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生物质热转化过程中积灰沾污结渣特性及趋势预测研究进展

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安全与环境学报 2024年第3期24卷 882-890页

作者：姚锡文许克强刘清华许开立东北大学资源与土木工程学院沈阳110819

为阐明生物质灰的沾污结渣特性及其趋势预测研究现状,使生物质能热转化利用过程更加安全,在综合分析生物质灰沾污结渣的危害及机制的基础上,从沾污结渣特性与沾污结渣预测两方面归纳国内外研究进展,梳理出影响结渣的主要因素——灰分组... 详细信息

为阐明生物质灰的沾污结渣特性及其趋势预测研究现状,使生物质能热转化利用过程更加安全,在综合分析生物质灰沾污结渣的危害及机制的基础上,从沾污结渣特性与沾污结渣预测两方面归纳国内外研究进展,梳理出影响结渣的主要因素——灰分组成、反应温度、气氛和添加剂等;并对沾污结渣趋势的预测方法和研究趋势进行分析。针对实际工程中锅炉受热面结渣和腐蚀问题,可以采用混烧、混入添加剂、水洗、酸洗、改变受热面材料、优化锅炉和烟道结构设计、优化反应条件等措施解决。在生物质灰沾污结渣趋势预测方面,目前并没有完整的统一标准,简单沿用煤灰的结渣指标存在严重的不适应性,且现有的预测方法通常只考虑固态或熔融成分对结渣的影响,而忽略了碱金属、氯、硫等元素挥发与温度变化的关系。因此,以热转化过程中碱金属的气-固分配趋势为基础,结合不同温度下生物质灰的特点及成灰特性,建立适用于不同温度下生物质灰的沾污结渣预测模型,是下一步研究应重点关注的问题。

关键词：安全工程生物质灰沾污结渣碱金属结渣指标

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云边端协同下的织机设备信息采集与监测系统

纺织学报 2024年第8期45卷 215-224页

作者：戴宁徐开心胡旭东徐郁山浙江理工大学浙江省现代纺织装备技术重点实验室浙江杭州310018 浙江理工大学纺织科学与工程学院(国际丝绸学院) 浙江杭州310018 浙江康立自控科技有限公司浙江绍兴312500

针对现阶段采用传统单一化上层云端对织造信息进行集中管理,易产生信息传输困难、可靠性低等情况,设计了一套基于云边端协同的织机设备信息采集与监测系统。首先,从中心云端、边缘端和设备终端对系统的总体架构进行设计;再从信息通信协... 详细信息

针对现阶段采用传统单一化上层云端对织造信息进行集中管理,易产生信息传输困难、可靠性低等情况,设计了一套基于云边端协同的织机设备信息采集与监测系统。首先,从中心云端、边缘端和设备终端对系统的总体架构进行设计;再从信息通信协同、数据存储协同和计算服务协同这3个方面对织机设备信息的通信、存储和应用服务展开研究;最后,以石家庄某织布车间的必佳乐OMNIpLUS-340型喷气织机作为测试对象验证系统的可靠性。结果表明,与纯云端通信模式对比,所设计系统平均通信延迟时间下降了20.8 s,平均通信吞吐率下降了446.58 Mb/h,为织造智能化生产提供了高可靠、高质量的数据支撑。

关键词：智能织造云边端协同织机信息采集设备状态监测

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改进型卷积神经网络无人机工地识别

中国测试 2024年第6期50卷 191-196页

作者：潘昱辰徐浩钱夔徐伟敏徐腾飞南京工程学院自动化学院江苏南京210044 南京睿捷智慧交通科技研究院江苏南京210044

现有通用目标检测算法在无人机工地识别任务中容易产生精度低下等问题,针对该问题,该文提出一种卷积神经网络模型,用于复杂环境下相似目标检测。该模型首先利用无人机高空拍摄图片作为数据集,通过高斯模糊、图像变换等方法进行数据增强... 详细信息

现有通用目标检测算法在无人机工地识别任务中容易产生精度低下等问题,针对该问题,该文提出一种卷积神经网络模型,用于复杂环境下相似目标检测。该模型首先利用无人机高空拍摄图片作为数据集,通过高斯模糊、图像变换等方法进行数据增强,为模型泛化能力的提高提供数据支撑。然后基于Darknet-53特征提取网络实现多尺度特征融合,通过在网络模型中添加Spp-net(spatial pyramid pooling networks)应对模型中特征易消失问题。最后优化损失函数,解决模型正负样本不均衡问题。实验结果证明该模型mAp值达到84.94%,可为城市内土地规划、施工和违章搭建监管等领域提供技术支撑。

关键词：工地识别卷积神经网络损失函数数据增强

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1例甲巯咪唑乳膏治疗口服不耐受的甲状腺功能亢进症病例报道

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上海交通大学学报（医学版） 2024年第3期44卷 412-416页

作者：徐婷张豫文上海交通大学医学院附属瑞金医院药剂科上海200025 上海交通大学医学院附属瑞金医院内分泌代谢病科上海200025

患者老年男性,因“甲巯咪唑口服不耐受,已行放射性碘治疗6月”就诊,存在甲状腺功能亢进症疗效与不良反应的矛盾,结合患者意愿,临床采用甲巯咪唑乳膏局部外用的治疗方案。12周的随诊中,患者症状明显缓解,甲状腺功能明显改善,且血常规和... 详细信息

患者老年男性,因“甲巯咪唑口服不耐受,已行放射性碘治疗6月”就诊,存在甲状腺功能亢进症疗效与不良反应的矛盾,结合患者意愿,临床采用甲巯咪唑乳膏局部外用的治疗方案。12周的随诊中,患者症状明显缓解,甲状腺功能明显改善,且血常规和肝功能未出现明显异常。该病例在用药选择上打破常规思维,结合药物效应动力学、药物代谢动力学理论基础和医师临床经验摸索制定甲巯咪唑乳膏初始量和减药量,亦为此制剂用药提供临床参考意见。

关键词：甲巯咪唑乳膏甲状腺功能亢进症粒细胞减少

Gastrodin Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice via Modulating Gut Microbiota and Inhibiting NF- κB Signaling pathway

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Food Science and Human Wellness 2024年

作者： Xinyi Gao Xianjun Liu Xianglong Meng Mingchuan Wang Mengyuan Wang Boyao Sun Chengxuan Jia Jintian Gao Chengyi xu Hao Li yang Jiang Department of Gastrointestinal Colorectal and Anal Surgery The China-Japan Union Hospital of Jilin University College of Biological and Food Engineering Jilin Engineering Normal University Department of Burns Surgery The First Hospital of Jilin University Medical Faculty Hetao College Deartment of Nephrology The Second Hospital of Jilin University

Gastrodin (GAS)， the principal bioactive composition of Gastrodia elata Blume， has potential for pharmaceutical applications. Several studies in recent years have shown that GAS may enhance neurotrophic benefits， reduce inflammation， and act as an antioxidant. In this study， we sought to identify the molecular mechanisms underlying the protective benefits of GAS against colitis induced by dextran sodium sulfate (DSS) in mice. GAS (200 mg/kg) significantly ameliorated the severity of colitis in mice caused by DSS， as evidenced by an increase in colon length， a reduction in disease activity index， a decrease in tissue damage， and a reduction in body weight loss. Additionally， GAS inhibited DSS-induced hyperactivation of inflammation-related NF-κB signaling pathways to reduce the production of inflammatory mediators， thereby mitigating the inflammatory response in mice. Furthermore， the administration of GAS restored the function of the gastrointestinal barrier by increasing the count of goblet cells， as well as the levels of tight junction-associated proteins， including ZO-1， Occludin， and Claudin-3. GAS also influenced the overall richness of the gut microbiota， as shown by 16S rRNA sequencing analysis， consequently boosting the proliferative rate of probiotic species， such as Lachnospiraceae and Muribaculaceae， while reducing the richness of harmful bacteria including Escherichia＿Shigella， Enterobacteriaceae， Bacteroidaceae， and Bacteroides. GAS (200 mg/kg) alleviated ulcerative colitis (UC) by modulating gut dysbiosis， as demonstrated by a fecal microbial transplantation (FMT) test. Furthermore， inflammatory damage induced by lipopolysaccharide (LpS) was averted in RAW264.7 cells by GAS administration， hence preventing the NF-κB signaling pathway from being activated in these experimental conditions conducted in vitro. Overall， the data indicate that GAS treatment effectively reduces Colitis caused by DSS by regulating gut microbiota， suppressing inflammation， and

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Effectiveness and safety of Jiawei Xiaoyao pill(加味逍遥丸)in the treatment of premenstrual syndrome(liver depression,spleen deficiency,and blood-heat syndrome):a multi-center,randomized,placebo-controlled trial

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Journal of Traditional Chinese Medicine 2024年第2期44卷 373-380页

作者： LI Xiyu yANG yanhong SUN Jian NIE Quanfang LIU Lifen LI Guifen yU Junping ZHANG Zhuangjin xu yi ZOU Ting SHI yun Department of Gynecology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Gynecology Luoyang 1st Hospital of TCMLuoyang 471099China Department of Gynecology Zaozhuang Hospital of TCMZaozhuang 277099China Department of Gynecology and Obstetrics Loudi Central HospitalLoudi 417099China Department of Gynecology and Obstetrics Yiyang 1st Hospital of TCMYiyang 413002China Department of Gynecology Harrison International Peace HospitalHengshui 053000China Department of Gynecology and Obstetrics Shanxi Fenyang HospitalFenyang 032299China Department of Gynecology and Obstetrics Hengyang Chinese Medicine HospitalHengyang 421001China Scientific Research Institute of Beijing Tongrentang Technology Development Co. Ltd.Beijing 100061China Female Reproductive and Health Medicine Research Committee of Chinese Traditional Medicine Association Beijing 100061China

OBJECTIVE:To investigate the effectiveness and safety of Jiawei Xiaoyao pill(加味逍遥丸,JXp)in the treatment of symptoms associated with premenstrual syndrome(pMS).METHODS:A total of 144 regularly menstruating women with pMS were recruited at 8 sites in China from August 2017 to December 2018,and randomized to receive either a JXp or a matching placebo(12 g/d,6 g twice a day)for 3 menstrual *** primary indicator was the reduced Daily Record of Severity of problems(DRSp)scores in the luteal phase after 3 months of *** safety outcomes included clinical adverse events(AEs),adverse reactions(ARs),changes in vital signs,and laboratory ***:JXp surpassed the placebo in reducing DRSp scores(psychological/somatic dysfunction)in the luteal phase over 3 menstrual cycles of treatment(pFAS=0.002,pppS=0.001).Additionally,there were no significant differences in the incidence of AEs,severe AEs,withdrawal due to AEs and ARs between the two groups(all p>0.05),and no clinically significant adverse medical events related to the test drug ***:JXp was superior to the placebo in relieving the symptoms associated with pMS,which signified that JXp may be effective,safe,and welltolerated as an alternative therapy.

关键词： premenstrual syndrome randomized controlled trial double-blind method Jiawei Xiaoyao pill

细菌细胞表面展示技术及其在环境修复领域的应用研究进展

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微生物学通报 2024年第6期51卷 1854-1872页

作者：王旭徐微周宁一丁俊美云南师范大学生命科学学院生物能源持续开发利用教育部工程研究中心云南昆明650500 上海交通大学生命科学技术学院微生物代谢国家重点实验室上海200240

细菌细胞表面展示是一项重要的生物工程技术,其将外源靶标蛋白、多肽或其他生物大分子表达于细菌表面,以更好地实现其功能。该技术在生物催化、生物修复、生物传感器和疫苗设计等多个领域得到广泛应用。本文首先对革兰氏阴性细菌和革兰... 详细信息

细菌细胞表面展示是一项重要的生物工程技术,其将外源靶标蛋白、多肽或其他生物大分子表达于细菌表面,以更好地实现其功能。该技术在生物催化、生物修复、生物传感器和疫苗设计等多个领域得到广泛应用。本文首先对革兰氏阴性细菌和革兰氏阳性细菌的表面展示系统进行介绍,概括了目前已知的主要宿主菌和锚定蛋白种类;然后重点阐述了细菌表面展示技术在生物修复领域的最新应用研究进展;最后总结了细菌表面展示技术在应用中存在的局限性,并展望了未来可能的发展方向,以期深入扩大和拓展该技术在生物修复实践中的具体应用。

关键词：细菌细胞表面展示锚定蛋白生物修复全细胞催化剂

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： yanxi Li Jing xue yuejia Ma Ke ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in parkinson's disease models exposed to manganese compared to normal parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

清肺排毒汤联合西医治疗新型冠状病毒肺炎临床疗效的Meta分析

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中国免疫学杂志 2024年第2期40卷 360-365页

作者：王钰徐义峰董辛徐小港江西中医药大学南昌330004 江西中医药大学科技学院南昌330004

目的:系统评价清肺排毒汤治疗新型冠状病毒肺炎(COVID-19)的临床疗效与安全性。方法:检索中国知网、万方、维普、pubmed、Embase、Cochrane Library等数据库,检索时间截至2022年4月20日,筛选有关清肺排毒汤联合西医治疗COVID-19的临床... 详细信息

目的:系统评价清肺排毒汤治疗新型冠状病毒肺炎(COVID-19)的临床疗效与安全性。方法:检索中国知网、万方、维普、pubmed、Embase、Cochrane Library等数据库,检索时间截至2022年4月20日,筛选有关清肺排毒汤联合西医治疗COVID-19的临床疗效研究。采用Cochrane偏倚风险评价工具对纳入的研究进行风险评估及质量评价,提取相关数据,采用State17.0软件进行Meta分析,Begg’s检验分析发表偏倚。结果:最终纳入6篇临床疗效研究共602例患者,其中实验组采用清肺排毒汤联合西医治疗295例,对照组单纯西医治疗307例。Meta分析结果显示,实验组在提高临床有效率[RR=1.17,95%CI(1.09,1.26),ppp=0.002],缩短核酸转阴时间[WMD=-6.56,95%CI(-10.37,-2.75),p=0.0007]、住院天数[WMD=-4.75,95%CI(-6.26,-3.25),p<0.00001]等方面的作用优于对照组。结论:清肺排毒汤联合西医常规疗法可有效改善COVID-19临床症状,具有一定的疗效和安全性,但仍需大量高质量研究证实疗效。

关键词：清肺排毒汤新型冠状病毒肺炎(COVID-19) Meta分析中西医结合临床疗效