检索结果-南通市图书馆

Evaluation of particle packing models by comparing with published test results

在线全文

学校读者我要写书评

暂无评论

Particuology 2014年第5期12卷 108-115页

作者： k.W.Chan A.k.H.kwan Department of Civil Engineering The University of Hong Kong

The existing particle packing density models each with two or more parameters accounting for certain particle interactions （the loosening effect parameter, wall effect parameter, wedging effect parameter, and compaction index, denoted by a, b, c, and k, respectively） may be classified into the 2-parameter model （with a and b incorporated）, the compressible model （with a, b, and 1（incorporated）, and the 3- parameter model （with a, b, and c incorporated）. This paper evaluates these models by comparing their respective packing density predictions with the test results published in the literature. It was found that their accuracy varies with both the size ratio and volumetric fractions of the binary mix. In general, when the size ratio is larger than 0.65, all the packing models are sufficiently accurate. However, when the size ratio is smaller than 0.65, some of them become inaccurate and the errors tend to be larger at around the volumetric fractions giving maximum packing density. Relatively, the 3-parameter model is the most accurate and widely applicable.

关键词： Packing density Particle packing models Particle interactions

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Cultural Diplomacy and Internationalization of Higher Education:The Experience of Three Confucius Institutes in Canada

在线全文

学校读者我要写书评

暂无评论

Frontiers of Education in China 2014年第1期9卷 110-126页

作者： Covina y.W.kwan Ontario Institute for Studies in Education University of TorontoTorontoM5S 1V6Canada

This paper is based on a study of three Confucius Institutes in *** research aims to explore the nature of operations at Confucius Institutes,ranging from the selection of partnering Chinese universities,to the program planning at each individual ***,it focuses on the perceived impacts of the Confucius Institute partnership on the Canadian hosting *** was collected through interviews with key administrative staff from three Canadian *** theoretical framework of constructivism from international relations theory and concepts drawn from the literature on the internationalization of higher education were used to analyze the *** issues revealed from the data include the host’s perception of Confucius Institutes as China’s cultural diplomacy and soft power strategy,the progression of partnerships between Canada and China over time,and university autonomy.

关键词： Confucius Institute cultural diplomacy internationalization of higher education Chinese-Canadian university partnership

Design and fabrication of automated sedimentation-based separation and siphon-based extraction for detection of allergic reaction on a centrifugal microfluidic disc

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Optics Letters 2010年第10期8卷 957-959页

作者： Q. L. Chen H. P. Ho k. L. Cheung S. k. kong y. k. Suen y. W. kwan C. k. Wong Center for Advanced Research in Photonics and Department of Electronic Engineering The Chinese University of Hong Kong Hong Kong China Department of Biochemistry The Chinese University of Hong Kong Hong Kong China School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Hong Kong China

We report the design and fabrication of a novel and fully integrated polymer-based centrifugal microfluidic disc for rapid automatic allergens detection. All essential steps for a single test including flow valving, sequencing, mixing, separation, extraction, and sedimentation for final detection are automatically conducted within 30 min on a centrifugal microfluidic disc. Our design features a siphon-based valving and analyte extraction structure where the released analyte is separated and subsequently extracted by a siphon valve into the detection chamber. Incorporating the siphon valve and a series of capillary valves, we realize automated detection of allergic reaction on a centrifugal microfluidic disc.

关键词： Adaptive optics Diffuse optical imaging Photolithography Polydimethylsiloxane Polymethyl methacrylate

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词：

Learning of medical pharmacology via innovation:a personal experience at McMaster and in Asia

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第9期25卷 84-92页

作者： Chiu-yin kwan Canada Department of Medicine HSC-4N40 Faculty of Health Sciences Hamilton L8N 3Z5 McMaster University Ontario

Pharmacology in the traditional medical curriculum has been treated as a discrete "preclinical" discipline identifying itself distinctly different from the other preclinical sciences or clinical subjects in knowledge base as well as learning/teaching instructions. It is usually run in series with other pre-clinical courses (eg, anatomy, biochemistry, physiology etc), but in parallel with other paraclinical courses such as pathology, microbiology and community medicine. Clinical pharmacology was only introduced relatively recently designed to overcome the perceived deficiency in "preclinical" pharmacology regarding its therapeutic relevance and application to medicine. In many universities, both preclinical and clinical pharmacology courses co-exist, usually independently offered by two separate, sometimes non-interacting Departments of Pharmacology and Clinical Pharmacology. In this model, pharmacology is generally taught in a teacher-centered, discipline-oriented, and knowledge-based curriculum. Further

关键词： problem-based learning pharmacology medical education self-directed learning small group tutorial

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Analytical Method for Designing Grating Compensated Dispersion-Managed Soliton Systems

在线全文

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 655-656页

作者： y. H. C. kwan k. Nakkeeran P. k. A. Wai Photonics Research Centre and Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hung Hom Hong KongPhotonics Research Centre and Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hung Hom Hong KongPhotonics Research Centre and Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hung Hom Hong Kong

We show a useful analytical method to design grating compensated dispersion-managed systems. Our method is in good agreement with the numerical results even in the presence of group delay ripples in the chirped fiber ... 详细信息

关键词： for in FWHM In of GDR Analytical Method for Designing Grating Compensated Dispersion-Managed Soliton Systems

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code