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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang gao Xinyue Wang Shijie Su Weicheng Feng yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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A township-level assessment of forest fragmentation using morphological spatial pattern analysis in Qujing,Yunnan Province,China

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Journal of Mountain Science 2021年第12期18卷 3125-3137页

作者： HUANG Xiao-yuan YE Yuan-hui ZHANG Zhuo-ya YE Jiang-xia gao Jie Marc BOGONOVICH ZHANG Xing School of Geography and Ecotourism(SGE) Southwest Forestry University(SWFU)Kunming 650224China Peking university No.5 Yiheyuan Road Haidian DistrictBeijing 100871China China Agricultural University No.17 Qinghua Road EastHaidian DistrictBeijing 100083China Hebei university of environmental Engineering No.8 Jingang DistrictQinhuangdao 066102China

Forest fragmentation is an integral part of global *** forest fragmentation patterns and dynamics are of great significance for maintaining ecosystem *** are great differences in the interference of natural and human factors on forests in different towns of mountainous cities,and the characteristics of forest fragmentation are also obviously *** fragmentation has been broadly studied,yet,it remains poorly understood at the township-scale within mountainous *** this study,the spatial form of forest landscape and forest fragmentation modes of towns were examined in Qujing City,Yunnan Province,China for the years of 2006 and 2016,relying heavily on the morphological spatial pattern analysis(MSPA)and K-means clustering *** in 2016 showed that the forest landscape morphology of Qujing could be divided into seven classes:core,perforation,islet,bridge,edge,branch and ring;with landscape areas of 41.94%,1.22%,7.04%,11.12%,23.26%,11.74%and 3.68%*** with 2006,the changes of landscape area were 1.71%,0.02%,0.30%,1.65%,0.20%,0.19%and 0.05%*** townships in Qujing varied significantly in their landscape fragmentation patterns,and these patterns were spatially *** forest landscape forms have positive spatial correlations and *** forest fragmentation modes of towns can be divided into four types:Low anthropogenic towns,high anthropogenic towns,complex terrain towns and gentle terrain *** ways of human activities play a decisive role in forest landscape *** expansion of construction land and agricultural land intensifies forest fragmentation;however,man-made orderly and planned ecological restoration will greatly improve the forest coverage and improve the spatial form of urban forest landscape.

关键词： Forest fragmentation Morphological spatial pattern analysis Morphological type China

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The day after the 7th day of the Creation:Breakthrough of human embryo in vitro culture

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Science China(Life Sciences) 2017年第6期60卷 665-667页

作者： hui gao Wei Li State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Since the creation of intelligent creatures,we are no longer the puppets of the *** thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for *** 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.

关键词： embryo ultimate thinking Harvey intelligent Creation creation reproduction oocyte dream

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Physical layer security of underlay cognitive radio using maximal ratio combining

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Frontiers of Information Technology & Electronic Engineering 2016年第9期17卷 929-937页

作者： hui ZHAO Dan-yang WANG Chao-qing TANG ya-ping LIU gao-feng PAN Ting-ting LI Yun-fei CHEN School of Electronic and Information Engineering Southwest University School of Electrical & Electronic Engineering Newcastle University School of Mathematics and Statistics Southwest University School of Engineering University of Warwick

We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(SU-TX) that transmits confidential messages to another secondary user(SU-RX) equipped with M(M ≥ 1)antennas where the MRC technique is adopted to improve its received signal-to-noise ratio. Meanwhile, an eavesdropper equipped with N(N ≥ 1) antennas adopts the MRC scheme to overhear the information between SU-TX and SU-RX. SU-TX adopts the underlay strategy to guarantee the service quality of the primary user without spectrum sensing. We derive the closed-form expressions for an exact and asymptotic secrecy outage probability.

关键词： Cognitive radio networks Maximal ratio combining Secrecy outage probability Single-input multiple-output

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Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao gao Wenlong Liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

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Regulation of scleral fibroblast differentiation by bone morphogenetic protein-2

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 152-156页

作者： Hong-hui Li Li-Jun Huo Zhen-ya gao Feng Zhao Jun-Wen Zeng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen University

Bone morphogenesis proteins(BMPs) are multi-functional growth factors. They are expressed in retina,retinal pigment epithelium(RPE) and sclera and serve as a regulator in the growth and development of the eye. This article reviewed the chondrogenic potency of the sclera,biochemical and pathological changes of myopic scleral tissue and the differentiation of chondrogenesis by BMP-2. We proposed the hypothesis that BMP-2 can regulate differentiate of scleral fibroblasts and affect the development of myopia.

关键词： bone morphogenetic protein-2 sclera myopia

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Liquid Crystalline Microdroplets of Graphene Oxide via Microfluidics

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Chinese Journal of Polymer Science 2021年第12期39卷 1657-1664页

作者： Piao Ma Peng Li ya Wang Dan Chang Wei-Wei gao Chao gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China

Study of stable liquid crystal(LC)microdroplets is of great significance for LC dynamics in con fined space or at topological ***,the fabrication of LC microdroplets with diverse shape without ionic gelati on agents still remai ns challe nging due to the fluid ***,we utilize the microfluidic tech no logy to prepare graphe ne oxide(GO)LC microdroplets with various morphologies based on the anomalous rheological property of GO aqueous *** from LC of one-dimensional polymer,LC containing two-dimensional GO sheets exhibits considerable viscoelasticity and weak extensibility,resulting from the planar molecular conformation and the absence of intermolecular entangleme *** low exte risibility ensures that GO aqueous suspension is discretized into mono dispersed microdroplets rather than thin thread in the microfluidic *** large viscoelasticity and ultra-1 ong relaxation time of GO LC enable the diverse stable morphologies of *** droplet morphology is well con trolled from sphere to teardrop by modulati ng the competition between GO viscoelasticity and in terfacial ten *** two-dimensional GO LC featuri ng unique rheological property provides a novel system for the microfluidic field,and corresponding topological stability enriches the LC dyn amics and ope ns a new pathway for desig ning graphe ne-based materials.

关键词： Graphene oxide Liquid crystal Microdroplets Microfluidics

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Elevated levels of serum antibodies against alpha-1,6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis

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Protein & Cell 2011年第9期2卷 739-744页

作者： hui Dai Xiao-Ming gao Department of Immunology Peking University Health Science CenterPeking UniversityBeijing 100083China Institute of Biology and Medical Sciences Soochow UniversitySuzhou 215123China

This study was undertaken to investigate whether levels of anti-alpha-1,6-glucan antibodies in human sera correlate with rheumatoid arthritis(RA)and systemic lupus erythematosus(SLE).Serum samples were collected from patients with SLE(n=30),RA(n=30)and healthy adult ***,IgA and IgM levels against alpha-1,6-glucan were measured using enzyme linked immunosorbent ***-alpha-1,6-glucan IgG prevalence was raised in patients with active SLE(73.3%)and RA(60%)compared with healthy controls(13.3%).Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor(r=0.642;p<0.05)in RA patients or anti-nuclear antibodies(r=0.675;p<0.05)in SLE patients was *** significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different *** conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.

关键词： autoantibody anti-alpha-1 6-glucan autoimmune diseases systemic lupus erythematosus rheumatoid arthritis

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High-temperature wetting behavior between slag and refractory

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Journal of Iron and Steel Research International 2024年第6期31卷 1304-1319页

作者： Yong-xin Wang ya-ge Li ya-bo gao Zhong Huang Hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Slag corrosion is one of the main factors of the damage of refractory,and its primary manifestations involve the melting of refractory in slag and the slag penetration into refractory,both of which are highly related to the wetting behavior between slag and *** high-temperature wettability could be characterized by parameters including the surface tension,adhesion work,and spreading coefficient of the slag on refractory surface,and it could be suppressed by altering the slag/refractory interface,thus resulting in an improved anti-corrosion *** this,the key knowledges of the slag corrosion,theory of wetting behavior and test of high-temperature contact angle were firstly ***,the major factors influencing the high-temperature slag wetting behavior were discussed based on the aspects of slag composition,refractory composition,and surface ***,the future research direction was proposed in this field.

关键词： High-temperature wetting Refractory Slag corrosion Surface tension

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Non-hallucinogenic Psychedelic Analog Design:A Promising Direction for Depression Treatment

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Neuroscience Bulletin 2023年第1期39卷 170-172页

作者： ya-Nan Yin Tian-Ming gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong Province Key Laboratory of Psychiatric DisordersDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Depression is the most common neuropsychiatric disorder,affecting 350million people worldwide;it has been a leading cause of suicide,causing serious harm to family members and consuming a large amount of social *** onset time of traditional antidepressants is usually 3-4 weeks,and there is no ameliorating effect in nearly one-third of patients with depression.

关键词： consuming patients Depression

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