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Lesions of mediodorsal thalamic nucleus reverse abnormal firing of the medial prefrontal cortex neurons in parkinsonian rats

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Neural Regeneration Research 2019年第9期14卷 1635-1642页

作者： Ling-Ling Fan Bo Deng Jun-bao yan Zhi-Hong Hu Ai-Hong Ren Dong-Wei yang Department of Physiology Medical College Henan University of Science and Technology

The dysfunction of the medial prefrontal cortex is associated with affective disorders and non-motor features in Parkinson’s ***,the exact role of the mediodorsal thalamic nucleus in the function of the prefrontal cortex remains *** study the possible effects of the mediodorsal thalamic nucleus on the neurological function of the medial prefrontal cortex,a model of Parkinson’s disease was established by injecting 8μg 6-hydroxydopamine into the substantia nigra compacta of *** 1 or 3 weeks,0.3μg ibotenic acid was injected into the mediodorsal thalamic nucleus of the *** 3 or 5 weeks after the initial injury,neuronal discharge in medial prefrontal cortex of rat brain was determined *** numbers of dopamine-positive neurons and tyrosine hydroxylase immunoreactivity in substantia nigra compacta and ventral tegmental area were detected by immunohistochemical *** demonstrated that after injury,the immunoreactivity of dopamine neurons and tyrosine hydroxylase decreased in the substantia nigra compacta and ventral tegmental areas of *** with normal medial prefrontal cortical neurons,at 3 and 5 weeks after substantia nigra compacta injury,the discharge frequency of pyramidal neurons increased and the discharge pattern of these neurons tended to be a burst-discharge,with an increased discharge *** discharge frequency of interneurons decreased and the discharge pattern also tended to be a burst-discharge,but the discharge interval was only higher at 3 *** 3 weeks after the combined lesions,the discharge frequency,discharge pattern and discharge interval were restored to a normal level in pyramidal neurons and interneurons in medial prefrontal *** findings have confirmed that mediodorsal thalamic nucleus is involved in regulating neuronal activities of the medial prefrontal *** changes in the function of the mediodorsal thalamic nucleus may be associated with the abnorma

关键词： nerve regeneration Parkinson's disease mediodorsal thalamic nucleus medial prefrontal cortex pyramidal neurons interneurons discharge neural regeneration

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Fluorinated p-n Type Copolyfluorene as Polymer Electret for Stable Nonvolatile Organic Transistor Memory Device

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Chinese Journal of Polymer Science 2016年第10期34卷 1183-1195页

作者： Bin Liu yan bao Hai-feng Ling Wen-sai Zhu Rui-jun Gong Jin-yi Lin 解令海仪明东黄维 Centre for Molecular Systems and Organic Devices Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts & Telecommunications Nanjing 210023 China Key Laboratory of Flexible Electronics & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced Materials Nanjing Tech University Nanjing 211816 China

Abstract In this study, a kind of fluorinated copolyfluorene, named poly[（4-（octyloxy）-9,9-diphenylfluorene-2,7-diyl）-alt- （2,3,5,6-tetrafluoro-1,4-phenylene）] （PODPF-TFP）, is synthesized by facile palladium-based direct aromatization. Compared to the non-fluorinated counterpart, poly[（4-（octyloxy）-9,9-diphenylfluorene-2,7-diyl）-alt-（p-phenylene）] （PODPF-P）, deeper HOMO/LUMO energy level combined with steric hindrance effect endow PODPF-TFP with excellent spectra and morphology stability. Finally, organic field-effect transistor （OFET） memory devices are fabricated with PODPF-P/PODPF- TFP as the dielectric layers, and they both exhibit flash type storage characteristic. Owing to the electronegativity of fluorine atom, the device based on PODPF-TFP exhibits larger memory window and more stable Ion/Ioff ratio during a retention time of 10^4 s as well as a better aging stability. The present study suggests that fluorinated p-n copolyfluorene electrets could enhance the capabilities of charge trapping and storage, which are promising for OFET memory devices.

关键词： p-n copolyfluorenes Fluorine atom Direct aromatization Polymer dielectric Transistor memory.

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Cache-Conscious Index Mechanism for Main-Memory Databases

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 309-312页

作者： SUN Li-mei SONG bao-yan YU Ya-xin LI Fang-fang YU Ge School of Information Science and Engineering Northeastern University Shenyang 110004 Liaoning China

Recent studies have addressed that the cache be havior is important in the design of main memory index structures. Cache-conscious indices such as the CSB^＋-tree are shown to outperform conventional main memory indices such as the AVL-tree and the T-tree. This paper proposes a cacheconscious version of the T-tree, CST-tree, defined according to the cache-conscious definition. To separate the keys within a node into two parts, the CST-tree can gain higher cache hit ratio.

关键词： index structure main memory database real time application cache-conscious T-tree indexing CST-tree indexing

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Discussion on Collection of Clinical Questions in International Clinical Practice Guidelines of Acupuncture-Moxibustion

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Chinese Journal of Integrative Medicine 2023年第4期29卷 353-360页

作者： WU Xiao-dong ZHAO Nan-qi DING Nan YUAN Jing-yun DONG Guo-feng WANG Xin LIU bao-yan Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China College of Acupuncture and Massage Beijing University of Chinese MedicineBeijing 100029China

The clinical questions of acupuncture-moxibustion(Acup-Mox)guidelines are complicated,including not only the curative effect of Acup-Mox intervention measures,but also the operational elements of *** paper aimed to put forward the idea and process of collecting clinical questions in developing international acupuncture clinical practice *** experience was collected and the idea of collecting clinical questions of Acup-Mox was formed through expert consultation and discussion in combination with expert *** on the characteristics of Acup-Mox *** paper put forward the thinking of collecting elements of clinical questions following the intervention-population-outcome-control(I-P-O-C)inquiry process,according to the discipline of *** was emphasized that in the process of collecting clinical questions,"treatable population"and"alleviable outcome indicators"for a specific Acup-Mox intervention with certain therapeutic effect should be focused on,so as to highlight the pertinence of clinical questions of AcupMox guidelines in terms of population and outcome elements.

关键词： acupuncture-moxibustion intervention Chinese medicine I-P-O-C inquiry process suitable population outcome evaluation

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Recommendations for Acupuncture in Clinical Practice Guidelines of the National Guideline Clearinghouse

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Chinese Journal of Integrative Medicine 2017年第11期23卷 864-870页

作者： GUO Yao ZHAO Hong WANG Fang LI Si-nuo SUN Yu-xiu HAN Ming-juan LIU bao-yan College of Acupuncture and Orthopedics Hubei University of Chinese Medicine Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Department of Acupuncture Guang'anmen Hospital China Academy of Chinese Medical Science Data Centre of Traditional Chinese Medicine China Academy of Chinese Medical Sciences

Objective： To organize the clinical practice guidelines（CPGs） related to acupuncture included in the National Guideline Clearinghouse（NGC） to systematically summarize the diseases and disorders most commonly treated with acupuncture, the strength of recommendations for acupuncture and the quality of evidence. Methods： The NGC database was systematically searched for guidelines that included acupuncture as an intervention. Two independent reviewers studied the summaries and the full texts of the guidelines and included guidelines based on the inclusion and exclusion criteria. Thirty-nine guidelines were collected with 80 recommendations. The Appraisal of Guidelines for Research and Evaluation（AGREE） Ⅱ instrument was used to assess the quality of these guidelines. Results： Of the 80 recommendations on acupuncture, 49 recommendations were clearly for acupuncture, 25 recommendations were against acupuncture and 6 recommendations did not indicate any clear recommendations, 37 recommendations were for painful diseases/disorders, and 12 recommendations were for non-painful diseases/disorders. Locomotor system disorders were the most common in the painful diseases/disorders category. Out of all the recommendations for acupuncture, most recommendations（87.76%） were weak in strength, and most of the evidence（40.84%） was of low quality. Conclusion： In the National Guideline Clearinghouse, the recommendations for acupuncture focus on painful diseases/disorders. The recommendations in the guidelines are not high in strength, and most of the evidence is moderate or low in quality.

关键词： acupuncture clinical practice guidelines National Guideline Clearinghouse

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Pregnancy Benefit of Acupuncture on in vitro Fertilization:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2023年第11期29卷 1021-1032页

作者： ZHANG Hao-ran ZHANG Cheng MA Pei-hong SUN Cheng-yi SUN Chong-yang LIU Xiao-yu PU Zhen-qing LIN Yu-han LIU bao-yan LIU Cun-zhi yan Shi-yan College of Preschool Education Beijing Youth Politics CollegeBeijing(100102)China School of Acupuncture Moxibustion and TuinaBeijing University of Chinese MedicineBeijing(100029)China School of Acupuncture and Moxibustion Tianjin University of Traditional Chinese MedicineTianjin(301617)China China Academy of Chinese Medical Sciences Beijing(100091)China

Background:Currently,more and more infertility couples are opting for combined acupuncture to improve success rate of in vitro fertilization(IVF).However,evidence from acupuncture for improving IVF pregnancy outcomes remains a matter of ***:To quantitatively summarized the evidence of the efficacy of acupuncture among women undergoing IVF by means of systematic review and ***:Four English(PubMed,Web of Science,EMBASE,and Cochrane Register of Controlled Clinical Trials)and Four Chinese databases(Wanfang Databases,Chinese National Knowledge Infrastructure,Chinese Science and Technology Periodical Database,and SinoMed)were searched from database inception until July 2,*** controlled trials(RCTs)that evaluated the acupuncture’s effects for women undergoing IVF were *** subgroup analysis was conducted with respect to the age of participants,different acupuncture types,type of control,acupuncture timing,geographical origin of the study,whether or not repeated IVF failure,and acupuncture *** analyses were predefined to explore the robustness of *** primary outcomes were clinical pregnancy rate(CPR)and live birth rate(LBR),and the secondary outcomes were ongoing pregnancy rate and miscarriage *** effects model with I^(2)statistics were used to quantify *** bias was estimated by funnel plots and Egger’s ***:A total of 58eligible RCTs representing 10,968 women undergoing IVF for pregnant success were *** CPR and LBR showed a significant difference between acupuncture and control groups[69 comparisons,relative risk(RR)1.19,95%confidence intervals(CI)1.12 to 1.25,I^(2)=0],extremely low evidence;23 comparisons,RR 1.11,95%CI 1.02 to 1.21,I^(2)=14.6,low evidence,*** transcutaneous electrical acupoint stimulation showed a positive effect on both CPR(16 comparisons,RR 1.17,95%CI 1.06 to 1.29;I^(2)=0,moderate evidence)and LBR(9 comparisons,R

关键词： acupuncture Acupuncture stimulation

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Passivity Control for Uncertain T-S Fuzzy Descriptor Systems

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自动化学报 2006年第5期32卷 674-679页

作者： ZHU bao-yan ZHANG Qing-Ling TONG Shao-Cheng Institute of Systems Science Northeastern University Shenyang 110004 College of Sciences Shenyang Jianzhu University Shenyang 110168 Department of Mathematics and Physics Liaoning Institute of Technology Jinzhou 121001

By means of matrix decomposition method a criterion is presented for the admissibility of T-S fuzzy descriptor system. Then, the problem of passivity control is studied for a kind of T-S fuzzy descriptor system with uncertain parameters, and sufficient conditions which make the closed-loop system admissible and strictly passive are obtained based on linear matrix inequality (LMI). The nonstrict LMIs restricted conditions which characterize the descriptor system are transformed into strict ones, so testing admissibility and passivity of the system can be finished simultaneously. The design scheme of state feedback controller is also obtained. Finally, a numerical example is given to show the validity and feasibility of the proposed approach.

关键词： Uncertain T-S fuzzy descriptor systems admissibility passivity linear matrix inequality (LMI)

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Effect of interrupted endogenous BMP/Smad signaling on growth and steroidogenesis of porcine granulosa cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第9期11卷 719-727页

作者： Wei WANG Li WANG Xin-xiu LI Xia CHEN Hai-yan ZHANG Yu HE Jing-jing WANG Yong-yan ZHAO bao-le ZHANG Yin-xue XU College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China

Bone morphogenetic proteins(BMPs) play a critical role in the growth and steroidogenesis of granulosa cells(GCs).BMP signals act through membrane-bound heteromeric serine/threonine kinase *** ligand binding,BMPs activate intracellular Smad proteins and regulate growth and apoptosis in various cell *** objective of this study was to demonstrate the effects of BMP/Smad signal on growth and steroidogenesis of porcine GCs.A strategy of RNA interference(RNAi)-mediated 'gene silencing' of Smad4,a core molecule mediating the intracellular BMP/Smad signal transduction pathways,was used to interrupt endogenous BMP/Smad *** indicate that Smad4-small interfering RNA(siRNA) caused specific inhibition of Smad4 mRNA and protein expression after *** endogenous BMP/Smad signaling significantly inhibited growth,and induced apoptosis of porcine GCs,while decreasing estradiol *** addition,interrupted BMP/Smad signaling significantly(P<0.05) changed the expression of Cyclin D2,CDK4,Bcl-2,and *** findings provide new insights into how BMP/Smad signaling regulates the growth and steroidogenesis of porcine GCs.

关键词： Porcine granulosa cells Bone morphogenetic protein(BMP)/Smad Smad4 RNA interference(RNAi) Growth Steroidogenesis

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A solar radio dynamic spectrograph with flexible temporal-spectral resolution

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Research in Astronomy and Astrophysics 2017年第9期17卷 111-118页

作者： Qing-Fu Du Lei Chen Yue-Chang Zhao Xin Li yan Zhou Jun-Rui Zhang Fa-bao yan Shi-Wei Feng Chuan-yang Li Yao Chen School of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China Institute of Space Sciences Shandong UniversityWeihai 264209China hjc-8555@***

Observation and research on solar radio emission have unique scientific values in solar and space physics and related space weather forecasting applications, since the observed spectral structures may carry important information about energetic electrons and underlying physical mechanisms. In this study, we present the design of a novel dynamic spectrograph that has been installed at the Chashan Solar Radio Observatory operated by the Laboratory for Radio Technologies, Institute of Space Sciences at Shandong University. The spectrograph is characterized by real-time storage of digitized radio intensity data in the time domain and its capability to perform off-line spectral analysis of the radio spectra. The analog signals received via antennas and amplified with a low-noise amplifier are converted into digital data at a speed reaching up to 32 k data points per millisecond. The digital data are then saved into a high- speed electronic disk for further off-line spectral analysis. Using different word lengths （1-32k） and time cadences （5 ms-10 s） for off-line fast Fourier transform analysis, we can obtain the dynamic spectrum of a radio burst with different （user-defined） temporal （5 ms-10 s） and spectral （3 kHz-320kHz） resolutions. This enables great flexibility and convenience in data analysis of solar radio bursts, especially when some specific fine spectral structures are under study.

关键词： Sun: radio radiation-- radiation: dynamics-- instrumentation: spectrographs-- methods data analysis -- techniques: image processing

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中空SiO_2微球的制备及其在缓/控释应用中的新进展

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无机材料学报 2016年第12期31卷 1269-1278页

作者：鲍艳王彤陕西科技大学轻工科学与工程学院西安710021

中空二氧化硅(SiO_2)微球具有特殊的内部空腔、吸附渗透性好、物质传递可控等优异性能,可储存负载并缓慢释放药物、香精、染料、菌素等客体分子,因此在药物缓释、医学成像、环境保护以及化妆品等领域有着广阔的应用前景。根据国内外研... 详细信息

中空二氧化硅(SiO_2)微球具有特殊的内部空腔、吸附渗透性好、物质传递可控等优异性能,可储存负载并缓慢释放药物、香精、染料、菌素等客体分子,因此在药物缓释、医学成像、环境保护以及化妆品等领域有着广阔的应用前景。根据国内外研究进展,本文归纳对比了中空SiO_2微球几种制备方法之间的优劣差异,着重阐述了其作为缓控释载体表现出的持久性和高效性,以及功能化的有机/无机杂化微球在响应性控释方面的优越性。并对中空SiO_2微球作为新型缓控释载体的发展前景进行了展望。

关键词：中空SiO2微球传统模板法自模板法缓释响应性控释综述

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