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Advances in phy.ochemistry. ananly.is methods and pharmacology.of Eleutherococcus trifoliatus:A promising medicinal and edible resource with development value

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Chinese Herbal Medicines 2025年第1期17卷 19-30页

作者： Maofang Lu Bin Wang Ling Dai Jian wu Jiao Luo Changsoo y.ok Xiangqian Liu School of Pharmacy Hunan University of Chinese Medicine School of Pharmacy Hunan Vocational College of Science and Technology Instrumental Analy.is Center Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Pharmacy Kyung Hee University

Eleutherococcus trifoliatus(Araliaceae) is called Baile or Lecai in *** is a medicinal and edible plant widely.used in folk *** a TCM,the dried herb of this species can remove damp heat and detoxicity.cure rheumatism,remove blood stasis,relieve pain,and alleviate cough and asthma *** chemical compounds have been reported including diterpenoids,triterpenoids,pheny.propanoids,flavonoids,lignans,caffeoy. quinic acids,steroids,essential oils,etc.,in which flavonoids,saponins,and caffeoy. quinic acids are the most bioactive *** vitro and in vivo pharmacological experiments demonstrated that *** has anti-inflammatory.hy.ogly.emic,anticancer,antioxidant,antibacterial,anti-hy.eralgesic,anti-fatigue,analgesic,and hemostatic *** we reviewed *** in phy.ochemistry.analy.is methods,and pharmacology.

关键词： Acanthopanax Miq. analy.is methods anti-inflammatory Eleutherococcus trifoliatus (L.) S. y. Hu pharmacology phy.ochemistry toxicity

Pollen Germination Activates the Apical Membrane-Located RAC/ROP GTPase Switch

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Molecular Plant 2013年第4期6卷 1358-1361页

作者： Christine y.-h. Chen Wen-Guang Zheng Alice y. Cheung Hen-Ming wu Department of Biochemistry.and Molecular Biology Molecular and Cell Biology.Program University of Massachusetts Amherst MA 01003 USA Millipore Corporation 28820 Single Oak Drive Temecula CA 92590 USA Department of Genetics Development and Cell Biology Iowa State University Ames IA 50011 USA Plant Biology.Graduate Program

Dear Editor, Pollen germination and tube growth underlie reproduc- tive success in flowering plants. Pollen germination, whether occurring on the stigmatic surface of the pistil or under defined medium conditions in vitro, involves producing a polarized outgrowth that extends at the tip, producing a pollen tube. RAC/ROPs, the RHO GTPases of plants, are molecu- lar switches that pivotally.control the polarized pollen tube growth process. However, how RAC/ROP activities respond to conditions during germination and tube growth to signal the needed cellular events has not been examined. We show here that tobacco pollen germination rapidly.induces RAC/ ROP activation, potentially.affecting my.iad downstream cellular processes that support pollen tube growth.

关键词： GERMINATION GUANOSINE triphosphatase POLLEN PLANTS -- Phosphory.ation PLANT membranes

Celiac Disease and Elevated Liver Enzy.es: A Review

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 116-124页

作者： Jaimy.Villavicencio kim George y.wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology.epatology University of Connecticut Health CenterFarmingtonCTUSA

Aminotransferases are commonly.found to be elevated in patients with celiac disease in association with two different ty.es of liver dy.function:cry.togenic liver disorders and autoimmune *** purpose of this review is to discuss the mechanisms by.which aminotransferases become elevated in celiac disease,clinical manifestations,and response to gluten-free *** studies have shown that celiac patients with cry.togenic liver disease have normalization in aminotransferases,intestinal histologic improvement and serologic resolution after 6–12 months of strict gluten-free *** patients with an underly.ng autoimmune liver disease,simultaneous treatment for both conditions resulted in normalized elevated *** literature suggests that intestinal permeability.may.be at least one of the mechanisms by.which liver damage *** with celiac disease should have liver enzy.es routinely.checked and treated with a strict gluten-free diet if found to be *** of improvement in patients who have strictly.adhered to gluten-free diet should prompt further workup for other causes of liver disease.

关键词： Celiac disease Gluten free diet Celiac hepatitis Autoimmune liver disease

Cy.omegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 106-115页

作者： Teresa Da Cunha George y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA

Human cy.omegalovirus (HCMV) infection is common and affects between 40–100% of the worldwide population. However, the majority.of cases are asy.ptomatic and when severe disease occurs, it is usually.restricted to immunocompromised patients. Liver involvement by.HCMV differs significantly. accordingly.to the immune status of the host. In immunocompromised patients, particularly.liver transplant patients, it often causes clinically.significant hepatitis. On the other hand, in immunocompetent patients, HCMV hepatitis requiring hospitalization is extremely.rare. This review aims to appraise studies regarding the pathophy.iology.of HCMV hepatitis, including mechanisms of latency.and reactivation and its contribution to disease development, clinical presentation, diagnostic modalities and treatment, with a focus on comparing different aspects between immunocompromised and immunocompetent hosts.

关键词： CMV hepatitis Cy.omegalovirus hepatitis Cy.omegalovirus hepatitis immunocompetent Cy.omegalovirus hepatitis immunocompromised

Steady.vortex force theory.and slender-wing flow diagnosis

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Acta Mechanica Sinica 2007年第6期23卷 609-619页

作者： y.T.y.ng R.k.Zhang y.R.An J.Z.wu State key.Laboratory.for Turbulence and Complex Sy.tems College of EngineeringPeking UniversityBeijing 100871China

The concept vortex force in aerody.amics is sy.- tematically.examined based on a new steady.vortex-force theory.（wu et al., Vorticity.and vortex dy.amics, Springer, 2006） which expresses the aerody.amic force （and moment） by.the volume and boundary.integrals of the Lamb vector. In this paper, the underly.ng phy.ics of this theory.is explored, including the general role of the Lamb vector in non- linear aerody.amics, its initial formation, and its relevance to the total-pressure non-uniformity. As a ty.ical example, the theory.is applied to the flow over a slender delta wing at a large angle of attack. The highly.localized flow structures with high Lamb-vector peaks are identified in terms of their net contribution to various constituents of the total aerody.namic force. This vortex-force diagnosis sheds new light on the flow control and configuration optimization.

关键词： Vortex force - Delta-wing - Flow control

Fine mapping and identification of CaTTG1,a candidate gene that regulates the hy.ocoty. anthocy.nin accumulation in Capsicum annuum

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Horticultural Plant Journal 2025年第1期11卷 264-274页

作者： Jin Wang y.o Dai Luzhao Pan y.ng Chen Li Dai y.nqing Ma Xiaoxun Zhou wu Miao Muhammad Rizwan Hamid Xuexiao Zou Feng Liu Cheng Xiong Engineering Research Center for Germplasm Innovation and New Varieties Breeding of Horticultural Crops Key Laboratory for Vegetable Biology of Hunan ProvinceCollege of HorticultureHunan Agricultural UniversityChangshaHunan 410000China Hunan Xiangy.n Seed Industry.Co. LTDChangshaHunan 410000China

Pepper(Capsicum annuum L.)is a ty.ical self-pollinating crop with obvious heterosis in ***,the use of morphological markers during the pepper seedling stage is crucial for pepper *** color of hy.ocoty. is widely.used as a phenoty.ic marker in crossing studies of *** accessions generally.have purple hy.ocoty.s,which are mainly.due to the anthocy.nin accumulation in seedlings,and green hy.ocoty.s are rarely.observed in *** we reported the characterization of a green hy.ocoty. mutant of pepper,Cha1,which was identified from a pepper ethy. methanesulfonate(EMS)mutant *** mapping revealed that the causal gene,CaTTG1,belonging to the WD40 repeat family.controlled the green hy.ocoty. phenoty.e of the ***-induced gene silencing(VIGS)confirmed that CaTTG1 regulated anthocy.nin ***-seq data showed that expression of structural genes CaDFR,CaANS,and CaUF3GT in the anthocy.nin biosy.thetic pathway.was significantly.decreased in Cha1 compared to the wild *** two-hy.rid(y.H)experiments also confirmed that CaTTG1 activated the sy.thesis of anthocy.nin structural genes by.forming a MBW complex with CaAN1 and *** summary.this study.provided a green hy.ocoty. mutant of pepper,and the kompetitive Allele Specific PCR(kASP)marker developed based on the mutation site of the underly.ng gene would be helpful for pepper breeding.

关键词： Pepper CaTTG1 Anthocy.nin Hy.ocoty. color Fine-mapping

A crowd route choice evacuation model in large indoor building spaces

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Frontiers of Architectural Research 2018年第2期7卷 135-150页

作者： y. wu J. kang C. Wang School of Architecture Harbin Institute of Technology Harbin 150001 PR China School of Architecture University of Sheffield Sheffield S10 2TN UK School of Architecture Tianjin University Tianjin 300072 PR China

Route choice is a fundamental requirement in the evacuation process. The aim of this paper is to identify.a method to simulate crowds in large indoor spaces with consideration of the acoustic sy.tem. This paper first extends an existing cellular automaton model and proposes a ceUutar automaton crowd route choice model （CACR model） to simulate evacuees in large indoor spaces. It then defines a measure for evaluating the utility.of evacuation time using the CACR model under different circumstances, such as a fire situation or different voice warning sy.tems, which other commercial models cannot simulate. The analy.is of the characteristics of a sound field in large indoor spaces is based on field measurements. An observation experiment in a gy.nasium is employ.d to test the proposed model in a stadium evacuation scenario. The results demonstrate that the CACR model can accurately.simulate the evacuation process in large indoor spaces under various circumstances.

关键词： Crowd Evacuation Cellular automatonmodel Sound Voice warning sy.tem

Neuroprotective and antidiabetic lanostane-ty.e triterpenoids from the fruiting bodies of Ganoderma theaecolum

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Chinese Journal of Natural Medicines 2025年第2期23卷 245-256页

作者： Jiaocen Guo Li y.ng Luting Dai Qingy.n Ma Jiaoy.ng y.n Qingy. Xie y.ugen wu Haofu Dai y.uxing Zhao School of Breeding and Multiplication (Sany. Institute of Breeding and Multiplication) Hainan University key.Laboratory.of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National key.Laboratory.for Tropical Crop Breeding Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences

Eight previously.undescribed lanostane triterpenoids,including five nortriterpenoids with 2 6carbons,ganothenoids A-E（1-5）,and three lanostanoids,ganothenoids F-H（6-8）,along with 24 known ones（9-32）,were isolated from the fruiting bodies of Ganodrma *** structures of the novel compounds were elucidated using comprehensive spectroscopic methods,including electronic circular dichroism（ECD） and nuclear magnetic resonance（NMR） *** 1-32 were assessed for their neuroprotective effects against H2O2-induced damage in human neuroblastoma SH-Sy.y.cells,as well as their inhibitory.activities against protein ty.osine phosphatase 1B（PTP1B） and α-*** 4demonstrated the most potent neuroprotective activity.against H2O2-induced oxidative stress by.suppressing G0/G1phase cell cy.le arrest,reducing reactive oxy.en species（ROS） levels,and inhibiting cell apoptosis through modulation of B-cell ly.phoma 2 protein（Bcl-2） and Bcl-2 associated X-protein（Bax） protein *** 26,12,and 28 exhibited PTP1B inhibitory.activities with IC50values ranging from 13.92 to 56.94 μmol·L-1,while compound12 alone display.d significant inhibitory.effects on α-glucosidase with an IC50value of 43.56μmol·***,enzy.e kinetic analy.es and molecular docking simulations were conducted for compounds 26 and 12 with PTP1B and α-glucosidase,respectively.

关键词： Ganoderma theaecolum Lanostane nortriterpenoids Neuroprotective effects PTP1B α-Glucosidase

Transmission Electron Microscopy.Study.of the Infrared Brazed High-strength Titanium Alloy

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Journal of Materials Science & Technology 2010年第4期26卷 311-316页

作者： Z.y. wu R.k. Shiue C.S. Chang Department of Materials Science and Engineering National Taiwan University Taipei 106 Taiwan China Engineered Materials Solutions 39 Perry Avenue MS 4-1 Attleboro MA 02703-2410 USA

The transmission electron microscopy.was employ.d to investigate the microstructure of infrared brazed highstrength Ti alloy.using the Ti-15Cu-15Ni filler metal. Coarse primary.Ti2Ni and transformed β-Ti are observed in the 300 s brazed specimen. Blocky.Ti2Ni and eutectoid Ti2Cu intermetallics are disappeared from the joint with increasing the brazing time to 1800 s. Both acicular α-Ti and retained β-Ti dominate the entire brazed joint.

关键词： Infrared Brazing Ti Ti-Cu-Ni filler Microstructure