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Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan ng Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity vary.ng between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Modeling the high-energy emission from the gamma-ray binary 1FGL J1018.6–5856

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Research in Astronomy and Astrophysics 2021年第8期21卷 46-58页

作者： A-ming Chen Chowing ng Jumpei Takata yun-Wei yu School of physics Huazhong University of Science and TechnologyWuhan 430074China Department of Physics The University of Hong KongPokfulam RoadHong KongChina College of Physical Science and Technology Central China Normal UniversityWuhan 430079China

1FGL J1018.6–5856 is a high mass gamma-ray binary containing a compact object orbiting around a massive star with a period of 16.544 *** the compact object is a pulsar,non-thermal emissions are likely produced by electrons accelerated at the termination shock,and may also originate from the magnetosphere and the un-shocked wind of the *** this paper,we investigate the non-thermal emissions from the wind and the shock with different viewing geometries and study the multi-wavelength emissions from 1FGL J1018.6–*** present the analysis results of the Fermi/LAT using nearly 10 years of *** phase-resolved spectra indicate that the Ge V emissions comprise a rather steady component that does not vary with orbital motion and a modulated component that shows flux maximum around inferior *** ke V/Te V light curves of 1FGL J1018.6–5856 also exhibit a sharp peak around inferior conjunction,which are attributed to the boosted emission from the shock,while the broad sinusoidal modulations could be originating from the deflected shock tail at a larger *** modulations of Ge V flux are likely caused by the boosted synchrotron emission from the shock and the IC emission from the unshocked pulsar wind,while the steady component comes from the outer gap of the pulsar ***,we discuss the similarities and differences of 1FGL J1018.6–5856 with other binaries,like LS 5039.

关键词： binaries:close gamma rays:stars X-rays:binaries radiation mechanisms:non-thermal

A Tribute to Two Humanistic Educators in China:Lu Jie and Tao Xingzhi

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Frontiers of Education in China 2021年第1期16卷 113-125页

作者： Peter Tze ming ng Department of Cultural and Religious Studies The Chinese University of Hong KongHong Hong SAR 999077China

On the December 25,2020,*** Jie,the Emeritus Professor and former Dean of the Faculty of Education at Nanjing Normal University passed *** sudden news struck me and recalled my nearly 30 years’friendship with *** since 1991,stirring up also my memories of pre-1949 Christian colleges of China,and the promotion of“education of love”at Ginling College and Nanjing Normal University,from the time of *** yifang,*** Vautrin,*** Xingzhi and *** *** this paper,I shall recall the various meetings with *** Jie,and how her life has inspired my re-thinking of the development of“education of love”in China.I shall relate especially her humanistic educational ideals,especially the“education for life”and“cultivating human beings”with *** Xingzhi’s“education of love.”Their educational ideals reflected the humanistic education taught at the University of Nanking and Ginling College in the first half of 20th century *** the two colleges had brought in a Western style of education,they had exemplified good models of indigenization,especially regarding how humanistic education could become Sinifized in Chinese soil today.

关键词： Chinese educators humanistic education Lu Jie Tao Xingzhi Ginling College University of Nanking Nanjing Normal University(NNU)

Neutrophil diversity and plasticity:Implications for organ transplantation

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Cellular & Molecular Immunology 2023年第9期20卷 993-1001页

作者： Junwen Qu Jingsi Jin ming Zhang Lai Guan ng Shanghai Immune Therapy Institute Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Urology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China

Neutrophils,as the first defenders against external microbes and stimuli,are highly active and finely regulated innate immune *** evidence has challenged the conventional dogma that neutrophils are a homogeneous population with a short lifespan that promotes tissue *** findings on neutrophil diversity and plasticity in homeostatic and disease states have centered on neutrophils in the *** contrast,a comprehensive understanding of tissue-specialized neutrophils in health and disease is still *** article will first discuss how multiomics advances have contributed to our understanding of neutrophil heterogeneity and diversification in resting and pathological *** discussion will be followed by a focus on the heterogeneity and role of neutrophils in solid organ transplantation and how neutrophils may contribute to transplant-related *** goal of this article is to provide an overview of the research on the involvement of neutrophils in transplantation,with the aim that this may draw attention to an underappreciated area of neutrophil research.

关键词： Neutrophil Heterogeneity Transplantation

On the first negative Hecke eigenvalue of an automorphic representation of GL_(2)(A_(Q))

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Science China Mathematics 2021年第11期64卷 2381-2394页

作者： yuk-Kam Lau ming Ho ng Hengcai Tang y.ngnan Wang Department of Mathematics The University of Hong KongHong KongChina Department of Mathematics The Chinese University of Hong KongHong KongChina Institute of Modern Mathematics School of Mathematics and StatisticsHenan UniversityKaifeng 475004China Shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and StatisticsShenzhen UniversityShenzhen 518060China

Letπbe a self-dual irreducible cuspidal automorphic representation of GL_(2)(A_(Q))with trivial central *** Hecke eigenvalue λπ(n)is a real multiplicative function in *** show that λπ(n)<0 for some n< 详细信息

关键词： automorphic representation Hecke eigenvalue Maass cusp form sign change

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Resurgence of the Study of China’s Christian Higher Education since 1980s

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Frontiers of Education in China 2019年第3期14卷 364-386页

作者： Peter Tze ming ng Faculty of Arts Shanghai UniversityShanghai 200444China

Christian higher education(CHE)had been totally disappeared from the China mainland since the 1950s,and related studies only revived in the past 40 years since Deng Xiaoping’s reform and opening up policy in *** present paper is an attempt to report what had happened in the past 40 years,and to illustrate some significant contributions the resurgence of the study of CHE had made to the academia in the development of higher education in *** forms of representation of CHE are found and new approaches to the study of CHE are also explored.

关键词： Christian higher education(CHE) reform and opening up China university education Christian colleges Zhang Kaiyuan