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Topographic tear film trend and new parameters for noninvasive break up time test

International Journal of Ophthalmology(English edition) 2022年第12期15卷 1932-1939页

作者： yakup acet Department of Ophthalmology Mardin Training and Research HospitalMardin 47100Turkey

AIM:To evaluate the quantitative and qualitative results of the noninvasive tear film break-up time(NI-BUT)test and investigate the predictive ability of the new NIBUT parameter in discriminating between normal Ocular Surface Disease Index(OSDI;scores≤12)and abnormal OSDI(scores≥13).METHODS:A total of 341 eyes of 341 volunteers who applied for routine eye outpatient control were included in the prospective *** participants'noninvasive first tear film break-up time(NIF-BUT),noninvasive average tear film break-up time(NIAvg-BUT)and average value of the first three break-up time(A3F-BUT)were analyzed.A3F-BUT,the new NI-BUT parameter,is calculated by adding the NIF-BUT value to the 2^(nd )break-up time value that has a difference of at most 1 second from the NIF-BUT value and to the 3^(rd) break-up time and then dividing the respective sum by *** operating characteristic(ROC)curve and forward logistic regression analyses were performed to determine the parameter that had the best predictive ability between the OSDI ***:The NI-BUT values of 255 eyes of 255 volunteers included in the study were analyzed *** mean NIF-BUT,NIAvg-BUT,and A3F-BUT values were calculated as 5.3±3.0,8±3.1,and 5.8±3.0 seconds,*** three parameters were found to be significantly lower in the abnormal OSDI group(P=0.014,0.034,and 0.011,respectively).The area under the curve(AUC)of the A3F-BUT to predict abnormal OSDI was AUC=0.625(0.529-0.720),P=0.011 and NIF-BUT was AUC=0.599(0.502-0.696),P=*** A3F-BUT parameter and NIF-BUT parameters were found to be significantly efficient in discriminating abnormal ***:The new parameter for the NI-BUT test has more predictive ability in the discrimination of OSDI groups.

关键词： noninvasive break-up time Ocular Surface Disease Index tear film topographic break-up time test

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Potassium tert-Butoxide Catalyzed Synthesis and Characterization of Novel 3-Aryl-3-（phenylthio）-1-（thiophen-3-yl）- propan-l-one Derivatives

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Chinese Journal of Chemistry 2012年第2期30卷 341-344页

作者： Budak, yakup Department of Chemistry Faculty of Arts and Sciences Gaziosmanpasa University 60250 Tokat Turkey

A series of thiophenyl-containing 3-thiophene derivatives （4a--4i） were prepared via the reaction of chalcone-analogua compounds （3a--3i） and thiophenol in the presence of catalytic amount of KOBu-t in CH2C12 with moderate to high yields. The mechanistic pathway of the reaction was explained by the Michael-type addition of thiophenol to chalcone derivatives （3a--3i）.

关键词： 1-(thiophen-3-yl)ethanone Michael addition potassiumtert-butoxide chalcone catalysis

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Multiple exp-function method for soliton solutions of nonlinear evolution equations

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Chinese Physics B 2017年第7期26卷 20-26页

作者： yakup Yιldιrιm Emrullah Yasar Department of Mathematics Faculty of Arts and Sciences Uludag University

We applied the multiple exp-function scheme to the（2＋1）-dimensional Sawada-Kotera（SK） equation and（3＋1）-dimensional nonlinear evolution equation and analytic particular solutions have been deduced. The analytic particular solutions contain one-soliton, two-soliton, and three-soliton type solutions. With the assistance of Maple, we demonstrated the efficiency and advantages of the procedure that generalizes Hirota＇s perturbation scheme. The obtained solutions can be used as a benchmark for numerical solutions and describe the physical phenomena behind the model.

关键词： (2+1)-dimensional Sawada-Kotera(SK) equation (3+1)-dimensional nonlinear evolution equation(NLEE) multiple exp-function method multiple wave solutions

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An in-depth review of theory of the TOPSIS method:An experimental analysis

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Journal of Management Analytics 2020年第2期7卷 281-300页

作者： yakup Celikbilek Fatih Tuysuz Department of Management Information Systems Istanbul Gelisim UniversityIstanbulTurkey Department of Industrial Engineering Istanbul University-CerrahpaşaIstanbulTurkey

Decision-making is an important part of daily and business life for both individuals and *** the multi-criteria decision-making methods provide decision makers the necessary tools,they have differences in terms of the assumptions and fundamental ***,selecting the right decision-making method is at least as important as making the ***(Technique for Order Performance by Similarity to Ideal Solution)method,which is one of the most widely used multi-criteria decision-making methods,has gained attention of researchers and thus various improved versions of the method have been *** study considers the conventional TOPSIS method and experimentally displays the underlying reasons of the lacks of the conventional TOPSIS method by using a simulation *** experimental analysis based on simulation with an application is used to reveal theoretical fundamentals of the TOPSIS method to better understand it and contribute to its improvement.

关键词： TOPSIS Multiple criteria analysis simulation analysis Euclidean distance n-dimensionality

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Dynamical Analysis of Sputtering at Threshold Energy Range： Modelling of Ar＋Ni（100） Collision System

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Chinese Physics Letters 2008年第2期25卷 730-733页

作者： HUNDUR yakup GUVENC Ziya B HIPPLER Rainer Department of Physics Istanbul Technical University Istanbul TR-34469 Turkey Electronic and Communication Engineering Cankaya University Balgat Ankara TR-06530 Turkey Institut für Physik Ernst-Moritz-Arndt Universitate Greifswald Greifswald D-17489 Germany

The sputtering process of Ar＋Ni（100） collision systems is investigated by means of constant energy molecular dynamics simulations. The Ni（100） slab is mimicked by an embedded-atom potential, and the interaction between the projectile and the surface is modelled by using the reparametrized ZBL potential. Ni atom emission from the lattice is analysed over the range of 20-50 eV collision energy. Sputtering yield, angular and energy distributions of the scattered Ar and of the sputtered Ni atoms are calculated, and compared to the available theoretical and experimental data.

关键词： SURFACE YIELD

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Case of takotsubo cardiomyopathy after surgical treatment of liver hydatid cyst: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7187-7192页

作者： yakup Altaş Ülfet Abdullayeva Department of Cardiology Private Melikgazi HospitalKayseri 38030Turkey Department of General Surgery Private Melikgazi HospitalKayseri 38030Turkey

BACKGROUND Takotsubo cardiomyopathy,also called apical ballooning syndrome,is a disease that is often triggered by stress factors in postmenopausal women and mimics acute coronary *** aim of this article is to draw attention to takotsubo cardiomyopathy after surgical treatment of liver hydatid *** SUMMARY A 50-year-old diabetic and hypertensive female patient was evaluated preoperatively before general surgery for liver hydatid cyst,and no cardiac problems were *** patient was discharged on the 3rd postoperative day without any postoperative *** postoperative day 5,the patient presented to the emergency department with fever,shortness of breath,chills,and shivering and was hospitalized with the diagnosis of *** troponin levels remained high during *** was performed on postoperative day 7,after which the patient was referred to a tertiary center with the diagnosis of non-ST-elevation myocardial infarction due to akinesia in the apical *** angiography performed at the tertiary center showed normal coronary anatomy,and the patient was diagnosed with takotsubo *** Takotsubo cardiomyopathy mimicking myocardial infarction without ST segment elevation may develop after surgical treatment of liver hydatid cyst.

关键词： Takotsubo cardiomyopathy Liver hydatid cyst Noncardiac surgery Coronary angiography Echocardiography Case report

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Advancing hepatocellular carcinoma treatment with hepatic arterial infusion chemotherapy

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World Journal of Gastrointestinal Oncology 2024年第12期16卷 4757-4761页

作者： Eda Caliskan Yildirim yakup Ergun Department of Medical Oncology Sincan Training and Research HospitalAnkara 06100Türkiye Department of Medical Oncology Bower HospitalDiyarbakır 21100Türkiye

Hepatocellular carcinoma(HCC)remains a major challenge in oncology,being a leading cause of cancer-related mortality ***-stage HCC is typically treated with surgical resection,transplantation,or ablation,while advanced-stage HCC relies on systemic therapies like sorafenib and newer combinations such as *** these advancements,there is still a need for effective treatments for unresectable HCC,especially in cases with macroscopic vascular *** arterial infusion chemotherapy(HAIC)has demonstrated promising outcomes in Asia for the treatment of unresectable HCC,yet its application in Western countries has been relatively *** letter reviews the recent meta-analysis by Zhou et al published in the World Journal of Gastrointestinal Oncology,which demonstrates the efficacy and safety of HAIC vs *** analysis includes 9 randomized controlled trials and 35 cohort studies,highlighting significant improvements in overall survival,progressionfree survival,and objective response rates with HAIC and its *** editorial explores the reasons behind the limited use of HAIC in Western *** underscores the potential of HAIC to enhance treatment outcomes for advanced HCC and calls for more research and broader adoption of HAIC in clinical practice globally.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Tyrosine kinase inhibitors Immunotherapy Survival

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Molecular Dynamics Study of a Thermal Expansion Coefficient： Ti Bulk with an Elastic Minimum image Method

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Chinese Physics Letters 2006年第5期23卷 1068-1071页

作者： yakup Hundur Rainer Hippler Ziya B. Güven Department of Physics Istanbul Technical University Ayazaga Istanbul TR-34469 Turkey Institut für Physik Ernst-Moritz-Arndt-Universitat Greifswald DomstraBe 10a D-17487 Greifswald. Germany Electronic and Communication Engineering Cankaya University Balgat Ankara TR-06530 Turkey

Linear thermal expansion coefficient （TEC） of Ti bulk is investigated by means of molecular dynamics simulation. The elastic minimum image convention of periodic boundary conditions is introduced to allow the bulk to adjust its size according to the new fixed temperature. The TEC and the specific heat of Ti are compared to the available theoretical and experimental data.

关键词： TITANIUM

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Effect of early atopic sensitization in children aged 0–2 years on the development of asthma symptoms at 9–11 years of age

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World Journal of Pediatrics 2022年第11期18卷 753-760页

作者： Himmet Haluk Akar Ebru Nadir Burçin Beken yakup Yeşil Division of Pediatric Immunology and Allergy University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Division of Pediatrics University of Istanbul Health SciencesKanuni Sultan Suleyman Training and Research HospitalIstanbulTurkey Department of Pediatric Immunology and Allergy School of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulTurkey

Background Personal genetic predisposition and early life environmental factors are important for the development of childhood *** aimed to search whether egg,milk and mite sensitizations at 0–2 years old are risk factors for asthma symptoms at 9–11 years *** A total of 210 wheezer children who had specific immunoglobulin(Ig)E in 2010–2012 were included in the study(followed by pediatric allergy).Patients were divided into non-atopic(group 1,n=157)and atopic patients[groups 2–7,n=53(5 patients were in both group 4 and group 5)]based on *** the International Study of Asthma and Allergy in Childhood questionnaire,current wheeze(CW,2nd question),exercise wheezing(EW,7th question),and dry cough(DC,8th question)were ***,parental allergies,eczema at 0–2 years,current eosinophil percentage and total IgE were *** Eczema was observed as an important risk factor[CW:odds ratio(OR)=2.83,95%confidence interval(CI)=1.54–5.23,P≤0.001;EW:OR=2.71,95%CI=1.33–5.54,P=0.006;DC:OR=3.03,95%CI=1.47–6.25,P=0.003],whereas having no atopic sensitization at 0–2-year-old(group 1)was found as a significant protective factor for asthma at 9–11 years old(CW:OR=0.32,95%CI=0.15–0.70,P=0.004;EW:OR=0.21,95%CI 0.10–0.44,P≤0.001;DC:OR=0.25,95%CI=0.10–0.59,P=0.002).Conclusion Early personal eczema is a significant risk factor for the development of asthma symptoms at 9–11 years old,whereas not having an allergic sensitization at 0–2 years old(group 1)is an important protective factor.

关键词： Asthma Children Risk factors

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N_(2)and Ar dilution on the premixed biogas jet flame under external acoustic enforcement

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Propulsion and Power Research 2023年第4期12卷 486-504页

作者： Bugrahan Alabas Ilker Yılmaz yakupÇam Department of Aeronautical Engineering Faculty of Aeronautics and AstronauticsErciyes UniversityKayseri 38039Turkey Department of Energy Systems Engineering Faculty of TechnologyGazi UniversityAnkara 06560Turkey Department of Aircraft Maintenance and Repair Faculty of Aeronautics and AstronauticsErciyes UniversityKayseri 38039Turkey

In this study,combustion instabilities and flue gas emission changes under different dilutions of N_(2)(nitrogen)and Ar(argon)of a promising biogas mixture(70%CH4-30%CO_(2))in the fight against greenhouse gas emissions were *** the experiments,additions were made from 0%to 50%at intervals of 10%for both *** order to detect the instability of the flame,external acoustic enforcements at different frequencies was applied through the speakers placed in the combustion chamber *** dynamic pressure fluctuation values were *** results showed that low dilution ratios were effective in reducing flame instability for both inert ***,as the dilution ratio increased,the fuel/air mixture became leaner and blowoff *** the case of comparing two different gases,it has been observed that the effect of argon gas on reducing dynamic pressure fluctuation is *** outlet temperature and brightness values of the flame decreased in both Ar and N_(2)*** and NOx emissions increased with increasing diluent volume for all dilution *** the emissions of the two diluent gases are compared,the CO emission,which was 3134 ppm in the undiluted condition,increased up to 4949 ppm in 50%Ar dilution,while it increased to 4521 ppm in 50%N_(2)dilution.

关键词： Biogas Combustion instabilities Pollutant emissions Gas turbine combustor Dilution

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