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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang yan Sun lingxiao Deng Melissa Walker Chen Chen Heqiao Dai qi han Ying Ding Yongzhi Xia George Smith Rui li Nai-Kui liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Dual characteristic of trace rare earth elements in a commercial casting Al-Cu-X alloy

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Rare Metals 2015年第5期34卷 308-313页

作者： li Fan qi-Tang Hao Wen-ke han State key Laboratory of Solidification Processing Northwestern Polytechnical University School of Materials Science and Engineering Northwestern Polytechnical University

The effect of rare earth elements on microstructure and mechanical properties of casting Al-Cu-X alloy （X = Mn, Ti, V, Cd, Zr） was investigated in as-cast and T6 conditions. Microstructure evolution was characterized by optical microscopy, scanning electron microscopy, and transmission electron microscopy. RE-containing intermetallic compounds （IMCs） formed in this alloy were indentified by X-ray diffraction （XRD） and energy dispersive spectroscopy （EDS）. It is shown that the additions of RE （60Ce-40La, wt%） result in the formation of Ce-rich blocky-shaped A12o（Ti, V）2RE and La-rich skeletal-shaped A18Cu4RE. Tensile results of samples after T6 treatment indicate that the strength and ductility increase slightly to 480 MPa and 9.7 %, respectively, with RE content increasing from 0 wt% to 0.3 wt%. This is due to the combinative hardening effects of reduced grain size, enhanced precipitation of 0＇（Al2Cu） phase and Al20 Cu2Mn3 dispersed particles, and minor La-rich IMCs at the grain boundaries of α-Al dendrites. The decrease of strength of 0.5 wt% RE-added sample is ascribed to the aggregation of Al20（Ti, V）2RE IMCs inside the grains. The dual characteristic of rare earth elements was also discussed in terms of its positive and negative effects on mechanical properties.

关键词： Aluminum alloys Rare earth Microstructure Mechanical property Intermetallic compounds

A Note on Symplectic Algorithm

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Communications in Theoretical Physics 2001年第7期36卷 11-18页

作者： GUO han-Ying li Yu-qi WU ke Institute of Theoretical Physics Academia Sinica P.O. Box 2735 Beijing 100080 China Institute of Theoretical Physics Academia Sinica P.O. Box 2735 Beijing 100080 China Institute of Theoretical Physics Academia Sinica P.O. Box 2735 Beijing 100080 China

We present the symplectic algorithm in the Lagrangian formalism for the Hamiltonian systems by virtue of the noncommutative differential calculus with respect to the discrete time and the Euler-Lagrange cohomological ... 详细信息

关键词： symplectic algorithm, Lagrangian formalism, Euler-Lagrange cohomology

Crystal-chemistry insight into the photocatalytic activity of BiOCI_(x)Br_(1_x)nanoplate solid solutions

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Frontiers of Materials Science 2017年第2期11卷 120-129页

作者： Huan-yan XU Xu han Qu TAN ke-Jia WU Shu-yan qi School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040China

In this study,a facile alcoholysis method was developed to synthesize BiOCI_(x)Br_(1_x)nanoplates at room temperature and atmospheric *** this route,strong acid or alkaline environment was absolutely avoided to realize the high exposure of{001}crystal *** regular changes in XRD peaks and cell parameters as a function of the Br content strongly declared that the obtained BiOCIxBrl_x products belonged to a group of solid *** 2D nanosheets with in-plane wrinkles were clearly observed in TEM ***,as the Br content increased,band gaps of BiOCI_(x)Br_(1_x)solid solutions gradually *** photocatalytic degradation of RhB under simulated sunlight irradiation indicated that ***0.5 had the best photocatalytic *** the viewpoint of crystal chemistry,the photocatalytic activity of BiOCI_(x)Br_(1_x)solid solutions was closely related with the exposure amount of{001}facets,interlayer spacing of(001)plane and energy-level position of valence band.

关键词： BiOCI_(x)Br_(1_x)solid solutions {001}facets exposure internal electric field interlayer spacing energy-level position

Effect of Short-Range Ordering on the Strength-Ductility Synergy of Fine-Grained Cu–Mn Alloys at Different Temperatures

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Acta Metallurgica Sinica(English Letters) 2022年第4期35卷 651-661页

作者： qi-Ming Wang yan-Jie Zhang Dong han Xiao-Wu li Department of Materials Physics and Chemistry School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China State key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China key Laboratory for Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

Uniaxial tensile tests were carried out at room temperature(RT)and 250℃,respectively,to investigate the effect of shortrange ordering(SRO)on the mechanical properties and deformation micromechanism of fine-grained(FG)Cu–Mn alloys with high stacking fault *** results show that at RT,with the increase in SRO degree,the strength of FG Cu–Mn alloys is improved without a loss of ductility,and corresponding deformation micromechanism is mainly manifested by a decrease in the size of dislocation *** contrast,at a high temperature of 250℃,the SRO degree becomes violently enhanced with increasing Mn content,and the deformation microstructures thus transform from dislocation cells to planar slip bands and even to deformation twins,significantly enhancing the work hardening capacity of the alloys and thus achieving a better strength-ductility synergy of FG Cu–Mn alloys.

关键词： Fine-grained Cu–Mn alloy Short-range ordering Stacking fault energy Temperature Strength-ductility synergy Deformation micromechanism

In vitro effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803 cells

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World Journal of Gastroenterology 2005年第33期11卷 5136-5141页

作者： li-Feng qi Zi-Rong Xu yan li Xia Jiang Xin-yan han Nanobiology Laboratory of Animal Science College Zhejiang UniversityHangzhou 310029 Zhejiang Province China

AIM： To investigate the effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803 in vitro and the possible mechanisms involved. METHODS： Chitosan nanoparticles were characterized by particle size, zeta potential, and morphology. After treatment with various concentrations of chitosan nanoparticles （25, 50, 75, 100 μg/mL） at various time intervals, cell proliferation, ultrastructural changes, DNA fragmentation, mitochondrial membrane potential （MMP）, cell cycle phase distribution and apoptotic peaks of MGC803 cells were analyzed by MTT assay, electron microscopy, DNA agarose gel electrophoresis, and flow cytometry. RESULTS： Chitosan nanoparticles exhibited a small particle size as 65 nm and a high surface charge as 52 mV. Chitosan nanoparticles markedly inhibited cell proliferation of MGC803 cells with an ICso value of 5.3 μg/mL 48 h after treatment. After treatment with chitosan nanoparticles, the typical necrotic cell morphology was observed by electron microscopy, a typical DNA degradation associated with necrosis was determined by DNA agarose electrophoresis. Flow cytometry showed the loss of MMP and occurrence of apoptosis in chitosan nanoparticles-treated cells. CONCLUSION： Chitosan nanoparticles effectively inhibit the proliferation of human gastric carcinoma cell line MGC803 in vitro through multiple mechanisms, and may be a beneficial agent against human carcinoma.

关键词： Chitosan nanoparticles Gastric carcinoma Necrosis Apoptosis

In Situ Synthesis of Cuprous Oxide/Cellulose Nanofibers Gel and Antibacterial Properties

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Computers, Materials & Continua 2018年第9期56卷 517-527页

作者： Ying Hu qinfei ke Zhe li Wanli han Zhiyong yan Engineering Research Center of Technical Textiles Donghua UniversityShanghai201620China key Laboratory of Yarn Material Manufacturing and Processing of Zhejiang Province Jiaxing UniversityJiaxing314001China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta30318USA

Cellulose nanofibers were synthesized by acetobacter xylinum(xylinum 1.1812).The cellulose nanofibers with 30-90 nm width constructed three-dimension network gel,which could be used as a wound dressing since it can provide moist environment to a ***,cellulose nanofibers have no antimicrobial activity to prevent wound *** achieve antimicrobial activity,the cellulose nanofibers can load cuprous oxide(Cu2O)particles on the *** cuprous oxide is a kind of safe antibacterial *** copper ions can be reduced into cuprous oxides by reducing agents such as glucose,N2H4 and sodium *** cellulose nanofibers network gel was soaked in CuSO4 solution and filled with copper *** cuprous oxide nanoparticles were in situ synthesized by glucose and embedded in cellulose nanofibers *** morphologies and structure of the composite gel were analyzed by FESEM,FTIR,WAXRD and inductively coupled plasma(ICP).The sizes of Cu2O embedded in cellulose nanofibers network are 200-500 nm *** peak at 605 cm−1 attributed to Cu(I)-O vibration of Cu2O shits to 611 cm−1 in the Cu2O/cellulose *** Cu2O/cellulose nanofibers composite reveals the obvious characteristic XRD pattern of Cu2O and the results of ICP show that the content of Cu2O in the composite is 13.1%.The antibacterial tests prove that the Cu2O/cellulose nanofibers composite has the high antibacterial activities which is higher against *** than against ***.

关键词： Cellulose nanofiber cuprous oxide in situ synthesis antibacterial

Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue

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World Journal of Gastroenterology 2005年第30期11卷 4661-4666页

作者： Shi-Fang Yuan Kai-Zong li ling Wang ke-Feng Dou Zhen yan Wei han Ying-qi Zhang Department of Vascular and Endocrine Surgery Xijing Hospital The Fourth Military Medical University Xi'an 710033 Shaanxi Province China Department of Hepatobiliary Surgery Xijing Hospital The Fourth Military Medical University Xi'an 710033 Shaanxi Province China Biotechnology Center The Fourth Military Medical University Xi'an 710033 Shaanxi Province China

AIM： To investigate the relation between MUC1 expression, distribution, and prognosis in hepatocellular and cholangiocarcinoma （HCC and CC） and cirrhotic liver tissues, and their significance in HCC and CC diagnosis. METHODS： Expression and distribution of MUC1 were examined by immunohistochemical assay with anti-MUC1 mAb in 59 samples of HCC and 37 samples of CC, 20 samples of cirrhotic liver tissues, and 10 samples of normal liver tissues, seeking possible associations between MUC1 positive expression, distribution in HCC and CC （primary liver cancer, PLC） cases and the studied clinical data. RESULTS： Immunohistochemical analysis of MUC1 expression showed that in the 96 PLC samples, 68 （70.8%） were strong positive, and 6 （6.2%） were weak positive. Only 4 in the 20 cirrhotic liver tissues were found to be weak positive, while no expression of MUC1 was detected in normal liver tissues. Apparently, the high expression rate of MUC1 in PLC tissues was statistically significant in comparison to that in cirrhotic and normal liver tissues. The expressed MUC1 protein, stained in dark brownish or brownish-yellow particles, chiefly localized on the cancer cell membranes or in cytoplasm. In the 68 strong positive samples, 40 were detected on cell membrane and the other 28 were in cytoplasm. In addition, follow-up studies of those PLC cases demonstrated that MUC1 expression on cell membrane or in cytoplasm was closely associated with PLC prognosis. The expression of HUC1 in PLC had little statistical significance in respect of the pathological types and sizes of the tumors, but a strong relationship regarding histological differentiation, metastasis of lymph nodes, portal canal emboli, and post-operational recurrence of the carcinomas. After 3 years of tumor excision, the metastasis rate in MUC1 positive expression group （67.6%） was much higher than that in MUC1 weak expression group （33.3%） and negative expression group （31.8%）, and thus the survival rate in MUC1-positive exp

关键词： MUC1 Primary liver carcinoma Prognosis Immunohistochemistry

Accelerated Aging Behaviors and Mechanism of Fluoroelastomer in Lubricating Oil Medium

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Chinese Journal of Polymer Science 2020年第8期38卷 853-866,I0007页

作者： qi-Long Wang Jing-ke Pei Gao li Xi He yan-Hua Niu Guang-Xian li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu 610065China

The aging behaviors and mechanism of fluoroelastomer(FKM)under lubricating oil(FKM-O)and air(FKM-A,as a comparison)at elevated temperatures were studied from both physical and chemical *** obvious changes of mechanical and swelling performances indicate that the coupling effect of lubricating oil and temperature causes more serious deterioration of FKM-O compared to that of ***,much stronger temperature dependence of both bulk properties and micro-structures for FKM-O is ***-stage physical diffusion process is defined in FKM-O due to the competition between oil diffusion and elastic retraction of *** results reveal that the dehydrofluorination reaction causes the fracture of C-F bonds and produces a large number of C=C bonds in the *** coupling effect of oil medium and high temperature could accelerate the scission of C=C bonds and generate a series of fragments with different molecular *** TGA results,crosslinking density Ve,and glass transition temperature Tg derived from different measurements coherently demonstrate the network destruction in the initial stage and the simultaneous reconstruction occurring at the final *** newly formed local network induced by reconstruction cannot compensate the break of the original rubber network and thus only provides lower tensile strength and thermal stability.

关键词： Fluoroelastomer Aging behaviors Mechanism Lubricating oil Network reconstruction