检索结果-南通市图书馆

World Journal of Gastroenterology 2024年第8期30卷 843-854页

作者： Hong-Xiao Wu Xiao-yan Ding ya-wen xu Ming-Hua Yu Xiao-Mi Li Na Deng Jing-Long Chen Cancer Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Hepatocellular carcinoma(HCC)patients complicated with portal vein tumor thrombus(PVTT)exhibit poor prognoses and treatment *** To investigate efficacies and safety of the combination of PD-1 inhibitor,transcatheter arterial chemoembolization(TACE)and Lenvatinib in HCC subjects comorbid with *** From January 2019 to December 2020,HCC patients with PVTT types Ⅰ-Ⅳ were retrospectively enrolled at Beijing Ditan *** were distributed to either the PTL or TACE/Lenvatinib(TL)*** median progression-free survival(mPFS)was set as the primary endpoint,while parameters like median overall survival,objective response rate,disease control rate(DCR),and toxicity level served as secondary *** Forty-one eligible patients were finally recruited for this study and divided into the PTL(n=18)and TL(n=23)*** a median follow-up of 21.8 months,the DCRs were 88.9%and 60.9%in the PTL and TL groups(P=0.046),***,mPFS indicated significant improvement(HR=0.25;P<0.001)in PTL-treated patients(5.4 months)compared to TL-treated(2.7 months)*** were no treatment-related deaths or differences in adverse events in either *** A triplet regimen of PTL was safe and well-tolerated as well as exhibited favorable efficacy over the TL regimen for advanced-stage HCC patients with PVTT types Ⅰ-Ⅳ.

关键词： Hepatocellular carcinoma Transcatheter arterial chemoembolization Lenvatinib PD-1 inhibitor Portal vein tumor thrombus

Corneal endothelial cells and acoustic cavitation in phacoemulsification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第8期11卷 1712-1718页

作者： Kai Chen wen-ya xu Si-Si Sun Hong-Wei Zhou Department of Ophthalmology Lianshui County People's HospitalHuai’an 223400Jiangsu ProvinceChina Department of Ophthalmology Huai’an 82 HospitalHuai'an 223001Jiangsu ProvinceChina Department of Industrial Engineering Tsinghua UniversityBeijing 100084China

Postoperative complications of phacoemulsification,such as corneal edema caused by human corneal endothelial cell(CEC)injury,are still a matter of *** several factors are known to cause CEC damage,the influence of ultrasound on the formation of free radicals during surgery should be *** in aqueous humor induces cavitation and promotes the formation of hydroxyl radicals or reactive oxygen species(ROS).ROS-induced apoptosis and autophagy in phacoemulsification have been suggested to significantly promote CEC *** cannot regenerate after injury,and measures must be taken to prevent the loss of CEC after phacoemulsification or other CEC *** can reduce the oxidative stress injury of CEC during *** from rabbit eye studies shows that ascorbic acid infusion during operation or local application of ascorbic acid during phacoemulsification has a protective effect by scavenging free radicals or reducing oxidative *** in experiments and clinical practice,hydrogen dissolved in the irrigating solution can also prevent CEC damage during phacoemulsification ***(AST)can inhibit oxidative damage,thereby protecting different cells from most pathological conditions,such as myocardial cells,luteinized granulosa cells of the ovary,umbilical vascular endothelial cells,and human retina pigment epithelium cell line(ARPE-19).However,existing research has not focused on the application of AST to prevent oxidative stress during phacoemulsification,and the related mechanisms need to be *** Rho related helical coil kinase inhibitor Y-27632 can inhibit CEC apoptosis after *** experiments are required to confirm whether its effect is realized through improving the ROS clearance ability of CEC.

关键词： Cataract Phacoemulsification Corneal endothelial cells Ultrasound Acoustic cavitation Oxidative stress Antioxidant

Influence of tectonic preservation conditions on the nanopore structure of shale reservoir: A case study of Wufeng-Longmaxi Formation shale in western Hubei area, south China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2203-2217页

作者： Meng Xiang Shang xu ya-Ru wen Qi-yang Gou Bing-Chang Liu National Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) Hubei Key Laboratory of Resources and Eco-environment Geology Hubei Geological Survey Key Laboratory of Tectonics and Petroleum Resources Ministry of Education China University of Geosciences

Tectonism is one of the dominant factors affecting the shale pore structure. However, the control of shale pore structure by tectonic movements is still controversial, which limits the research progress of shale gas accumulation mechanism in the complex tectonic region of southern China. In this study, 34 samples were collected from two exploratory wells located in different tectonic locations. Diverse experiments,e.g., organic geochemistry, XRD analysis, FE-SEM, low-pressure gas adsorption, and high-pressure mercury intrusion, were conducted to fully characterize the shale reservoir. The TOC, Ro, and mineral composition of the shale samples between the two wells are similar, which reflects that the shale samples of the two wells have proximate pores-generating capacity and pores-supporting ***, the pore characteristics of shale samples from two wells are significantly different. Compared with the stabilized zone shale, the porosity, pore volume, and specific surface area of the deformed zone shale were reduced by 60.61%, 64.85%, and 27.81%, respectively. Moreover, the macroscopic and fine pores were reduced by 54.01% and 84.95%, respectively. Fault activity and uplift denudation are not conducive to pore preservation, and the rigid basement of Huangling uplift can promote pore preservation. These three factors are important reasons for controlling the difference in pore structure between two wells shales. We established a conceptual model of shale pores evolution under different tectonic preservation conditions. This study is significant to clarify the scale of shale gas formation and enrichment in complex tectonic regions, and helps in the selection of shale sweet spots.

关键词： Shale gas Pore structure Tectonic preservation conditions Shale gas enrichment mechanism

Sulfonated poly(aryl ether ketone sulfone)modified by polyoxometalates LaW_(10) clusters for proton exchange membranes with high proton conduction performance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2024年第2期6卷 454-464页

作者： Meng-Long Liu xu Han wen-wen He Feng-Yu Jiang Fang Ji Wang-Wang Shen Tao Zhou Jing-Mei xu ya-Qian Lan School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China School of Chemistry South China Normal UniversityGuangzhou 510006China

Polyoxometalates(POMs)are classified as solid superacids which can exhibit notable proton conductivity,making them a promising functional inorganic filler for enhancing the proton conductivity of proton exchange membranes(PEMs).In this study,a series of hybrid membranes were obtained by molecular-level hybridization of Weakley-type POM Na_(7)H_(2)LaW_(10)O_(36)(LaW_(10))clusters into sulfonated poly(aryl ether ketone sulfone)(SPAEKS).All hybrid membranes exhibited greater proton conductivity than the pristine membrane in the 30–80℃temperature *** the doping amount of LaW 10 reached 7 wt.%,the proton conductivity of M-LaW 10^(-7)achieved 64 mS·cm^(−1)at 80℃.Lanthanide ions'high coordination number property and variable coordination environment can aid to attract more water molecules from the *** 10 and these bound water can construct denser hydrogen bonds with–SO_(3)H of *** intensive hydrogen bonds will facilitate the constitution of more continuous proton transport channels,and improve the proton conductivity of the hybrid *** work off ers a fresh approach to using POMs containing rare-earth components in PEMs.

关键词： Polyoxometalates Rare-earth elements Sulfonated poly(arylene ether ketone sulfone) Proton exchange membranes

维普期刊数据库

Current and Potential Roles of Ferroptosis in Bladder Cancer

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第1期44卷 51-63页

作者： wen-xin AN Radheshyam Gupta Kun ZHAI ya-ru WANG Wan-hai xu yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer

Unconditionally stable Crank-Nicolson algorithm with enhanced absorption for rotationally symmetric multi-scale problems in anisotropic magnetized plasma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第1期35卷 65-73页

作者： wen Yi WANG Junxiang xu Hongbing School of Automatic Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Beijing Institute of Aerospace Systems Engineering Beijing 100076China

Large calculation error can be formed by directly employing the conventional Yee’s grid to curve *** order to alleviate such condition,unconditionally stable CrankNicolson Douglas-Gunn(CNDG)algorithm with is proposed for rotationally symmetric multi-scale problems in anisotropic magnetized *** the CNDG algorithm,an alternative scheme for the simulation of anisotropic plasma is proposed in body-of-revolution *** perfectly matched layer(CPML)formulation is proposed to efficiently solve the open region *** example is carried out for the illustration of effectiveness including the efficiency,resources,and *** the results,it can be concluded that the proposed scheme shows considerable performance during the simulation.

关键词： anisotropic magnetized plasma body-of-revolution(BOR) Crank-Nicolson Douglas-Gunn(CNDG) finite-difference time-domain(FDTD) perfectly matched layer(PML) rotationally symmetric multi-scale problems

维普期刊数据库

Can the lower urinary tract storage symptoms be completely resolved after plasmakinetic enucleation of the prostate？

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第6期19卷 655-658页

作者： Bing-Kun Li Bin-Shen Chen Yu-Hong Xin Chun-Xiao Liu Shao-Bo Zheng ya-wen xu Hu-Lin Li Yong Zou Li-Ping Li Department of Urology Zhujiang Hospital Southern Medical University Guangzhou 510282 China Department of Urology The People's Hospital of Jiangmen Jiangmen 529020 China Department of Urology Zhongshan Hospital Fudan University Shanghai 200032 China.

The aim of this study was to determine whether the lower urinary tract storage symptoms of benign prostatic obstruction （BPO） could be completely resolved after plasmakinetic enucleation of the prostate （PKEP） and the possible predictors of persistent symptoms. Two hundred and sixty-seven cases of BPO performed PKEP from July 2008 to June 2009 were retrospectively analyzed. Five-year postoperative data were collected and compared with the preoperative data. According to the urodynamic results, the patients were divided into involuntary detrusor contraction （IDC） group （n = 95） and no IDC group （n = 172） preoperatively; the patients with IDC were divided into IDC-persistent group （n = 33） and IDC-resolved group （n = 62） after PKER The predictors of persistent IDC were analyzed. Compared with the preoperative data, the 5-year postoperative data showed that the IDC rate was lower （P --- 0.000）, Overactive Bladder Symptom Score （OABSS） was lower （P = 0.000）, maximum cystometric capacity （MCC） was larger （P= 0.000）, Prostate volume （PV） was smaller （P= 0.000）, and prostate-specific antigen （PSA） was lower （P= 0.000）. Compared with the no IDC group, the IDC group showed that the age was older （P = 0.016）, MCC was smaller （P = 0.004）, PSA was higher （P = 0.016）, and Chronic Inflammation rate was higher （P = 0.004）. Compared with IDC-resolved group after PKER IDC-persistent group showed that the age was older （P = 0.019）, MCC was smaller （P = 0.000）, PSA was higher （P = 0.013）, and Chronic Ihflammation rate was higher （P = 0.032）. The present study shows that the storage symptoms are still needed to be focused on after PKER The advanced patient age, MCC, PSA, and chronic inflammation may be the important clinical predictors of persistent IDC.

关键词： age factors benign prostatic obstruction lower urinary tract storage symptoms plasmakinetic enucleation of the prostate urodynamic parameter

Efficient and precise genomic deletion in rice using enhanced prime editing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

aBIOTECH 2024年第2期5卷 214-218页

作者： Mengyuan Liu Xiang Zhang wen xu Guiting Kang ya Liu Xinxiang Liu wen Ren Jiuran Zhao Jinxiao yang Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Efficient and precise genomic deletion shows promise for investigating the function of proteins in plant research and enhancing agricultural *** this study,we tested the PRIME-Del(PDel)strategy using a pair of prime editing guide RNAs(pegRNAs)that targeted opposite DNA strands and achieved an average deletion efficiency of 55.8%for 60 bp fragment deletions at six endogenous ***,as high as 84.2%precise deletion efficiency was obtained for a 2000 bp deletion at the OsGS1 site in transgenic rice *** add the bases that were unintentionally deleted between the two nicking sequences,we used the PDel/Syn strategy,which introduced multiple synonymous base mutations in the region that had to be patched in the RT *** PDel/Syn strategy achieved an average of 58.1%deletion efficiency at six endogenous targets,which was higher than the PDel *** strategies presented in this study contribute to achieving more accurate and flexible deletions in transgenic rice plants.

关键词： Prime editing Precise genomic deletion CRISPR Cas9

IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第4期32卷 625-641页

作者： wen GE ya LI YUTING RUAN NINGXIA WU PEI MA TONGPENG xu YONGQIAN SHU YINGWEI WANG wen QIU CHENHUI ZHAO Department of Immunology Nanjing Medical UniversityNanjing210000China Key Laboratory of Immunological Environment and Disease Nanjing Medical UniversityNanjing210000China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Jiangsu Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjing210000China

The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains *** the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and *** investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to ***,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and ***,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all ***,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.

关键词： NSCLC cell migration and invasion IL-17 p300 STAT3 MMP19 Acetylation and phosphorylation

Characteristics and geological significance of the stress state of the lithosphere in the Qinghai-Tibetan Plateau and its neighboring areas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第6期67卷 1836-1855页

作者： Qianwen ZHANG ya xu Wei CHU Shupeng LU Key Lab of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The present-day lithospheric stress state of the Qinghai-Tibetan Plateau and neighboring areas is controlled by both the lithosphere itself and the underlying *** other words,the stress is affected by the gravitational potential energy(GPE)difference caused by the change in the density distribution within the lithosphere and the drag force on the base of the lithosphere caused by mantle *** study of the lithospheric stress state plays an important role in further understanding the dynamic background and mechanism for the evolution of the Qinghai-Tibetan *** this study,the Crust1.0 crustal density model combined with the S40RTS mantle shear wave velocity variation model was used to calculate the *** EGM2008gravity field model was used to calculate the drag force from mantle convection at the base of the *** lithospheric and joint stress fields of the two sources were obtained by solving the force balance under the thin sheet *** way,we could comprehensively analyze the characteristics of the stress state within the *** regions were classified according to the GPE stress field,mantle drag force stress field,the relative magnitude of the two stress fields,and correlation between the two stress fields and surface *** lithospheric stress fields of the Tarim Basin and other stable blocks are mainly controlled by the GPE *** lithospheric stress field in the collision zone between the Indian Plate and the QinghaiTibetan Plateau is predominantly controlled by the deep mantle drag *** lithospheric stress field in the interior of the Plateau is controlled by both GPE and mantle *** correlation between the lithospheric stress field and surface deformation at the southeast margin of the Qinghai-Tibetan Plateau is *** is hypothesized that the presence of lower crustal flow with lower effective viscosity leads to crust-mantle decoupling,and the mantle drag force has a weaker influe

关键词： Qinghai-Tibetan Plateau Gravitational potential energy Mantle convection Lithospheric deviatoric stress field GPS strain rate field

维普期刊数据库