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Opportunities for production and property research of neutron-rich nuclei around n=126 at HIAF

nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： shao-Bo Ma Li-na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-yu Sun Shu-Wen Tang yu-Hong yu Xin-Tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEn nishina Center Saitama 351-0198Japan northwest normal University Lanzhou 730070China

The study of nuclide production and its properties in the n=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around n=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around n=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many.new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many.nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near n=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around n=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation neutron-rich nuclei around n=126 Mass measurement Lifetime

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A Simple Egg Membrane Patch Bridging Method for Repairing Tympanic Membrane Perforation

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Journal of Clinical and nursing Research 2024年第8期8卷 264-269页

作者： Xing Huang Xuping Wang Bin Li Lumei shao Ping Li Department of Otorhinolaryngology and Head and neck Surgery Taikang Xianlin Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210023Jiangsu ProvinceChina

Objective:To analyze the clinical effect of a simple egg membrane patch bridging method in repairing tympanic membrane ***:A total of 93 tympanic membrane perforation patients admitted to the hospital between September 2022 and October 2023 were selected and divided into two groups according to the random number table *** control group implemented the conventional treatment(n=46 cases),and the patch group adopted the simple egg membrane patch bridging method(n=47 cases).The healing rate of the tympanic membrane,the air-bone gap,the air conduction hearing threshold,the dry ear rate,and the incidence of complications in both groups were compared before and after ***:The healing rate of the tympanic membrane in the patch group was significantly higher than that of the control group(95.75%vs.76.09%),with Pno difference in the air-bone gap and air conduction hearing threshold levels between the two groups before treatment(P>0.05),and the hearing indexes of the patch group were significantly lower than those of the control group 3 months after treatment(Py ear rate in the patch group was significantly higher than that of the control group after treatment(85.11%vs.67.39%),and the total incidence of complications was also significantly lower than that of the control group(6.38%vs.21.74%),with Pne patch bridging method is effective in repairing tympanic membrane perforation,which can effectively improve patients’hearing levels and reduce the occurrence of post-treatment ***,it is worth popularizing and apply.ng in the clinic.

关键词： Egg membrane Patch bridging method Tympanic membrane perforation Hearing level

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Transmission of ceftazidime-avibactam-resistant Escherichia coli among pets,veterinarians and animal hospital environment

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Biosafety and Health 2024年第3期6卷 191-198页

作者： Hegen Dai Dongy.n shao yu Song Qi An Zhenbiao Zhang Haixia Zhang Siyu Chen Congming Wu Jianzhong Shen y.nli Lyu y.ng Wang Shizhen Ma Zhaofei Xia national Key Laboratory of Veterinary Public Health Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Key Laboratory of Animal Antimicrobial Resistance Surveillance Ministry of Agriculture and Rural AffairsCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Department of Clinical Veterinary Medicine College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Shanxi Key Laboratory for Modernization of TCVM College of Veterinary MedicineShanxi Agricultural UniversityTaiyuan 030801China Ruichen Pet Hospital Group Co. LtdXiamen 361004China

Ceftazidime-avibactam (CZA) is a recently approved combination synthetic β-lactamase inhibitor used in human clinical medicine. Cases of CZA resistance in humans have already been reported, but limited research has investigated CZA resistance in pets. This study explored the prevalence and transmission of CZA-resistant Escherichia coli (CZAREC) among pets, their owners, veterinarians, and the environment in animal hospitals. A total of 5,419 clinical samples were collected from dogs and cats, along with samples from the environment (n = 5,843), veterinarians (n = 557), and pet owners (n = 368) in animal hospitals. From these samples, 760 Escherichia coli (E. coli) isolates were obtained, out of which 60 were identified as CZAREC. These included 34 isolates from the environment (9.14 %, n = 372), three from veterinarians (8.11 %, n = 37), and 23 from animals (6.82 %, n = 337). no CZAREC isolates were found in pet owners. The predominant sequence types of CZARECs were ST156 (n = 20), ST410 (n = 19) and ST101 (n = 7). Bayesian analysis revealed six clusters comprising 47 isolates from the hospital environment, pets, and veterinaries, display.ng genetic relatedness of less than 100 core genome single nucleotide polymorphisms (cgSnPs) between any two isolates in each cluster. Some CZAREC isolates with high genetic similarity persisted in the same animal hospital for four to six months. Moreover, discriminant analysis of principal components indicated that most isolates from different hosts shared a genetic source in the human/dog/cat merged cluster. Overall, evidence of CZARECs transmission was found among pets, the environment, and veterinarians in animal hospitals. The findings emphasize the importance of monitoring CZARECs in the veterinary clinical setting to ensure the health of both pets and humans.

关键词： Ceftazidime-avibactam(CZA) Escherichia coli(E.coli) Pets Animal hospital environment Veterinarians

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Identification and effective regulation of scarb1 gene involved in pigmentation change in autotetraploid Carassius auratus

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Zoological Research 2024年第2期45卷 381-397页

作者： Xi-Dan Xu yue Zhou Chong-Qing Wang Xu Huang Kun Zhang Xiao-Wei Xu Li-Wen He Xin-yue Zhang Xin-Zhu Fu Ming Ma Qin-Bo Qin shao-Jun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education MinistryCollege of Life SciencesHunan Normal UniversityChangshaHunan 410081China nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511458China Hunan yuelu Mountain Science and Technology Co.Ltd.for Aquatic Breeding ChangshaHunan 410081China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangshaHunan 410081China

The autotetraploid Carassius auratus(4nRR,4n=200,RRRR)is derived from whole-genome duplication of Carassius auratus red var.(RCC,2n=100,RR).In the current study,we demonstrated that chromatophores and pigment changes directly caused the coloration and variation of 4nRR skin(red in RCC,brownish-yellow in4nRR).To further explore the molecular mechanisms underly.ng coloration formation and variation in 4nRR,we performed transcriptome profiling and molecular functional verification in RCC and *** revealed that scarb1,associated with carotenoid metabolism,underwent significant down-regulation in *** editing of this candidate pigment gene provided clear evidence of its significant role in RCC ***,we identified four divergent scarb1 homeologs in 4nRR:two original scarb1 homeologs from RCC and two duplicated ***,three of these homeologs possessed two highly conserved alleles,exhibiting biased and allelespecific expression in the ***,after precise editing of both the original and duplicated scarb1homeologs and/or alleles,4nRR individuals,whether singly or multiply mutated,displayed a transition from brownishyellow skin to a cy.n-gray ***,the proportional areas of the cy.n-gray regions displayed a gene-dose *** findings illustrate the subfunctionalization of duplicated scarb1,with all scarb1genes synergistically and equally contributing to the pigmentation of *** is the first report concerning the functional differentiation of duplicated homeologs in an autopolyploidfish,substantially.nrichingour understanding of coloration formation and change within this group of organisms.

关键词： Autopolyploidization Coloration change scarb1 Functional differentiation Genetic changes

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银耳多糖对力竭运动小鼠氧化性损伤所致疲劳的缓解作用

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食品工业科技 2024年第4期45卷 328-335页

作者：黄小兰黄少波邵丽重庆对外经贸学院重庆401520 重庆市开州区中医院骨伤科重庆405400 重庆市开州区中医院儿科重庆405400

目的:探讨银耳多糖(Tremella fuciformis polysaccharides,TFP)对小鼠力竭运动性氧化损伤的影响,并分析其机制。方法:采用TFP处理L6细胞48 h,CCK-8法检测L6的活力;L6细胞设置3组,包括对照组、H_(2)O_(2)组、H_(2)O_(2)+TFP组,孵育48 h,生化分析仪检测乳酸(Lactic Acid,LA)水平,Western blot实验检测nrf2、nQO1和HO-1蛋白水平;将C57BL/6小鼠随机分为4组(每组n=10),包括模型组、模型+TFP组(50、100、200 mg/kg),模型+TFP组连续灌胃TFP,模型组灌胃相同剂量的蒸馏水,每天1次,连续2周。末次给药30 min后进行力竭运动,记录力竭游泳运动时间,采用酶联免疫吸附试验(ELISA)检测肝糖原(LG)、骨骼肌糖原(MG);ELISA法检测血尿素氮(BUn)、LA、ROS、丙二醛(MDA)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)、TnF-α、IL-6、nF-κBp65水平。Western blot实验检测nrf2、nQO1、HO-1蛋白水平。结果:H_(2)O_(2)组L6细胞的LA水平极显著(Pnrf2、nQO1、HO-1蛋白水平极显著(Pnrf2、nQO1、HO-1表达。TFP显著延长力竭游泳时间(Pn(PnF-α、IL-6、nF-κBp65的水平;与模型组比较,TFP显著增加nrf2(PnQO-1(Pnrf2/HO-1信号通路相关。

关键词：银耳多糖游泳力竭运动 nrf2/HO-1信号通路氧化应激炎症

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Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

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China Geology 2024年第2期7卷 171-187页

作者： Wei Wang yuan-dong Huang Chong Xu Xiao-yi shao Lei Li Li-ye Feng Hui-ran Gao yu-long Cui Shuai Wu Zhi-qiang y.ng Kai Ma national Institute of natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained natural Hazards Dynamics Ministry of Emergency Management of Chin12eijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China no.3 Bureau of China Metallurgical Geology Bureau Taiyuan 030031China

The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to ***,the northwestern margin of this region,characterised by limited human activities and challenging transportation,remains insufficiently explored concerning landslide occurrence and *** the planning and construction of the Xinjiang-Tibet Railway,a comprehensive investigation into disastrous landslides in this area is essential for effective disaster preparedness and mitigation *** using the human-computer interaction interpretation approach,the authors established a landslide database encompassing 13003 landslides,collectively spanning an area of 3351.24 km^(2)(36°n-40°n,73°E-78°E).The database incorporates diverse topographical and environmental parameters,including regional elevation,slope angle,slope aspect,distance to faults,distance to roads,distance to rivers,annual precipitation,and *** statistical characteristics of number and area of landslides,landslide number density(LnD),and landslide area percentage(LAP)are *** authors found that a predominant concentration of landslide origins within high slope angle regions,with the highest incidence observed in intervals characterised by average slopes of 20°to 30°,maximum slope angle above 80°,along with orientations towards the north(n),northeast(nE),and southwest(SW).Additionally,elevations above 4.5 km,distance to rivers below 1 km,rainfall between 20-30 mm and 30-40 mm emerge as particularly susceptible to landslide *** study area’s geological composition primarily comprises Mesozoic and Upper Paleozoic *** fault and human engineering activities have different degrees of influence on landslide ***,the significance of the landslide database,the relationship between landslide distribution and environmental factors,and the geometric and morphological characteristics of landslides are *** landslide H/L ratios in the study area are

关键词： Landslides Human-computer interaction interpretation Landslide database Spatial distribution Earthquake Rainfall Human engineering activity Qinghai-Tibet Plateau Geological hazards survey engineering

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RuCo alloy.nanoparticles embedded within n-doped porous two-dimensional carbon nanosheets:a high-performance hydrogen evolution reaction catalyst

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Tungsten 2024年第1期6卷 114-123页

作者： Jin-Hui Wang shao-Wei y.ng Fu-Bin Ma yi-Ke Zhao Shi-nuo Zhao Zheng-yu Xiong Dong Cai Hai-Dong Shen Kai Zhu Qiu-yu Zhang yue-Ling Cao Tian-Shuai Wang He-Peng Zhang Research and Development Institute of northwestern Polytechnical University in Shenzhen Shenzhen 518057China Xi’an Key Laboratory of Functional Organic Porous Materials School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710129China School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China Chongqing Science and Technology Innovation Center of northwestern Polytechnical University Chongqing 401135China

Developing cost-effective electrocatalysts with high activity and stability especially at high current density is of great significance for the large-scale commercial application of electrochemical water splitting to hydrogen production but still remains ***,we report an effective confinement pyrolysis strategy to fabricate embedded ruthenium-cobalt nanoclusters supported on n-doped porous two-dimensional carbon nanosheets(RuCo@Cn).Markedly,the embedded structure can effectively prevent the migration,agglomeration,and leaching of nanoparticles,thus endowing the RuCo@Cn catalyst with high *** be exact,high stability with up to 650 h can be achieved at high current density(-500 and-1000 mA·cm^(-2)).Besides,the RuCo@Cn catalysts also exhibit highly reactive with low overpotentials of only 11mV at-10 mA·cm^(-2).Density functional theory calculations reveal that the introduction of cobalt reduces the decomposition barrier of H_(2)O for RuCo@Cn alloy,thus promoting hydrogen evolution reaction.

关键词： Hydrogen evolution reaction Confinement pyrolysis strategy Mosaic structure Stability

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Atomically dispersed calcium as solid strong base catalyst with high activity and stability

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Green Energy & Environment 2024年第10期 1619-1626页

作者： Xiang-Bin shao Zhi-Wei Xing Si-yu Liu Ke-Xin Miao Shi-Chao Qi Song-Song Peng Xiao-Qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)College of Chemical EngineeringNanjing Tech University30 South Puzhu Road

Solid strong base catalysts are highly attractive for diverse reactions owing to their advantages of neglectable corrosion,facile separation,and environmental ***,their widespread applications are impeded by basic components aggregation and low *** this work,we fabricate single calcium atoms on graphene （denoted as Ca1/G） by use of a redox strategy for the first time,producing solid strong base catalyst with high activity and *** precursor Ca（nO3）2is first reduced to CaO at 400℃ by the support graphene,forming CaO/G with conventional basic sites,and the subsequent reduction at 850℃ results in the generation of Ca1/G with atomically dispersed *** characterizations reveal that Ca single atoms are anchored on graphene in tetra-coordination （Ca–C2–n2） where n is in situ doped from Ca（nO3）*** atomically dispersed Ca,along with their anchoring on the support,endow Ca1/G with high activity and stability toward the transesterification reaction of ethylene carbonate with *** turnover frequency value reaches 128.0 h-1on Ca1/G,which is much higher than the traditional counterpart CaO/G and various reported solid strong bases (2.9–46.2 h-1).Moreover,the activity of Ca1/G is well maintained during 5 cycles,while 60% of activity is lost for the conventional analogue CaO/G due to the leaching of Ca.

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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KOnG Zi Qing LIU Li Qun HUAnG De Qin WAnG yu Tong LI Jing Jie ZHAnG Zheng WAnG Xi Xi LIU Chuan Ling ZHAnG ya Di shao Jia Kang ZHU yi Min CHEn yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(n=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(Pncreased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,Pn’s R=0.159,Pnalysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may.not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

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Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-y.ng y.n Hong Lv Jing-Cheng y.ng Chao you Zi-Ang Li Ding Ma yi Xiao Jia Hu Wen-Tao y.ng yi-Zhou Jiang Jun Xu Zhi-Ming shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TnBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TnBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TnBC cohort(n=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy.number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TnBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TnBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank Pn framework and neural network models were externally validated on the TnBC cases from TCGA(n=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

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