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A self-crosslinking,double-functional group modified bacterial cellulose gel used for antibacterial and healing of infected wound

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Bioactive Materials 2022年第11期7卷 248-260页

作者： yajie Xie Kun Qiao Lina Yue Tao tang Yudong Zheng Shihui Zhu Huiyi Yang Ziyuan Fang School of Material Science and Engineering University of Science and Technology BeijingBeijingChina Hebei Key Laboratory of Hazardous Chemicals Safety and Control Technology School of Chemical and Environmental EngineeringNorth China Institute of Science and TechnologyLangfang065201HebeiChina Department of Burn Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai200433China

Cellulose/chitosan composite,as a mature commercial antibacterial dressing,is an important type of wound repair ***,how to achieve the perfect compound of two components and improve antibacterial activity is a major,lingering *** this study,a bifunctional group modified bacterial cellulose(DCBC)was prepared by carboxymethylation and selective ***,the chitosan(CS)was compounded in the network of DCBC by self-crosslinking to form dialdehyde carboxymethyl bacterial cellulose/chitosan composites(S-DCBC/CS).The aldehyde group can react with amino of CS by Schiff base *** carboxyl group of DCBC and the amorphous distribution of CS molecular chains increase the antimicrobial properties of *** bacteriostatic rate of composites could be higher than 95%.Bacteria can be attracted onto the surface of composites,what we call it“directional adhesion antibacterial effects”.In particular,a kind of large animal wound model,deep II degree infected scald of Bama miniature pig,was used to research the antimicrobial and healing properties of *** S-DCBC/CS can effectively inhibit bacterial proliferation of wound and kill the *** wound healing rate of S-DCBC/CS was up to 80%after three *** composites show better antibacterial and promoting concrescence effects than traditional chitosan dressings.

关键词： Self-crosslinking Bacterial cellulose Cell migration Wound healing Antimicrobial properties

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一种辐向分裂变压器的结构分析

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变压器 2024年第1期61卷 1-4页

作者：范利东张亚杰杭州钱江电气集团股份有限公司浙江杭州311243 保定天威集团特变电气有限公司河北保定071056

本文作者介绍了一种低压辐向分裂变压器的结构,外侧低压绕组在中部断开,高压绕组分接线从中断处引出。针对这种结构进行了磁场仿真和电场仿真,并与试验结果进行了对比。

关键词：分裂变压器辐向仿真

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The levels of osteopontin in human milk of Chinese mothers and its associations with maternal body composition

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Food Science and Human Wellness 2022年第5期11卷 1419-1427页

作者： Huijuan Ruan Qingya tang Xuan Zhao yajie Zhang Xuelin Zhao Yi Xiang Wei Geng Yi Feng Wei Cai Department of Clinical Nutrition Xinhua Hospital Affi liated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric ResearchXinhua Hospital Affi liated to Shanghai Jiao Tong University School of Medicine Shanghai 200092China Department of Pediatric Surgery Xinhua Hospital Affi liated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Objective:This study explored the content and change trend of osteopontin(OPN)in breast milk and analyzed the relationship between OPN in breast milk and maternal body ***:Breast-feeding mothers were recruited in Xinhua Hospital to collect breast milk and provide pertinent *** content of OPN in breast milk was determined by enzyme-linked immunosorbent assay(ELISA).Determination of protein content in human milk was performed via the BCA *** maternal body composition was determined by the bioelectrical impedance *** glucocorticoid receptorα,adiponectin,insulin,and leptin were determined by *** 25 was used for statistical ***:In the longitudinal cohort,106 mothers provided 318 milk samples at different lactation *** results indicate that the OPN showed dynamic *** levels were(343.2±163.5)mg/L during 1-14 days postpartum,(228.4±121.5)mg/L during 2-4 months postpartum,and(204.8±100.6)mg/L during 5-7 months *** content of OPN was very high in the first 1-14 days postpartum and then *** with early postpartum milk,the OPN content of mature milk showed a significant relationship with maternal weight-related *** body composition analysis was performed in 88 women at the mature milk *** results show that the OPN in milk is related to the mother’s body composition,especially the content of skeletal muscle mass,but not to relevant humoral ***:The levels of OPN in human milk of Chinese mothers showed dynamic changes with the extension of lactation *** OPN in human milk was related to the mother’s body composition but not related to related humoral factors.

关键词： Osteopontin Human milk Body composition Breastfeeding

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Boost photothermal theranostics via self-assembly-induced crystallization(SAIC)

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Aggregate 2022年第5期3卷 194-204页

作者： Xueluer Mu Fapu Wu Ying tang Rui Wang yajie Li Kaixuan Li Chunfeng Li Yingxi Lu Xianfeng Zhou Zhibo Li Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department College of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdaoP.R.China College of Material Science and Engineering Qingdao University of Science and TechnologyQingdaoP.R.China College of Chemical Engineering Qingdao University of Science and TechnologyQingdaoP.R.China

Owing to the intrinsic advantages of spatiotemporal selectivity,photothermal theranostics have become the advancing edge of precision medicine for *** photothermal transduction agents(PTAs)with near-infrared(NIR)absorption,high photothermal conversion efficiency,robust photothermal stability,and good accumulation in tumors,is particularly ***,we report a new concept,self-assembly-induced crystallization(SAIC),which can serve as a mechanism that dramatically boosts photothermal behaviors of PTA in NIR *** a proof of concept,three heptamethine cyanine molecules with internal degrees of freedom(geometry and intramolecular interaction)are designed to fine-tune their ***,Cy7-TCF-EMBI molecules with rigid and planar skeletons self-assemble into a crystalline state to maximize their packing density and improve the charge transfer,both of which contribute to nonradiative decay for energy dissipation as *** high packing density also renders an ideal scaffold for controlling intermolecular interactions to exhibit better photothermal stability,and endows an anisotropic three-dimensional architecture for passive tumor ***“SAIC”strategy may offer a conceptually novel,practically simple but effective approach to unveil the structure–property relationship that could provide some general rules in rational design of PTAs,and paves the way for a next generation of supramolecular medicine for photothermal theranostics.

关键词： crystallization photothermal theranostic self-assembly small molecule supramolecular medicine

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全胸腔镜与正中开胸手术治疗肥厚型梗阻性心肌病的倾向性评分匹配分析

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中国胸心血管外科临床杂志 2021年第6期28卷 656-662页

作者：陈钊刘健唐亚捷赵俊飞魏培坚马介旭刘彦俊谢斌黄焕雷袁海云朱伟刘辉曹忠明郭惠明广东省人民医院广东省医学科学院广东省心血管病研究所心脏外科广州510080 广东省人民医院广东省医学科学院广东省心血管病研究所成人超声科广州510080 广东省人民医院广东省医学科学院影像医学部放射科广州510080

目的通过对比正中开胸改良Morrow手术,探索全胸腔镜下经左房二尖瓣入路心肌切除术(totally endoscopic transmitral myectomy,TETM)治疗符合手术指征的肥厚型梗阻性心肌病(hypertrophic obstructive cardiomyopathy,HOCM)患者的有效性、安全性。方法本研究选取2019年我院收治的符合手术指征的HOCM 38例患者,其中女24例、男14例,年龄56(44~68)岁。根据手术方式,将其分为TETM组18例,传统正中开胸组20例。应用倾向性评分匹配筛选合适病例后,对两组患者资料进行对比分析。结果两组均无死亡,无室间隔穿孔、左室流出道残留梗阻和Ⅲ度房室传导阻滞。倾向性评分匹配后,相对于传统正中开胸手术,TETM组在住ICU时间[(41.5±5.0)h vs.(53.0±24.0)h,P=0.620],呼吸机使用时间[(19.5±9.2)h vs.(38.0±24.0)h,P=0.463],体外循环时间[(190.7±45.6)min vs.(156.0±70.7)min,P=0.627],主动脉阻断时间[(100.1±25.3)min vs.(94.5±57.3)min,P=0.915],左室流出道压差[(17.0±1.4)mm Hg vs.(5.0±0.5)mm Hg,P=0.053],左房前后径[(37.0±1.3)mm vs.(40.0±0.7)mm,P=0.090],室间隔厚度[(12.5±0.7)mm vs.(13.0±1.4)mm,P=0.712],左室后壁厚度[(10.0±1.4)mm vs.(10.5±2.1)mm,P=0.811],左室舒张末期内径[(43.5±3.5)mm vs.(46.0±4.2)mm,P=0.589],二尖瓣反流程度(1.0±0.2 vs. 0.7±0.5,P=0.500)等方面差异均无统计学意义。随访(6±3)个月,无死亡患者,TETM组1例因二尖瓣A3区撕裂,术后3个月行再次二尖瓣成形术。结论 TETM是一种安全有效的术式,能很好地暴露中部梗阻部位的室间隔,并能有效消除左室流出道梗阻引起收缩期二尖瓣前叶前向运动综合征相关的二尖瓣反流。

关键词：肥厚型梗阻性心肌病微创手术全胸腔镜改良Morrow手术

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单硝酸异山梨酯联合早期心脏康复对PCI后患者心功能及左心室重构的影响

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实用心脑肺血管病杂志 2024年第7期32卷 106-109页

作者：唐萌吴尽李茉张淼门苗罗晶路璐韩雅婧田迎春孙雅洁首都医科大学附属北京安贞医院心内科北京市100029

目的探讨单硝酸异山梨酯联合早期心脏康复对PCI后患者心功能及左心室重构的影响。方法选取2022年1月—2023年4月首都医科大学附属北京安贞医院收治的PCI后患者133例为研究对象,采用随机数字表法将其分为对照组(n=44)、单硝酸异山梨酯... 详细信息

目的探讨单硝酸异山梨酯联合早期心脏康复对PCI后患者心功能及左心室重构的影响。方法选取2022年1月—2023年4月首都医科大学附属北京安贞医院收治的PCI后患者133例为研究对象,采用随机数字表法将其分为对照组(n=44)、单硝酸异山梨酯组(n=45)及联合组(n=44)。对照组患者PCI后接受阿托伐他汀治疗联合常规康复;单硝酸异山梨酯组患者接受阿托伐他汀联合单硝酸异山梨酯治疗,在此基础上进行常规康复;联合组患者在单硝酸异山梨酯组基础上进行早期心脏康复,三组均干预4周。比较三组干预前后心功能指标、左心室重构指标、运动耐量指标。结果干预4周后,单硝酸异山梨酯组、联合组N末端脑钠肽前体(NT-proBNP)、左心室短轴缩短率(LVFS)低于对照组,联合组NT-proBNP、LVFS低于单硝酸异山梨酯组(P<0.05)。干预4周后,单硝酸异山梨酯组、联合组左心室收缩期纵向峰值应变率低于对照组,左心室舒张早期纵向峰值应变率高于对照组(P<0.05);干预4周后,联合组左心室收缩期纵向峰值应变率低于单硝酸异山梨酯组,左心室舒张早期纵向峰值应变率高于单硝酸异山梨酯组(P<0.05)。干预4周后,单硝酸异山梨酯组、联合组6分钟步行距离(6MWD)、运动终点时间长于对照组,运动期间最大心率慢于对照组(P<0.05);干预4周后,联合组6MWD、运动终点时间长于单硝酸异山梨酯组,运动期间最大心率慢于单硝酸异山梨酯组(P<0.05)。结论单硝酸异山梨酯联合早期心脏运动康复能有效改善PCI后患者心功能,减轻左心室重构,增加患者运动耐量。

关键词：心脏康复单硝酸异山梨酯经皮冠状动脉介入治疗心功能心室重构

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启航幼儿园,九寨沟,四川,中国

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世界建筑 2024年第3期 96-97页

作者：无杨远景黄瑾郑泽旭何亚洁杨宗祥隋佳音唐帅马智超李凯璇广州市东意建筑设计咨询有限公司不详东意建筑南社·建筑

该项目为2017年九寨沟地震的灾后重建项目,由深圳壹基金公益基金会联合国家专项资金提供支持。新建的优质公办幼儿园承载着社区与地方发展的希望。风景、地形、城镇、社区与儿童是设计的核心议题。

关键词：公办幼儿园公益基金会壹基金九寨沟地震核心议题启航社区

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贝莱斯芽孢杆菌S3-1与蚯蚓粪混合改良剂的制备及其土壤改良效果的研究

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上海师范大学学报（自然科学版中英文） 2024年第4期53卷 512-521页

作者：哈米古丽·吐尔逊江杨宁徐兆丰唐筱茸余雅婷田雅洁肖明上海师范大学生命科学学院上海200234

天然有机肥在提高土壤的肥力、促进作物生长等方面有着举足轻重的地位.此前的研究中已发现菌株S3-1与蚯蚓粪共同施用时可以显著提高土壤肥力.本研究在此基础上,对实验样地、蚯蚓粪与商品菌肥进行了选择,根据比例制备改良剂.关于改良剂... 详细信息

天然有机肥在提高土壤的肥力、促进作物生长等方面有着举足轻重的地位.此前的研究中已发现菌株S3-1与蚯蚓粪共同施用时可以显著提高土壤肥力.本研究在此基础上,对实验样地、蚯蚓粪与商品菌肥进行了选择,根据比例制备改良剂.关于改良剂对土壤环境因子的影响等问题,进行了长达270 d的原位修复实验.实验样地分别为草坪地以及商品菌肥和蚯蚓粪处理地,设置了对照组、单独施加蚯蚓粪组、改良剂处理组、S3-1菌液处理组以及商品菌肥平行实验处理组.结果发现:酸碱中性磷酸酶活性提升率依次为25.44%,20.32%和18.33%;真菌数量随着时间周期的增长率分别为9.92%,41.98%和51.65%,细菌数量的增长速率逐从20.70%~36.12%渐变大为36.12%~80.35%.原位修复实验条件下,脲酶和蔗糖酶活性提升率也显著增强.微生物改良剂用更安全更环保的方法,促进了土壤恢复到自然状态,本研究为改良剂的广泛使用性奠定了实践基础.

关键词：微生物改良剂原位改良蚯蚓粪贝莱斯芽孢杆菌土壤酶活性

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Rare-Earth-Controlled Aminoacid-Decorated Arsenotungstates:Syntheses,Structures and Properties

Rare-Earth-Controlled Aminoacid-Decorated Arsenotungstates:S...

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中国化学会第八届全国配位化学会议

作者： Yamin Li yajie Liu Zhigang tang Junwei Zhao Henan Key Laboratory of Polyoxometalate Chemistry Institute of Molecular and Crystal EngineeringCollege of Chemistry and Chemical Engineering Henan University

Through simple aqueous assembly strategy of Na WO·2 H O,NaAsO,L-alanine(L-ala) and RE(NO)·6 H O in acidic aqueous solution with the attendance of dimethylamine hydrochloride[1],several kinds of organic-inorganic hybrid L-alaine-decorated and RE-substituted arsenotungstates[H N(CH)] Na H[RE W(H O)(L-ala) O(OH)(B-α-AsW O)]·nH O(RE = Ho,Er,n = 50;RE =Yb,Lu,n = 43) for type 1,[H N(CH)]Na H[RE W Na(H O)(L-ala) O(B-α-AsW O)]·50 H O(RE= Eu) for type 2 and[H N(CH)]Na H[RE W(H O)(L-ala) O(OH)(B-α-AsW O)]·54 H O(RE =Tb,Gd) for type 3 have been prepared and structurally characterized by IR spectra,elemental analysis,single-crystal X-ray diffraction and thermogravimetric *** tetrameric arsenotungstates possess four-leaved clover-like structure with a RE-W-ala cluster sandwiched by two {As WO} building block that is different from the configuration of versatile precursor and the major differences among three types are the number of L-ala ***,the luminescent properties and lifetime decay behaviors of 2-Eu,3-Tb and1-Dy as well as the chromaticity color coordinates of them have been *** addition,the electrochemical property of 2-Eu have been further investigated too[2].

关键词： arsenotungstate luminescence electrochemistry

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Influence of holoparasitic plant Cuscuta japonica on growth and alkaloid content of its host shrub Catharanthus roseus: a field experiment

Influence of holoparasitic plant Cuscuta japonica on growth ...

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中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Xiaoju Zhao yajie Pan Huafeng Chen Zhonghua tang School of Forestry Northeast Forestry University College of Bioengineering Daqing Normal University The Key Laboratory of Plant Ecology Northeast Forestry University

Japanese dodder（Cuscuta japonica） is a flowering,parasitic weed that causes major yield losses on crop and forest *** present field study,the influence of Cuscuta on the growth and secondary metabolite of its host medicinal shrub Madagascar periwinkle（Catharanthus roseus） was *** and reproductive growth of the host plant Catharanthus were measured at intervals from 0 to 60 days after inoculation（DAI）,and content of three alkaloids,naturally produced by the host,in the host and parasite were measured by HPLC at intervals from 15 to 45 *** infection significantly inhibited biomass accumulation and reproductive growth of Catharanthus,and aerial parts of the host died by 60 *** of alkaloids vinblastine,vindoline and catharanthine in inoculated Catharanthus were lower than in uninoculated control plants,both in immature leaf and in mature leaf,except the alkaloids contents were elevated in host immature leaf compared with uninoculated control plants immature leaf at 15 *** host plant thus actively responded to dodder infection by accumulating alkaloids act as a defense molecule at 15 *** alkaloids produced by host plants accumulated in dodder at 15-45 DAI,and the alkaloid content in dodder reached a maximum at 45 *** alkaloids transported from host to parasite act as a sink,the high content of alkaloids in dodder be cytotoxic and accelerated the onset of senescence.

关键词： Cuscuta Catharanthus roseus alkaloid Vegetative growth reproductive growth

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