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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang y.Chang H.S.Chen S.M.Chen y.Chen y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng y.y.ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.y.Guo L.Guo X.H.Guo y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger y.K.Heng A.Higuera y.K.Hor y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.y.Ma y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.y.Wang R.G.Wang W.Wang W.Wang X.Wang y.Wang y.F.Wang Z.Wang Z.Wang Z.M.Wang H.y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.yang L.yang y.Z.yang H.F.yao M.ye M.yeh B.L.young H.Z.yu Z.y.yu B.B.yue S.Zeng y.Zeng L.Zhan C.Zhang F.y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang y.M.Zhang y.X.Zhang y.y.Zhang Z.J.Zhang Z.P.Zhang Z.y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 Brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and Technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint Institute for Nuclear Research DubnaMoscow Region Beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

Magnitude, spatial patterns and drivers of methane fluxes from coastal salt marshes and mangrove forests in China

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Science China Earth Sciences 2025年第3期68卷 850-866页

作者： yixuan yU Derrick y.F.LAI Minjie HU Chuan TONG Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education Fujian Normal University School of Geographical Sciences Fujian Normal University Department of Geography and Resource Management The Chinese University of Hong Kong

Methane（CH4） is a highly potent greenhouse gas due to its high radiative forcing and global warming *** the magnitude, spatial patterns, and drivers of CH4emission from wetlands at the regional scale is crucial for formulating suitable strategies to mitigate future climate change. In this study, we synthesized the CH4flux data reported for major plant communities in the coastal salt marshes and mangrove forests in China and produced a spatial map of CH4fluxes from the mangrove sediments and salt marshes in China based on the results of machine learning models. Moreover, we examined the main drivers of CH4flux from these coastal wetlands and estimated the annual CH4emissions from the salt marshes and mangrove forests in different coastal provinces of China using a bottom-up approach. Our results showed that the mean CH4fluxes from the salt marsh and mangrove ecosystems in China were 2.22±0.29 and 2.26±0.55 mg m-2h-1, respectively. Across China, the total annual CH4emission from salt marshes was 31,179.75 Mg CH4a-1, while that from mangroves was 5,533.97 Mg CH4a-1with the sediments contributing to 12.7%(701.64 Mg CH4a-1) of the total efflux. The salt marshes and mangroves in China accounted for 2.75% and 0.14%–0.15% of the global annual CH4emissions from these two ecosystems,respectively. Moreover, we found that CH4emissions from the salt marshes and mangroves could offset the cooling impact arising from net carbon dioxide uptake by 88% and 53%, respectively, over a 100-year time scale. Mean annual temperature, soil moisture, and soil organic carbon content were the main factors controlling CH4emissions from these coastal ***, we found that CH4fluxes from the salt marshes in China decreased with latitude, which implied a possible increase in marsh CH4emission in response to global warming that should be considered carefully when developing nature-based climate solutions to achieve national goals for carbon neutrality.

关键词： Salt marsh Mangrove Methane flux Spatial pattern Driving factors China

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Breaking new ground in photocatalysis:lutetium texaphyrin as a trigger for pyroptosis through biomolecular photoredox reactions

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Science China Chemistry 2025年第1期68卷 1-2页

作者： Qihang ding Mengrong He Meijia Gu Department of Chemistry Korea UniversitySeoul 02841Republic of Korea Department of Ultrasound Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE) School of Pharmaceutical SciencesWuhan UniversityWuhan 430071China

Malignant neoplasms consistently pose a significant threat to global public health^([1,2]).In recent years,immunotherapy has demonstrated remarkable clinical success;however,its efficacy is limited by the scarcity of immune cell infiltration within tumor *** pyroptosis,a gasdermin-mediated process characterized by cellular swelling,rupture,and the release of intracellular contents such as IL-1β,IL-18,ATP,HMGB1,plays a crucial role in this context^([3,4]).

关键词： neoplasms clinical rupture

Advancements in implantable temperature sensors:Materials,mechanisms,and biological applications

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Journal of Semiconductors 2025年第1期46卷 166-177页

作者： Zhuofan yang Hongcheng Song He ding Beijing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and PhotonicsBeijing Institute of TechnologyBeijing 100081China Department of Urology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China

Implantable temperature sensors are revolutionizing physiological monitoring and playing a crucial role in diagnostics,therapeutics,and life sciences *** review classifies the materials used in these sensors into three categories:metal-based,inorganic semiconductor,and organic semiconductor ***-based materials are widely used in medical and industrial applications due to their linearity,stability,and *** semiconductors provide rapid response times and high miniaturization potential,making them promising for biomedical and environmental *** semiconductors offer high sensitivity and ease of processing,enabling the development of flexible and stretchable *** review analyzes recent studies for each material type,covering design principles,performance characteristics,and applications,highlighting key advantages and challenges regarding miniaturization,sensitivity,response time,and ***,critical performance parameters of implantable temperature sensors based on different material types are summarized,providing valuable references for future sensor design and *** future development of implantable temperature sensors is discussed,focusing on improving biocompatibility,long-term stability,and multifunctional *** advancements are expected to expand the application potential of implantable sensors in telemedicine and dynamic physiological monitoring.

关键词： implantable temperature sensors biological applications flexible electronics

Two-plasmon-decay instability stimulated by dual laser beams in inertial confinement fusion

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Matter and Radiation at Extremes 2025年第1期10卷 48-56页

作者： C.-W.Lian y.Ji R.yan J.Li L.-F.Wang y.-K.ding J.Zheng Department of Modern Mechanics University of Science and Technology of ChinaHefeiAnhui 230026China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Two-plasmon-decay instability(TPD)poses a critical target preheating risk in direct-drive inertial confinement *** this paper,TPD collectively driven by dual laser beams consisting of a normal-incidence laser beam(Beam-N)and a large-angle-incidence laser beam(Beam-L)is investigated via particle-in-cell *** is found that significant TPD growth can develop in this regime at previously unexpected low laser intensities if the intensity of Beam-L exceeds the large-angle-incidence *** beams contribute to the growth of TPD in a“seed-amplification”manner in which the absolute instability driven by Beam-L provides the seeds that are convectively amplified by Beam-N,making TPD energetically important and causing significant pump depletion and hot-electron generation.

关键词： laser pump decay

Tragedy and Modernity:Two Misconstrued Cause/Effect Relationships

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中国比较文学 2025年第01期 93-104页

作者： ding Ersu the School of English Studies Shanghai International Studies University

“悲剧”与“现代性”通常被视为两个互不相干的概念，前者泛指展现人间苦难的文学作品，后者标识人类文明演变的最新阶段，但在20世纪初期和中期，有不少中外学者曾在这两者之间做出因果连接。乔治·斯坦纳及其追随者认为，现代社会崇... 详细信息

“悲剧”与“现代性”通常被视为两个互不相干的概念，前者泛指展现人间苦难的文学作品，后者标识人类文明演变的最新阶段，但在20世纪初期和中期，有不少中外学者曾在这两者之间做出因果连接。乔治·斯坦纳及其追随者认为，现代社会崇尚科学理性，导致悲剧艺术在17世纪之后一蹶不振；胡适和许多同时代其他学人则将现代性在中国姗姗来迟部分归咎于悲剧的缺失。拨开历史的迷雾，我们现在可以清晰地看到，这两个论断其实都站不住脚，因为它们基于过分狭隘的悲剧定义，而且错误地坚持悲剧的凄惨结局不可或缺。

关键词：悲剧悲剧理论现代性悲剧的死亡欢乐结局

Satellite-assisted 6G wide-area edge intelligence:dynamics-aware task offloading and resource allocation for remote IoT services

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Science China(Information Sciences) 2025年第2期68卷 248-268页

作者： Di ZHAO Rui ding Bin SONG State Key Laboratory of Integrated Services Networks Xidian University Hangzhou Institute of Technology Xidian University China Satellite Network Group Co. Ltd.

Future 6G networks will integrate non-terrestrial communication with mobile edge computing to enable wide-area edge intelligence, providing ubiquitous communication and computation services for everyone and everything. In this paper, we introduce the intelligent cloud-edge-device architecture into low Earth orbit(LEO) satellite-supported remote Internet of Things(IoT) networks to facilitate latency-sensitive and compute-intensive IoT applications. However, the dynamic spatio-temporal characteristics inherent in LEO satellite networks, such as the high volatility of task traffic and the high mobility of space nodes, pose severe challenges. For efficient task execution, we investigate the joint optimization of cross-region task offloading and cross-domain resource allocation, and innovatively propose a spatio-temporal attention-based proximal policy optimization(STA-PPO) algorithm. Specifically, the temporal attention-based actor network analyzes the timing dependencies of task arrival and makes time-variant decisions. Simultaneously, the spatial attention-based critic network captures the spatial variations of satellite motion and evaluates the topology-related value. We verify the effectiveness of the cloud-edge-device collaboration through extensive simulations. Numerical results demonstrate that the STA-PPO algorithm outperforms benchmarks, showing the lowest system delay and the highest link throughput.

关键词： 6G wide-area edge intelligence cross-region task offloading cross-domain resource allocation spatio-temporal attention proximal policy optimization

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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise