几何误差和积分近似误差.在计算PHT内核系数时利用三角函数的对称性和查找表减少三角函数的计算次数,以提... 详细信息

将极坐标下计算Zernike矩的方法推广到笛卡尔坐标下PHT矩的计算中.对极坐标进行设计和规划,以消除笛卡尔坐标下PHT矩计算中存在的几何误差和积分近似误差.在计算PHT内核系数时利用三角函数的对称性和查找表减少三角函数的计算次数,以提高运算速度并消除迭代累计误差.最后通过实验对提出的快速极坐标PHT方法进行验证,并与笛卡尔坐标下的PHT计算方法进行对比,结果表明,极坐标下的快速PHT算法在重建精度、旋转缩放不变性、计算速度等方面都优于笛卡尔坐标下的PHT计算方法.

关键词：极坐标谐波变换正交矩几何不变性

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基于LLE和PSO的快速虹膜图像重构算法

华南理工大学学报（自然科学版） 2018年第1期46卷 97-102页

作者：沃焱吴嘉茜华南理工大学计算机科学与工程学院广东广州510006

虹膜特征码Iriscode具有高效的识别性能,被广泛应用于虹膜识别系统中.随着人们对生物特征安全问题的重视,如何从Iriscode重构虹膜图像以评判虹膜识别系统的安全性已成为一个研究热点.文中对Iriscode重构虹膜图像问题进行了分析,构建了... 详细信息

虹膜特征码Iriscode具有高效的识别性能,被广泛应用于虹膜识别系统中.随着人们对生物特征安全问题的重视,如何从Iriscode重构虹膜图像以评判虹膜识别系统的安全性已成为一个研究热点.文中对Iriscode重构虹膜图像问题进行了分析,构建了虹膜重构优化模型,并提出两阶段的快速虹膜重构算法.将提取Iriscode的过程视为距离保持的降维过程,在第一阶段中根据待测Iriscode的近邻,采用局部线性嵌入算法重构出若干非精确的虹膜重构图像;第二阶段利用粒子群优化算法,将前一阶段获得的非精确虹膜图像作为初始粒子进行迭代搜索,以获得精确结果.实验表明,本算法获得的重构虹膜图像能够通过虹膜识别系统,达到伪造攻击的目的.相比于其他重构算法,在时间及伪造成功率上都有提高.

关键词：虹膜图像重构局部线性嵌入算法粒子群优化算法虹膜特征码

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利用特征显著度提取地形特征线的方法

武汉大学学报（信息科学版） 2018年第3期43卷 342-348页

作者：邹昆沃焱徐翔电子科技大学中山学院计算机学院华南理工大学计算机科学与工程学院

针对现有的地形特征线提取方法不能根据特征强弱对提取结果进行方便的筛选控制的问题,提出了一种基于特征显著度的山脊和山谷线提取方法。首先,对数字高程模型数据进行高斯滤波和下采样;然后,通过全局断面扫描确定特征点,并根据高度、... 详细信息

针对现有的地形特征线提取方法不能根据特征强弱对提取结果进行方便的筛选控制的问题,提出了一种基于特征显著度的山脊和山谷线提取方法。首先,对数字高程模型数据进行高斯滤波和下采样;然后,通过全局断面扫描确定特征点,并根据高度、高度落差和坡度计算特征显著度,在进行特征延伸后构造特征图,利用最小生成树算法得到特征森林;随后进行枝干分解并计算各枝干的特征显著度,根据特征显著度进行枝干裁剪;最后,通过尾钩剔除、位置修正和平滑等后处理得到最终特征线。实验结果表明,该方法能提供给用户方便有效的手段以根据特征显著度对特征进行筛选控制,提取的特征线与实际地形相符,有良好的抗噪能力且能较好地处理平坦地形特征。

关键词：地形特征线山脊线山谷线特征显著度数字高程模型

NIR-II live imaging study on the degradation pattern of collagen in the mouse model

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Regenerative Biomaterials 2023年第1期10卷 271-279页

作者： Huizhu Li Xinxian Meng Huaixuan Sheng Sijia Feng Yuzhou Chen Dandan Sheng Liman Sai Yueming Wang Mo Chen yan wo Shaoqing Feng Hossein Baharvand yanglai Gao Yunxia Li Jun Chen Department of Sports Medicine Sports Medicine Institute of Fudan UniversityHuashan HospitalFudan UniversityShanghai 200040China Department of Plastic and Reconstructive Surgery School of MedicineShanghai Jiao Tong UniversityShanghai Ninth People’s HospitalShanghai 200011China Department of Physics Shanghai Normal UniversityShanghai 200234China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehran ***Iran Department of Developmental Biology School of Basic Sciences and Advanced Technologies in BiologyUniversity of Science and CultureTehran ***Iran Hexi College ZhangyeGansu 73400China

The degradation of collagen in different body parts is a critical point for designing collagen-based biomedical ***,three kinds of collagens labeled by second near-infrared(NIR-II)quantum dots(QDs),including collagen with low crosslinking degree(LC),middle crosslinking degree(MC)and high crosslinking degree(HC),were injected into the subcutaneous tissue,muscle and joints of the mouse model,respectively,in order to investigate the in vivo degradation pattern of collagen by NIR-II live *** results of NIR-II imaging indicated that all tested collagens could be fully degraded after 35 days in the subcutaneous tissue,muscle and joints of the mouse ***,the average degradation rate of subcutaneous tissue(k=0.13)and muscle(k=0.23)was slower than that of the joints(shoulder:k=0.42,knee:k=0.55).Specifically,the degradation rate of HC(k=0.13)was slower than LC(k=0.30)in muscle,while HC showed the fastest degradation rate in the shoulder and knee *** summary,NIR-II imaging could precisely identify the in vivo degradation rate of ***,the degradation rate of collagen was more closely related to the implanted body parts rather than the crosslinking degree of collagen,which was slower in the subcutaneous tissue and muscle compared to the joints in the mouse model.

关键词： collagen degradation rate NIR-II live imaging in vivo crosslinking degree