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Utilization of A New Microbial Transglutaminase from Streptomyces for The Formation of Edible Soybean Protein Films

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中国粮油学报 2002年第G期17卷 41-50页

作者： wangzhang ChinaNationalInstituteofFoodandFermentationIndustries Beijing100027

Soybean protein isolate(SPI) was used to investigate the formation of edible protein films through an enzymatic cross-linking method with a purified microbial transglutaminse(MTG) produced and purified from a new effective strain Streptomyces ***.L-M1 preserved in my laboratory,followed by the addition of glycerol and suitable heating and drying *** partially-purified skimmed soybean protein powder(SSP) and whey protein isolates(WPI) were used as the substitutes partially replacing the expensive SPI products,and purified β-lactoglobulin was taken as the positive control of *** effects of the concentrations of the three substitutes and their relative ratios have been compared with SPI as a control,and the methodologies of MTG treatment were *** have also been approached for the films formation-enhancing substances such as *** the results,the three alternatives could also form high efficient edible films in the optimal operation conditions *** films made with SPI alternatives,thin around 50 μm,had the microscopic homogenous network structures,without any holes by naked *** tests for the properties of these films showed that they had high water-keeping capacity.and strong elasticity,that the ultimate tensile sterength(TS)and the elongation at break(Eb) had been remarkably increased(TS>5 MPa,Eb>50%,respectively),and that the prevention rates against the permeability of water vapor and oxygen in air were also upgraded more than 85% and 70%,respectively.

关键词：链霉菌微生物法可食用薄膜大豆蛋白制造

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy.and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy.and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Evolutionary Design of Boolean Functions

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Wuhan University Journal of Natural Sciences 2005年第1期10卷 179-182页

作者： wangzhang-yi ZHANGHuan-guo QINZhong-ping MENGQing-shu SchoolofComputer WuhanUniversityWuhan430072HubeiChina SchoolofSoftware HuazhongUniversityofScienceandTechnologyWuhan430074HubeiChina

We use evolutionaly computing to synthesize Boolean functions randomly Byusing specific crossover and mutation operator, in evolving process and modifying search space andfitness function, we get some high non-linearity functions which have other good cryptographycharacteristics such as autocorrelation etc Comparing to other heuristic search techniques,evolutionary computing approach is more effective because of global search strategy.and implicitparallelism.

关键词： Boolean function non-linearity evolutionary computing

A Proof for the Nonexistence of Some Homogeneous Bent Functions

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Wuhan University Journal of Natural Sciences 2005年第3期10卷 504-506页

作者： MENGQing-shu ZHANGHuan-guo QINZhong-ping wangzhang-yi SchoolofComputer WuhanUniversityWuhan430072HubeiChina SchoolofSoftware HuazhongUniversityotScienceandTechnologyWuhan430074HubeiChina

By the relationship between the first linear spectra of a function at partialpoints and the Hamming weights of the sub-functions, and by the Hamming weight of homogenousBoolean function, it is proved that there exist ... 详细信息

关键词： homogeneous bent functions Walsh transformation Hamming weight

Crystallization-induced phosphorescence, remarkable mechanochromism, and grinding enhanced emission of benzophenone-aromatic amine conjugates

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Chinese Chemical Letters 2018年第10期29卷 1533-1536页

作者： Weijian Luo yiren Zhang yongyang Gong Qing Zhou yongming Zhang wangzhang y.an Shanghai Key Lab of Electrical Insulation and Thermal Aging Shanghai Electrochemical Energy Devices Research CenterSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong University

Pure organic luminogens with efficient room temperature phosphorescence（RTP） and remarkable mechanochromism are highly desired in view of their fundamental significance and technical applications. Herein, four twisted pure organic luminogens based on benzophenone and aromatic amines were synthesized and their photophysical properties were thoroughly investigated. They exhibit crystallization-induced phosphorescence（CIP）, giving bright fluorescence and phosphorescence dual emission in crystals. Upon grinding, they become amorphous and emit predominantly red-shifted fluorescence, demonstrating remarkable mechanochromism. Furthermore, three of them even demonstrate greatly enhanced emission upon grinding, which is rarely observed in twisted D-A structured luminogens.

关键词： Crystallization-induced phosphorescence Room temperature phosphorescence Mechanochromism Benzophenone Aromatic amines

1-((12-Bromododecyl)oxy)-4-((4-(4-pentylcyclohexyl)phenyl)ethynyl) benzene: Liquid crystal with aggregation-induced emission characteristics

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Science China Chemistry 2013年第9期56卷 1191-1196页

作者： CHEN yaFei LIN JieSheng y.an wangzhang yU ZhenQiang LAM Jacky Wingyip TANG Ben Zhong Shenzhen Key Laboratory of Functional Polymers School of Chemistry and Chemical EngineeringShenzhen University National Institutes for Food and Drug Control School of Chemistry.and Chemical engineering Shanghai Jiao Tong University Department of Chemistry The Hong Kong University of Science & Technology

The luminescent liquid crystals (LLCs) are expected to solve the conflicts between the aggregation caused quenching and the requirement of aggregation or self-organization for LCs. Herein, we developed a new strategy of applying aggregation-induced emission (AIE) phenomenon to the molecular design of LCs towards LLCs. In this report, a calamitic liquid crystal based on tolane with AIE characteristics was successfully synthesized and the chemical structure was characterized by 1H, 13C NMR, and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) high-resolution mass spectra. The fluorescence behavior was studied by fluorescence spectroscopy.and the liquid crystal phase behaviors were investigated by differential scanning calorimetry (DSC), polarized optical microscopy (POM). The crystal structure was obtained by X-ray diffraction crystallography with P1 space group. Results demonstrated that the sample was AIE active and the LC phases sequence during cooling was nematic, smectic C and smectic B phase.

关键词： aggregation-induced emission tolane liquid crystal phase behavior

Machine learning design of 400 MPa grade biodegradable Zn-Mn based alloys with appropriate corrosion rates

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International Journal of Minerals,Metallurgy.and Materials 2024年第12期31卷 2727-2736页

作者： wangzhang Chen Wei Gou yageng Li Xiangmin Li Meng Li Jianxin Hou Xiaotong Zhang Zhangzhi Shi Luning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Computer and Communication Engineering Shunde Innovation SchoolUniversity of Science and Technology BeijingShunde 528399China

The commonly used trial-and-error method of biodegradable Zn alloys is costly.and *** this study,based on the self-built database of biodegradable Zn alloys,two machine learning models are established by the first time to predict the ultimate tensile strength(UTS)and immersion corrosion rate(CR)of biodegradable Zn alloys.A real-time visualization interface has been established to design Zn-Mn based alloys;a representative alloy is *** tensile mechanical properties and immersion corrosion rate tests,its UTS reaches 420 MPa,and the prediction error is only 0.95%.CR is 73μm/a and the prediction error is 5.5%,which elevates 50 MPa grade of UTS and owns appropriate corrosion ***,influences of the selected features on UTS and CR are discussed in *** combined application of UTS and CR model provides a new strategy for synergistically regulating comprehens-ive properties of biodegradable Zn alloys.

关键词： Zn alloys machine learning alloy design performance prediction

D-A structured high efficiency solid luminogens with tunable emissions： Molecular design and photophysical properties

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Chinese Chemical Letters 2017年第11期28卷 2133-2138页

作者： yunzhong Wang Zihan He Gan Chen Tong Shan wangzhang y.an Ping Lu yongming Zhang School Of Chemistry.and Chemical Engineering Shanghai Key Lab of Electrical Insulation and Thermal Aging Shanghai Electrochemical Energy Devices Research Center Shanghai Jiao Tong University Shanghai 200240 China State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012 China

Fabrication of efficient solid luminogens with tunable emission is both fundamentally significant and technically important. Herein, based on our previous strategy for the construction of efficient and multifunctional solid luminogens through the combination of diverse aggregation-induced emission （ALE） units with other functional moieties, a group of luminophores with electron donor-acceptor （D-A） structure and typical intramolecular charge transfer （ICT） characteristics, namely CZ-DCDPP, DPA-DCDPP and DBPA-DCDPP were synthesized and investigated. The presence of twisting and AlE-active 2,3- dicyano-S,6-diphenylpyrazine （DCDPP） moiety endows them highly emissive in the solid states, whereas the introduction of arylamines with varied electron-donating capacity.and different conjugation render them with tunable solid emissions from green to red. While CZ-DCDPP and DPA-DCDPP solids exhibit distinct mechanochromism, both DPA-DCDPP and DBPA-DCDPP solids can generate efficient red emission. Owing to their high efficiency, remarkable thermal and morphological stabilities and moreover red emission, they are promising for diverse optoelectronic and biological applications.

关键词： Aggregation-induced emission lntramolecutar charge transfer Electron donor-acceptor Efficient solid luminogens Luminescence mechanochromism Red emission