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Influence of High-Density Bedding Plane Characteristics on Hydraulic Fracture Propagation in Shale Oil Reservoir

Computer Modeling in Engineering & Sciences 2024年第9期140卷 3051-3071页

作者： Xiao yan Di wang Haitao Yu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Beijing102206China State Energy Center for Shale Oil Research and Development Beijing102206China Department of Geotechnical Engineering College of Civil Engineering Tongji UniversityShanghai200092China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Key Laboratory of Deep Earth Science and Engineering(Sichuan University) Ministry of EducationChengdu610065China

The existence of high-density bedding planes is a typical characteristic of shale oil *** the behavior of hydraulic fracturing in high-density laminated rocks is significant for promoting shale oil *** this study,a hydraulic fracturing model considering tensile failure and frictional slip of the bedding planes is established within the framework of the unified pipe-interface element method(UP-IEM).The model developed for simulating the interaction between the hydraulic fracture and the bedding plane is validated by comparison with experimental *** hydraulic fracturing patterns in sealed and unsealed bedding planes are ***,the effects of differential stress,bedding plane permeability,spacing,and the friction coefficient of the bedding plane are *** results showed that a single main fracture crossing the bedding planes is more likely to form in sealed bedding planes under high differential *** decrease in bedding plane permeability and the increase in the friction coefficient also promote the fracture propagating perpendicular to the bedding *** with high-density bedding planes has a poorer fracturing effect than that with low-density bedding planes,as the hydraulic fracture is prone to initiate and propagate along the bedding ***,higher injection pressure is needed to maintain fracture propagation along the *** increase in bedding density will lead to a smaller fracturing *** fluid seepage into the bedding planes slows shale *** is recommended that increasing the injection flow rate,selecting alternative fracturing fluids,and employing multi-well/multi-cluster fracturing may be efficient methods to improve energy production in shale oil reservoirs.

关键词： Hydraulic fracturing bedding planes shale unified pipe-interface element method

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Cervical cancer prevention in China: where are we now, and what's next?

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Cancer Biology & Medicine 2024年第3期21卷 213-217页

作者： Huijiao yan Qiankun wang Youlin Qiao School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

Cervical cancer(CC) epidemiology CC, the fourth most frequently diagnosed malignancy in women worldwide, is a major global health challenge, particularly in low-resource regions. Approximately 88.1% of the 604,000 CC new cases occurred in low-and middle-income countries in 2020, and more than 90% of the 342,000 CC deaths occurred in low-and middle-income countries in 2020~1.

关键词： prevention Cervical epidemiology

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Effect on serum metabolomics of rats with premature ovarian insufficiency by Zhibian(BL54) through Shuidao(ST28) acupuncture

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Journal of Traditional Chinese Medicine 2024年第4期44卷 722-733页

作者： yan Jing FENG Huimin QIU Fang wang Haijun YIN Luyun JIN Xiaofei ZHAO Jiyu wang Hongyang yan Xiaoqin Second Clinical College of Shanxi University of Traditional Chinese Medicine Jinzhong 030619China Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Cervical and Lumbar Vertebral Diseases Jinzhong Hospital Affiliated to Shanxi University of Traditional Chinese MedicineJinzhong 030600China

OBJECTIVE:To analyze the serum metabolic targets of the"Zhibian(BL54)through Shuidao(ST28)"acupuncture technique in cyclophosphamide(CTX)-induced premature ovarian insufficiency(POI)model rats and to elucidate the potential molecular mechanism of acupuncture in improving ***:We used an intraperitoneal injection of CTX to establish the POI rat model(POI group)and compared serum hormone levels and ovarian histopathological changes to evaluate the effect of the Zhibian(BL54)through Shuidao(ST28)technique(ZS+POI group)on ovarian ***,nontargeted metabolomics was performed using rat serum by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS).RESULTS:After acupuncture intervention,the serum hormone levels and ovarian pathological morphology of POI rats were effectively ***,UPLC-Q-TOF/MS results showed that the ZS+POI group showed a significant reversal of the levels of 6 differential *** them,the levels of four serum metabolic markers,divanillyltetrahydrofuran ferulate,trans-ferulic acid,tryptamine,and neuraminic acid,increased *** analysis of biological effects showed that all metabolites were involved in the regulation of reproductive hormone levels and antioxidant and antiapoptotic ***:The"Zhibian(BL54)through Shuidao(ST28)"acupuncture method may improve the ovarian function of POI rats by regulating serum metabolite markers to exert antioxidant and antiapoptotic effects,which provides a theoretical basis for the clinical application of acupuncture in the treatment of POI.

关键词： acupuncture premature ovarian insufficiency metabolomics ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry Zhibian(BL54)through Shuidao(ST28)

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Application of Bionic Technology in Marine Cruise Equipment:Research Progress and Development Trends

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Journal of Bionic Engineering 2024年第3期21卷 1117-1155页

作者： Kunhui Luo Lan yan Zhiyi Zhu Zhongqiu wang Hongru wang Feng Jiang School of Electromechanical and Automation Huaqiao UniversityXiamen36102China National Local Joint Engineering Research Center for Intelligent Manufacturing Technology of Brittle Material Products Xiamen361021China Institute of Oceanographic Instrumentation Shandong Academy of SciencesQilu University of Technology(Shandong Academy of Sciences)Qingdao266100China Shandong Provincial Key Laboratory of Marine Monitoring Instrument Equipment Technology Qingdao266100China National Engineering and Technological Research Center of Marine Monitoring Equipment Qingdao266100China Institute of Manufacturing Engineering Huaqiao UniversityXiamen361021China

This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development *** cruising is a crucial means of gaining insights into the marine environment and conducting scientific ***,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine *** technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread *** article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface *** summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising ***,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising *** application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.

关键词： Marine cruising equipment Bionic technology Propulsion methods Drag reduction Surface antifouling

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Development status and prospect of underground thermal energy storage technology

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Journal of Groundwater Science and Engineering 2024年第1期12卷 92-108页

作者： Ying-nan Zhang yan-guang Liu Kai Bian Guo-qiang Zhou Xin wang Mei-hua Wei School of Earth science and Engineering Hebei University of EngineeringHandan 056038Hebei ProvinceChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Shanxi Key Laboratory for Exploration and Exploitation of Geothermal Resources Taiyuan 030024China Shanxi Geological Engineering Exploration Institute Taiyuan 030024China

Underground Thermal Energy Storage(UTES)store unstable and non-continuous energy underground,releasing stable heat energy on *** effectively improve energy utilization and optimize energy *** UTES technology advances,accommodating greater depth,higher temperature and multi-energy complementarity,new research challenges *** paper comprehensively provides a systematic summary of the current research status of *** categorized different types of UTES systems,analyzes the applicability of key technologies of UTES,and evaluate their economic and environmental ***,this paper identifies existing issues with UTES,such as injection blockage,wellbore scaling and corrosion,seepage and heat transfer in cracks,*** suggests deepening the research on blockage formation mechanism and plugging prevention technology,improving the study of anticorrosive materials and water treatment technology,and enhancing the investigation of reservoir fracture network characterization technology and seepage heat *** recommendations serve as valuable references for promoting the high-quality development of UTES.

关键词： Aquifer thermal energy storage Borehole thermal energy storage Cavern thermal energy storage Thermal energy storage technology Benefit evaluation

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Geophysical prediction of organic matter abundance in source rocks based on geochemical analysis:A case study of southwestern Bozhong Sag,Bohai Sea,China

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Petroleum Science 2024年第1期21卷 31-53页

作者： Xiang wang guang-Di Liu Xiao-Lin wang Jin-Feng Ma Zhen-Liang wang Fei-Long wang Ze-Zhang Song Chang-Yu Fan State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Continental Dynamics Northwest UniversityXi'an710069ShaanxiChina Department of Geology Northwest UniversityXi'an710069ShaanxiChina CNOOC Tianjin Branch Company Tianjin300459China

The Bozhong Sag is the largest petroliferous sag in the Bohai Bay Basin,and the source rocks of Paleogene Dongying and Shahejie Formations were buried *** of the drillings were located at the structural high,and there were few wells that met good quality source rocks,so it is difficult to evaluate the source rocks in the study area precisely by geochemical analysis *** on the Rock-Eval pyrolysis,total organic carbon(TOC)testing,the organic matter(OM)abundance of Paleogene source rocks in the southwestern Bozhong Sag were evaluated,including the lower of second member of Dongying Formation(E_(3)d2L),the third member of Dongying Formation(E_(3)d_(3)),the first and second members of Shahejie Formation(E_(2)s_(1+2)),the third member of Shahejie Formation(E_(2)s_(3)).The results indicate that the E_(2)s_(1+2)and E_(2)s_(3)have better hydrocarbon generative potentials with the highest OM abundance,the E_(3)d_(3)are of the second good quality,and the E_(3)d2L have poor to fair hydrocarbon generative ***,the well logs were applied to predict TOC and residual hydrocarbon generation potential(S_(2))based on the sedimentary facies classification,usingΔlogR,generalizedΔlogR,logging multiple linear regression and BP neural network *** various methods were compared,and the BP neural network method have relatively better prediction *** on the pre-stack simultaneous inversion(P-wave impedance,P-wave velocity and density inversion results)and the post-stack seismic attributes,the three-dimensional(3D)seismic prediction of TOC and S_(2)was carried *** results show that the seismic near well prediction results of TOC and S_(2)based on seismic multi-attributes analysis correspond well with the results of well logging methods,and the plane prediction results are identical with the sedimentary facies map in the study *** TOC and S_(2)values of E_(2)s_(1+2)and E_(2)s_(3)are higher than those in E_(3)d_(3)and E_(3)d_(2)L,basicall

关键词： Total organic carbon(TOC) Residual hydrocarbon generation potential(S_(2)) Geophysical prediction Seismic attribute Bozhong Sag Bohai Bay Basin

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Research progress on temperature field evolution of hot reservoirs under low-temperature tailwater reinjection

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Journal of Groundwater Science and Engineering 2024年第2期12卷 205-222页

作者： Xin wang Guo-qiang Zhou yan-guang Liu Ying-nan Zhang Mei-hua Wei Kai Bian School of Earth science and Engineering Hebei University of EngineeringHandan 056038HebeiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Technology Innovation Center of Geothermal&Hot Dry Rock Exploration and Development Ministry of Natural ResourcesShijiazhuang 050061China Shanxi Key Laboratory for Exploration and Exploitation of Geothermal Resources Taiyuan 030024China Shanxi Geological Engineering Exploration Institute Taiyuan 030024China

This paper focuses on the study of the evolutionary mechanism governing the temperature field of geothermal reservoir under low-temperature tailwater reinjection conditions,which is crucial for the sustainable geothermal energy *** advancing exploitation of geothermal resources deepens,precise understanding of this mechanism becomes paramount for devising effective reinjection strategies,optimizing reservoir utilization,and bolstering the economic viability of geothermal energy *** article presents a comprehensive review of temperature field evolution across diverse heterogeneous thermal reservoirs under low-temperature tailwater reinjection conditions,and analyzes key factors influ-encing this *** evaluates existing research methods,highlighting their strengths and *** study identifies gaps in the application of rock seepage and heat transfer theories on a large scale,alongside the need for enhanced accuracy in field test results,particularly regarding computational effi-ciency of fractured thermal reservoir models under multi-well reinjection *** address these shortcomings,the study proposes conducting large-scale rock seepage and heat transfer experiments,coupled with multi-tracer techniques for field testing,aimed at optimizing fractured thermal reservoir models'computational efficiency under multi-well reinjection ***,it suggests integrat-ing deep learning methods into research *** initiatives are of significance in deepening the understanding of the evolution process of the temperature field in deep thermal reservoirs and enhancing the sustainability of deep geothermal resource development.

关键词： Geothermal reinjection Seepage heat transfer Tracer test Numerical simulation Thermal breakthrough

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Excess pore pressure behavior and evolution in deep coalbed methane reservoirs

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International Journal of Mining Science and Technology 2024年第6期34卷 763-781页

作者： Changqing Liu Zhaobiao yang Yong Qin Xia yan Yunhai wang Zhe wang Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process Ministry of EducationChina University of Mining and TechnologyXuzhou 221008China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China National Engineering Research Center of Coalbed Methane Development&Utilization Beijing 100095China PetroChina Coalbed Methane Company Limited Beijing 102200China SINOPEC East China Oil and Gas Company Nanjing 210000China

Deep coalbed methane(DCBM),an unconventional gas reservoir,has undergone significant advancements in recent years,sparking a growing interest in assessing pore pressure dynamics within these *** some production data analysis techniques have been adapted from conventional oil and gas wells,there remains a gap in the understanding of pore pressure generation and evolution,particularly in wells subjected to large-scale hydraulic *** address this gap,a novel technique called excess pore pressure analysis(EPPA)has been introduced to the coal seam gas industry for the first time to our knowledge,which employs dual-phase flow principles based on consolidation *** technique focuses on the generation and dissipation for excess pore-water pressure(EPWP)and excess pore-gas pressure(EPGP)in stimulated deep coal *** have been developed respectively and numerical solutions have been provided using the finite element method(FEM).Application of this model to a representative field example reveals that excess pore pressure arises from rapid loading,with overburden weight transferred under undrained condition due to intense hydraulic fracturing,which significantly redistributes the weight-bearing role from the solid coal structure to the injected fluid and liberated gas within artificial pores over a brief ***,field application indicates that the dissipation of EPWP and EPGP can be actually considered as the process of well production,where methane and water are extracted from deep coalbed methane wells,leading to consolidation for the artificial ***,history matching results demonstrate that the excess-pressure model established in this study provides a better explanation for the declining trends observed in both gas and water production curves,compared to conventional practices in coalbed methane reservoir engineering and petroleum *** research not only enhances the understanding of DCBM re

关键词： Deep coalbed methane Consolidation Excess pore-water pressure Excess pore-gas pressure Production data analysis

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PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： yan wang Feng Li Shuang wang Jiaqi Meng Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

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A low-profile metamaterial absorber with ultrawideband reflectionless and wide-angular stability

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Defence Technology（防务技术） 2024年第4期34卷 258-268页

作者： Feihong Lin Zhongming yan Ping wang Yu wang Hongcheng Zhou Haoran Lu School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle Ministry of EducationChengdu 610031China China Academy of Launch Vehicle Technology Beijing 100076China

An ultrawideband reflectionless metamaterial absorber(MA)is proposed by replacing the metallic ground with the complementary split-ring resonator(CSRR)*** proposed MA exhibits-10 d B reflectivity spectrum from 1 GHz to 20 GHz,which maintains more than 90%absorption from 1.5 GHz to20 ***,it achieves angle stability for TE and TM polarization at oblique incident angles up to 40°and 65°,*** achieve broadband absorption spectrum,we have adopted a single-layer high-impedance surface(HIS)loaded with a double-layer magnetic material(MM)*** further realize the RCS reduction into a lower frequency range,we have employed the scattering cancellation technology into the traditional metallic ***,we have fabricated a sample exhibiting the 10 d B RCS reduction from 1 GHz to 20 GHz with a thickness of 10 *** and simulation results confirm that the proposed MA exhibits excellent comprehensive performance,making it suitable for many practical applications.

关键词： Metamaterial absorber(MA) Magnetic material(MM) High-impedance surface(HIS) Scattering cancellation technology Ultrawideband Wide-angular stable

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