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伴RBD帕金森病患者认知障碍高危因素及预测模型

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脑与神经疾病杂志 2025年第1期33卷 24-28页

作者：朱梦琪王宁阜阳市第三人民医院神经内科

目的探究伴快速眼动期睡眠行为障碍(RBD)的帕金森病(PD)患者认知障碍高危因素,并据此构建预测模型。方法选取2020年6月至2023年11月阜阳市第三人民医院神经内科收治的236例伴RBD的PD患者为研究对象,依据是否并发认知功能障碍将其分为... 详细信息

目的探究伴快速眼动期睡眠行为障碍(RBD)的帕金森病(PD)患者认知障碍高危因素,并据此构建预测模型。方法选取2020年6月至2023年11月阜阳市第三人民医院神经内科收治的236例伴RBD的PD患者为研究对象,依据是否并发认知功能障碍将其分为认知障碍组与非认知障碍组。采用一般资料调查问卷、蒙特利尔认知评估量表(MoCA)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表17项(HAMD-17)、国际PD和运动障碍协会统一PD评定量表第2部分、第3部分(MDS-UPDRSⅡ、MDS-UPDRSⅢ)、Hoehn yahr (H-y)分级及实验室检查指标进行评定。采用单因素及Logistic多因素回归分析影响伴RBD的PD患者认知障碍的因素,并构建预测模型评价其预测效能。结果 236例伴RBD的PD患者MoCA评分为(20.49±4.06)分,其中y分级、MDS-UPDRSⅡ评分、MDS-UPDRSⅢ评分、HAMD-17评分、游离甲状腺素(FT4)、超敏C反应蛋白(hs-CRP)均可能为伴RBD的PD患者认知障碍的影响因素(~均P<0.05);Logistic回归分析显示,农药接触史、MDS-UPDRSⅡ评分、MDSUPDRSⅢ评分、HAMD-17评分、FT4、hs-CRP均是其风险因素(P<0.05);受试者特征曲线(ROC)曲线分析可知,Logistic回归模型预测伴RBD的PD患者认知障碍的曲线下面积(AUC)为0.966,95%CI为0.945～0.987,P<0.001,敏感度90.86%,特异度为93.44%。结论农药接触史、MDS-UPDRSⅡ评分、MDS-UPDRSⅢ评分、HAMD-17评分、FT4、hs-CRP均是影响伴RBD的PD患者认知障碍的影响因素,且据此构建的预测模型具有良好预测价值,可为临床制定防治方案提供依据。

关键词：快速眼动期睡眠行为障碍帕金森认知障碍高危因素预测模型

Seasonal Forecast of South China Sea Summer Monsoon Onset Disturbed by Cold Tongue La Niña in the Past Decade

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Advances in Atmospheric Sciences 2021年第1期38卷 147-155页

作者： ning JIAng Congwen ZHU State Key Laboratory of Severe Weather and Institute of Climate System Chinese Academy of Meteorological SciencesBeijing 100081China

It has been suggested that a warm(cold)ENSO event in winter is mostly followed by a late(early)onset of the South China Sea(SCS)summer monsoon(SCSSM)in *** results show this positive relationship,which is mainly determined by their phase correlation,has been broken under recent rapid global warming since 2011,due to the disturbance of cold tongue(CT)La Niña *** from its canonical counterpart,a CT La Niña event is characterized by surface meridional wind divergences in the central-eastern equatorial Pacific,which can delay the SCSSM onset by enhanced convections in the warming Indian Ocean and the western subtropical *** to the increased Indian−western Pacific warming and the prevalent CT La Niña events,empirical seasonal forecasting of SCSSM onset based on ENSO may be challenged in the future.

关键词： monsoon onset SCSSM ENSO cold tongue La Niña seasonal forecast

Role of mechanical stretching and lipopolysaccharide in early apoptosis and IL-8 of alveolar epithelial typeⅡcells A549

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 638-644页

作者： Qiao-Ming ning Xiao-ning Sun Xin-Kai Zhao Department of Anesthesiology Hainan Provincial Hospital

Objective:To investigate the effects of mechanical stretching and lipopolysaccharide(LPS) on the early apoptosis and IL-8 production of alveolar epithelial type II cells ***:The experimental matrix consisted of three integrated *** the first study,A549 cells were subjected to different stretching strain frequency and duration time to see the effects on the early *** the second study,A549 cells were subjected to mechanical stretch(13%4 h, 0.3 Hz) and LPS(1 or 100 ng/mL) to see whether mechanical strain and LPS also have an addictive effect on the early *** the third study to investigate whether this addictive effect could be induced by LPS and mechanical stretch on IL-8 production,A549 cells were subjected to LPS(100 ng/mL) and mechanical strain(13%.0.3 Hz,4 h).Real time PCR and enzyme linked immunosorbent assay were used to measure mRN A and protein level of *** early apoptosis was detected by flow ***:Mechanical stretch induced the early apoptosis in a force and frequency and time-dependent *** the presence of LPS,mechanical stretch enhanced LPS-induced early apoptosis,especially in 100 ng/mL IPS group compared with 1 ng/ mL LPS and the control *** stretch increased IL-8 production and enhanced LPS-induced IL-8 screation both in mRNA and protein ***:Mechanical stretch can induce the early apoptosis and IL-8 *** stretch and LPS have an addictive effect on the early apoptosis and IL-8 production in alveolar type 2 cells,which is one of the mechanisms of ventilator-induced lung injury.

关键词： Mechanical stretch Early apoptosis Human alveolar typeⅡepithelial cells Lipopolysaccharide IL-8

Partial Wave Analysis of J/ψ Decays into ρρπ

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Communications in Theoretical Physics 2007年第2X期48卷 313-318页

作者： ZHAng Zhen-Xia WU ning Department of Physics Peking University Beijing 100871 China Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China

The possible place to search for exotic states in J/ψ hadronic decays is in J/ψ →ρρπ. Because of the symmetry of identical particle and the symmetry of isospin, the physical analysis on this channel is quite complicated. In this paper, the method to use the partial wave analysis based on covariant helicity amplitude analysis to study the invariant mass spectrum of ρρπ and to find the evidence of exotic states in ρρπ spectrum is discussed. The decay amplitude for the decay sequence J/ψ→ρX, X →ρπ is given first. Then we discuss how to realize the identical particle symmetry and the isospin symmetry in the decay amplitude, which is the key point in the analysis of this channel. Then the total decay amplitude of this channel including all decay components is given. After that, how to identify the exotic states in the ρρπ spectrum is discussed. What is discussed in this paper is the theoretical basis on experimentally searching for exotic states at BEPC/BES.

关键词： covariant helicity-coupling amplitudes exotic state

Characterizations of plurisubharmonic functions

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Science China Mathematics 2021年第9期64卷 1959-1970页

作者： Fusheng Deng Jiafu ning Zhiwei Wang School of Mathematical Sciences University of Chinese Academy of SciencesBeijing100049China School of Mathematics and Statistics HNP-LAMA Central South UniversityChangsha410083China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing100875China

We give characterizations of(quasi-)plurisubharmonic functions in terms of L^(p)-estimates of■and Lp-extensions of holomorphic functions.

关键词： plurisubharmonic function H?rmander’s L2-estimate Ohsawa-Takegoshi extension theorem characterization of plurisubharmonicity

Development and Characterization of Microsatellite Markers for Harpadon nehereus Based on High-Throughput Sequencing and Cross-Species Amplification in Three Myctophiformes Fishes

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Journal of Ocean University of China 2023年第1期22卷 181-188页

作者： HUAng Xinxin ning Zijun y.ng Tianyan Fisheries College Zhejiang Ocean UniversityZhoushan 316022China

Harpadon nehereus is a widespread economical fish found in the coastal seas of China and has important ecological value in the marine ecosystem.H_(o)wever,its germplasm resources have been seriously degraded due to natural factors and anthropogenic *** this study,high-throughput sequencing was applied to search for microsatellite loci in *** transcriptome to provide references for its resource conservation and *** loci were developed by non-denaturing polyacrylamide gel electrophoresis,and their cross-species amplified ability was detected in three related species.A total of 5652 microsatellites were identified from 16974320 *** the primer pairs designed for 100 SSRs for PCR amplification,80%were successfully amplified,and 26 loci were polymorphic with a high number of alleles from 3 to 11 *** expected(H_(e))and observed(H_(o))heterozygosities were 0.355–0.885 and 0.375–0.958,*** of the loci were highly polymorphic(polymorphism information content:0.316–0.852;mean:0.713),and these markers can be applied in the population genetic diversity research of ***.H_(o)wever,the transferability of these primers was low,probably because of the close relation of the collected *** follow-up work,simple sequence repeats will be excavated with genome-based technologies,and related species will be gathered to address the present inadequacies.

关键词： Harpadon nehereus microsatellite markers high-throughput sequencing cross-species amplification

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Comparison of different pseudo-linear estimators for vision-based target motion estimation

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Control Theory and Technology 2023年第3期21卷 448-457页

作者： Zian ning yin Zhang Shiyu Zhao Department of Computer Science and Technology Zhejiang UniversityHangzhou 310058ZhejiangChina School of Engineering Westlake UniversityHangzhou 310024ZhejiangChina

Vision-based target motion estimation based Kalman filtering or least-squares estimators is an important problem in many tasks such as vision-based swarming or vision-based target *** this paper,we focus on a problem that is very specific yet we believe *** is,from the vision measurements,we can formulate various *** and how the measurements should be used?These problems are very fundamental,but we notice that practitioners usually do not pay special attention to them and often make *** by this,we formulate three pseudo-linear measurements based on the bearing and angle measurements,which are standard vision measurements that can be *** estimators based on Kalman filtering and least-squares estimation are established and compared based on numerical *** is revealed that correctly analyzing the covariance noises is critical for the Kalman filtering-based *** the variance of the original measurement noise is unknown,the pseudo-linear least-squares estimator that has the smallest magnitude of the transformed noise can be a good choice.

关键词： Pseudo-linear measurements Kalman filter Least-squares estimator Vision-based target motion analysis Fisher information

Fractional Schrodinger Equations with Logarithmic and Critical Nonlinearities

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Acta Mathematica Sinica,English Series 2023年第2期39卷 285-325页

作者： Hai ning FAN Bin Lin ZHAng School of Mathematics China University of Mining and TechnologyXuzhou221116China College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao266590China

In this paper,we study a class of the fractional Schrodinger equations involving logarithmic and critical *** using the Nehari manifold method and the concentration compactness principle,we show that the above problem admits at least one ground state solution and one ground state sign-changing ***,by using variational methods,we prove that how the coefficient function of the critical nonlinearity affects the number of positive *** main feature which distinguishes this paper from other related works lies in the fact that it is the first attempt to study the existence and multiplicity for the above problem involving both logarithmic and critical nonlinearities.

关键词： Logarithmic nonlinearity critical Sobolev exponent fractional Schr?dinger equation ground state solution sign-changing solution

Precise bounded-concurrent zero-knowledge proofs for NP

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Science China(Information Sciences) 2010年第9期53卷 1738-1752页

作者： ning Ding DaWu Gu 1. Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

Precise concurrent zero-knowledge is a new notion introduced by Pandey et *** Eurocrypt’*** notion captures the idea that the view of any verifier in concurrent interaction can be reconstructed in almost the same *** et *** constructed some precise concurrent zero-knowledge argument *** this paper we construct a precise bounded-concurrent zero-knowledge proof for NP,which has the precision p(n,y) = poly(n) + O(ny).Bounded-concurrency means that an a-priori bound on the number of concurrent sessions is specified before the protocol is *** result holds even if adversarial verifiers adopt the dynamic scheduling *** make no setup *** advantage of proof systems over argument systems is that the soundness property of proof systems can resist computationally-unbounded adversarial provers,while that of argument systems can only resist polynomial-time adversarial provers.

关键词： interactive proofs and arguments zero-knowledge precise zero-knowledge proofs of knowledge bounded concurrency