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International Journal of Minerals,Metallurgy and Materials 2013年第7期20卷 684-692页

作者： ya-jun su Xin-hua Liu Yong-fu Wu Hai-you Huang Jian-xin Xie Key Laboratory for Advanced Materials Processing (Ministry of Education) Institute of Advanced Materials and Technology Uni- versity of Science and Technology Beijing

The steady-state temperature field of horizontal core-filling continuous casting （HCFC） for producing copper cladding aluminum rods was simulated by finite element method to investigate the effects of key processing parameters on the positions of solid-liquid interfaces （SLIs） of copper and aluminum. It is found that mandrel tube length and mean withdrawing speed have significant effects on the SLI positions of both copper and aluminum. Aluminum casting temperature （TAI）（1003-1123 K） and secondary cooling water flux （600-900 L.h-1） have little effect on the SLI of copper but cause the SLI of aluminum to move 2-4 mm. When TA1 is in a range of 1043-1123 K, the liquid aluminum can fill continuously into the pre-solidified copper tube. Based on the numerical simulation, reasonable processing parameters were determined.

关键词： metal cladding copper aluminum continuous casting interfaces computer simulation

Liquid crystal character controlled by complementary discotic molecules mixtures： Columnar stacking type and mesophase temperature range

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Chinese Chemical Letters 2016年第3期27卷 475-480页

作者： yan Li Ming-Guang Li ya-jun su Jian-Gang Liu yan-Chun Han Shi-jun Zheng Li-Xiang Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of the Chinese Academy of Sciences Beijing 100049 China School of Materials Science and Engineering Zhengzhou University Zhengzhou 450052 China

In this work, the mesophase properties were tuned via mixing two discotic molecules with structural complementarity. Compared with the liquid crystalline hexakis（n-hexyloxy）triphenylene（H6TP）materials（columnar hexagonal phase from 53 ℃ to 91 ℃）, mesophase types as well as phase transition temperatures varied with the introduction of crystalline hexaazatriphenylene derivative（PBH）molecules. The introduction of less than 33% amount of PBH disrupted the columnar hexagonal phase formed by H6 TP remarkably, followed by the decreased clearing temperatures of liquid crystals. As the PBH amount was further increased, the destroyed columnar hexagonal phase was turned into the columnar rectangular phase, in which H6 TP and PBH molecules together formed the columnar mesophase. The formation of new mesophase contributed to the enlarged mesophase temperature（from44 ℃ to 144 ℃）. We speculated that the alkyl chains interaction induced by the PBH component competed with the strong p–p stacking between H6 TP molecules, thus altering the liquid crystalline properties including mesophase types and phase transition temperatures.

关键词： Alkyl chains packing Mesophase type Liquid crystals Phase transitions Mixture

Synthesis dibromo substituted BOPHY dye for the singlet oxygen generation

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Chinese Chemical Letters 2016年第2期27卷 190-194页

作者： Tian-Fang Cui Jing Zhang Xin-Dong Jiang ya-jun su Chang-Liang sun Jiu-Li Zhao College of Applied Chemistry Key Laboratory of Rare-earth Chemistry and Applying Liaoning Province Shenyang University of Chemical Technology Center of Physical and Chemistry Test Shenyang University of Chemical Technology

A dibromo substituted BOPHY derivative（2） was prepared and found to exhibit photo-sensitization capability. Rapid oxidation of 80% DPBF at the first 6 min was observed suggesting that 2 is a superior photo-sensitizer than methylene blue. The HOMO-LUMO band gap for the lowest energy absorption bands of the BOPHY 1 is smaller than that of PS 2, which is in good agreement with the red shift in the absorption observed between 1 and 2.

关键词： BOPHY Singlet oxygen Photosensitizer Photophysical property DFT

Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam Kim jun su Park En Hyung Kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** suMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid subcutaneous fat Autologous whole blood injection Laser therapy Case report

喀斯特典型生态系统土壤有机碳积累特征与稳定机制

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农业现代化研究 2018年第6期39卷 907-915页

作者：陈香碧何寻阳胡亚军苏以荣中国科学院亚热带农业生态研究所亚热带农业生态过程重点实验室湖南长沙410125

土壤有机碳是衡量生态系统稳定性、土壤健康与肥力水平的重要指标。喀斯特峰丛洼地土壤具有土被不连续、土层浅薄、高钙、微碱性等特点,造成其有机碳分布、积累与稳定机制有别于其它岩性发育的土壤。基于此,我们在过去10年研究中,建立... 详细信息

土壤有机碳是衡量生态系统稳定性、土壤健康与肥力水平的重要指标。喀斯特峰丛洼地土壤具有土被不连续、土层浅薄、高钙、微碱性等特点,造成其有机碳分布、积累与稳定机制有别于其它岩性发育的土壤。基于此,我们在过去10年研究中,建立了基于探地雷达技术的喀斯特非连续性土壤及其有机碳分布的研究方法,研究了土壤微生物总量及其群落、碳氮循环相关功能微生物群落对喀斯特生态系统退化的响应,探讨了喀斯特土壤丛枝菌根真菌群落分布特征及其对岩性、坡位等立地条件的响应,明确了外源有机碳和无机碳(碳酸钙)输入对喀斯特土壤有机碳矿化和积累的影响,从团聚体稳定性、有机碳矿化、激发效应、微生物生物量碳周转角度明确了土壤有机碳的稳定性以黑色石灰土>棕色石灰土>红壤,初步阐明了喀斯特土壤有机碳的稳定性机制,并研发了土壤垂直漏失阻控技术、桑枝原位快速腐熟技术等喀斯特区土壤改良的关键技术。其结果对于揭示喀斯特生态系统土壤有机碳积累与稳定机制、评估喀斯特区土壤固碳的效应与潜力、提升喀斯特生态系统的可持续性有重要科学意义。

关键词：喀斯特峰丛洼地生态系统退化土壤有机碳微生物丛植菌根真菌稳定机制

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氧化铝覆炭载体的制备及抗结焦性能考察

石油大学学报（自然科学版） 2003年第2期27卷 98-100,104页

作者：杨继涛黄亚茹苏君雅孙在春刘金河田然张志华石油大学化工学院北京102249 石油大学化学化工学院山东东营257061 中国石油天然气股份有限公司大庆石化分公司研究院黑龙江大庆163714

将炭载体和γ Al2 O3 载体的优势合为一体 ,可克服两者的不足。以烯烃、芳烃及支链芳烃中的 3种化合物作为覆炭原料 ,制备出了γ Al2 O3 覆炭载体 ,并对其制备条件、抗结焦性能及部分表面性质进行了考察。在覆炭时间相同的条件下 ,3种... 详细信息

将炭载体和γ Al2 O3 载体的优势合为一体 ,可克服两者的不足。以烯烃、芳烃及支链芳烃中的 3种化合物作为覆炭原料 ,制备出了γ Al2 O3 覆炭载体 ,并对其制备条件、抗结焦性能及部分表面性质进行了考察。在覆炭时间相同的条件下 ,3种烃类原料覆炭量由高到低依次为 :烯烃 ,芳烃 ,支链芳烃。覆炭载体的抗结焦性能优于未覆炭的γ Al2 O3 载体 ;覆炭载体上的炭以非结晶形式均匀地分布于γ Al2 O3 表面上 ,覆炭使γ Al2 O3 载体上的中强酸中心显著减少 ,从而有利于改善覆炭载体的抗结焦性能。

关键词：氧化铝覆炭载体催化剂制备抗结焦性能覆炭原料表面性质

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan jun Yin Department of Thoracic surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Theoretical Investigation on Hyperfine Structures of Perfluoropolyether Radicals

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Chemical Research in Chinese Universities 2011年第1期27卷 117-122页

作者： DONG su-li LIU ya-jun Key Laboratory of Theoretical and Computational Photochemistry Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 P. R. China

The geometries of CF3OCF2, CF3OCFCF3 and CF3OCF2CF2 radicals were investigated by density functional theory（DFT） method. The calculated results indicate that all the three radicals have pyramidal shapes at their centers, and the aC is one top of the pyramids. Based on the DFT optimized geometries, the hyperfine coupling constants（hfec＇s） of the 19F atoms of the three radicals were calculated by B3LYP, MP2（full） and QCISD（full） methods. The calculated values agree with the experimental values, especially for the a values of Fa, the a values are 125.6× 10 -4, 104.2× 10 - 4, and 83.2×10 -4 T of CF3OCF2, CF3OCFCF3 and CF3OCF2CF2, respectively. These results better explain the experimental observation.

关键词： Perfluoropolyether radical Hyperfine coupling constant Density functional theory

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad junaid Eun Jeong Lee su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics