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Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 249-256页

作者： Ming-Da wang Chen Yuan Ke-Chun wang nan-ya wang Ying-Jian Liang Hong Zhu Xiang-Min Tong Tian yang Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Department of Clinical Laboratory Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDepartment of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor *** study aimed to evaluate the efficacy and safety of Renshenguben(RSGB)oral solution,a ginseng-based traditional Chinese medicine,in alleviating CRF in patients with advanced hepatocellular carcinoma(HCC)receiving antitumor ***:In this prospective,open-label,controlled,multicenter study,patients with advanced HCC at BCLC stage C and a brief fatigue inventory(BFI)score of≥4 were *** were assigned to the RSGB group(RSGB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FACT-Hep)scores at weeks 4 and 8 after *** events(AEs)and toxicities were ***:A total of 409 participants were enrolled,with 206 assigned to the RSGB *** week 4,there was a trend towards improvement,but the differences were not statistically *** week 8,the RSGB group exhibited a significantly lower MFI score(P<0.05)compared to the control group,indicating improved fatigue ***,the RSGB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8(P<0.05).Subgroup analyses among patients receiving various antitumor treatments showed similar *** linear regression analyses revealed that the RSGB group experienced a significantly substantial decrease in MFI,BFI,and FACT-Hep scores at week *** serious drug-related AEs or toxicities were ***:RSGB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period,with no discernible *** findings support the potential of RSGB oral solution as an adjunctive treatment for managing CRF in this patient population.

关键词： Cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution Efficacy Safety Ginseng

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Mitigated reaction kinetics between lithium metal anodes and electrolytes by alloying lithium metal with low-content magnesium

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Journal of Energy Chemistry 2024年第8期95卷 644-650,I0014页

作者： yang-yang wang ya-nan wang nan yao Shu-Yu Sun Xiao-Qing Ding Chen-Xi Bi Qian-Kui Zhang Zhao Zheng Cheng-Bin Jin Bo-Quan Li Xue-Qiang Zhang Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018ZhejiangChina

Lithium(Li)metal is regarded as a promising anode candidate for high-energy-density rechargeable ***,Li metal is highly reactive against electrolytes,leading to rapid decay of active Li metal ***,alloying Li metal with low-content magnesium(Mg)is proposed to mitigate the reaction kinetics between Li metal anodes and *** atoms enter the lattice of Li atoms,forming solid solution due to the low amount(5 wt%)of *** atoms mainly concentrate near the surface of Mg-alloyed Li metal *** reactivity of Mg-alloyed Li metal is mitigated kinetically,which results from the electron transfer from Li to Mg atoms due to the electronegativity *** on quantitative experimental analysis,the consumption rate of active Li and electrolytes is decreased by using Mgalloyed Li metal anodes,which increases the cycle life of Li metal batteries under demanding ***,a pouch cell(1.25 Ah)with Mg-alloyed Li metal anodes delivers an energy density of 340 Wh kg^(-1)and a cycle life of 100 *** work inspires the strategy of modifying Li metal anodes to kinetically mitigate the side reactions with electrolytes.

关键词： Lithium metal anodes Alloying Anode/electrolyte interface Reaction kinetics Pouch cell

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Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： ya-nan wang Xiang-yang Zhai Zheng wang Chun-Ling Gao Sui-Cai Mi Wen-Li Tang Xue-Min Fu Huai-Bang Li Li-Feng Yue Peng-Fei Li Sheng-yan Xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND Jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,yangzheng Xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

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A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus

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Acta Mechanica Sinica 2012年第6期28卷 1678-1692页

作者： Qing-Hua Qin ya-nan wang Research School of Engineering The Australian National University

A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.

关键词： Cortical bone remodeling Cell population dy-namics Mechanotransduction Mechanosensitivity Bonefracture energy - Bone mineral content

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Convergence of the viscosity solution of non-autonomous Hamilton-Jacobi equations

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Science China Mathematics 2021年第8期64卷 1789-1800页

作者： Cui Chen ya-nan wang Jun yan The Faculty of Science Jiangsu UniversityZhenjiang 212013China School of Mathematical Sciences Nanjing Normal UniversityNanjing 210097China School of Mathematical Sciences Fudan UniversityShanghai 200433China Shanghai Key Laboratory for Contemporary Applied Mathematics Shanghai 200433China

In this paper,we investigate the non-autonomous Hamilton-Jacobi equation{ə_(t)u+H(t,x,ə_(x)=0,u(x,t)_(0))=φ(x),x∈M where H is 1-periodic with respect to t and M is a compact Riemannian manifold without *** obtain the viscosity solution denoted by T_(t_(0))^(t)φ(x)and show T_(t_(0))^(t)φ(x)converges uniformly to a time-periodic viscosity solution u^(*)(x,t)ofə_(t)u+H(t,x,ə_(x)u,u)=0.

关键词： Hamilton-Jacobi equation viscosity solution large-time behavior

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Multi-factor high-order intuitionistic fuzzy timeseries forecasting model

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Journal of Systems Engineering and Electronics 2016年第5期27卷 1054-1062页

作者： ya'nan wang Yingjie Lei yang Lei Xiaoshi Fan Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China Department of Electronics Technology Engineering University of Armed Police ForceXi'an 710051China

Fuzzy sets theory cannot describe the neutrality degreeof data, which has largely limited the objectivity of fuzzy time seriesin uncertain data forecasting. With this regard, a multi-factor highorderintuitionistic fuzzy time series forecasting model is built. Inthe new model, a fuzzy clustering algorithm is used to get unequalintervals, and a more objective technique for ascertaining membershipand non-membership functions of the intuitionistic fuzzy setis proposed. On these bases, forecast rules based on multidimensionalintuitionistic fuzzy modus ponens inference are ***, contrast experiments on the daily mean temperature ofBeijing are carried out, which show that the novel model has aclear advantage of improving the forecast accuracy.

关键词： multi-factor high-order intuitionistic fuzzy time series,forecasting model intuitionistic fuzzy inference.

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Modeling electric field of power metal-oxide-semiconductor field-effect transistor with dielectric trench based on Schwarz–Christoffel transformation

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Chinese Physics B 2019年第5期28卷 366-373页

作者： Zhi-Gang wang Tao Liao ya-nan wang School of Information Science and Technology Southwest Jiao Tong University

A power metal-oxide-semiconductor field-effect transistor(MOSFET) with dielectric trench is investigated to enhance the reversed blocking capability. The dielectric trench with a low permittivity to reduce the electric field at reversed blocking state has been studied. To analyze the electric field, the drift region is segmented into four regions, where the conformal mapping method based on Schwarz–Christoffel transformation has been applied. According to the analysis, the improvement in the electric field for using the low permittivity trench is mainly due to the two electric field peaks generated in the drift region around this dielectric trench. The analytical results of the electric field and the potential models are in good agreement with the simulation results.

关键词： conformal mapping Schwarz–Christoffel transformation electric field trench metal-oxidesemiconductor field-effect transistor (MOSFET) breakdown voltage

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Carbene-enabled ether activation through the formation of oxonium: a theoretical view

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Organic Chemistry Frontiers 2022年第5期9卷 1247-1253页

作者： ya-nan wang Xinghua wang Shi-Jun Li Yu Lan College of Chemistry and Institute of Green CatalysisZhengzhou University100 Science AvenueZhengzhou 450001HenanP.R.China School of Chemistry and Chemical Engineering and Chongqing Key Laboratory of Theoretical and Computational ChemistryChongqing UniversityChongqing 400030P.R.China

Here,we report a theoretical investigation of the reactivity and chemoselectivity of carbene-enabled ether *** mechanism obtained from DFT calculations revealed that the final products were dependent on the stability of the oxonium intermediate,which was afforded by nucleophilic attack of the corresponding ether onto a carbene ***,we found that the nucleophilicity of ethers was crucial but not their *** decomposition analysis based on absolutely localized molecular orbitals showed that the nucleophilicity of ethers was critical for polarization and charge transfer,leading to the chemoselectivity.

关键词： activation absolutely carbene

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Accidental discovery of appendiceal carcinoma during gynecological surgery:A case report

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World Journal of Clinical Cases 2022年第22期10卷 8040-8044页

作者： Lin wang yan Dong ya-Hui Chen ya-nan wang Lin Sun Department of Clinical Medicine Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Obstetrics and Gynecology The Affiliated Hospital of Jining Medical UniversityJining 272000Shandong ProvinceChina

BACKGROUND Malignant tumors of the appendix are extremely rare,constituting about 1%of all gastrointestinal ***,pathology identifies these tumors during or after appendectomy because they are difficult to detect at the preoperative *** case report aims to introduce the definitive diagnosis and treatment of mucinous adenocarcinoma of the *** SUMMARY A 49-year-old female patient came to our hospital with right lower abdominal pain,nausea,and vomiting for three *** was no change in the menstrual *** ultrasound showed a cystic,solid mass in the right *** enhanced computed tomography showed a thick *** was found on exploration of the appendix during gynecological *** right colon was *** surgery,the patient received chemotherapy and is recovering *** Appendiceal carcinoma is frequently found during or after surgery,and both preoperative examination and early evaluation of clinical manifestations are extremely important.

关键词： Abdominal pain Pelvic mass Appendix carcinoma Mucinous adenocarcinoma Case report

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Brain tumors:Cancer stem-like cells interact with tumor microenvironment

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World Journal of Stem Cells 2020年第12期12卷 1439-1454页

作者： Hai-Long Liu ya-nan wang Shi-Yu Feng Department of Neurosurgery Chinese PLA General HospitalBeijing 100853China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Cancer stem-like cells(CSCs)with potential of self-renewal drive *** tumor microenvironment(TME)has been identified as a critical regulator of malignancy *** researchers are searching new ways to characterize tumors with the goal of predicting how they respond to ***,we describe the striking parallels between normal stem cells and *** review the microenvironmental aspects of brain tumors,in particular composition and vital roles of immune cells infiltrating glioma and *** highlighting that CSCs cooperate with TME via various cellular communication approaches,we discuss the recent advances in therapeutic strategies targeting the components of *** of the complex and interconnected factors can facilitate the development of promising treatments for these deadly malignancies.

关键词： Cancer stem-like cells Microenvironment Brain tumor Inflammation Clinical application Glioma

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