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Effect of diethylstilbestrol on polyamine metabolism in hamster epididymis

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Asian Journal of Andrology 2003年第4期5卷 301-306页

作者： Masato ohe Shigeru Matsuzaki Department of Biochemistry Dokkyo University School of Medicine Mibu 321-0293 Tochigi JapanDepartment of Biochemistry Dokkyo University School of Medicine Mibu 321-0293 Tochigi Japan

Aim: To investigate the effect of diethylstilbestrol (DES), one of the most potent endocrine disruptors, on the metabolism of polyamines in hamster epididymis. Methods: Male golden hamsters of 7-week-old were kept under a light and dark cycle of 14 h and 10 h for 1 week to stimulate maximally the gonadal function. DES was injected subcutaneously at doses of 0.01 mg·kg-1·day-1, 0.1 mg·kg-1·day-1 and 1 mg·kg-1·day-1 for one week. Results: DES treatment caused a significant decrease in the weight of epididymis. The activity of epididymal ornithine decar boxylase (ODC) increased 1 day after DES treatment, kept at a high level for 4 days and then decreased to nearly normal level at day 7. The activity of spermidine/spermine N1-acetyltransferase (SSAT) also increased transiently after DES treatment. The contents of putrescine, spermidine, spermine and N1-acetylspermidine were increased 1 day -4 days after DES treatment and restored to normal at day 7. All these changes showed a marked difference between the caput and the cauda. Conclusion: The polyamine biosynthesis in the hamster epididymis can be affected by DES, a xenoestrogen. DES may probably affect polyamine metabolism in the epididymis by regulating the rate-limiting enzymes involved in the polyamine biosynthesis.

关键词： diethylstilbestrol polyamines ornithine decarboxylase spermidine/spermine N1-acetyltransferase

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi yukihide Momozawa yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito y.ichiro ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi yamaura Maiko Matsuda yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko yoshida yasushi Goto Tatsuya yoshida Taiki yamaji Makoto Sonobe Shinichi Toyooka Kazue yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada y.ichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno yasushi yatabe Kuniko Sunami Tomoyuki Hishida yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki yokose Kazuyoshi Ishigaki Toshiteru Nagashima yoichi Ohtaki Kazuhiro Imai Ken Takasawa yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa yuichi Shiraishi Hiroyoshi Nishikawa yoshinori Murakami Michiaki Kubo Fumihiko Matsuda y.ichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Cyclooxygenase 2 1195G〉A polymorphism is associated with chronic obstructive pulmonary disease in Japanese and Chinese patients

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Chinese Medical Journal 2013年第12期126卷 2215-2221页

作者： CHEN Li-jun XU Wang yasuyuki Taooka Miki ohe Hitoshi Takahashi Akihisa Sutani Takashige Kuraki Takeshi Isobe Department of Internal Medicine Division of Clinical Oncology & Respiratory Medicine Shimane University Faculty of Medicine 89-1 Enya cho Izumo Shimane 6938501 Japan Department of Respiratory Medicine Second Affiliated Hospitalof Ning Xia Medical University Yinchuan Ningxia 750001 China Department of Dermatology Shimane University Faculty of Medicine 89-1 Enyacho Izumo Shimane 6938501 Japan

Background Cyclooxygenase-2 （COX-2） is overexpressed during airway inflammation in chronic obstructive pulmonary disease （COPD） *** nucleotide polymorphisms （SNPs） in the COX-2 promoter might contribute to differential COX-2 expression and subsequent interindividual variability in susceptibility to *** investigated the association between COX-2 （-765G〉C,-1195G〉A） polymorphisms and COPD susceptibility in Japanese and Chinese *** COX-2 genotypes were determined by polymerase chain reaction,restriction fragment length polymorphism in 230 COPD patients （103 Japanese and 127 Chinese） and 273 healthy controls （129 Japanese and 144 Chinese）.Results The frequency of-1195AA homozygote was significantly higher than the controls in Chinese COPD （adjusted OR=2.43,95% CI 1.14-4.19）,Japanese COPD （adjusted OR=-2.25,95% Cl 1.06-4.76） and combined COPD groups （adjusted OR=2.26,95% CI 1.34-3.99）.There was no difference in COX-2-765G〉C polymorphism between COPD and control groups in either Japanese or Chinese,while more Chinese individuals carried the-765C allele than Japanese in both groups （15.3% vs.2.9% in COPD,18.8% vs.5.5% in control）.Chinese individuals with the haplotype-765G：-1195A were at higher risk for COPD （adjusted OR=1.93,95% CI 1.05-3.55）.Conclusions The COX-2-1195AA genotype is associated with increased risk for COPD in both Japanese and Chinese *** COX-2-765G〉C polymorphism was not associated with COPD in either ethnic group,the-765C allele frequency was higher in Chinese than Japanese and haplotype-765G-1195A may confer susceptibility to COPD in Chinese.

关键词： cyclooxygenase-2 polymorphisms chronic obstructive pulmonary disease Japanese, Chinese

Surgical strategy in case with co-existence of malignant oligodendroglioma and arteriovenous malformation: A case report

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Case Reports in Clinical Medicine 2013年第8期2卷 473-478页

作者： Hirohito yano Noriyuki Nakayama Naoyuki ohe Toshinori Takagi Jun Shinoda Toru Iwama Chubu Medical Center for Prolonged Traumatic Brain Dysfunction Department of Neurosurgery Kizawa Memorial Hospital Minokamo Japan Department of Neurosurgery Gifu University Graduate School of Medicine Gifu Japan Department of Neurosurgery Gifu University Graduate School of Medicine Gifu Japan

A brain tumor associated with an arteriovenous malformation (AVM) is very rare. A 42-year-old female presented with two separate lesions in her right frontal lobe on MRI. An angiogram diagnosed one of the lesions as an AVM. The second lesion appeared to be a tumor. Tumor removal was difficult due to bleeding from the nearby AVM, necessitating removal of the AVM and allowing complete excision of the tumor. Histopathological analysis revealed the tumor was an anaplastic oligodendroglioma. There was no recurrence of the tumor 5 year after completion of therapy. We discuss the operative strategy in case of synchronous diseases and provide a review of the literature.

关键词： Oligodendroglioma Arteriovenous Malformation Co-Existence

ADSORPTION BEHAVIORS OF 2-CHLOROPHENOL USING CHARCOAL AND ACTIVATED CARBON PREPARED FROM BAMBOO

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ADSORPTION BEHAVIORS OF 2-CHLOROPHENOL USING CHARCOAL AND AC...

A new diagnostic feasibility for cardiomyopathy utilizing acoustic microscopy

第二届中日化工学术研讨会

作者： KAORU ohe DAIGOROU SASAKI KATSUyA KAIKAKE SHIGEO NAKAMURA yOSHINARI BABA Department of Applied Chemistry Miyazaki Universitiy Miyazaki 889-2192 Japan Department of Applied Chemistry Miyazaki Universitiy Miyazaki 889-2192 Japan Department of Applied Chemistry Miyazaki Universitiy Miyazaki 889-2192 Japan Department of Applied Chemistry Miyazaki Universitiy Miyazaki 889-2192 Japan Department of Applied Chemistry Miyazaki Universitiy Miyazaki 889-2192 Japan

＜正＞ Adsorption behaviors were investigated for 2-chlorophenol, one of the precursors of dioxin, on charcoal （CB） and activated carbon （ACB） prepared from bamboo, and activated carbon （AC） prepared from coconut shell. The adsorption percent on all adsorbents showed more than 90% in the region of pH 2-7. CB showed decrease of adsorption percentage in the region of more than pH 7, indicating that the electrostatic repulsion causes between carboxylate ion on surface of CB and 2-chlorophenol dissociated in the region of high pH. The adsorptions of 2-chlorophenol on CB, ACB and AC were represented by the Langmuir adsorption isotherm and their adsorption capacities were 0. 30, 1. 53 and 3. 66 mmol/g, respectively. This result was the same as the order of their specific surface areas. 2-Chlorophenol adsorbed on adsorbents was easily desorbed by methanol.

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World Journal of Cardiovascular Diseases 2013年第1期3卷 22-30页

作者： yoichi Nakamura Kengo Fukushima Kusano Kazufumi Nakamura Kazuto Kobayashi Naohiro Hozumi yoshifumi Saijo Tohru ohe Biomedical Imaging Laboratory Graduate School of Biomedical Engineering Tohoku University Sendai Japan Department of Cardiology Sakakibara Heart Institute of Okayama Okayama Japan Department of Cardiovascular Medicine Matsuyama Shimin Hospital Matsuyama Japan Department of Research and Development Honda Electronics Co. Ltd. Toyohashi Japan epartment of Cardiovascular Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan Toyohashi University of Technology International Cooperation Center for Engineering Education Development Toyohashi Japan

Aims: Dilated cardiomyopathy often shows left ventricular systolic dysfunction, although histologically it always exhibits non-specific abnormality. We hypothesized that myocyte sound speed might be altered due to incomplete protein accumulation in cells. Methods and Results: Ninety eight biopsied samples were obtained from 49 patients comprising 43 with clinical dilated cardiomyopathy and 6 with hypertrophic cardiomyopathy. Sound speed was evaluated in deparaffinized 10 μm thick sections using an acoustic microscope (frequency range: 50 - 105 MHz). Conventional histology revealed 7 cases of persistent myocarditis derived from clinical dilated cardio- myopathy samples. Histology of the remaining dilated cardiomyopathy patients indicated non-specific abnormality. All hypertrophic cardiomyopathy cases exhibited myocardial disarray. Ten normal autopsied hearts were compared as controls. The sound speed of controls was 1627 ± 30m/sec. The sound speed in dilated cardiomyopathy samples (1700 ±51m/sec) was 1.045-fold faster compared to controls. The sound speed in hypertrophic cardiomyopathy samples (1734 ±51m/sec, 1.066-fold compared to controls) was faster than that of the myocarditis group (1672 ±30m/sec, 1.028-fold) (P = 0.0218). Furtheremore, desmin expression was evaluated as extent of emergence (grading 0 - 4). The desmin expression score in hypertrophic cardiomyopathy samples (2.7 ± 0.8) was significantly higher than in other groups (dilated 2.0 ± 1.4, myocarditis 1.6 ± 1.5 vs., controls 0, P ≤ 0.0001, 0.0001, 0.0129, respectively). Conclusion: Cardio-myopathy enhanced the sound speed, which correlated with the elasticity of myocytes, following the impaired compliance of left ventricle, despite the absence of histological changes. The elevation of sound speed of myocytes may be linked to cytoskeletal changes. Myocyte sound speed may be a new diagnostic tool for diagnosis of idiopathic cardiomyopathy independently of conventional histological diagnosis.

关键词： Cardiomyopathy Acoustic Microscopy Heart Failure Myocytes Sound Speed Diagnosis

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基于H_∞算法的飞机机翼结冰气动参数辨识

航空学报 2018年第3期39卷 66-77页

作者：丁娣车竞钱炜祺汪清中国空气动力研究与发展中心空气动力学国家重点实验室绵阳621000 中国空气动力研究与发展中心计算空气动力研究所绵阳621000

针对国内大型飞机结冰防护需求,开展针对大型结冰研究样机的H_∞算法参数辨识结冰探测研究。首先通过参数调节选取一组合适的H_∞算法参数,利用考虑测量噪声的结冰研究样机飞行仿真数据验证H_∞算法的辨识能力,由结果对比发现辨识算法... 详细信息

针对国内大型飞机结冰防护需求,开展针对大型结冰研究样机的H_∞算法参数辨识结冰探测研究。首先通过参数调节选取一组合适的H_∞算法参数,利用考虑测量噪声的结冰研究样机飞行仿真数据验证H_∞算法的辨识能力,由结果对比发现辨识算法能够跟踪飞机气动导数随结冰累积过程的变化趋势,辨识精度较高,其最大归一化平方根(RMS)误差仅为真值的11%;分析了H_∞算法对81种不同结冰累积过程的辨识能力,通过结果分析发现结冰累积时间较长且结冰速度较慢的情况辨识效果较差,结冰累积时间在100~300s之间辨识精度较高;最后利用蒙特卡罗仿真分析了不同测量噪声大小对H_∞算法辨识精度和跟踪延时的影响,给出了3个纵向气动导数在随机误差影响下的辨识误差和跟踪延时的统计结果,发现在给定噪声标准差变化范围内,升力和俯仰力矩关于迎角的导数能够得到较为准确的辨识结果,二者的归一化平方根误差均值仅为各自真值的1.8%和4%,其预报延时均值最大仅为3s和9.5s。

关键词： H∞滤波飞机结冰探测结冰累积过程测量噪声参数辨识

分析型反射电子显微镜和表面科学——实验技术和发展

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物理学进展 1991年第1期11卷 1-16页

作者：王中林 Microstructural Physics Cavendish Laboratory University of Cambridge Madingley Road

本文综述了反射电子显微术(REM)和反射电子能量损失谱(REELS)在表面科学中的应用。较详细地给出了用这些方法研究表面原子结构、化学成份和电子态的基本实验和理论,指出了发展这一学科对表面研究的重要性。

关键词：反射电子显微镜表面科学

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国立能乐堂,日本

世界建筑 1984年第2期 40-41页

作者：村松伸大江宏建筑事务所

这座能乐堂是为普及和振兴能乐而建的,其功能包括演出、资料的收集和展览、培养青年能乐家等。这座建筑从外观到内部设计都采用了日本传统的建筑手法。进正门后,经过前院进到门厅;从门厅到演出厅,要通过几条空间富于变化的走廊。这些走... 详细信息

这座能乐堂是为普及和振兴能乐而建的,其功能包括演出、资料的收集和展览、培养青年能乐家等。这座建筑从外观到内部设计都采用了日本传统的建筑手法。进正门后,经过前院进到门厅;从门厅到演出厅,要通过几条空间富于变化的走廊。这些走廊从功能来看是多余的。但是,正是这些多余的走廊体现了日本式的空间。参观者必须拐几次弯才可到达要去的空间;而每次拐弯都会感觉到空间的微妙的变化。

关键词：能乐戏曲建筑师美术家日本