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Comparison of survival between adolescent and young adult vs older patients with hepatocellular carcinoma

World Journal of Gastrointestinal Oncology 2020年第12期12卷 1394-1406页

作者： Jie Ren ying-Mu Tong Rui-Xia Cui Zi Wang Qing-Lin Li Wei liu Kai Qu jing-yao Zhang Chang liu yong Wan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of SICU The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Geriatric Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Due to the special clinical features and biologic characteristics of adolescent and young adult(AyA)cancers,AyA cancers are different from cancers in children and elderly ***,there are few reports on AyA hepatocellular carcinoma(HCC).AIM To investigate the overall survival(OS)of AyA(15-39 years)and elderly(40-74 years)patients with *** The data of all the HCC cases were extracted from the Surveillance,Epidemiology,and End Results database from 2004 to 2015 and were then divided into two groups based on age:AyA group(15-39 years)and older group(40-74 years).Kaplan-Meier curves and log-rank tests were used to compare the OS of the two *** score matching(PSM)was employed to analyze the OS difference between the two *** Cox proportional hazards regression model was used to perform multivariate analysis to explore the risk factors for OS of HCC *** Compared to elderly cancer patients,AyA patients with HCC had a worse Surveillance,Epidemiology,and End Results stage,including the distant stage(22.1%vs 15.4%,Py to receive surgery(64.5%vs 47.5%,PyA group had a longer survival in months(median:20.00,interquartile range[IQR]:5.00-62.50)than the older group(median:15.00,IQR:4.00-40.00)(PyA group still had a longer survival in months(median:21.00,IQR:5.00-64.50)than the older group(median:18.00,IQR:6.00-53.00)(Pysis,the Cox proportional hazards regression model showed that in AJCC I/II HCC patients,advanced age(HR=1.749,95%CI:1.352-2.263,P<0.001)was a risk factor for OS,while it was not a risk factor in AJCC III/IV HCC patients(HR=1.186,95%

关键词： Adolescent and young adults Older adults Hepatocellular carcinoma Overall survival Propensity score matching Risk factor

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Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis

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Bioactive Materials 2022年第11期7卷 406-424页

作者： Jin Wang Si-an Xie Ning Li Tao Zhang Weijuan yao Hucheng Zhao Wei Pang Lili Han Jiayu liu jing Zhou Department of Physiology and Pathophysiology School of Basic Medical SciencesHemorheology CenterSchool of Basic Medical SciencesPeking UniversityBeijingPR China Key Laboratory of Molecular Cardiovascular Science Ministry of EducationBeijingPR China National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing Key Laboratory of Cardiovascular Receptors ResearchPeking UniversityBeijingPR China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijingPR China Center for Biomechanics and Bioengineering Key Laboratory of Microgravity(National Microgravity Laboratory)And Beijing Key Laboratory of Engineered Construction and MechanobiologyInstitute of MechanicsChinese Academy of SciencesBeijingPR China School of Engineering Sciences University of Chinese Academy of SciencesBeijingPR China Department of Vascular Surgery Peking University People’s HospitalBeijingPR China Institute of Biomechanics and Medical Engineering School of Aerospace EngineeringTsinghua UniversityBeijingPR China

Vascular smooth muscle cell (vSMC) is highly plastic as its phenotype can change in response to mechanical cues inherent to the extracellular matrix (ECM). VSMC may be activated from its quiescent contractile phenotype to a proinflammatory phenotype, whereby the cell secretes chemotactic and inflammatory cytokines, e.g. MCP1 and IL6, to functionally regulate monocyte and macrophage infiltration during the development of various vascular diseases including arteriosclerosis. Here, by culturing vSMCs on polyacrylamide (PA) substrates with variable elastic moduli, we discovered a role of discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds collagens, in mediating the mechanical regulation of vSMC gene expression, phenotype, and proinflammatory responses. We found that ECM stiffness induced DDR1 phosphorylation, oligomerization, and endocytosis to repress the expression of DNA methyltransferase 1 (DNMT1), very likely in a collagen-independent manner. The DDR1-to-DNMT1 signaling was sequentially mediated by the extracellular signal-regulated kinases (ERKs) and p53 pathways. ECM stiffness primed vSMC to a proinflammatory phenotype and this regulation was diminished by DDR1 inhibition. In agreement with the in vitro findings, increased DDR1 phosphorylation was observed in human arterial stiffening. DDR1 inhibition in mouse attenuated the acute injury or adenine diet-induced vascular stiffening and inflammation. Furthermore, mouse vasculature with SMC-specific deletion of Dnmt1 exhibited proinflammatory and stiffening phenotypes. Our study demonstrates a role of SMC DDR1 in perceiving the mechanical microenvironments and down-regulating expression of DNMT1 to result in vascular pathologies and has potential implications for optimization of engineering artificial vascular grafts and vascular networks.

关键词： Matrix stiffness Inflammation DDR1 DNMT1 Mechanotransduction

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Pathogenicity and transcriptomic profiling reveals immunology molecular hallmarks after CA10 virus infection

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Animal Models and Experimental Medicine 2024年第5期7卷 717-731页

作者： Wanjun Peng jing Wu Binbin Zhao Lihong Zhang Xin Chen Xiaohui Wei Na Rong yunlin Han Jiangning liu NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

Background:Hand,foot and mouth disease(HFMD)is a common infectious disease caused by viral infection by a variety of enteroviruses,with coxsackievirus A 10(CA10)having become more prevalent in recent ***:In this study,models of CA10 infection were established in 7-day-old Institute of Cancer Research(ICR)mice by intraperitoneal injection to analyze the pathogenicity of the *** sequencing analysis was used to screen the differentially expressed genes(DEGs)after CA10 *** A 16(CA16)and enterovirus 71(EV71)infections were also compared with ***:After CA10 virus infection,the mice showed paralysis of the hind limbs at 3 days post infection and weight loss at 5 days post *** observed viral replication in various tissues and severe inflammatory cell infiltration in skeletal *** RNA-sequencing analysis showed that the DEGs in blood,muscle,thymus and spleen showed heterogeneity after CA10 infection and the most upregulated DEGs in muscle were enriched in immune-related *** with CA16 and EV71 infection,CA10 may have an inhibitory effect on T helper(Th)cell differentiation and cell ***,the common DEGs in the three viruses were most enriched in the immune system response,including the Toll-l ike receptor pathway and the nucleotide-binding and oligomerization domain(NOD)-l ike ***:Our findings revealed a group of genes that coordinate in response to CA10 infection,which increases our understanding of the pathological mechanism of HFMD.

关键词： CA10 HFMD RNA-Seq

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Efficacy of Solitaire AB stent-release angioplasty in acute middle cerebral artery atherosclerosis obliterative cerebral infarction

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World Journal of Clinical Cases 2021年第19期9卷 5028-5036页

作者： Xi-Feng Wang Ming Wang Gang Li Xue-yu Xu Wei Shen jing liu Shuang-Shuang Xiao Jiang-Hong Zhou Department of Neurology Puai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430033Hubei ProvinceChina

BACKGROUND In both national and international studies,the safety and effectiveness of treatment with the Solitaire stent in patients with ischemic stroke caused by acute large vessel occlusion were good,and the disability rate was significantly ***,there are currently only a few reports on the differences in endovascular treatment for different etiological classifications,especially in the anterior cranial circulation,aorta atherosclerotic stenosis,and acute *** To investigate the efficacy of Solitaire AB stent-release angioplasty in patients with acute middle cerebral artery atherosclerosis obliterative cerebral *** Twenty-five patients with acute middle cerebral atherosclerosis obliterative cerebral infarction were retrospectively enrolled in this study from January 2017 to December *** Solitaire AB stent was used to improve anterior blood flow to maintain modified cerebral infarction thrombolysis[modified thrombolysis in cerebral infarction(mTICI)]at the 2b/3 level or above,the stent was then unfolded and *** All 25 patients underwent successful surgery,with an average recanalization time of 23 *** patient died of cerebral hemorrhage and cerebral herniation after the *** National Institutes of Health Stroke Scale(NIHSS)scores immediately after surgery(7.5±5.6),at 24 h(5.5±5.6)and at 1 wk(3.6±6.7)compared with the preoperative NIHSS score(15.9±4.4),were significantly different(Py(the stenosis rate was 50%without clinical symptoms),the modified Rankin scale scores were 0 points in 14 cases(56%),1 point in 4 cases(16%),2 points in 2 cases(8%),3 points in 3 cases(12%),4 points in 1 case(4%),and 6 points in 1 case(4%).CONCLUSION In acute middle cerebral artery atherosclerosis obliterative cerebral infarction,when the Solitaire AB stent is unfolded and the forward blood flow is maintained at mTICI level 2b/3 or higher,stent release may be a

关键词： Stent angioplasty Atherosclerosis obliterative Acute cerebral infarction

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Efficacy and safety of non-pharmacological interventions for irritable bowel syndrome in adults

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World Journal of Gastroenterology 2020年第41期26卷 6488-6509页

作者： yun-Kai Dai yun-Bo Wu Ru-liu Li Wei-jing Chen Chun-Zhi Tang Li-Ming Lu Ling Hu Institute of Gastroenterology Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Medical College of Acu-Moxi and Rehabilitation Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Although nonpharmacological interventions(NPI) for irritable bowel syndrome(IBS) have been applied clinically, their relative efficacy and safety are poorly *** To compare and rank different NPI in the treatment of *** Five electronic databases were searched from their inception to January 12, 2020. Data of included publications were analyzed using network meta-analysis(NMA). Quality of endpoints were assessed by tools of the Cochrane Handbook and the GRADEpro software. Pooled relative risk or standardized mean difference with their corresponding 95% confidence intervals were used for statistical analysis. Surface under the cumulative ranking curve(SUCRA) probability value was conducted to rank the examined interventions. Sensitivity analysis was performed to verify the robustness of results and test the source of *** Forty randomized controlled trials with 4196 participants were included in this NMA. Compared with routine pharmacotherapies and placebo, acupuncture and cognitive behavioral therapy(CBT) had better efficacy in relieving IBS symptoms. Based on the SUCRA values, acupuncture ranked first in improving overall clinical efficacy and avoiding adverse effects. CBT ranked first in lowering the scores of IBS symptom severity scale, self-rating anxiety scale and self-rating depression *** This study confirmed the efficacy and safety of NPI for improving IBS symptoms, which to some extent recommended several interventions for clinical practice.

关键词： Nonpharmacological interventions Irritable bowel syndrome Network meta-analysis Randomized controlled trials Adults Clinical practice

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Effect analysis of unilateral deaf adults wearing bone-conduction hearing aids:A case report

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Journal of Otology 2024年第4期19卷 207-213页

作者： Chenchen Xiang yi Wang Xiaozhu Cao Weiman Xv jing liu Nan Li Lumeng Han QIan Wang Fei Ji Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Peking University Third Hospital China Department of Stomatology First Medical CenterChinese PLA General HospitalBeijingChina

The prevalence of unilateral deafness(SSD)or asymmetric hearing loss(AHL)among patients with hearing impairments ranges from 7.2%to 15.0%,indicating a relatively significant ***,these individuals often overlook their hearing loss,resulting in delayed or inadequate *** oversight can lead to a lack of binaural summation and squelch effect,as well as the head shadow effect,which can significantly impact their speech recognition and sound localization abilities,especially in noisy ***,a groundbreaking Sound Bite™Pinyin® Bone Conduction Hearing Aid(HA)device has been has been introduced as a viable alternative to traditional percutaneous stimulation hearing assistance *** innovative device harnesses bone conduction technology to convey sound vibrations directly to the inner ear via the bones of the jaw and skull,effectively bypassing the air conduction pathway that is commonly compromised in individuals with hearing *** report details the evaluation and adjustment process of a HA device worn by a 31-year-old female patient who suffers from a congenital ossicular chain deformity in her right ear,while maintaining normal hearing in her left *** report comprehensively covers the hearing thresholds of the 31-year-old female patient on the day of fitting the hearing aid and one month *** also presents assessments of the hearing aid’s performance through the Abbreviated Profile of Hearing Aid Benefit(APHAB)questionnaire,conducted three days after adjustment,one month later,and one year ***,the report details the evaluation of the patient’s sound localization ability,comparing her performance before and after wearing the hearing aid ***,it includes measurements of her speech recognition ability for monosyllabic words and yang yang Ge words,which are specific tests in the Chinese language,conducted two years after the initial fitting of the hearing *** discovery that bone-anchor

关键词： Bone conduction hearing aid Abbreviated profile of hearing aid benefit Speech audiometry

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Neurotrophins and neural stem cells in posttraumatic brain injury repair

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Animal Models and Experimental Medicine 2024年第1期7卷 12-23页

作者： Wenwen Guo Ke liu yinghua Wang Xu Ge yifan Ma jing Qin Caiqin Zhang ya Zhao Changhong Shi Laboratory Animal Center Fourth Military Medical UniversityXi'anP.R.China Gansu University of Traditional Chinese Medicine LanzhouP.R.China Medical College of yan'an University Yan'anP.R.China

Traumatic brain injury(TBI)is the main cause of disability,mental health disorder,and even death,with its incidence and social costs rising *** different treatment strategies have been developed and tested to mitigate neurological decline,a definitive cure for these conditions remains *** have revealed that vari-ous neurotrophins represented by the brain-derived neurotrophic factor are the key regulators of neuroinflammation,apoptosis,blood-brain barrier permeability,neurite regeneration,and memory *** factors are instrumental in alleviating neu-roinflammation and promoting *** addition,neural stem cells(NSC)contribute to nerve repair through inherent neuroprotective and immunomodulatory properties,the release of neurotrophins,the activation of endogenous NSCs,and in-tercellular ***,innovative research proposals are emerging to combine BDNF and NSCs,enabling them to synergistically complement and promote each other in facilitating injury repair and improving neuron differentiation after *** this review,we summarize the mechanism of neurotrophins in promoting neurogen-esis and restoring neural function after TBI,comprehensively explore the potential therapeutic effects of various neurotrophins in basic research on TBI,and investigate their interaction with *** endeavor aims to provide a valuable insight into the clinical treatment and transformation of neurotrophins in TBI,thereby promoting the progress of TBI therapeutics.

关键词： mutual effect neural stem cells neurological function neurotrophins traumatic brain injury

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火星轨道器运动的轨道变化特征

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宇航学报 2008年第2期29卷 461-466页

作者：刘林汤靖师南京大学天文系

低地球卫星轨道半长径a和偏心率e的变化及其轨道寿命主要受大气作用的制约,而月球低轨卫星的相应变化及轨道寿命则主要受月球非球形引力位中的奇次带谐项J2l-1(l≥2)作用的制约,且与轨道倾角i有密切关系。然而,对于火星低轨卫星,因大气... 详细信息

低地球卫星轨道半长径a和偏心率e的变化及其轨道寿命主要受大气作用的制约,而月球低轨卫星的相应变化及轨道寿命则主要受月球非球形引力位中的奇次带谐项J2l-1(l≥2)作用的制约,且与轨道倾角i有密切关系。然而,对于火星低轨卫星,因大气作用较弱,其轨道偏心率e的变化以及相应的轨道寿命也主要决定于奇次带谐项J2l-1(l≥2),即通过对偏心率e的长周期摄动影响导致近火点高度hp有明显变化而制约其轨道寿命,但与倾角i的关系又不同于月球卫星。本文对此进行了理论分析,由此获得火星低轨卫星轨道变化的特征(特别是与地球卫星和月球卫星变化规律的差别),并有相应的数值验证。结果表明,火星低轨卫星的轨道偏心率e的变幅可达0.02~0.03,高度低于100km的近圆轨道,其近火点高度会很快降为零而与火星相'撞',但这主要发生在极轨(i=90°)卫星,随着i的减小,e的变化幅度也随之减小,这一特征确与月球低轨卫星有明显差别。

关键词：火星探测轨道器低轨卫星近星点高度轨道寿命

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Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy

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Chinese Journal of Cancer Research 2021年第4期33卷 447-456页

作者： Ning Li Xin Wang yuan Tang Dongbin Zhao yihebali Chi Lin yang Liming Jiang Jun Jiang Jinming Shi Wenyang liu Hua Ren Hui Fang yu Tang Bo Chen Ningning Lu Hao jing Shunan Qi Shulian Wang yueping liu yongwen Song yexiong Li jing Jin State Key Laboratory of Molecular Oncology Department of Radiation OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of Abdominal Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized *** examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative ***:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were *** patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were *** factors related to long-term prognosis were analyzed using univariate and multivariate *** down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term ***:The median follow-up period for survivors was 30 *** area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and *** curve analysis further affirmed that DDS had the largest net *** DDS cut-off value was *** and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,y;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS.

关键词： Gastric cancer preoperative chemoradiotherapy prediction long-term outcomes

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Portal inflow preservation during portal diversion in small-for-size syndrome

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World Journal of Gastroenterology 2014年第4期20卷 1021-1029页

作者： Xian-Qiang Wang yue-Fang Xu jing-Wang Tan Wen-Ping Lv Zhe liu Jian-Ping Zeng Jia-Hong Dong Department of Hepatobiliary Surgery Qilu Hospital Shandong University Department of Hepatobiliary Surgery the Chinese PLA General Hospital Department of Pharmacology First Hospital Affiliated to the Chinese PLA General Hospital Department of Hepatobiliary Surgery First Hospital Affiliated to the Chinese PLA General Hospital

AIM: To investigate the impact of portal inflow on liver remnants in a stable pig model of small-for-size syndrome.

关键词： Portal flow Portal diversion Small-for-size syndrome Mesocaval shunt

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