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Design of low-energy transfer from lunar orbit to asteroid in the Sun-Earth-Moon system

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Acta Mechanica Sinica 2014年第6期30卷 966-972页

作者： ya-min wang Dong Qiao Ping-Yuan Cui School of Aerospace Engineering Beijing Institute of Technology Key Laboratory of Dynamics and Control of Flight Vehicle Ministry of Education

Asteroid exploration trajectories which start from a lunar orbit are investigated in this *** is assumed that the probe departs from lunar orbit and returns to the vicinity of Earth,then escapes from the Earth by performing a perigee maneuver.A low-energy transfer in Sun-EarthMoon system is ***,the feasible region of lowenergy transfer from lunar orbit to perigee within 5 000 km height above the Earth surface in Sun-Earth-Moon system is calculated and *** transfer types are found,i.e.,large maneuver and fast transfers,small maneuver and fast transfers,and disordered and slow *** of feasibility trajectories belong to the first two ***,the lowenergy trajectory leg from lunar orbit to perigee and a heliocentric trajectory leg from perigee to asteroid are patched by a perigee *** optimal full-transfer trajectory is obtained by exploiting the differential evolution ***,taking 4179 Toutatis asteroid as the target,some low-energy transfer trajectories are obtained and analyzed.

关键词： Lunar orbit Asteroid exploration Low-energy transfer Sun-Earth-Moon system

Microdissection testicular extraction for a patient with transverse testicular ectopia and testicular fusion

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Asian Journal of Andrology 2018年第3期20卷 306-307页

作者： Chen Chen Yi-Chun wang ya-min wang Chao Qin Ning-Hong Song 0000 China.

Dear Editor, Transverse testicular ectopia （TTE） is a rare condition whereby both testes migrate toward the same hemiscrotum. Most of the cases （65%） are diagnosed intraoperatively during an inguinal hernia repai... 详细信息

关键词： SPERM EXTRACTION

Losartan improves erectile function through suppression of corporal apoptosis and oxidative stress in rats with cavernous nerve injury

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Asian Journal of Andrology 2019年第5期21卷 452-459页

作者： Yi wang Xiang-Hu Meng Qi-Jie Zhang ya-min wang Chen Chen Yi-Chun wang Xiang Zhou Cheng-Jian Ji Ning-Hong Song Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

This study aimed to investigate the functional and morphological changes in the corpus cavernosum after cavernous nerve(CN)injury or neurectomy and then reveal whether treatment with the angiotensin II Type 1 receptor antagonist losartan would improve erectile function as well as its potential mechanisms.A total of 48 10-week-old Sprague-Dawley male rats,weighing 300-350 g,were randomly divided into the following four groups(n=12 per group):sham operation(Sham)group,bilateral cavernous nerve injury(BOND group,losartaretreated BCNI(BCNI+Losartan)group,and bilateral cavernous neurectomy(Neurectomy)*** was administered once daily by oral gavage at a dose of 30 mg kg^-1 day^-1 for 4 weeks starting on the day of *** BCNI and the Neurectomy groups exhibited decreases in erectile response and increases in apoptosis and oxidative stress,compared with the Sham *** with losartan could have a modest effect on erectile function and significantly prevent corporal apoptosis and oxidative stress?The phospho-B-cell lymphoma 2(Bcl-2)-associated death promoter(p-Bad)/Bad and phospho-the protein kinase B(p-AKT)/AKT ratios were substantially lower,while the Bcl-2-associated X protein(Bax)/Bcl-2 ratio,nuclear factor erythroid 2-related factor 2(Nrf2)/Kelch-like ECH-associated protein 1(Keap-1),transforming growth factor-p 1(TGF-pi)and heme oxygenase-1(HO-1)levels,and caspase-3 activity were higher in the BCNI and Neurectomy groups than in the Sham *** 4 weeks of daily administration with losartan,these expression levels were remarkably attenuated compared with the BCNI *** together,our results suggested that early administration of losartan after CN injury could slightly improve erectile function and significantly reduce corporal apoptosis and oxidative stress by inhibiting the Akt/Bad/Bax/caspase-3 and Nrf2/Keap-1 pathways.

关键词： angiotensin II apoptosis erectile dysfunction fibrosis losartan oxidative stress

Ligand-controlled NiH-catalyzed regiodivergent hydroalkylation of 2-alkenylazaarenes

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Science China Chemistry 2024年第6期67卷 1935-1940页

作者： ya-Ping Shao Zhuo-min Chi Yong-min Liang State Key Laboratory of Applied Organic Chemistry School of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China

A nickel-hydride(Ni H)-catalyzed migratory and nonmigratory hydroalkylation reaction of 2-alkenyl azaarenes with alkyl iodines has been established through strategic modulation of N-or P-donor *** method enables the synthesis of diverseβ-orγ-branched aromatic *** mild regiodivergent protocols exhibit wide substrate scope,excellent functional tolerance,and great reaction yield with remarkable ***,deuterium labeling studies reveal Ni H-catalyzed interrupted chain-walking mode as the mechanism behind remotedβ-selective hydroalkylation reaction—an interesting phenomenon mediated through aromatic imine directing groups.

关键词： NiH regiodivergent hydroalkylation azaarenes interrupted chain-walking

Synthesis and Crystal Structure of a Novel Heptanuclear Ruthenium- and Sodium-containing Polyoxomolybdate [{Na(H_2O)_3}_2{Ru(dmso)_3}_2(MoO_4)_3]·_3H_2O

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Chinese Journal of Structural Chemistry 2006年第7期25卷 783-788页

作者： HUANG Xi-He XIANG Sheng-Chang FU Rui-Biao SHENG Tian-Lu ZHANG Jian-Jun LI ya-min wang Long-Sheng WU Xin-Tao State Key Laboratory of Structural Chemistry Fujian Institute of Research on theStructure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The title compound, [{Na（H2O）3}2lRu（dmso）3}2（MoO4）3]·3H2O, has been obtained by the reaction of Na2MoO4·2H2O with cis-Ru（dmso）4Cl2 in aqueous solution. Its crystal structure was determined by single-crystal X-ray diffraction method. The crystal crystallizes in the triclinic system, space group PI^- with a = 12.3333（3）, b = 12.6289（3）, c = 32.0284（14） A, α = 79.873（7）, β= 87.549（9）, γ = 64.500（4）°, V = 4429.5（2） A^3, Z = 4, Mr = 1358.85, Dc = 2.038 g/cm^3, F（000） = 2696 and μ = 1.874 mm^-1. The compound contains a novel pentanuclear triangle bipyramidal core, [{ Ru（dmso）3 } 2（MoO4）3]^2-, which consists of two { Ru（dmso）3 } ^2＋ fragments and three {μ2-MoO4}^2- units. Furthermore, the dmso ligands bridge the pentanuclear [Ru2Mo3] core and two [Na（H2O）3]^＋ fragments together, forming a neutral heptanuclear ruthenium- and sodiumcontaining polyoxomolybdate.

关键词： synthesis crystal structure ruthenium sodium polyoxomolybdate

Prostate-derived IL-1βupregulates expression of NMDA receptor in the paraventricular nucleus and shortens ejaculation latency in rats with experimental autoimmune prostatitis

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Asian Journal of Andrology 2022年第2期24卷 213-218页

作者： Jie yang Jiao-Chen Luan Jian-Huai Chen Qi-Jie Zhang Jian-Xin Xue ya-min wang Guo-Qing Zhu Ning-Hong Song Zeng-Jun wang Jia-Dong Xia Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210008China Department of Andrology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210008China Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of PhysiologyNanjing Medical UniversityNanjing 210008China

Experimental autoimmune prostatitis(EAP)-induced persistent inflammatory immune response can significantly upregulate the expression of N-methyl-D-aspartic acid(NMDA)receptors in the paraventricular nucleus(PVN).However,the mechanism has not yet been ***,we screened out the target prostate-derived inflammation cytokines(PDICs)by comparing the inflammatory cytokine levels in peripheral blood and cerebrospinal fluid(CSF)between EAP rats and their *** identifying the target PDIC,qualified males in initial copulatory behavior testing(CBT)were subjected to implanting tubes onto bilateral ***,they were randomly divided into four subgroups(EAP-1,EAP-2,Control-1,and Control-2).After 1-week recovery,EAP-1 rats were microinjected with the target PDIC inhibitor,Control-1 rats were microinjected with the target PDIC,while the EAP-2 and Control-2 subgroups were only treated with the same amount of artificial CSF(aCSF).Results showed that only interleukin-1β(IL-1β)had significantly increased mRNA-expression in the prostate of EAP rats compared to the controls(Pministration of IL-1β***,the Control-1 subgroup showed a gradually shortened EL(P<0.01)and a significantly higher NR1 expression(P=0.004)after homochronous IL-1β***,we identified IL-1βas the primary PDIC which shortens EL in EAP ***,further studies should be conducted to elucidate the specific molecular mechanisms throug

关键词： chronic prostatitis N-methyl-D-aspartic acid receptor paraventricular nucleus premature ejaculation prostate-derived inflammation cytokines sympathetic nervous system

Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 249-256页

作者： ming-Da wang Chen Yuan Ke-Chun wang Nan-ya wang Ying-Jian Liang Hong Zhu Xiang-min Tong Tian yang Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Department of Clinical Laboratory Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDepartment of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor *** study aimed to evaluate the efficacy and safety of Renshenguben(RSGB)oral solution,a ginseng-based traditional Chinese medicine,in alleviating CRF in patients with advanced hepatocellular carcinoma(HCC)receiving antitumor ***:In this prospective,open-label,controlled,multicenter study,patients with advanced HCC at BCLC stage C and a brief fatigue inventory(BFI)score of≥4 were *** were assigned to the RSGB group(RSGB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FACT-Hep)scores at weeks 4 and 8 after *** events(AEs)and toxicities were ***:A total of 409 participants were enrolled,with 206 assigned to the RSGB *** week 4,there was a trend towards improvement,but the differences were not statistically *** week 8,the RSGB group exhibited a significantly lower MFI score(P<0.05)compared to the control group,indicating improved fatigue ***,the RSGB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8(P<0.05).Subgroup analyses among patients receiving various antitumor treatments showed similar *** linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI,BFI,and FACT-Hep scores at week *** serious drug-related AEs or toxicities were ***:RSGB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period,with no discernible *** findings support the potential of RSGB oral solution as an adjunctive treatment for managing CRF in this patient population.

关键词： Cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution Efficacy Safety Ginseng

Sex-biased adaptation shapes uniparental gene pools in Tibetans

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Science China(Life Sciences) 2024年第3期67卷 611-613页

作者： min-Sheng Peng ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan School of Life SciencesYunnan UniversityKunming 650091China

During the past two decades, a series of archaeological and genetic investigations substantially improve our perception of the hominin settlement of the Tibetan Plateau(Zhang et al., 2022). In addition to the identifi... 详细信息

关键词： Tibetan Plateau altitude

Enterococcus faecalis provides protection during scavenging in carrion crow (Corvus corone)

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Zoological Research 2024年第3期45卷 451-463页

作者： Bin Hu Jia-min wang Qing-Xun Zhang Jing Xu ya-Nan Xing Bo wang Shu-Yi Han Hong-Xuan He CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing Milu Ecological Research Center Beijing 102600China Beijing Capital International Airport Co. Ltd.Beijing 101300China

The gut microbiota significantly influences host physiology and provides essential ecosystem *** diet can affect the composition of the gut microbiota,the gut microbiota can also help the host adapt to specific dietary *** carrion crow(Corvus corone),an urban facultative scavenger bird,hosts an abundance of pathogens due to its scavenging *** this,carrion crows infrequently exhibit illness,a phenomenon related to their unique physiological *** present,however,the role of the gut microbiota remains incompletely *** this study,we performed a comparative analysis using 16S rRNA amplicon sequencing technology to assess colonic content in carrion crows and 16 other bird species with different diets in Beijing,*** findings revealed that the dominant gut microbiota in carrion crows was primarily composed of Proteobacteria(75.51%)and Firmicutes(22.37%).Significant differences were observed in the relative abundance of Enterococcus faecalis among groups,highlighting its potential as a biomarker of facultative scavenging behavior in carrion ***,*** isolated from carrion crows was transplanted into model mice to explore the protective effects of this bacterial community against Salmonella enterica *** showed that *** down-regulated the expression of pro-inflammatory cytokines tumor necrosis factor alpha(TNF-α),interferon gamma(IFN-γ),and interleukin 6(IL-6),prevented *** colonization,and regulated the composition of gut microbiota in mice,thereby modulating the host’s immune regulatory ***,*** exerts immunoregulatory and anti-pathogenic functions in carrion crows engaged in scavenging behavior,offering a representative case of how the gut microbiota contributes to the protection of hosts with specialized diets.

关键词： Carrion crow Facultative scavenger Gut microbiota Enterococcus faecalis 16S rRNA sequencing