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“政治经济学”概念在近代中国的溯源与演变

中国经济史研究 2024年第1期 165-178页

作者：张亚光毕悦北京大学经济学院北京100871

“政治经济学”概念在近代中国的演变过程,也是政治经济学科从被动植入到与本土思想传统实现创造性结合,再到形成独立学术体系的过程。自19世纪中叶以来,“政治经济学”概念经历了多种译词并存的混用阶段、对“经济学”概念的借用阶段... 详细信息

“政治经济学”概念在近代中国的演变过程,也是政治经济学科从被动植入到与本土思想传统实现创造性结合,再到形成独立学术体系的过程。自19世纪中叶以来,“政治经济学”概念经历了多种译词并存的混用阶段、对“经济学”概念的借用阶段、受到学术分科体系影响的化用阶段,开辟了一条迥异于西方的术语演变路径,最终与马克思主义经济学说产生了更紧密的联系。对“政治经济学”概念及其演变的溯源,为理解当前国内经济学界研究范式的二元并立格局、探讨政治经济学在中国的发展趋向和时代使命提供了一个新的视角。

关键词：政治经济学概念史近代中国马克思主义

大规模直驱风电场经柔直送出系统交直流线路故障特征分析

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内蒙古电力技术 2024年第3期42卷 42-51页

作者：钟鸣杨志勇张亚光王超内蒙古电力(集团)有限责任公司内蒙古电力科学研究院分公司呼和浩特010020 内蒙古电力(集团)有限责任公司锡林郭勒供电公司内蒙古锡林浩特026000 内蒙古电力(集团)有限责任公司乌兰察布供电公司内蒙古乌兰察布012000 内蒙古工业大学电力学院呼和浩特010010

针对具有故障穿越策略的永磁风电场经多端柔性直流(Voltage Source Converter Based Multi-terminal Direct Current,VSC⁃MTDC)输电系统外送的交直流混联系统,分析故障穿越控制目标下受端交流电网故障和考虑输电线路频变特性的直流系统... 详细信息

针对具有故障穿越策略的永磁风电场经多端柔性直流(Voltage Source Converter Based Multi-terminal Direct Current,VSC⁃MTDC)输电系统外送的交直流混联系统,分析故障穿越控制目标下受端交流电网故障和考虑输电线路频变特性的直流系统输电线路故障发生后的故障特征,以及大时间尺度下,直流系统对交流故障的响应。研究结果表明:基于实时数字仿真(Real Time Digital Simulation,RTDS)搭建的交直流混联系统模型在有效控制故障发展的前提下,不同故障条件、控制策略下具有相对应的故障特征,如:交流并网线路故障时,负序电流将被抑制,换流站仅向故障点提供有限的正序电流,且优先输出无功功率,直流线路累积不平衡功率出现直流过电压现象,计及直流电压波动引起受端换流站的dq轴电流发生变化,造成交流线路故障电流短时间内增大约20%。直流线路发生单极接地故障时,故障极电压以最大700 kV/ms的速率迅速下降到0,非故障极电压上升为原来的两倍,且故障电流会随着接地电阻的增大而减小;当发生双极故障时,故障电流能够在数毫秒内达到额定电流的几十倍,最大速率可达8.25 kA/ms,严重威胁电力电子器件的安全,并且电压迅速降至0,此时通过混合直流断路器快速动作,在故障电流上升至额定电流2倍前切除故障线路,使系统满足N-1运行原则。仿真结果与理论分析结论相符。

关键词：风电场多端柔性直流输电交直流混联系统故障穿越策略故障特征 RTDS

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基于携带盐腐蚀介质的再生骨料混凝土性能劣化研究

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北方交通 2024年第4期 49-52,56页

作者：何涛卜久生费浩张亚光北京鼎瀚中航建设有限公司北京市100101 内蒙古自治区民航机场集团有限责任公司呼和浩特市010000

为量化分析盐腐蚀再生混凝土骨料对再生混凝土性能的影响,进行室内试验,采用浓度为3%、5%和7%的盐溶液持续浸泡再生粗骨料,并采用不同取代率的再生粗骨料分别替代天然骨料拌制再生混凝土,借助抗压强度、劈裂强度试验和抗氯离子渗透试验... 详细信息

为量化分析盐腐蚀再生混凝土骨料对再生混凝土性能的影响,进行室内试验,采用浓度为3%、5%和7%的盐溶液持续浸泡再生粗骨料,并采用不同取代率的再生粗骨料分别替代天然骨料拌制再生混凝土,借助抗压强度、劈裂强度试验和抗氯离子渗透试验获取不同再生混凝土的强度和耐久性演变规律。试验结果表明:携带盐腐蚀介质的再生粗骨料用于混凝土中,可影响再生混凝土的力学强度,混凝土的早期强度略微改善,而后期力学强度遭到劣化。

关键词：再生骨料盐腐蚀介质再生混凝土粗骨料

Dynamic compliance of energy-saving legged elastic parallel joints for quadruped robots:design and realization

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Frontiers of Mechanical Engineering 2024年第2期19卷 45-58页

作者： yaguang ZHU Minghuan zhang Xiaoyu zhang Haipeng QIN Key Laboratory of Road Construction Technology and Equipment of Ministry of Education School of Engineering MachineryChang’an UniversityXi’an 710064China State Key Laboratory of Robotics and Systems Harbin Institute of TechnologyHarbin 150001China

Achieving dynamic compliance for energy-efficient legged robot motion is a longstanding *** recent predictive control methods based on single-rigid-body models can generate dynamic motion,they all assume infinite energy,making them unsuitable for prolonged robot *** this issue necessitates a mechanical structure with energy storage and a dynamic control strategy that incorporates feedback to ensure *** work draws inspiration from the efficiency of bio-inspired muscle–tendon networks and proposes a controllable torsion spring leg *** design integrates a spring-loaded inverted pendulum model and adopts feedback delays and yield springs to enhance the delay effects.A leg control model that incorporates motor loads is developed to validate the response and dynamic performance of a leg with elastic *** model provides torque to the knee joint,effectively reducing the robot’s energy consumption through active or passive control *** benefits of the proposed approach in agile maneuvering of quadruped robot legs in a realistic scenario are demonstrated to validate the dynamic motion performance of the leg with elastic joints with the advantage of energy-efficient legs.

关键词： dynamic responsiveness energy dissipation legged locomotion parallel joints quadruped robot

A semi-analytical multi-harmonic balance method on full-3D contact model for dynamic analysis of dry friction systems

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Chinese Journal of Aeronautics 2024年第2期37卷 309-329页

作者： He SUN Dayi zhang yaguang WU Qingyang SHEN Dianyin HU Research Institute of Aero-Engine Beihang UniversityBeijing 100191China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100191China Sino-French Engineering School Beihang UniversityBeijing 100191China AECC Sichuan Gas Turbine Research Establishment Chengdu 610500China

Dry friction damping structures are widely-used in aero-engines to mitigate *** nonlinear nature of friction and the two-dimensional in-plane motion on the contact interface bring challenges to accurately and efficiently predict the forced response of frictionally damped *** state-of-the-art Multi-Harmonic Balance Method(MHBM)on quasi-3D contact model in engineering cannot precisely capture the kinematics on the friction interface although the efficiency is *** full-3D contact model can describe the constitutive relationship of the interface in a more accurate manner;however,the efficiency and convergence are not guaranteed for large-scale *** this paper,a semi-analytical MHBM on full-3D contact model is *** original Trajectory Tracking Method(TTM)for evaluating the contact force is reformulated to make the calculation more concise and the derivation of the Analytical Jacobian Matrix(AJM)*** on the chain rule of derivation,the AJM which is the core to upgrade the performance is *** a shrouded blade finite element model,the accuracy and efficiency of the proposed method are compared with both the MHBM on full-3D contact model with numerical Jacobian matrix and the MHBM on quasi-3D contact model with *** results show that the AJM improves significantly the efficiency of the MHBM on full-3D contact *** time cost of the proposed method is in the same order of magnitude as that of the MHBM on quasi-3D contact *** also confirm that the full-3D contact model is necessary for the dynamic analyses of shrouded *** one uses the quasi-3D model,the estimation relative error of damping can even reach 31.8%in some *** addition,the AJM also brings benefits for stability *** is highly recommended that engineers use the MHBM on full-3D contact model for the dynamic analysis and design of shrouded blades.

关键词： Dry friction damping Multi-harmonic balance method Trajectory tracking method Jacobian matrix Shrouded blade

Trim28 citrullination maintains mouse embryonic stem cell pluripotency via regulating Nanog and Klf4 transcription

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Science China(Life Sciences) 2023年第3期66卷 545-562页

作者： yaguang zhang Xiaowen Wan Lei Qiu Lian Zhou Qing Huang Mingtian Wei Xueqin Liu Sicheng Liu Bo zhang Junhong Han State Key Laboratory of Biotherapy and Cancer Center National Clinical Research Center for Geriatricsand Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China Department of Gastrointestinal Surgery and Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Protein citrullination,including histone H1 and H3 citrullination,is important for transcriptional regulation,DNA damage response,and pluripotency of embryonic stem cells(ESCs).Tripartite motif containing 28(Trim28),an embryonic development regulator involved in ESC self-renewal,has recently been identified as a novel substrate for citrullination by ***,the physiological functions of Trim28 citrullination and its role in regulating the chromatin structure and gene transcription of ESCs remain *** this paper,we show that Trim28 is specifically citrullinated in mouse ESCs(m ESCs),and that the loss of Trim28 citrullination induces loss of ***,Trim28 citrullination enhances the interaction of Trim28with Smarcad1 and prevents chromatin ***,Trim28 citrullination regulates m ESC pluripotency by promoting transcription of Nanog and Klf4 which it does by increasing the enrichment of H3K27ac and H3K4me3 and decreasing the enrichment of H3K9me3 in the transcriptional regulatory ***,our findings suggest that Trim28citrullination is the key for the epigenetic activation of pluripotency genes and pluripotency maintenance of ***,these results uncover a role Trim28 citrullination plays in pluripotency regulation and provide novel insight into how citrullination of proteins other than histones regulates chromatin compaction.

关键词： citrullination chromatin embryonic stem cell pluripotency Trim28

Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1357-1360页

作者： Xuyang Yang yaguang zhang Yang zhang Huifang Li Li Li Yangping Wu Xiangzheng Chen Lei Qiu Junhong Han Ziqiang Wang Colorectal Cancer Center Department of General SurgeryState Key Laboratory of Biotherapy and Cancer Centerand Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041 Sichuan ProvinceChina State Key Laboratory of Biotherapy and Cancer Center and Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041 Sichuan ProvinceChina Core Facility Institute of Clinical PathologyDepartment of Respiratory and Critical Care Medicineand Department of Liver Surgery&Liver TransplantationState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610041China

Dear Editor,To date,the effect of colorectal cancer(CRC)-derived extracellular vesicles(EVs)on liver pre-metastatic niche(PMN)remain incompletely understood.1 To investigate the role of CRC-derived EVs in the remodeling of the liver PMN,we isolated EVs from CT26 cell culture *** characteristics of EVs(the morphology,size,and markers)were identified by transmission electron microscopy(TEM),Nanoparticle Tracking Analysis(NTA),and western blotting(Supplementary Fig.S1a–e).Then,BALB/c mice with an intact liver immune status were pretreated with CRCderived EVs and phosphate-buffered saline(PBS)for one month,and a liver metastasis model was established via spleen injection of tumor cells to determine whether EVs influence liver metastasis(Fig.1a).Two hours after the operation,in vivo imaging indicated that the animal model was successfully established,and the tumor fluorescence intensity in the liver was consistent between the two groups(Supplementary Fig.S2a,b).Amazingly,the liver tumor fluorescence intensity in the EVs group was significantly stronger than that in the PBS group after 24 h(Fig.1b;Supplementary Fig.S2c,d).The number of liver tumor nodules in the EVs group was also significantly higher than that in the PBS group on day 4(Fig.1c;Supplementary Fig.S2e,f).

关键词： metastasis metastatic cancer

Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy

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Signal Transduction and Targeted Therapy 2023年第1期8卷 250-265页

作者： Yang Meng Lei Qiu Xinyi Zeng Xiaoyan Hu yaguang zhang Xiaowen Wan Xiaobing Mao Jian Wu Yongfeng Xu Qunli Xiong Zhixin Chen Bo zhang Junhong Han Research Laboratory of Tumor Epigenetics and Genomics Department of General SurgeryFrontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for GeriatricsState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Division of Cancer Cell Biology The Graduate School of Frontier SciencesThe University of Tokyo4-6-1 ShirokanedaiMinato-kuTokyo 108-8639Japan Division of Hematology/Oncology Department of MedicineVirginia Commonwealth UniversityRichmondVAUSA Abdominal Oncology Ward Cancer CenterWest China Hospital of Sichuan UniversityChengdu 610041China

Chemoresistance has long been the bottleneck of ovarian cancer(OC)*** has been shown that mitochondria play a crucial role in cell response to chemotherapy and that dysregulated mitochondrial dynamics is intricately linked with diseases like OC,but the underlying mechanisms remain ***,we demonstrate a new mechanism where CRL4^(CUL4A/DDB1)manipulates OC cell chemoresistance by regulating mitochondrial dynamics and ***4^(CUL4A/DDB1)depletion enhanced mitochondrial fission by upregulating AMPKα^(Thr172)and MFF^(Ser172/Ser146)phosphorylation,which in turn recruited DRP1 to ***4^(CUL4A/DDB1)loss stimulated mitophagy through the Parkin-PINK1 pathway to degrade the dysfunctional and fragmented ***,CRL4^(CUL4A/DDB1)loss inhibited OC cell proliferation,whereas inhibiting autophagy partially reversed this *** findings provide novel insight into the multifaceted function of the CRL4 E3 ubiquitin ligase complex in regulating mitochondrial fission,mitophagy,and OC *** of CRL4^(CUL4A/DDB1)and mitophagy may be a promising therapeutic strategy to overcome chemoresistance in OC.

关键词： inhibited cancer chemotherapy

The function and potential drug targets of tumour-associated Tregs for cancer immunotherapy

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Science China(Life Sciences) 2019年第2期62卷 179-186页

作者： Shanshan Yan yaguang zhang Bing Sun State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China University of Chinese Academy of Sciences

Regulatory T cells(Tregs) play an important role in maintaining self-tolerance and immune homeostasis, but they also play a negative role in evoking effective antitumour immune responses. There is ample evidence indicating that the depletion of Tregs or the inhibition of Treg function will enhance antitumour effects. However, it is unclear which surface molecules of Tregs are suitable targets for tumour immunotherapy with minimal toxic side effects, which is a central theme in the field of Treg-targeted immunotherapy. In this review, we focus on the regulatory mechanisms of Tregs, including intrinsic and extrinsic factors within the tumour microenvironment, and we address potential drug targets on Tregs for immunotherapy.

关键词： tumour-associated tregs regulation targets immunotherapy