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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： yanting Liu Wei Huang Jiayi Wen xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Finite deformation analysis of the rotating cylindrical hollow disk composed of functionally-graded incompressible hyper-elastic material

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1367-1384页

作者： Libiao xin yang WANG Zhiqiang LI y.B.LI College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Aeronautics and Astronautics Taiyuan University of TechnologyTaiyuan 030024China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNC 27606U.S.A.

The deformations and stresses of a rotating cylindrical hollow disk made of incompressible functionally-graded hyper-elastic material are theoretically analyzed based on the finite elasticity *** hyper-elastic material is described by a new micro-macro transition ***,the material shear modulus and density are assumed to be a function with a power law form through the radial direction,while the material inhomogeneity is thus reflected on the power index *** integral forms of the stretches and stress components are *** the obtained complicated integral forms,the composite trapezoidal rule is utilized to derive the analytical solutions,and the explicit solutions for both the stretches and the stress components are numerically *** comparing the results with two classic models,the superiority of the model in our work is ***,the distributions of the stretches and normalized stress components are discussed in detail under the effects of *** results indicate that the material inhomogeneity and the rotating angular velocity have significant effects on the distributions of the normalized radial and hoop stress components and the *** believe that by appropriately choosing the material inhomogeneity and configuration parameters,the functionally-graded material(FGM)hyper-elastic hollow cylindrical disk can be designed to meet some unique requirements in the application fields,e.g.,soft robotics,medical devices,and conventional aerospace and mechanical industries.

关键词： functionally-graded material(FGM) incompressible hyper-elastic model rotating hollow cylindrical disk

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Influence of Strong Electron-Electron Interaction on the Peierls Transition

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Chinese Physics Letters 1997年第1期14卷 63-66页

作者： HU Lian K.y.Szeto SUN xin Department of Physics South China Normal UniversityGuangzhou 510631 Department of Physics The Hong Kong University of Science and TechnologyHong Kong Department of Physics Fudan UniversityShanghai 200433

The influence of short-ranged Coulomb repulsion of strongly correlated electrons on the Peierls transition for a quasi-one-dimensional system is *** shows that the influence varies with the band filling and proves that the condition of single-occupation leads to a singularity on the density of states at half-filling which enhances *** also shows that dimerization is suppressed by the increase of U in the region of large-U and proves that increasing nearest-neighbor interaction V will suppress the Peierls transition temperature at half-filling,and strongly enhance it for band-filling at n≈1/4,which means the enhancement of tetramer-ization for a quarter-filled band.

关键词： Electron Peierls singularity

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Simplified theoretical analysis and numerical study on the dynamic behavior of FCP under blast loads

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Frontiers of Structural and Civil Engineering 2020年第4期14卷 983-997页

作者： Chunfeng ZHAO xin yE Avinash GAUTAM xin LU yLMO Anhui Key Laboratory of Civil Engineering Structures and Materials Hefei University of TechnologyHefei 230009China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024.China School of Civil Engineering Hefei University of TechnologyHefei 230009China Deparment of Civil and Environmental Enginering University of HoustonHoustonTX 77024USA

Precast concrete structures have developed rapidly in the last decades due to the advantages of better quality,non-pollution and fast construction with respect to conventional cast-in-place *** the present study,a theoretical model and nonlinear 3D model are developed and established to assess the dynamic behavior of precast concrete slabs under blast *** first,the 3D model is validated by an experiment performed by other *** verified model is adopted to investigate the blast performance of fabricated concrete panels(FCPs)in terms of parameters of the explosive charge,panel thickness,and reinforcement ***,a simplified theoretical model of the FCP under blast load is developed to predict the maximum *** is indicated that the theoretical model can precisely predict the maximum displacement of FCP under blast *** results show that the failure modes of the panels varied from bending failure to shear failure with the mass of TNT *** thickness of the panel,reinforcement ratio,and explosive charges have significant effects on the anti-blast capacity of the FCPs.

关键词： precast structure fabricated concrete panel blast resistance theory model empirical equation

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu yu Li-yun Zhou Xiao Huang xin-yue Li Ming-Ke Wang Ji-Shun yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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Site-Pairing of Electron in Doped C_(60)

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Chinese Physics Letters 1995年第8期12卷 453-456页

作者： ZHANG Guoping FU Rongtang SUN xin y.Takahashi T.D.Lee Laboratory and Department of Physics Fudan UniversityShanghai 200433 National Laboratory of Infrared Physics Shanghai 200083 Department of Material Science Fudan UniversityShanghai 200433 Department of Physics University of AlbertaEdmonton T6G 2J1Canada 不详

Going beyond both a simple perturbative theory and Hartree-Fock treatment,the Gutzwiller variational scheme is employed to clarify the possibility of electron site-pairing in doped C_(60).It is shown that this pairing can be induced by electron-phonon interaction rather than electron-electron *** results are supported by EPR experiments.

关键词： interaction. Electron Hartree

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Zero-Point Motions in Trans-Polyacetylene

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Chinese Physics Letters 1998年第9期15卷 674-676页

作者： FU Rong-tang RAO Xue-song SUN xin y.Kawazoe Department of Physics Fudan UniversityShanghai 2004331 Institute for Materials Research Tohoku UniversitySendai 980-77Japan

In order to substantiate the applicability of the Takayama-Lin-Liu-Maki model to conducting polymer,the Su-Schrieffer-Heeger model is generalized to include the effects of lattice zero-point motions on electronic *** the treatment of the white-noise approximation,some significant electronic properties of Peierls-Fröhlich states are *** finding shows that the correlation of lattice motions suppresses the effects of zero-point motions on the electronic properties more seriously.

关键词： properties lattice electronic

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Flow field generated by a dielectric barrier discharge plasma actuator in quiescent air at initiation stage

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Chinese Journal of Aeronautics 2021年第3期34卷 13-24页

作者： xin ZHANG y.D.CUI Chien Ming Jonathan TAy B.C.KHOO State Key Laboratory of Aerodynamics China Aerodynamics Research and Development CenterMianyang 621000China National University of Singapore Singapore 119260Singapore

A single Dielectric Barrier Discharge(DBD) plasma actuator driven by Alternating Current(AC) power, capable of inducing a starting vortex and a wall jet in quiescent air, is suited for low-Reynolds-number flow control. However, the starting vortex and the wall jet are usually observed after the plasma actuator has been operated for dozens of and hundreds of cycles of the voltage, respectively. The detail of the induced flow field at the initiation stage of the plasma actuator has rarely been addressed. At the initiation stage, a thin jet that provides the impetus for the entrainment of the induced flow at the beginning of the plasma actuation is first observed by using a high-accuracy phase-lock Schlieren technique and a high-speed Particle Image Velocimetry(PIV) system. This is the initial form of the momentum transfer from the plasma to the ***, an arched type jet is created by the plasma actuator. In addition, the whole development process of the induced flow field from the starting point of the thin jet to the quasi-steady stage of wall jet is presented for providing a comprehensive understanding of the plasma actuator and proposing a relevant enhancement of the numerical simulation model.

关键词： Dielectric barrier discharge Particle image velocimetry Plasma actuator Schlieren technique Wall jet

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Effect of sample size on the response of DEM samples with a realistic grading

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Particuology 2014年第4期12卷 107-115页

作者： xin Huang Kevin J.Hanley Catherine O'Sullivan Fiona C.y.Kwok Skempton Building Department of Civil and Environmental EngineeringImperial College LondonLondon SW7 2AZUnited Kingdom Haking Wong Building Department of Civil EngineeringThe University of Hong Kong

This paper shows that for DEM simulations of triaxial tests using samples with a grading that is repre- sentative of a real soil, the sample size significantly influences the observed material response. Four DEM samples with identical initial states were produced： three cylindrical samples bounded by rigid wails and one bounded by a cubical periodic cell, When subjected to triaxial loading, the samples with rigid boundaries were more dilative, stiffer and reached a higher peak stress ratio than the sample enclosed by periodic boundaries. For the rigid-wall samples, dilatancy increased and stiffness decreased with increasing sample size, The periodic sample was effectively homogeneous, The void ratio increased and the contact density decreased close to the rigid walls, This heterogeneity reduced with increasing sample size. The positions of the critical state lines （CSLs） of the overall response in e-log p＇ space were sensitive to the sample size, although no difference was observed between their slopes. The critical states of the interior regions of the rigid-wall-bounded samples approached that of the homogeneous periodic sample with increasing sample size. The ultimate strength of the material at the critical state is independent of sample size.

关键词： Discrete element method Sample size Rigid boundary Periodic boundary Critical state

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Impact of intracellular innate immune receptors on immunometabolism

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Cellular & Molecular Immunology 2022年第3期19卷 337-351页

作者： Wei-Chun Chou Elena Rampanelli xin Li Jenny P-y.Ting Lineberger Comprehensive Cancer Center University of North Carolina at Chapel HillChapel HillNC27599USA Department of Genetics University of North Carolina at Chapel HillChapel HillNC27599USA Amsterdam UMC(University Medical Center location AMC)Department of Experimental Vascular MedicineAGEM(Amsterdam Gastroenterology Endocrinology Metabolism)InstituteMeibergdreef 91105 AZAmsterdamThe Netherlands Comparative Immunology Research Center College of Veterinary MedicineChina Agricultural UniversityBeijing100193China

Immunometabolism,which is the metabolic reprogramming of anaerobic glycolysis,oxidative phosphorylation,and metabolite synthesis upon immune cell activation,has gained importance as a regulator of the homeostasis,activation,proliferation,and differentiation of innate and adaptive immune cell subsets that function as key factors in *** changes in epithelial and other stromal cells in response to different stimulatory signals are also crucial in infection,inflammation,cancer,autoimmune diseases,and metabolic *** crosstalk between the PI3K-AKT-mTOR and LKB1-AMPK signaling pathways is critical for modulating both immune and nonimmune cell *** bidirectional interaction between immune cells and metabolism is a topic of intense ***-like receptors(TLRs),cytokine receptors,and T and B cell receptors have been shown to activate multiple downstream metabolic ***,how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well *** goal of this review is to examine the link between immunometabolism and the functions of several intracellular innate immune sensors or receptors,such as nucleotide-binding and leucine-rich repeat-containing receptors(NLRs,or NOD-like receptors),absent in melanoma 2(AIM2)-like receptors(ALRs),and the cyclic dinucleotide receptor stimulator of interferon genes(STING).We will focus on recent advances and describe the impact of these intracellular innate immune receptors on multiple metabolic *** appropriate,this review will provide a brief contextual connection to pathogenic infections,autoimmune diseases,cancers,metabolic disorders,and/or inflammatory bowel diseases.

关键词： Immunometabolism NLRs NLRP3/AIM2 inflammasomes innate sensors/receptors STING AKT-mTOR

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