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Sy.ergistically.enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy.Chemistry 2025年第1期100卷 721-729页

作者： Guany. Luo min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang wang Deli wang Key.Laboratory.of Material Chemistry.for Energy.Conversion and Storage (Huazhong University.of Science and Technology. ministry.of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite cataly.t is vital to realize efficient ***,a sy.ergistic composite cataly.t consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct sy.ergistic electrocataly.ic *** from the ordered structure,sy.ergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocataly.ic performance for oxy.en reduction reaction （ORR） and hy.rogen evolution reaction （HER） with mass activity.of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability.test in acid solutions,with 13 mV decay.after 50,000 potential cy.les for ORR and a 2.7 mV decay.after 20,000 potential cy.les for *** integration strategy.of single-atomic sites coupled IMCs paves the way.for enhancing the activity.and durability.of Pt-based electrocataly.ts.

关键词： Sy.ergistic effect Intermetallics Single atomic sites Oxy.en reduction reaction Hy.rogen evolution reaction

Cortico-striatal gamma oscillations are modulated by.dopamine D3 receptors in dy.kinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei wang y.ewei Bi min Li Jiazhi Chen Zhuy.ng wang Huantao Wen ming Zhou minjie Luo wangming Zhang Neurosurgery.Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely.recognized hallmark of abnormal neural electrical activity.in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophy.iological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dy.kinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity.of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary.motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dy.kinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dy.kinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality.in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor play. a role in dy.kinesia-related oscillatory.activity.and that it has potential as a therapeutic target for levodopa-induced dy.kinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dy.kinesia local field potentials neuromodulation Parkinson’s disease primary.motor cortex

Establishment of human cerebral organoid sy.tems to model early.neural development and assess the central neurotoxicity.of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiy. Hu y.anqing Cao Chenglin Cai Guangming wang min Zhou Luy.ng Peng y.ntao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University. Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key.Laboratory.of Arrhy.hmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately.model early.human brain development and *** enable more consistent and intuitive reproduction of early.brain development,in this study.we incorporated forebrain organoid culture technology.into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only.7 day. during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new ty.e of human brain organoid *** cerebral organoid sy.tem replicated the temporospatial characteristics of early.human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical lay.r patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology.*** a proof of concept,we applied the heavy.metal cadmium to this newly.improved organoid sy.tem to test whether it could be used to evaluate the neurotoxicity.of environmental *** organoids exposed to cadmium for 7 or 14 day. manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity.accompanied by.compensatory.cell proliferation at ectopic *** convenience,flexibility.and controllability.of this newly.developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Porous Organic Cage‑Based Quasi‑Solid‑State Electroly.e with Cavity.Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan y.e‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key.Laboratory.of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key.Laboratory.of Energy.Conversion and Energy.Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity.and excellent host–guest property.hold great potentials in regulating ion transport behavior,y.t their feasibility.as solid-state electroly.es has never been testified in a practical ***,we design and fabricate a quasi-solid-state electroly.e(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity.induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity.of 1.25×10^(−4) S cm^(−1) with a low activation energy.of 0.17 *** allow for homogeneous Li deposition and highly.reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely.stable cy.ling performance with 85%capacity.retention after 1000 ***,our work demonstrates the practical applicability.of POC as SSEs for LMBs and could be extended to other energy.storage sy.tems,such as Na and K batteries.

关键词： Porous organic cage Cavity.induced anion-trapping Quasi-solid-state electroly.e Homogeneous Li+flux Lithium metal battery

De novo sy.thesis of atropisomeric benzofurans via Cu/SPDO complex cataly.ed asy.metric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-y. wang Ka Lu Ju-Song y.ng Fu-min Zhang Ai-Jun Ma Bao Du y.ng-Qiang Tu State Key.Laboratory.of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry.and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology.and Health Sciences Wuyi University

Herein, the de novo sy.thesis of atropisomeric benzofurans through the Cu/spirocy.lic-py.rolidine-oxazoline(SPDO) complex cataly.e asy.metric formal [3 + 2] cy.loaddition between quinones and y.amides is explored, producing a range of structurally.diverse axially.chiral benzofurans in satisfactory.y.elds with good to excellent enantioselectivities. Furthermore, density.functional theory.calculations were applied to explain the possible reaction mechanism.

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Experimental Observing Damage Evolution in Cement Pastes Exposed to External Sulfate Attack by.in situ X-ray.Computed Tomography

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Journal of Wuhan University.of Technology.Materials Science) 2025年第1期40卷 164-170页

作者： WU min CAO Kailei XIAO Weirong y. Zetai CAO Jierong DING Qingjun LI Jinhui China Railway.Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan Liuheng Bridge Phase II Project Zhoushan 316000China China Railway.Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key.Laboratory.of Silicate Material for Architecture(Wuhan University.of Technology. Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by.external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray.computed tomography.X-ray.CT)was used,i e,the tomography.sy.tem of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly.affects the damage mode of cement paste specimens during sulfate *** damage of ordinary.Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray.computed tomography

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zhey. Zhang min y. Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy.of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only.affects the brain,but also induces metabolic dy.function in peripheral organs and alters the gut *** aim of this study.was to investigate sy.temic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analy.ed peripheral organ metabolism and the gut microbiota in amy.oid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by.untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with y.unger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney.metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely.related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney.axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

“大、小、重、慢”疾病定义与全科医生“4善”定位的探讨

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中国全科医学 2025年第1期28卷 125-128页

作者：李敏王仲清华大学附属北京清华长庚医院临床医学院全科医学系北京市102218 北京清华长庚医院全科与健康医学部北京市102218

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善... 详细信息

随着我国医药卫生体制的深度改革,特别是分级诊疗制度的推进,全科医生在基层医疗保健体系中的角色日益重要。全科医生不仅是居民健康的第一道防线,更是常见疾病预防、诊断、治疗及健康教育的关键执行者。国家对全科医生提出了“小病善治、大病善识、重病善转、慢病善管”的临床定位。本文通过问答形式,分析“小、大、重、慢”疾病的分类与全科医生的“4善”定位,探讨全科医生在新医改时代下的重要职能及挑战。访谈者认为虽然分级诊疗制度旨在优化医疗资源配置,但在实践中仍面临“大、小、重、慢”疾病分类的模糊性和基层医疗资源的不均衡分配等问题。全科医生在这个体系中扮演着至关重要的角色,其需要具备综合的临床诊疗能力,并与专科医生共同制定临床判断标准和诊疗标准。为了应对这些挑战并充分发挥全科医生在现代医疗体系中的作用,迫切需要对全科医学教育和实践进行进一步改革与优化,同时强化全科医生的角色定位,以确保在提升医疗服务质量和效率的同时,实现公平和可持续的健康保障体系。

关键词：全科医学全科医生分级诊疗医疗体系改革疾病分类医疗资源优化

黄河下游流域的文化界说——兼论华北平原在黄河文化中的历史地位

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河北学刊 2025年第1期45卷 98-110页

作者：王志民宋宁山东师范大学齐鲁文化研究院

黄河下游流域与文化的界定,是黄河文化研究中的一个重大问题。论者将黄淮海平原的广阔区域都作为黄河下游流域的传统看法是不恰当的。淮河作为一条大河,自有其独立的流域范围,“夺淮入海”时期,黄河夺占淮河支流和主河道,主要系人为因... 详细信息

黄河下游流域与文化的界定,是黄河文化研究中的一个重大问题。论者将黄淮海平原的广阔区域都作为黄河下游流域的传统看法是不恰当的。淮河作为一条大河,自有其独立的流域范围,“夺淮入海”时期,黄河夺占淮河支流和主河道,主要系人为因素改道和维持所致,且多为河道游移、水系混乱的“地上河”,并未形成自己的“集水区”;在文化上,淮河文化是长江文化的亚文化,在春秋战国时期是长江楚文化的重要组成部分。故无论从流域还是文化上看,淮河流域都不能作为黄河下游流域看待。泰沂山西延伏脉以北的华北平原,是黄河天然形成的入海之地;在秦汉以前,是中华文明起源、三代文明奠基的重要区域之一,是春秋战国时代的文化重心,是实现秦汉“大一统”的经学繁荣基地和思想库。该地区在中华文明起源、形成及中华民族共同体奠基的重要历史时期作出了突出贡献,是奠定黄河文化为中华民族“根”与“魂”的核心区之一。华北平原及其文化就是黄河下游的流域与文化。

关键词：黄河下游文化界说华北平原黄河文化