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鸡的产蛋率和血浆中雌二醇、孕酮、睾酮的浓度之间的关系

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中国畜牧兽医 1984年第5期 36-36页

作者： y.tanabe 陈健秋

133日龄白来航（WL）、211日龄洛岛红（RIR）及其428日龄的杂种 F:(白来航（?）×洛岛红（?）)母鸡血浆中雌二醇、孕酮和睾酮的浓度通过放射免疫分析法测定。采血时间是13:00——15:00。白来航、洛岛红及杂种 F;达50%产蛋率的年龄分别是... 详细信息

133日龄白来航（WL）、211日龄洛岛红（RIR）及其428日龄的杂种 F:(白来航（?）×洛岛红（?）)母鸡血浆中雌二醇、孕酮和睾酮的浓度通过放射免疫分析法测定。采血时间是13:00——15:00。白来航、洛岛红及杂种 F;达50%产蛋率的年龄分别是165天、177天和152天;日产蛋率在203～217日龄分别是89.0,87.8和91.0%,在337～351日龄分别是81.1,71.0和81.8%;它们的血浆雌二醇浓度(微微

关键词：日龄孕酮孕激素雌二醇雌激素产蛋率血浆

CT碘剂延迟增强结合影像减影技术评估心肌梗死

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国际医学放射学杂志 2018年第3期 366-366页

作者： y.tanabe T.Kido A.Kurata T.Kouchi N.Fukuyama T.yokoi 陈祖钦 Department of Radiology Ehime University Graduate School of Medicine

摘要目的探讨CT碘剂延迟增强(LIE-CT)结合影像减影技术在心肌梗死(MI)评估中的可行性。方法应用心脏CT综合扫描方案和MRI钆剂延迟增强(LGE-MRI)评估27

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动态CT灌注成像识别心肌缺血与梗死,与心脏MR及SPECT进行比较

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国际医学放射学杂志 2017年第1期 100-100页

作者： y.tanabe T.Kido T.Uetani A.Kurata T.Kono A.Ogimoto 于静 Department of Radiology Ehime University Graduate School of Medicine

摘要目的通过与心脏MR(CMR)和SPECT比较,评估动态CT灌注成像参数心肌血流量发现心肌缺血与梗死的可行性。方法回顾性纳入经负荷动态CT灌注检查及SPECT

关键词： SPECT 特异度敏感度心肌缺血 CT 心肌灌注灌注成像 MR 心脏

高分化甲状腺癌放射碘治疗后(131)~I核素显像联合SPECT/CT的诊断价值

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国际医学放射学杂志 2013年第1期 79-79页

作者： y.Maruoka K.Abe S.Baba T.Isoda H.Sawamoto y.tanabe 范文骏 Departments of Clinical Radiology Graduate School of Medical SciencesKyushu UniversityMaidashi 3-1-1Higashi-kuFukuoka CityFukuoka 812-8582Japan

目的回顾性比较SPECT/CT和全身131I核素显像联合应用与仅行核素显像对于高分化甲状腺癌放射碘治疗后的新增诊断价值。材料与方法本回顾性研究经单位伦理委员会批准,无需签署知情同意书。研究包括2009年10月—2010年8月经放射碘治疗的高... 详细信息

目的回顾性比较SPECT/CT和全身131I核素显像联合应用与仅行核素显像对于高分化甲状腺癌放射碘治疗后的新增诊断价值。材料与方法本回顾性研究经单位伦理委员会批准,无需签署知情同意书。研究包括2009年10月—2010年8月经放射碘治疗的高分化甲状腺癌病人147例(男53例,女94例,平均年龄51岁)。每例病人均于放射碘治疗的同一天进行全身核素显像和SPECT/CT检查。全身核素显像中的每个放射性浓聚灶,根据甲状腺床内、淋巴结和远隔转移的摄取情况分为阳性和不能确定。采用常规McNemar检验对全身核素显像与SPECT/CT的检查结果进行比较评价。结果 SPECT/CT清晰地确定了甲状腺床内全身核素显像不能确定的全部5个"高摄取"病灶的起源(正常甲状腺残余组织或淋巴结转移)。对于核素显像诊断为转移淋巴结的108个放射性浓聚灶,其中的24个(22.2%)SPECT/CT改变了原来的结论(P<0.0001)。在SPECT/CT检查中,85个全身核素显像阳性的病灶中有1个证实为阴性(假阳性);在20个全身核素显像不能确定的病灶中,13个证实为阳性,7个证实为阴性。SPECT/CT检查还纠正了3个核素显像为假阴性的病灶。对于远隔转移灶,52个病灶中有24个(40%)的诊断结论被SPECT/CT修正(P<0.0001)。在SPECT/CT检查中,32个全身核素显像诊断为阳性的病灶中有1个被证实为阴性;20个全身核素显像不能确定的病灶中,11个证实为阳性,9个证实为阴性。对于全部147例病人,通过SPECT/CT检查改变了9例(6.1%)病人的临床分期和3例(2.0%)病人的治疗方案。结论与全身核素显像相比,SPECT/CT提高了131I在淋巴结转移和远隔转移内浓聚的发现和定位准确性。

关键词：放射碘全身病灶核素显像 SPECT/CT 甲状腺癌诊断价值高分化治疗后

钙化能否预测甲状腺乳头状癌病人接受131I治疗后淋巴结转移灶131I的浓聚?CT、131I全身扫描和18F-FDG PET/CT比较

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国际医学放射学杂志 2010年第2期 203-203页

作者： K.Kaneko K.Abe S.Baba y.tanabe H.yabuuchi M.Hatakenaka 袁瑛 Department of Clinical Radiology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

研究目的是阐明淋巴结钙化对甲状腺乳头状癌(PTC)病人131I治疗的预测价值。分析了19例PTC病人131I治疗期时CT上淋巴结钙化情况,并与131I全身核素扫描和

关键词：甲状腺乳头状癌淋巴结淋巴组织 FDG PET 病人

Origin of cells and network information

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World Journal of Stem Cells 2015年第3期7卷 535-540页

作者： Shihori tanabe National Institute of Health Sciences

All cells are derived from one cell, and the origin of different cell types is a subject of curiosity. Cells construct life through appropriately timed networks at each stage of development. Communication among cells and intracellular signaling are essential for cell differentiation and for life processes. Cellular molecular networks establish cell diversity and life. The investigation of the regulation of each gene in the genome within the cellular network is therefore of interest. Stem cells produce various cells that are suitable for specific purposes. The dynamics of the information in the cellular network changes as the status of cells is altered. The components of each cell are subject to investigation.

关键词： Stem cell Genome Network information Bioinformatics Gene Epithelial-mesenchymal transition

Signaling involved in stem cell reprogramming and differentiation

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World Journal of Stem Cells 2015年第7期7卷 992-998页

作者： Shihori tanabe National Institute of Health Sciences

Stem cell differentiation is regulated by multiple signaling events. Recent technical advances have reve-aled that differentiated cells can be reprogrammed into stem cells. The signals involved in stem cell pro-gramming are of major interest in stem cell research. The signaling mechanisms involved in regulating stem cell reprogramming and differentiation are the subject of intense study in the field of life sciences. In this review,the molecular interactions and signaling pathways related to stem cell differentiation are discussed.

关键词： Stem cell Signaling Differentiation Gene Genome Re

The role of protein phosphorylation in the regulation of class switch recombination

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BIOCELL 2020年第4期44卷 545-558页

作者： KANO tanabe RyUTARO KAJIHARA Department of Medical Technology Faculty of Health ScienceKumamoto Health Science UniversityKumamoto861-5598Japan Department of Biomedical Laboratory Sciences Faculty of Life SciencesKumamoto UniversityKumamoto862-0976Japan Center for Immunotherapy Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA

Antibody is an important part of adaptive immune system and is produced only by B *** are five main classes(IgM,IgD,IgG,IgA,IgE)and some subclasses in *** and IgD are produced by mature naïve B *** the other hand,IgG,IgA and IgE are produced by activated antigen-specific B cells via class switch recombination(CSR).CSR is the irreversible DNA rearrangement from upstream to downstream classes in immunoglobulin heavy chain ***-stimulations of CD40 ligand(CD40L)and cytokines are required for induction of CSR by activating several transcription *** signal transduction pathways involve many protein *** or dephosphorylation of cellular protein is an important kind of post-translational protein modification in intracellular signal *** the fact,more than one third of the intracellular proteins are said to be transiently phosphorylated in human.A protein kinase is an enzyme that catalyzes the addition of phosphate to substrate ***,a protein phosphatase catalyzes the removal of phosphate from the *** review focuses on the mechanism of CSR controlled by protein phosphorylation and *** provide the role of protein kinase and phosphatase in the regulation of class switch recombination.

关键词： Antibody Kinase Phosphatase Signal Transduction

Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury

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Neural Regeneration Research 2019年第11期14卷 1961-1967页

作者： Norio tanabe Tomoharu Kuboyama Chihiro Tohda Division of Neuromedical Science Institute of Natural Medicine University of Toyama

In chronic phase of spinal cord injury, functional recovery is more untreatable compared with early intervention in acute phase of spinal cord injury. In the last decade, several combination therapies successfully improved motor dysfunction in chronic spinal cord injury. However, their effectiveness is not sufficient. We previously found a new effective compound for spinal cord injury, matrine, which induced axonal growth and functional recovery in acute spinal cord injury mice via direct activation of extracellular heat shock protein 90. Although our previous study clarified that matrine was an activator of extracellular heat shock protein 90, the potential of matrine for spinal cord injury in chronic phase has not been sufficiently evaluated. Thus, this study aimed to investigate whether matrine ameliorates chronic spinal cord injury in mice. Once daily intragastric administration of matrine(100 μmol/kg per day) to spinal cord injury mice were starte at 28 days after injury, and continued for 154 days. Continuous mat rine treatment improved hindlimb motor function in chronic spinal cord injury mice. In injured spinal cords of the matrine-treated mice, the density of neurofilament-H-positive axons was increased. Moreover, matrine treatment increased the density of bassoon-positive presynapses in contact with choline acetyltransferase-positive motor neurons in the lumbar spinal cord. These findings suggest that matrine promotes remodeling and reconnection of neural circuits to regulate hindlimb movement. All protocols were approved by the Committee for Animal Care and Use of the Sugitani Campus of the University of Toyama(approval No. A2013 INM-1 and A2016 INM-3) on May 7, 2013 and May 17, 2016, respectively.

关键词： matrine chronic spinal cord injury axonal growth synaptogenesis hindlimb locomotor presynapse immunohistochemistry Basso Mouse Scale Body Support Score Sophora flavescens

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