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Heterostructured Co_(3)Se_(4)/CoSe_(2)@C nanoparticles attached on three-dimensional reduced graphene oxide as a promising anode towards Li-ion batteries

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Frontiers of Materials Science 2024年第2期18卷 101-115页

作者： Mingjun Pang Zhaoyang Song Miaomiao Mao shang Jiang Ruxia Zhang Runwei Wang Jianguo Zhao Engineering Research Center of Coal-based Ecological Carbon Sequestration Technology of the Ministry of Education Shanxi Datong UniversityDatong 037009China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

In situ carbon-coated Co_(3)Se_(4)/CoSe_(2)(Co_(x)Se_(y))nanoparticles(NPs)attached on three-dimensional(3D)reduced graphene oxide(rGO)sheets were skillfully developed in this work,which involved the environment-friendly hydrothermal method,freeze drying,and selenide *** the structure,the glucose-derived carbon layer exhibited significantly homogeneous dispersion under an argon *** structure not only has enhanced stability,but also can effectively mitigate the volume swell of Co_(x)Se_(y) *** resulted Co_(3)Sea/CoSe_(2)@C/rGO(CSe@C/rGO)exhibited a specific surface area(SSA)of 240.9 m^(2)·g^(-1),offering more electrochemically active sites for the storage of energy related to lithium *** rGO matrix held exceptional flexibility and functional structural rigidity,facilitating the swift ion intercalation and ensuring the high conductivity and recyclability of the *** applied to anodes designed for lithium-ion batteries(LiBs),this material demonstrated distinguished rate and ultra-high reversible capacity(872.98 mA·h·g^(-1) at 0.5 A·g^(-1)).Meanwhile,its capacity retention reached 119.5%after 500 cycles at 2 A·g^(-1),with a coulombic efficiency of 100%.This work potentially paves the way for generating fast and powerful metal selenide anodes and initiating LiBs with good performance.

关键词： CSe@C/rGO lithium-ion battery reduced graphene oxide electrochemicalperformance heterostructure

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Intrinsically asymmetric atomic character regulates piezoelectricity in two-dimensional materials

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Frontiers of physics 2024年第3期19卷 153-162页

作者： yun-Qin Li Qi-Wen He Dai-Song Tang Xiao shang Xiao-Chun Wang School of Physics Science and Information Technology Liaocheng UniversityLiaocheng 252000China Key Laboratory of Polar Materials and Devices Ministry of EducationDepartment of ElectronicsEast China Normal UniversityShanghai 200241China Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

Decreasing of layer thickness causes the decrease of polarization until it disappears due to the existence of depolarization ***,the search for strong piezoelectric materials is highly desirable for multifunctional ultra-thin piezoelectric ***,we propose a common strategy for achieving strong piezoelectric materials through the electronic asymmetry induced by the intrinsically asymmetric atomic character of different chalcogen ***,in the tetrahedral lattice structures,for example,M4X3y3(M=Pd/Ni,X/y=S,Se or Te,X≠y)monolayers are proved to display excellent out-of-plane ***4Se3Te3 possesses the largest piezoelectric coefficient d33 of 61.57 pm/V,which is much larger than that of most 2D *** the electronic asymmetry further increases the out-of-plane piezoelectricity of Janus M4X3y3 ***,the out-of-plane piezoelectricity is positively correlated with the ratio of electronegativity difference(Red)and the electric dipole moment(P).This work provides alternative materials for energy harvesting nano-devices or self-energized wearable devices,and supplies a valuable guideline for predicting 2D materials with strong out-of-plane piezoelectricity.

关键词： piezoelectricity intrinsically asymmetric atomic character ratio of electronegativity difference electric dipole moment first-principles calculations

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Risk factors,prognostic factors,and nomograms for distant metastasis in patients with diagnosed duodenal cancer:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1384-1420页

作者： Jia-Rong shang Chen-yi Xu Xiao-Xue Zhai Zhe Xu Jun Qian Department of Oncology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Proctology Nanjing Hospital of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Digestive Cancer Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Duodenal cancer is one of the most common subtypes of small intestinal cancer,and distant metastasis(DM)in this type of cancer still leads to poor *** nomograms have recently been used in tumor areas,no studies have focused on the diagnostic and prognostic evaluation of DM in patients with primary duodenal *** To develop and evaluate nomograms for predicting the risk of DM and person-alized prognosis in patients with duodenal *** Data on duodenal cancer patients diagnosed between 2010 and 2019 were extracted from the Surveillance,Epidemiology,and End Results *** and multivariate logistic regression analyses were used to identify independent risk factors for DM in patients with duodenal cancer,and univariate and multivariate Cox proportional hazards regression analyses were used to determine independent prognostic factors in duodenal cancer patients with *** novel nomograms were established,and the results were evaluated by receiver operating characteristic(ROC)curves,calibration curves,and decision curve analysis(DCA).RESULTS A total of 2603 patients with duodenal cancer were included,of whom 457 cases(17.56%)had DM at the time of *** analysis revealed independent risk factors for DM in duodenal cancer patients,including gender,grade,tumor size,T stage,and N stage(Pyses further identified independent prognostic factors for duodenal cancer patients with DM,including age,histological type,T stage,tumor grade,tumor size,bone metastasis,chemotherapy,and surgery(Py of the nomograms was validated in the training set,validation set,and expanded testing set using ROC curves,calibration curves,and DCA *** results of Kaplan-Meier survival curves(Py predicted the occurrence and prognosis of DM in patients with duodenal *** The two nomograms are expected as effective tools fo

关键词： Duodenal cancer Distant metastasis Nomogram Risk factors Prognostic factors

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Research and test of the measurement sensing device for the downforce of no-till planter row unit gauge wheels

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 250-259页

作者： Jiajie shang Liyi Liu Ruifeng Zhang Hongcheng Li Shouyin Hou Hongxin Liu Haitao Chen College of Engineering Northeast Agricultural UniversityHarbin 150036China College of Mechanical and Electrical Engineering Suqian UniversitySuqian 223800JiangsuChina

To effectively obtain the downforce of the gauge wheels in real time,mechanical models of the interaction among the ground,gauge wheels,gauge wheel arms,and depth adjustment lever were constructed.A measuring method was proposed for monitoring the downforce through a two-dimensional radial sensing device,and a corresponding prototype was *** simulation analysis of the sensing device with ANSyS,a 45°angle was determined to exist between the strain gauge axis and the sensing device axis,and the Wheatstone bridging circuit of R1+R3−R5−R7(R stands for resistance strain gauge,different figures represent the strain gauge number)and R2+R4−R6−R8 was *** to performance and calibration tests for the sensing device,the maximum interaction effect between the X and y axes was 2.52%,and the output signal was stable and *** standard error of the slope of the fitting equation of the downforce calculation model is *** to the field test,the average downforce of the gauge wheels was 1148,1017,843,and 713 N,at different sowing speeds of 6,8,10,and 12 km/h,*** coefficients of variation were 0.40,0.41,0.62,and 0.71,*** results indicate that the downforce fluctuation of the gauge wheels became more severe with increasing planting *** the strain simulation analysis and field test verified that the measurement method is accurate and reliable,the performance of the sensing device is stable,the measurement method and sensing device meet the application requirements and lay a foundation for the research of accurate and stable control of downforce of no-till planter.

关键词： no-till planter gauge wheel downforce two-dimensional radial force sensing device strain analysis measurement mode and method

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Neural stem cell-derived exosomes regulate cell proliferation,migration,and cell death of brain microvascular endothelial cells via the miR-9/Hes1 axis under hypoxia

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Animal Models and Experimental Medicine 2024年第1期7卷 24-35页

作者： Xiaojun Deng Xiaoyi Hu shang Wang Hui Zhao yaqin Wei Jiaqi Fu Wenhui Wu Jinming Liu Caicai Zhang Lili Wang Ping yuan Department of Critical Care Medicine Shanghai Sixth People's HospitalShanghai Jiao Tong UniversityShanghaiChina Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Institute of Bismuth Science University of Shanghai for Science and TechnologyShanghaiChina Department of Physiology Hainan Medical University HaikouHainanChina Department of Clinical Medical Laboratory Center Hangzhou Red Cross HospitalZhejiangChina

Background:Our previous study found that mouse embryonic neural stem cell(NSC)-derived exosomes(EXOs)regulated NSC differentiation via the miR-9/Hes1 ***,the effects of EXOs on brain microvascular endothelial cell(BMEC)dysfunction via the miR-9/Hes1 axis remain ***,the current study aimed to determine the effects of EXOs on BMEC proliferation,migration,and death via the miR-9/Hes1 ***:Immunofluorescence,quantitative real-time polymerase chain reaction,cell counting kit-8 assay,wound healing assay,calcein-acetoxymethyl/propidium iodide staining,and hematoxylin and eosin staining were used to determine the role and mechanism of EXOs on ***:EXOs promoted BMEC proliferation and migration and reduced cell death under hypoxic *** overexpression of miR-9 promoted BMEC prolifera-tion and migration and reduced cell death under hypoxic ***,miR-9 downregulation inhibited BMEC proliferation and migration and also promoted cell ***1 silencing ameliorated the effect of amtagomiR-9 on BMEC proliferation and migration and cell *** structures were observed in the regions of the hippocampus and cortex in hypoxia-induced ***,EXO treatment improved cerebrovascular ***:NSC-derived EXOs can promote BMEC proliferation and migra-tion and reduce cell death via the miR-9/Hes1 axis under hypoxic ***,EXO therapeutic strategies could be considered for hypoxia-induced vascular injury.

关键词： brain microvascular endothelial cells exosomes Hes1 miR-9 neural stem cells

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基于改进蝴蝶搜索算法的DGPS整周模糊度快速解算

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中国惯性技术学报 2024年第2期32卷 139-145页

作者：尚俊娜罗照旺杭州电子科技大学通信工程学院杭州310018

为了快速准确地解算差分全球定位系统(DGPS)整周模糊度,提出了一种改进蝴蝶搜索算法(IBOA)求解整周模糊度。首先在蝴蝶优化算法(BOA)的香味系数中加入一个自适应权重,弥补BOA算法觅食行为中较弱的搜索能力;其次使用动态切换概率权衡BOA... 详细信息

为了快速准确地解算差分全球定位系统(DGPS)整周模糊度,提出了一种改进蝴蝶搜索算法(IBOA)求解整周模糊度。首先在蝴蝶优化算法(BOA)的香味系数中加入一个自适应权重,弥补BOA算法觅食行为中较弱的搜索能力;其次使用动态切换概率权衡BOA算法中全局搜索与局部搜索的比例;最后在全局搜索和局部搜索阶段引入新的迭代位置更新策略,提升了算法全局搜索能力和跳出局部最优能力。与最小二乘模糊度降相关平差算法(LAMBDA)算法进行1000个历元数据的解算对比实验,结果表明所提算法的平均搜索成功率比LAMBDA算法提高了5.07%。

关键词：差分全球定位系统整周模糊度改进蝴蝶搜索算法自适应权重

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Experimental implementation of phase triplicator gratings in a spatial light modulator

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Chinese Optics Letters 2024年第2期22卷 64-69页

作者：高尚 María del Mar Sánchez-López Ignacio Moreno Instituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Física Aplicada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Materiales Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this work,we compare different methods for implementing a triplicator,a phase grating that generates three equiintense diffraction *** design with optimal efficiency features a continuous phase profile,which cannot be easily reproduced,and is typically affected by *** compare its performance with binary and sinusoidal phase *** also analyze the effect of quantizing the phase ***,a random approach is adopted to eliminate the additional harmonic *** all cases,a liquid-crystal-on-silicon spatial light modulator is employed to experimentally verify and compare the different approaches.

关键词： diffraction gratings phase modulation triplicator spatial light modulators

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Brillouin Klein space and half-turn space in three-dimensional acoustic crystals

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Science Bulletin 2024年第13期69卷 2050-2058页

作者： Zhenxiao Zhu Linyun yang Jien Wu yan Meng Xiang Xi Bei yan Jingming Chen Jiuyang Lu Xueqin Huang Weiyin Deng Ce shang Perry Ping Shum yihao yang Hongsheng Chen Kexin Xiang Gui-Geng Liu Zhengyou Liu Zhen Gao State Key Laboratory of Optical Fiber and Cable Manufacture Technology Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China Key Laboratory of Artificial Micro-and Nanostructures of Ministry of Education and School of Physics and Technology Wuhan UniversityWuhan 430072China King Abdullah University of Science and Technology(KAUST) Physical Science and Engineering Division(PSE)Thuwal 23955-6900Saudi Arabia Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationZJU-Hangzhou Global Science and Technology Innovation CenterCollege of Information Science and Electronic EngineeringZJU-UIUC InstituteZhejiang UniversityHangzhou 310027China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The Bloch band theory and Brillouin zone(BZ)that characterize wave-like behaviors in periodic mediums are two cornerstones of contemporary physics,ranging from condensed matter to topological *** theoretical breakthrough revealed that,under the projective symmetry algebra enforced by artificial gauge fields,the usual two-dimensional(2D)BZ(orientable Brillouin two-torus)can be fundamentally modified to a non-orientable Brillouin Klein bottle with radically distinct manifold ***,the physical consequence of artificial gauge fields on the more general three-dimensional(3D)BZ(orientable Brillouin three-torus)was so far ***,we theoretically discovered and experimentally observed that the fundamental domain and topology of the usual 3D BZ can be reduced to a non-orientable Brillouin Klein space or an orientable Brillouin half-turn space in a 3D acoustic crystal with artificial gauge *** experimentally identify peculiar 3D momentum-space non-symmorphic screw rotation and glide reflection symmetries in the measured band ***,we experimentally demonstrate a novel stacked weak Klein bottle insulator featuring a nonzero Z2 topological invariant and self-collimated topological surface states at two opposite surfaces related by a nonlocal twist,radically distinct from all previous 3D topological *** discovery not only fundamentally modifies the fundamental domain and topology of 3D BZ,but also opens the door towards a wealth of previously overlooked momentum-space multidimensional manifold topologies and novel gaugesymmetry-enriched topological physics and robust acoustic wave manipulations beyond the existing paradigms.

关键词： Momentum-space non-symmorphic symmetry Brillouin Klein space and half-turn space Acoustic Klein bottle insulator Self-collimated topological surface states

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.L.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.J.Li H.Liang J.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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TANK结合激酶1在PINK1/Parkin依赖性和非依赖性线粒体自噬中的作用研究进展

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生理学报 2024年第1期76卷 161-172页

作者：邓豪夏志尚画雨成都体育学院运动医学与健康学院成都610041 温州大学体育与健康学院温州325035 井冈山大学体育学院吉安343009

线粒体自噬是一种清除受损或多余线粒体的过程,在调节细胞内线粒体质量和维持线粒体能量代谢等方面发挥重要作用。TANK结合激酶1(TANK-binding kinase 1,TBK1)是一种多功能的丝氨酸/苏氨酸蛋白激酶,同时参与调控PTEN诱导假定激酶1(PTEN-... 详细信息

线粒体自噬是一种清除受损或多余线粒体的过程,在调节细胞内线粒体质量和维持线粒体能量代谢等方面发挥重要作用。TANK结合激酶1(TANK-binding kinase 1,TBK1)是一种多功能的丝氨酸/苏氨酸蛋白激酶,同时参与调控PTEN诱导假定激酶1(PTEN-induced putative kinase 1,PINK1)/Parkin依赖性和非依赖性线粒体自噬过程。近期研究表明,TBK1可磷酸化视神经蛋白(optineurin,OPTN)、p62/sequestosome-1、Ras相关GTP结合蛋白7(Ras-related GTP binding protein 7,Rab7)等自噬相关蛋白,并介导核点蛋白52(nuclear dot protein 52,NDP52)与UNC-51样自噬激活激酶1(UNC-51 like autophagy activating kinase 1,ULK1)复合物相结合,以及TAX1结合蛋白1(TAX1-binding protein 1,TAX1BP1)与微管相关蛋白1轻链3(microtubule-associated protein 1 light chain 3,LC3)相结合,从而增强PINK1/Parkin依赖性线粒体自噬。TBK1亦可作为AMP活化蛋白激酶(AMP-activatedproteinkinase,AMPK)/ULK1自噬通路的作用底物而被激活,再通过磷酸化动力相关蛋白1(dynamin-related protein 1,Drp1)、Rab7促进PINK1/Parkin非依赖性线粒体自噬。本文对TBK1在PINK1/Parkin依赖性和非依赖性线粒体自噬中的作用及机制进行了综述。

关键词：线粒体线粒体自噬 TANK结合激酶1 PTEN诱导假定激酶1 Parkin

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