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World Journal of Pediatrics 2024年第4期20卷 404-412页

作者： Xin‑Nan Zong Hui Li ya‑qin zhang Department of Growth and Development Capital Institute of PediatricsBeijing 100020China

Background A more comprehensive assessment of growth and nutrition in children is required in China due to rapid socioeconomic *** aimed to investigate height and body mass index(BMI)trajectories from 1975 to 2015 and the prevalence of stunting and obesity in 2016 among children in Chinese *** A total of 904,263 children from birth to 6.9 years were collected from a series of nationally representative surveys in *** and BMI trajectories and prevalence of stunting,underweight,overweight and obesity were *** The average height level of Chinese urban children under 7 years presented a positive secular trend from 1975 to 2015;however,a slowing tendency occurred in 2005‒*** apparent increase was observed at the 5th,50th and 95th percentiles of BMI in urban children aged 3 years and older,with a more prominent increase at the 95th *** total prevalence of stunting and underweight under 7 years was 1.4%and 2.0%,*** total prevalence of overweight and obesity under 7 years was 12.6%and 4.3%,respectively,with 12.7%and 4.9%for boys,12.6%and 3.6%for girls,12.1%and 4.0%in urban areas and 13.1%and 4.5%in suburban rural *** The average height level of Chinese urban children has reached World Health Organization child growth standards since 2005 and presented a slowing tendency in secular trend in 2005‒*** attention and efforts and public health interventions should be urgently made to combat overweight and obesity among preschool children.

关键词： Body mass index Children Height Obesity Stunting

Advances in immunotherapy for hepatitis B virus associated hepatocellular carcinoma patients

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World Journal of Hepatology 2024年第10期16卷 1158-1168页

作者： Wei-Hua Cao ya-qin zhang Xin-Xin Li Zi-Yu zhang Ming-Hui Li Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityPeking University Ditan Teaching HospitalBeijing 100015China

Hepatitis B virus(HBV)infection plays an important role in the occurrence and development of hepatocellular carcinoma(HCC),and the rate of HBV infection in liver cancer patients in China is as high as 92.05%.Due to long-term exposure to chronic antigens from the gut,the liver needs to maintain a certain level of immune tolerance,both to avoid severe inflammation caused by non-pathogenic antigens and to maintain the possibility of rapid and violent responses to infection and ***,HBV infection interacts with the tumor microenvironment(TME)through a highly complex and intertwined signaling pathway,which results in a special TME in *** to changes in the TME,tumor cells can evade immune surveillance by inhibiting tumor-specific T cell function through cytotoxic T-lymphocy-associated protein-4(CTLA-4)and programmed cell death 1(PD-1)/programmed cell death ligand 1(PD-L1).Interferons,as a class of immune factors with strong biological activity,can improve the TME of HBV-HCC through various *** recent years,the systematic treatment of HCC has gradually come out of the *** addition to the continuous emergence of new multi-target anti-vascular tyrosine kinase inhibitor drugs,immune checkpoint inhibitors have opened up a new avenue for the systematic treatment of *** present,immunotherapy based on PD-1/L1 inhibitors has gradually become a new direction of systematic treatment for HCC,and the disease charac-teristics of patients included in global clinical studies are different from those of Chinese ***,whether a group of HCC patients with HBV background and poor prognosis in China can also benefit from immunotherapy is an issue of wide *** review aims to elucidate the advances of immuno-therapy for HBV related HCC patients with regard to:(1)Immunotherapy based on interferons;(2)Immunotherapy based on PD-1/L1 inhibitors;(3)Immunotherapy based on CTLA4 inhibitors;(4)Adoptive cell transfer;(5)Combination immunotherapy str

关键词： Hepatitis B virus Hepatocellular carcinoma Immune checkpoint inhibitors Peginterferon alpha Systematic treatment

Comparison of updated birth weight,length and head circumference charts by gestational age in China with the INTERGROWTH-21 st NCSS charts:a population-based study

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World Journal of Pediatrics 2023年第1期19卷 96-105页

作者： ya-qin zhang Hui Li Xin-Nan Zong Hua-Hong Wu Department of Growth and Development Capital Institute of PediatricsNo.2Ya Bao RoadChaoyang DistrictBeijingChina

Background INTERGROWTH-21 st Newborn Cross-Sectional Study(NCSS)charts were established and recommended for global ***,whether one international reference is appropriate for all populations is still *** aim to compare the updated Chinese birth size charts by gestational age with INTERGROWTH-21st NCSS *** A cross-sectional survey was carried out,and the birth weight,length and head circumference of 24,375 infants born after uncomplicated pregnancies at gestational age ranging from 24+0 to 42+6 weeks were measured in 13 cities in China from 2015 to *** charts were *** measurements of all these infants were evaluated by the methods of calculating their Z scores using the INTERGROWTH-21 st *** prevalence of small for gestational age(SGA)and large for gestational age(LGA)based on birth weight was analyzed using Chinese charts and INTERGROWTH-21st *** The mean Z scores were 0.10 for birth weight,0.35 for length and-0.02 for head *** to the INTERGROWTH-21st charts,the Chinese birth weight percentile curves were higher except for the 90th percentile at 29-37 weeks gestational age,and the length percentile curves were higher after 33 weeks gestational age,while the 10th percentile of the head circumference was lower and the other percentiles were *** prevalence of SGA was 10.1%[95%confidence interval(CI)=9.7%-10.5%]using the Chinese birth weight chart and 6.5%(95%CI=6.2%-6.8%)using the INTERGROWTH-21 st birth weight *** prevalence of LGA was 9.9%(95%CI=9.5%-10.2%)and 8.2%(95%CI=7.9%-8.6%)using the Chinese and INTERGROWTH-21st birth weight charts,*** Chinese birth size charts based on infants born after uncomplicated pregnancies were different from the INTER-GROWTH-21st *** in the classification of newborns by the two charts should receive attention,and whether the application of INTERGROWTH-21st in Chinese newborns will lead to miscl

关键词： Birth length Birth weight Growth charts Head circumference Newborns

Changes of feeding patterns in Chinese city children under 2 years from 1985 to 2015: results from a series of national cross-sectional surveys

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World Journal of Pediatrics 2019年第2期15卷 176-181页

作者： Hua-Hong Wu ya-qin zhang Xin-Nan Zong Hui Li Department of Growth and Development Capital Institute of PediatricsYaBao RoadChaoYang DistrictBeijing 100020China

Background In China,as the social transformation and economic development from 1985 to 2015,children's feeding pattern has undergone some *** we aimed to analyze the secular trend on feeding patterns of city children in *** All data were from a series of national survey which implemented once every 10 years in China from 1985 to *** use same indexes to evaluate the feeding pattern of children in these four *** From 1985 to 2005,the exclusive breastfeeding rates in infants under 6 months of age decreased,especially in suburban areas decreased by 17.7%;the continuous breastfeeding rate of 1-year-old children in suburban area decreased from 60.1 to 27.6%.However,from 2005 to 2015,the exclusive breastfeeding rates under 6 months of age increased by 16.0% in urban areas and 5.9% in suburban areas;the continuous breastfeeding rate of 1-year-old children in urban increased from 17.0 to 36.0%.The overall feeding rate of complementary food in infants under 6 months of age declined from 1985 to 2015;the average age at introduction of all complementary foods was around 6 months of age in *** There is an obvious trend on feeding pattern of Chinese *** 1985 to 2005,the breastfeeding rate decreased,the duration time of breastfeeding was shortened and the age at introduction of complementary food was *** 2005 to 2015,the breastfeeding rate increased,the duration time of breastfeeding was prolonged,and the age at introduction of complementary food was postponed.

关键词： Breastfeeding Complementary feeding Infant and young children Secular change

Stimuli-Responsive lonic Liquids and the Regulation of Aggrega-tion Structure and Phase Behavior

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Chinese Journal of Chemistry 2021年第3期39卷 729-744页

作者： Xiao-qing Yuan ya-qin zhang Zhi-Yong Li Feng Huo Yi-Hui Dong Hong-yan He Beijing Key Laboratory of lonic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBejling 100190China Dalian National Laboratory for Clean Energy DalianLiaoning 116023China Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chermical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan 453007China

lonic liquids with stimuli-responsive characteristics are an essential branch in the comprehensive ionic liquids'family,which can meet the controllable and reversible needs in practical applications with different stimulation *** this review,we summarize the recent research progress of these stimuli-responsive ionic liquids,mainly focusing on their chemical structures,properties,responsive mechanism,aggregation structures,and phase behaviors,which were driven by external stimuli,such as CO2,magnetism,light,temperature,redox,and ***,the particular or potential applications of stimuli-responsive ionic liquids are expounded in various fields of science,including catalytic reaction,extraction,separation,nano-material preparation,and gas *** the end,the challenges and strategies of the subject are briefly *** is expected that this review will contribute to the rational design and applications of stimu-liresponsive ionic liquids in the future.

关键词： lonic liquids Stimuli Responsive Aggregation Phase behavior

Ray targeting for optimizing smooth freeform surfaces for LED non-rotational illumination

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第10期14卷 785-791页

作者： Reng-mao WU Peng LIU ya-qin zhang Zhen-rong ZHENG Hai-feng LI Xu LIU State Key Laboratory of Modern Optical Instrumentations Zhejiang University

We propose an effective optimization method for generating smooth freeform surfaces for light-emitting diode(LED)non-rotational illumination based on ray *** method begins with a starting design and goes through two optimization *** initial estimate is determined using a partial differential equation(PDE)method and a variable separation *** the first optimization step the merit function is developed with ray targeting to ensure the shape of the illumination *** purpose of the second optimization is to further improve the optical performance by constructing the merit function with uniformity and *** freeform reflective and refractive surfaces,which can produce a uniform rectangular illumination without rotational symmetry,are designed using this *** results show that uniform rectangular illumination is achieved and that smooth freeform surfaces are *** ray targeting,the design efficiency can be significantly enhanced,and excellent optical performance can be achieved.

关键词： Illumination design Freeform surface Non-imaging optics Computation methods

Non-dimensional analysis on blast wave propagation in foam concrete:Minimum thickness to avoid stress enhancement

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Defence Technology（防务技术） 2024年第6期36卷 30-46页

作者： ya yang Xiangzhen Kong qin Fang State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing 210007JiangsuChina

Foam concrete is a prospective material in defense engineering to protect structures due to its high energy absorption capability resulted from the long plateau ***,stress enhancement rather than stress mitigation may happen when foam concrete is used as sacrificial claddings placed in the path of an incoming blast *** investigate this interesting phenomenon,a one-dimensional difference model for blast wave propagation in foam concrete is firstly proposed and numerically solved by improving the second-order Godunov *** difference model and numerical algorithm are validated against experimental results including both the stress mitigation and the stress *** difference model is then used to numerically analyze the blast wave propagation and deformation of material in which the effects of blast loads,stress-strain relation and length of foam concrete are *** particular,the concept of minimum thickness of foam concrete to avoid stress enhancement is ***,non-dimensional analysis on the minimum thickness is conducted and an empirical formula is proposed by curve-fitting the numerical data,which can provide a reference for the application of foam concrete in defense engineering.

关键词： Foam concrete Blast wave propagation Non-dimensional analysis Stress enhancement

Numerical study on the blocking effect of skin on Flash-Ball Impact and damage assessment

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Defence Technology（防务技术） 2024年第3期33卷 532-545页

作者： Dihua Ouyang Chunwei qin Xiaowen qin Qiantao zhang Xingyu Liu Xi'an University of Architecture and Technology Xi'an 710055China Analysis and Testing Center Xi'an University of Architecture and TechnologyXi'an 710055China Engineering University of PAP Xi'an 710086China

To explore the response law of non-lethal large-size kinetic energy projectiles to blunt attack on skin tissue,and to evaluate the skin injury characteristics of the attacked personnel and the use safety of kinetic energy *** on the LS-DYNA simulation software,a three-layer skin simulation model and a Flash-Ball rubber bullet model are established,and the force-time and deformation-time biomechanical corridors of the Flash-Ball rubber bullet impacting human skin tissue are *** corridor curve and the energy transfer and diffusion are analyzed and *** safety evaluation of the damage caused by the rubber bullet shooting a human body at different distances is carried out using the empirical formula of the penetration ***,the safe shooting distance is *** results show that the model used in the simulation has a good correlation with the experimental data,its biomechanical corridor characteristics are different from those of conventional vehicle impact and smallsize projectile response *** energy transfer and action time of medium and low-speed impact may cause greater *** fat layer is the largest energy absorption *** minimum safe shooting distance to ensure skin tissue from penetrating damage is 15.8 m,and the limit specific kinetic energy of skin damage is 7.88 J/cm^(2).This study can be extended to the study of biomechanical response law and safety evaluation under the impact of the same type of large kinetic energy projectile,which provides an important theoretical reference for the police to use large kinetic energy projectiles to conduct safe shooting in peacekeeping operations.

关键词： KIPs Blunt strike Biomechanical response Damage analysis

Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2380-2393页

作者： Qi-Feng Wang Zong-Wei Li Hai-Feng Zhou Kun-Zhong Zhu ya-Jing Wang ya-qin Wang Yue-Wei zhang Department of Hepatobiliary Pancreatic Center Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua UniversityBeijing 102218China Department of Hepatobiliary and Pancreatic Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina

Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy *** review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical *** of October 25,2023,51 articles have been retrieved based on keyword predictions and *** eligible articles were selected for inclusion in this *** literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging *** above indicators and their combined forms showed excellent predictive effects in retrospective *** review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system.

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Prediction Prognosis Imaging Biomarkers Genomics

Game theory based finite-time formation control using artificial potentials for tethered space net robot

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Chinese Journal of Aeronautics 2024年第8期37卷 358-372页

作者： Yifeng MA Yizhai zhang Panfeng HUANG ya LIU Fan zhang The Research Center for Intelligent Robotics School of AstronauticsNorthwestern Polytechnical UniversityXi’an 710072China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The Tethered Space Net Robot(TSNR)is an innovative solution for active space debris capture and *** large envelope and simple capture method make it an attractive option for this ***,capturing maneuverable debris with the flexible and elastic underactuated net poses significant *** address this,a novel formation control method for the TSNR is proposed through the integration of differential game theory and robust adaptive control in this ***,the trajectory of the TSNR is obtained through the solution of a real-time feedback pursuit-evasion game with a dynamic target,where the primary condition is to ensure the stability of the ***,to minimize tracking errors and maintain a specific configuration,a robust adaptive formation control scheme with Artificial Potential Field(APF)based on a Finite-Time Convergent Extended State Observer(FTCESO)is *** proposed control method has a key advantage in suppressing complex oscillations by a new adaptive law,thus precisely maintaining the ***,numerical simulations are performed to demonstrate the effectiveness of the proposed scheme.

关键词： Game theory Formation control Artificial potential field Relative distance constraint Tethered space net robot(TSNR)