Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy

作     者：Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin Ning Li;Xin Wang;Yuan Tang;Dongbin Zhao;Yihebali Chi;Lin Yang;Liming Jiang;Jun Jiang;Jinming Shi;Wenyang Liu;Hua Ren;Hui Fang;Yu Tang;Bo Chen;Ningning Lu;Hao Jing;Shunan Qi;Shulian Wang;Yueping Liu;Yongwen Song;Yexiong Li;Jing Jin

作者机构：State Key Laboratory of Molecular OncologyDepartment of Radiation OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100021China Department of Abdominal Surgical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of RadiologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2021年第33卷第4期

页      面：447-456页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.81773241 and No.81871509) 

主　　题：Gastric cancer preoperative chemoradiotherapy prediction long-term outcomes 

摘      要：Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized *** examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative ***:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were *** patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were *** factors related to long-term prognosis were analyzed using univariate and multivariate *** down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term ***:The median follow-up period for survivors was 30 *** area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and *** curve analysis further affirmed that DDS had the largest net *** DDS cut-off value was *** and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,0.001 and0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS.