Boost photothermal theranostics via self-assembly-induced crystallization(SAIC)

作     者：Xueluer Mu Fapu Wu Ying Tang Rui Wang Yajie Li Kaixuan Li Chunfeng Li Yingxi Lu Xianfeng Zhou Zhibo Li 

作者机构：Key Lab of Biobased Polymer Materials of Shandong Provincial Education DepartmentCollege of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdaoP.R.China College of Material Science and EngineeringQingdao University of Science and TechnologyQingdaoP.R.China College of Chemical EngineeringQingdao University of Science and TechnologyQingdaoP.R.China 

出 版 物：《Aggregate》 (聚集体（英文）)

年 卷 期：2022年第3卷第5期

页      面：194-204页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0807[工学-动力工程及工程热物理] 0703[理学-化学] 0813[工学-建筑学] 0814[工学-土木工程] 0701[理学-数学] 0702[理学-物理学] 070101[理学-基础数学] 

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:22071128,51773107,51690152 Taishan Scholars Project of Shandong Province,Grant/Award Number:tsqn201812072 Major Scientific and Technological In-novation Projects of key R&D programs in Shandong Province,Grant/Award Number:2019JZZY021007 Shan-dong Provincial Natural Science Foundation,Grant/Award Number:ZR2020ZD31 

主　　题：crystallization photothermal theranostic self-assembly small molecule supramolecular medicine 

摘      要：Owing to the intrinsic advantages of spatiotemporal selectivity,photothermal theranostics have become the advancing edge of precision medicine for *** photothermal transduction agents(PTAs)with near-infrared(NIR)absorption,high photothermal conversion efficiency,robust photothermal stability,and good accumulation in tumors,is particularly ***,we report a new concept,self-assembly-induced crystallization(SAIC),which can serve as a mechanism that dramatically boosts photothermal behaviors of PTA in NIR *** a proof of concept,three heptamethine cyanine molecules with internal degrees of freedom(geometry and intramolecular interaction)are designed to fine-tune their ***,Cy7-TCF-EMBI molecules with rigid and planar skeletons self-assemble into a crystalline state to maximize their packing density and improve the charge transfer,both of which contribute to nonradiative decay for energy dissipation as *** high packing density also renders an ideal scaffold for controlling intermolecular interactions to exhibit better photothermal stability,and endows an anisotropic three-dimensional architecture for passive tumor ***“SAICstrategy may offer a conceptually novel,practically simple but effective approach to unveil the structure–property relationship that could provide some general rules in rational design of PTAs,and paves the way for a next generation of supramolecular medicine for photothermal theranostics.