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A network pharmacology-based strategy for predicting the protect-ive mechanism of Ginkgo biloba on damaged retinal ganglion cells

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Chinese Journal of Natural Medicines 2022年第1期20卷 54-66页

作者： yU Hua dong Li-Hong ZHAng yan LIU qiang Chaohu Hospital Affiliated to Anhui Medical University Hefei 230000China

Hallmarks of the pathophysiology of glaucoma are oxidative stress and apoptotic death of retinal ganglion cells(RGCs).Ginkgo biloba extract(EGb)with multi-target,multi-pathway functions has been reported to exert positive pharmacological effects on oxidative stress and damaged ***,the ingredients and anti-apoptotic targets of EGb in the treatment of open-angle glaucoma(OAG)have not been fully ***,in-depth analysis is necessary for further *** biloba-re-lated and anti-apoptotic targets were identified and then combined to obtain the intersection,representing the potential anti-apoptotic targets of Ginkgo *** addition,compound-anti-apoptotic target and OAG-target protein-protein interaction network were merged to obtain five core genes and compound-OAG-anti-apoptotic target protein-protein interaction ***,the active com-pounds and anti-apoptotic targets of Ginkgo biloba in the treatment of OAG were identified,namely luteolin,β-sitosterol,kaempferol,stigmasterol,quercetin,and p53,Bax,Bcl-2,Caspase-3 and Caspase-9,*** the anti-apoptotic targets of Ginkgo biloba in the treatment of OAG,Gene Ontology(GO)and pathway analysis were executed to confirm the gene functions of Ginkgo biloba in antagonizing apoptosis of *** pathway enrichment was mainly involved in transcriptional activation of p53 responsive genes,activation of caspases and apoptotic ***,we confirmed the results of the network analysis by H2O2 treated RGC-5 cells in *** results demonstrated that EGb protection can effectively diminish H2O2-induced apoptosis by inhibiting p53 acetylation,reducing the ratio of Bax/Bcl-2 and suppressing the expression of specific cleavage of Caspase-9 and Caspase-3.

关键词： Ginkgo biloba Oxidative stress Retinal ganglion cells Apoptosis p53 Acetylation

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PAM-PAA microgel inverse opal photonic crystal and pH response

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Chinese Chemical Letters 2007年第11期18卷 1395-1398页

作者： y.ng qiang He Xiao dong Wang Jian y.ng Wang yan Feng y.ng qiang Zhao Xiu dong you School of Science Tianjin University Tianjin 300072 China Insititute of Medical Equipment Academy of Military Medical Sciences Tianjin 300161 China

The colloidal crystal template or opal with a closed-packed face-centered cubic （fcc） lattice was prepared from monodisperse polystyrene （PS） spheres by vertical sedimentation. The template provided void space for infiltration of monomer precursor composed of acrylate acid, acrylamide and ammonium-persulfate, as well as microgel from the subsequent copolymerization. The sample was immersed in dimethylbenzene for completely removing PS spheres to form PAM inverse opal hydrogels （IOHPAM） or PAM/PAA inverse opal hydrogels （IOHPAM/PAA） photonic crystals. The PS spheres were replaced by air spheres, which interconnected each other through the windows. The study of responses to pH show that there are two peaks for both IOHPAM and IOHPAM/PAA films, but the IOHPAM/PAA peaks shift to higher pH, and the peaks are independent with the AA content.

关键词： Photonic crystal pH response PAM/PAA Opal Inverse opal hydrogel

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NUMERICAL SIMULATION OF TWO-DIMENSIONAL DAM-BREAK FLOWS IN CURVED CHANNELS

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Journal of Hydrodynamics 2007年第6期19卷 726-735页

作者： BAI yu-chuan XU dong LU dong-qiang Institute for Sediment on River and Coast 300072 China Shanghai Institute of Applied Mathematics Engineering School of Civil Engineering Tianjin University Tianjin and Mechanics Shanghai University Shanghai 200072 China

Two-dimensional transient dam-break flows in a river with bends were theoretically studied. The river was modeled as a curved channel with a constant width and a flat bottom. The water was assumed to be an incompressible and homogeneous fluid. A channel-fitted orthogonal curvilinear coordinate system was established and the corresponding two-dimensional shallow-water equations were derived for this system. The governing equations with well-posed initial and boundary conditions were numerically solved in a rectangular domain by use of the Godunov-type finite-difference scheme, which can capture the hydraulic jump of dam-break flows. The comparison between the obtained numerical results and the experimental data of Miller and Chaudry in a semicircle channel shows the validity of the present numerical scheme. The mathematical model and the numerical method were applied to the dam-break flows in channels with various curvatures. Based on the numerical results, the influence of river curvatures on the dam-break flows was analyzed in details.

关键词： dam-break flow shallow-water equations,channel bend curvilinear coordinate Godunov-type finite-difference scheme

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Visible-Light-Catalyzed Phosphonation-Annulation： An Efficient Strategyto Synthesize β-Phosphonopyrrolidines and β-Phosphonolactones

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Chinese Journal of Chemistry 2018年第11期36卷 1052-1058页

作者： Chong Li Zhi-Chao Qi qiang y.ng Xiao-yue qiang Shang-dong y.ng State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou Gansu 730000 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences LanzhouGansu 730000 China

A new type of phosphine radical precursor for C—P bond formation has been developed and successfully used in visible‐light‐catalyzed phosphonation‐annulation of unsaturated sulfonamides and carboxylic acids. The catalytic process is simple and green accessible, and no additional oxidant or base is needed. Mechanistic studies suggest that the reaction proceeds via a single electron transfer pathway.

关键词： phosphanes heterocycles annulation photocatalysis radicals

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Iridium and B(C_(6)F_(5))_(3) co-catalyzed chemoselective deoxygenative reduction of tertiary amides:application to the efficient synthesis and late-stage modification of pharmaceuticals

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Science China Chemistry 2023年第4期66卷 1094-1100页

作者： Feng Han Guang-Sheng Lu dong-Ping Wu Pei-qiang Huang Department of Chemistry Fujian Provincial Key Laboratory of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

The Vaska’s complex—tris(pentafluorophenyl)borane combination was found to be a highly efficient cooperative catalysis system for the hydrosilylative reduction of tertiary amides to yield amines under mild *** reaction shows high chemoselectivity,tolerating halide,phenolyl,alkenyl,nitro,nitrile,ester,azido,ketone,and enone functional *** unsubstituted cyclohexanone carboxamide,two variations were established to achieve either catalytic concomitant reduction of the two carbonyl groups or selective reduction of the amide *** protocol was applied to the efficient synthesis and latestage modification of several pharmaceuticals and ***,we showed that by simply prolonging reaction time to 24–28 h,the reaction can reach an exceptionally high efficiency with turnover number(TON)up to 9.8×10^(6) and turnover frequency(TOF)up to 408,333 at a quite low catalyst loading of 0.00001 mol%(S/C(Ir)=10,000,000).

关键词： amide reduction cooperative catalysis chemoselectivity hydrosilylation amines

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Study of detonation wave contours in EFP warhead

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Defence Technology（防务技术） 2016年第2期12卷 129-133页

作者： Xu-dong ZU Zheng-xiang HUAng Chuan-sheng ZHU qiang-qiang XIAO School of Mechanical Engineering Nanjing University of Science and Technology

An analytical model for calculating the propagation time of shock wave in a wave shaper is presented in this study. The calculated results show that the contours of three typical detonation waves, such as conical detonation wave, spherical detonation wave, and planar detonation wave, can be formed in the main charge by changing the thickness of wave *** results show that the planar detonation wave do better than the conical detonation and the spherical detonation wave in increasing the length–diameter ratio of explosively-formed projectiles(EFP) and keep the nose of EFP integrated. The detonation wave can increase the length–diameter ratio of EFP when the wave shaper has the suitable thickness.

关键词：爆轰波 EFP 轮廓战斗部爆炸成形弹丸计算结果传播时间圆锥形

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Model-based risk assessment on dynamic control of twin-column continuous capture under feedstock variations

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Chinese Journal of Chemical Engineering 2024年第10期74卷 22-30页

作者： yu Fan Liang-Zhi Qiao Shan-Jing yao dong-qiang Lin Key Laboratory of Biomass Chemical Engineering of Ministry of Education Zhejiang Key Laboratory of Smart BiomaterialsCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Dynamic control is essential to guarantee the stable performance of continuous *** dynamic control strategy has been developed to ensure a consistent protein load in twincolumn CaptureSMB continuous capture by integrating the UV signal of *** this study,the process risk of CaptureSMB continuous capture under AutoMAb control towards the feedstock variations was assessed by a mechanistic model developed by *** effects of target protein and impurities under the variation range of±10 mAU·min^(-1) on load amount,protein loss,process productivity,and resin capacity utilization were *** results showed that the CaptureSMB process could be successfully controlled by AutoMAb towards increased or slightly decreased concentration of ***,the load process would be out of control with drastically decreased target protein or impurities,and the decreased impurities would lead to protein *** was found that AutoMAb control would cause 44.7%non-operational areas and 18.3%protein loss areas in the variation range of±10 mAU·min^(-1).To improve the stability of the CaptureSMB process,a modified AutoMAb control that would stop the load procedure when the absolute value of the integral area reached the preset value,was proposed to reduce the risk of protein loss and the non-operational area.

关键词： Continuous chromatography Process control Feedstock variations Mechanistic modeling Purification

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The international Human Genome Project:A milestone for life sciences and humanity--The three stages and three major impacts of the HGP,and three contributions by China

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Quantitative Biology 2021年第3期9卷 229-241页

作者： Wei dong Boqing qiang Huanming y.ng BGI-Beijing Beijing 101318China The State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China BGI-Shenzhen Shenzhen 518083China University of Chinese Academy of Sciences Beijing 100049China

The year 2021 marks the 20th anniversary of the official publication of the first draft of a human genome sequence generated by the Human Genome Project(HGP)consortium[1].The whole world has further acknowledged the ... 详细信息

关键词： Human life humanity

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Effects of Zr Content on the Microstructures and Tensile Properties of Ti-3Al-8V-6Cr-4Mo-xZr Alloys

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Acta Metallurgica Sinica(English Letters) 2016年第8期29卷 722-726页

作者： Hong-Bo Ba Li-Min dong Zhi-qiang Zhang dong-Sheng Xu Rui y.ng Institute of Metal Research Chinese Academy of Sciences School of Material Science and Engineering Liaoning University of Technology

The microstructural evolution and tensile properties of Ti-3Al-8V-6Cr-4Mo-xZr（x = 0,2,4 and 6） titanium alloys were *** precipitated phases and tensile fracture morphologies were observed using scanning electron microscopy and transmission electron *** results show that the presence of trace impurity Si and the addition of Zr induce the formation of（TiZr）_6Si_3 *** quantity of silicides increases with Zr content *** dispersed silicides refined the grain size of β Zr-containing alloys,and the grain size decreases significantly with Zr content *** these microstructural changes,the strength of the alloys is enhanced gradually with the increase of Zr content,which is attributed to the combination of precipitation strengthening and grain refinement.

关键词： Titanium alloy Microstructure Silicide Grain size Tensile properties

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Liver transplantation for hepatocellular carcinoma beyond the Milan criteria: A review

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World Journal of Gastroenterology 2016年第12期22卷 3325-3334页

作者： dong-Wei Xu Ping Wan qiang Xia Department of Liver Surgery Ren Ji Hospital School of Medicine Shanghai Jiao Tong University

Liver transplantation(LT) has been accepted as an effective therapy for hepatocellular carcinoma(HCC). The Milan criteria(MC) are widely used across the world to select LT candidates in HCC patients. However, the MC may be too strict because a substantial subset of patients who have HCC exceed the MC and who would benefit from LT may be unnecessarily excluded from the waiting list. In recent years, many extended criteria beyond the MC were raised, which were proved to be able to yield similar outcomes compared with those patients meeting the MC. Because the simple use of tumor size and number was insufficient to indicate HCC biological features and to predict the risk of tumor recurrence, some biological markers such as Alphafetoprotein, Des-Gamma-carboxy prothrombin and the neutrophil-to-lymphocyte ratio were useful in selecting LT candidates in HCC patients beyond the MC. For patients with advanced HCC, downstaging therapy is an effective way to reduce the tumor stage to fulfill the MC by using liver-directed therapy such as transarterial chemoembolization, radiofrequency ablation and percutaneous ethanol injection. This article reviews the recent advances in LT for HCC beyond the MC.

关键词： Liver transplantation Biological marker Milan criteria Hepatocellular carcinoma Downstaging therapy Adjuvant treatment

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