检索结果-南通市图书馆

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

引用

Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao y.unghy. moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

引用

Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

引用

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

引用

Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Weapon effectiveness and the shapes of damage functions

引用

Defence Technology（防务技术） 2021年第2期17卷 617-632页

作者： Sei-Hoon moon th R&D Institute Agency for Defense DevelopmentYusungDaejeon305-152Republic of Korea Department of Mechanical and Aerospace Engineering Naval Postgraduate School MontereyCA93940USA

This paper provides a review of methods of assessing a fragmentation weapon’s effectiveness against a point target or an area target with keeping the focus on the necessity of using the Carleton damage function with the correct shape ***,cookie-cutter damage functions are redefined to preserve the shape factor of and to have the same lethal area as the corresponding Carleton damage ***,closed-form solutions of the effectiveness methods are obtained by using those cookie-cutter damage functions and the Carleton damage ***,the closed-form solutions are applied to calculate the probability of damaging a point target and the expected fractional damage to an area target for several attack scenarios by using cookie-cutter damage functions and the Carleton damage functions with different shape *** comparison of the calculation results shows that using cookie-cutter damage functions or the Carleton damage function with a wrong shape factor results in quite significant differences from using the original Carleton damage function with a correct shape factor when weapon’s delivery error deviations are less than or comparable to the lengths of the lethal area and the aim point is far from a *** effectiveness methods improved in this paper will be useful for mission planning utilizing the precision-guided munitions in circumstances where the collateral damage should be reduced.

关键词： Weapon effectiveness Point target Area target Cookie-cutter damage function Carleton damage function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mineralogical characteristics of bentonites occurring in Ningcheng and Jianping area,China

引用

Science China Earth Sciences 2010年第4期53卷 541-549页

作者： GU JaRang moon yongHee moon HiSoo Department of Earth System Sciences Yonsei University Institute of Earth Atmosphere Astronomy BK21 yonsei University

This study is focused on the basic mineralogical and chemical characteristics of some selected samples from Jianping(JP) and Ningcheng(NC) area,*** were studied using X-ray diffraction(XRD),expandability,Greene-Kelly test,specific surface area,cation exchange capacity(CEC),differential thermal analysis(DTA),and chemical *** bulk samples consist of mainly montmorillonites along with appreciable amounts of cristobalite and with small amounts of quartz,feldspar and *** basal spacings of montmorillonites in all these examined samples show at about 1.5 nm,indicating that pre-dominant cations were *** crystallite thickness of the present sample lies from 0.449 to 0.710 nm(4.58-7.24 layers).As Greene-Kelly test,samples from Ningcheng area confirmed appreciable amount of beidellite component but samples from Jianping area did not contain anything about *** area of samples varies from 671 to 766 m2 g-1 depending on the amounts of *** CEC ranges from 70.30 to 82.75 meq 100g-1 in y higher amount of SiO2 than those from Jianping area,possibly due to difference of parent rock *** element(y,Nb,Ce and Zr) data are plotted on acidic to intermediate *** is apparent that no large chemical transfer would have been necessary during alteration.

关键词： montmorillonite beidellite expandability Greene-Kelly test trace element

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Faraday rotations,ellipticity,and circular dichroism in magneto-optical spectrum of moire superlattices

引用

Chinese Physics B 2021年第7期30卷 18-32页

作者： J A Crosse Pilkyung moon Arts and Sciences New York University ShanghaiShanghai 200122China NyU-ECNU Institute of Physics at NyU Shanghai Shanghai 200062China Department of Physics New York UniversityNew York 10003USA

We study the magneto-optical conductivity of a number of van der Waals heterostructures,namely,twisted bilayer graphene,AB–AB and AB–BA stacked twisted double bilayer graphene and monolayer graphene and AB-stacked bilayer graphene on hexagonal boron *** the magnetic field increases,the absorption spectrum exhibits a self-similar recursive pattern reflecting the fractal nature of the energy *** twisted bilayer graphene displays only weak circular dichroism,the other four structures display strong circular dichroism with monolayer graphene and AB-stacked bilayer graphene on hexagonal boron nitride being particularly pronounced owing to strong inversion symmetry breaking properties of the hexagonal boron nitride *** the left and right circularly polarized light interact with these structures differently,plane-polarized incident light undergoes a Faraday rotation and gains an ellipticity when *** size of the respective angles is on the order of a degree.

关键词： 2D-materials van der Waals heterostructures magneto-optical conductivity graphene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of Cobalt Containing Block Copolymers Via Ring Opening Metathesis Polymerizastion (ROMP)

引用

Journal of Rare Earths 2004年第Z2期22卷 145-152页

作者： Bongjin moon Minhyuk Kang Departmen of Chemistry Sogang UniversityShinsoo-Dong 1-1Mapo-GuSeoul121-742Korea Departmen of ChemistrySogang UniversityShinsoo-Dong 1-1Mapo-GuSeoul121-742Korea

In order to realize a metal containing nano-structure, a block-copolymer containing alkynyl groups in one block was designed and synthesized by living ring opening metathesis polymerization (ROMP) technique. The newly developed bis-3-bromopyridine complex of Grubbs catalyst was employed in the series of polymerization and it yielded the desired polymers with great molecular weight control and narrow polydispersities. The characteristics of the block copolymers were investigated by gel permeation chromatography, H- and 13H- NMR spectroscopy. Complexation of the alkynyl group containing block copolymers by treatment with dicobalt octacarbonyl occurred smoothly in 5 min at room temperature. GPC analysis before and after cobalt complexation indicated a significant increase of the hydrodynamic volume. AFM images of the films before and after the complexation also showed a noticeable change in its morphology where grain sizes become smaller and more regular upon complexation.

关键词： ring opening metathesis polymerization (ROMP) metal containing block copolymer polynorbornene derivative

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temporal and Spatial Requirement of EMF1 Activity for Arabidopsis Vegetative and Reproductive Development

引用

Molecular Plant 2009年第4期2卷 643-653页

作者： Rosario Sanchez Minjung y. Kim Myriam Calonje yong-Hwan moon Z. Renee Sung Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA Present address: Heidelberg Institute for Plant Science Biodiversity and Plant Systematics Heidelberg University 69120 Heidelberg Germany Present address: Department of Molecular Biology Pusan National University 30 Jangjeon-dong Geumjeong-gu Busan 609-735 Korea

EMBRyONIC FLOWER （EMF） genes are required to maintain vegetative development via repression of flower homeotic genes in Arabidopsis. Removal of EMF gene function caused plants to flower upon germination, producing abnormal and sterile flowers. The pleiotropic effect of ernfl mutation suggests its requirement for gene programs involved in diverse developmental processes. Transgenic plants harboring EMF1 promoter：：glucuronidase （GUS） reporter gene were generated to investigate the temporal and spatial expression pattern of EMF1. These plants displayed differential GUS activity in vegetative and flower tissues, consistent with the role of EMF1 in regulating multiple gene programs. EMFI：：GUS expression pattern in emf mutants suggests organ-specific auto-regulation. Sense- and antisense （as） EMF1 cDNA were expressed under the control of stage- and tissue-specific promoters in transgenic plants. Characterization of these transgenic plants showed that EMF1 activity is required in meristematic as well as differentiating tissues to rescue emf mutant phenotype. Temporal removal or reduction of EMF1 activity in the embryo or shoot apex of wild-type seedlings was sufficient to cause early flowering and terminal flower formation in adult plants. Such reproductive cell memory is reflected in the flower MADS-box gene activity expressed prior to flowering in these early flowering plants. However, temporal removal of EMF1 activity in flower meristem did not affect flower development. Our results are consistent with EMF1＇s primary role in repressing flowering in order to allow for vegetative growth.

关键词： EMF1 stage-specific promoter early flowering reproductive cell memory vegetative/reproductive development repression of flower MADS-box genes.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strong enhancement of magnetic order from bulk to stretched monolayer FeSe as Hund’s metals

引用

npj Computational Materials 2020年第1期6卷 448-453页

作者： Chang-youn moon Advanced Instrumentation Institute Korea Research Institute of Standards and ScienceYuseongDaejeonRepublic of Korea

Despite of the importance of magnetism in possible relation to other key properties in iron-based superconductors,its understanding is still far from complete especially for FeSe *** one hand,the origin of the absence of magnetic orders in bulk FeSe is yet to be *** the other hand,it is still not clear how close monolayer FeSe on SrTiO_(3),with the highest transition temperature among iron-based superconductors,is to a magnetic *** we investigate magnetic properties of bulk and monolayer FeSe using dynamical mean-field theory combined with density-functional *** find that suppressed magnetic order in bulk FeSe is associated with the reduction of interorbital charge fluctuations,an effect of Hund’s coupling,enhanced by a larger crystal-field ***,spatial isolation of Fe atoms in expanded monolayer FeSe leads into a strong magnetic order,which is completely destroyed by a small electron *** work provides a comprehensive understanding of the magnetic order in iron-based superconductors and other general multi-orbital correlated systems as Hund’s metals.

关键词： theory monolayer orbital

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：