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Jigsaw-Sketch: a fast and accurate algorithm for finding top-k elephant flows in high-speed networks

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Science China(Information Sciences) 2024年第4期67卷 113-130页

作者： Boyu ZHANG He HUANG yu-e sun yang DU Dan WANG School of Computer Science and Technology Soochow University School of Rail Transportation Soochow University

Finding top-k elephant flows in high-speed networks is one of the most fundamental network measurement tasks. It is more challenging than per-flow size estimation since the IDs and sizes of top-k flows must be tracked simultaneously. Most existing studies only record the IDs of a small number of elephant flows to fit their estimators in the extremely limited high-speed on-chip memory. However, these solutions need too many memory accesses when a packet arrives to track the elephant flows with high accuracy, which limits their practicability. Therefore, this paper proposes Jigsaw-Sketch, a new algorithm to find the top-k elephant flows with much fewer memory accesses while achieving high memory.efficiency and accuracy. In this design, we propose a novel two-stage jigsaw storage scheme, which can capture the candidate top-k flows from massive network steams efficiently, and further find the top-k elephant flows with high memory.efficiency and only a few memory accesses for each packet. extensive experimental results based on real network traces show that Jigsaw-Sketch improves the packet processing throughput by at least 86%, while achieving smaller memory footprints and higher accuracy compared to the SOTA.

关键词： sketch top-$k$ network measurement elephant flow high-speed networks

New record of the feather star Palaeocomatella hiwia(echinodermata:Crinoidea:Comatulida)from Zhenbei Seamount in South China Sea:new insights into the taxonomic position of Palaeocomatella

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Journal of Oceanology and Limnology 2024年第1期42卷 244-251页

作者： Shao’e sun Zijie MeI Zhongli SHA Jing WANG Nansheng CHeN Department of Marine Organism Taxonomy and Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Marine ecology and environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China Shandong Province Key Laboratory of experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

One specimen belonging to the family Comatellinae was collected from the Zhenbei Seamount(332.5–478.2 m)in the South China Sea in July *** on the morphological characters,the specimen was identified as Palaeocomatella hiwia McKnight,*** is first recorded from China Sea and redescribed in *** specimen differs from the original description from New Zealand for never showing syzygy at br4+5 or br5+6 on interior and br1+2 on exterior ***,it is much conform to the redescription to specimens from Indonesia,with only differences in position of the second syzygy and distalmost pinnule *** is deposited in the Institute of Oceanology,Chinese Academy of *** analy.es based on the mitochondrial c oxidase subunit I(COI)and 16S rRNA genes indicated that *** was nested within the tribe Phanogeniini and clustered with Aphanocomaster ***,*** showed same morphological features in terms of mouth placement,comb location,and number of comb teeth rows as other genera of ***,we suggest that the genus Palaeocomatella should be put in the tribe Phanogeniini.

关键词： new record Palaeocomatella hiwia McKnight 1977 South China Sea phylogenetic relationship taxonomy

A bacterial protein Rhp-PSP inhibits plant viral proliferation through endoribonuclease activity

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Journal of Integrative Agriculture 2024年第6期23卷 1967-1978页

作者： Lijie Chen Qianze Peng Xiaohua Du Weixing Zhang Ju’e Cheng Shu’e sun Deyong Zhang Pin Su yong Liu Longping Branch College of BiologyHunan UniversityChangsha 410082China State Key Laboratory of Hybrid Rice/Institute of Plant Protection Hunan Academy of Agricultural SciencesChangsha 410125China

Plant virus causes massive crop losses ***,there is currently no effective measure to control plant viral ***,we identify an antiviral protein Rhp-PSP,produced by the bacterial Rhodopseudomonas palustris strain *** this study,we discover that the antiviral activity of Rhp-PSP relies on its endoribonuclease *** the arginine(R)residue at position 129 onto alanine(A)abolishs its endoribonuclease activity on coat protein(CP)RNA of tobacco mosaic virus(TMV),consequentially,compromises the antiviral activity of *** investigation demonstrates that,the mutant Rhp-PSP^(R129A)is unable to form the homotrimer as the wild ty.e,indicating the importance of quaternary junction for the endoribonuclease *** of Rhp-PSP in Nicotiana benthamiana significantly.enhances the resistance against TMV of seedlings,while expression of Rhp-PSP^(R129A)did not,confirming that endoribonuclease activity is responsible for the antiviral activity of *** addition,foliar spray of Rhp-PSP solution on tomato and pepper plants significantly reduces the disease index of viral diseases,indicating that Rhp-PSP shows potential to develop antiviral agent in practice.

关键词： Rhodopseudomonas palustris Rhp-PSP tobacco mosaic virus endoribonuclease antiviral activity

Rational surface charge engineering of haloalkane dehalogenase for boosting the enzymatic performance in organic solvent solutions

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Chinese Journal of Chemical engineering 2024年第1期65卷 276-285页

作者： yin Wu yan sun Department of Biochemical engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzy.es in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant e16R/e93R/e121R/e257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-ty.e *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly.enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzy.e molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzy.e performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

The Functional Redundancy of Neddylation e2s and e3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di Wu yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation e2-e3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenoty.e,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these e2s or e3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation e2s or e3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenoty.es than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenoty.es seen at the very.early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenoty.es of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analy.es revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenoty.es seen in mice with double e3-null than with double e2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 e3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Understanding the spectrum of non-motor symptoms in multiple sclerosis:insights from animal models

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Neural Regeneration Research 2024年第1期19卷 84-91页

作者： Poornima D.e.Weerasinghe-Mudiyanselage Joong-sun Kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR programChonnam National UniversityGwangjuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea

Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological *** addition to experiencing motor disability,patients with multiple sclerosis also experience a variety of nonmotor symptoms,including cognitive deficits,anxiety,depression,sensory impairments,and ***,the pathogenesis and treatment of such non-motor symptoms in multiple scle rosis are still under *** studies for multiple sclerosis benefit from the use of disease-appropriate animal models,including experimental autoimmune *** to understanding the pathophysiology and developing treatments for non-motor symptoms,it is critical to chara cterize the animal model in terms of its ability to replicate certain non-motor features of multiple *** such,no single animal model can mimic the entire spectrum of *** review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying ***,we highlighted gaps in the literature to explain the nonmotor aspects of multiple sclerosis in expe rimental animal models,which will serve as the basis for future studies.

关键词： anxiety cognitive deficit depression experimental autoimmune encephalomyelitis motor disability neurological disorder pain pathophysiology preclinical study sensory impairments

Blindness-free beam scanning antenna with array of array architecture: principle,design,and experiment

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Science China(Information Sciences) 2024年第3期67卷 209-224页

作者： Jianxu sun yujian CHeNG School of electronic Science and engineering University of electronic Science and Technology of China

This paper presents a 66–76-GHz sparsely.excited phased array antenna with the array of array(Ao A) architecture for eliminating the blindness and suppressing the grating lobe when scanning. For the array antennas printed on the thick dielectric layers with high relative permittivity, scanning blindness appears and seriously impacts the radiation performance. To address this issue, the Ao A topology is developed first. It finds that the scanning blindness appears due to the coupling of the radiating Floquet modes to the non-radiating surface wave(SW) modes. Therefore, the array is divided into two ty.es of domino *** inner-phase distributions are introduced into the domino subarrays to break the one-to-one relationship between the Floquet mode and the SW mode. Then, the blindness inside ±60° scanning volume is eliminated by the aperiodic subarrays. Meanwhile, the aperiodic inner-phase distributions enhance the aperiodicity of the array and contribute to suppressing the grating lobe when scanning. Next, the meta-surface-based dipole with the shorted post is chosen as the unit cell for the proposed aperiodic array. Based on these methods,the array achieves the wide-scanning performance of ±60° in the e-plane and ±30° in the H-plane, without the blindness and the grating lobe. Finally, the 16×16 array is built and simulated with the dimension of32 mm × 32 mm. At the highest operating frequency, the simulated gains are 28.42, 25.17, and 24.01 d Bi when scanning to the broadside, 50° in the e-plane, and 30° in the H-plane, respectively. Compared to the ideal gain, it shows that the simulated radiation efficiency is about 84.13%, 62.08%, and 35.23% when scanning to the broadside, 50° in the e-plane, and 30° in the H-plane, respectively. The worst transmission coefficient, i.e., the worst isolation, is-11.97 d B between the central element and its two adjacent elements in the e-plane. The array prototy.es are fabricated, and the experiments are carried out to ver

关键词： 6G communication systems phased array AoA aperiodic subarray wideband wide-scanning surface-wave scanning blindness grating lobe

Strong Subgame Consistency of the Core in Stochastic Network Formation Games

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Journal of the Operations Research Society of China 2024年第1期12卷 189-213页

作者： Ping sun elena Parilina Faculty of Applied Mathematics and Control Processes Saint Petersburg State UniversitySaint Petersburg199034Russia

We consider a model of network formation as a stochastic game with random duration proposed initially in sun and Parilina(Autom Remote Control 82(6):1065–1082,2021).In the model,the leader first suggests a joint project to other players,i.e.,the network connecting ***,the players are allowed to form fresh links with each other updating the initially proposed *** stage payoff of any player is defined depending on the network *** are two ty.es of randomness in the network formation process:(i)links may fail to be formed with different probabilities although players intend to establish them,(ii)the game process may terminate at any stage or transit to the next stage with a certain probability ***,a network is formed as a result of players’decisions and realization of random *** cooperative version of the stochastic game is *** particular,we examine the properties of subgame consistency as well as strong subgame consistency of the *** provide a pay.ent mechanism or regularization of the core elements to sustain its subgame consistency and avoid the player’s deviations from the cooperative *** addition,the distribution procedure of the core elements is regularized in case there are negative pay.ents to achieve only nonnegative pay.ents to the players at any *** sufficient condition of a strongly subgame consistent core is also *** illustrate our theoretical results with a numerical example.

关键词： Stochastic game Network formation Core Strong subgame consistency

effect of nourishing yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： sun yanyan XUe yuanyuan sun Wen WANG yonghong yU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJeCTIVe:To elucidate the mechanism of the nourishing yin and purging fire Chinese herbal mixture(NyPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NyPF and normal saline group(NS).Rats in the L,NyPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NyPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-e1),and on the day when the second estrous interphase occurred in rats of L group(L-e2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NyPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(Pe rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(Pereas RFRP-3 m RNA level was significantly higher in the NyPF group than that in the L group(Pe ovarian index of the L and NS groups was significantly higher than that of the N group(Pestradiol(e2)level of the NyPF group was significantly lower than that of the N and NS groups(Pypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NyPF groups(Pereas hypothalamic RFRP-3 m RNA level in the L,NyPF,and NS groups was significantly lower than that in the N group(Pe1,e2 level of the L and NS groups was significantly higher than that of the N group(Per

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing yin and Purging Fire