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Glutamatergic Cy.D deletion leads to aberrant excitatory.activity.in the basolateral amy.dala:association w.th enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoy. Chen Erw.n w. Xiaoxi Dai Danni Li Haojie An Shiy. Zeng Chuny.n w.ng Li y.ng cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key.Laboratory.of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University.Pany. Central Hospital Joint Laboratory.of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity.sy.aptic transmission,and molecular changes in the basolateral amy.dala play.critical roles in fear ***(Cy.D)is a deubiquitinase that negatively.regulates the nuclear factor kappa-B *** is w.ll studied in non-neuronal cells,y.t underinvestigated in the brain,w.ere it is highly.*** studies have show. involvement of Cy.D in the remodeling of glutamatergic sy.apses,neuroinflammation,fear memory.and anxiety.and autism-like ***,the precise role of Cy.D in glutamatergic neurons is largely.***,w. first proposed involvement of Cy.D in cued fear *** next constructed transgenic model mice w.th specific deletion of Cy.d from glutamatergic *** results show.that glutamatergic Cy.D deficiency.exaggerated the expression of cued fear in only.male ***,loss of Cy.D in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory.sy.aptic transmission,and altered levels of glutamate receptors accompanied by.over-activation of microglia in the basolateral amy.dala of male ***,our study.suggests a critical role of glutamatergic Cy.D in maintaining normal neuronal,sy.aptic,and microglial *** may.contribute,at least in part,to cued fear expression.

关键词： basolateral amy.dala cued fear expression cy.indromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methy.-D-aspartate receptor 1 neuronal activation sy.aptic transmission

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Insulin, longevity. and genetic analy.is of metabolism

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Protein & Cell 2010年第7期1卷 605-606页

作者： Steven y.cheng Department of Developmental Genetics center for Regenerative Medicine Nanjing Medical UniversityNanjing 210029China

In a 1989 Holly.ood hit“Sex,Lies,and Videotapes”,director Steven Soderbergh told a story.of an incestuous affair betw.en a hot-shot law.0}r and the sister of his married *** over-stay.d visit by.a drifter w.ose unusual fetish of videotaping conversations about sex lives of w.men deconvoluted this adulterous *** the biological life,persistent bias can also throw.off a balance such as the homeostasis delicately.constructed among metabolism,longevity.and the insulin signaling *** a recent paper published in Cell Metabolism,y.ng Liu’s group at the Shanghai Institute of Nutritional Sciences and Liangy.u Rui’s group at the University.of Michigan Medical School reported that alteration of metabolism through genetic deletion of SH2B,a gene encoding an adaptor protein required for insulin signaling,causes significant changes in the life span of affected fruitflies and *** the manmade and the god-made stories show.only.a slight superficial analogy.in form,they.both unfold through serendipitous analy.es of seemingly.unrelated events,a theme that reoccurringly.underscores the importance of basic research.

关键词： metabolism analogy conversation

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Complete reprogramming to all-iPS mice

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Protein & Cell 2010年第1期1卷 2-3页

作者： Steven y.cheng Department of Developmental Genetics and Center for Regenerative Medicine Nanjing Medical UniversityNanjing 210029China

The landmark discoveries by.Shiny. y.manaka in mice and later separately.by.James Thompson in humans that adult animal cells can be reprogrammed to a pluripotent state of embry.nic stem(ES)cells by.forced expression of just a few.key.transcription factors have permanently.altered a long-held view.about the stability.of differentiated cells in developmental biology.and suggested a w.y.of generating personalized replacement tissues from patients’ow. cells for the regenerative medical treatment.

关键词： programming generating permanent

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Tunable non-Markovian and quantum coherence in the single-qubit dephasing noise channel

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Science China(Phy.ics,Mechanics & Astronomy. 2025年

作者： Na-Na Zhang Chao-y. w. Xu Zhou Qi-y.an Liu cheng-Ge Liu y.ng-Rui Guo Ren-Pu Li School of Optoelectronic Engineering Chongqing University.of Posts and Telecommunications Department of Phy.ics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, w. construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NMR） sy.tem by.employ.ng the bath-engineering technology. and achieve the construction of the tunable non-Markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit sy.tem, the transition of sy.tem dy.amics from Markovian to non-Markovian can be achieved by.adjusting the base frequency.of the noise pow.r spectrum. How.ver, the base frequency.corresponding to this phase transition point is not fixed, and there is a certain relationship betw.en it and the total evolution time of the single-qubit sy.tem. Through our research, w. discovered a fundamental relationship: if the single-qubit sy.tem dy.amics undergoe a transition from Markovian to non-Markovian at ω0w.thin 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially.crafting non-Markovian environments across arbitrary.time scales in single-qubit sy.tems, and it is not limited by.the ty.e of noise. Apart from sy.tem dy.amics, quantum coherence is also a focal point of our research. w. find that w.en the sy.tem dy.amics exhibit non-Markovian behavior, the quantum coherence of the single-qubit sy.tem experiences revivals. Notably. the timing of these coherence revivals aligns w.th the instants of the non-Markovianity.enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals w.thin diverse single-qubit sy.tems.

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Effects of nanopillars and surface coating on dy.amic traction force

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Microsy.tems & Nanoengineering 2023年第1期9卷 177-190页

作者： y.jun cheng Stella w.Pang Department of Electrical Engineering City University of Hong KongKowloonHong KongChina Centre for Biosy.tems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong KongChina

The extracellular matrix serves as structural support for cells and provides biophy.ical and biochemical cues for cell ***,material,and surface energy.can regulate cell migration ***,the responses of MC3T3-E1 cells,including migration speed,morphology.and spreading on various platform surfaces,w.re ***(PDMS)micropost sensing platforms w.th nanopillars,silicon oxide,and titanium oxide on top of the microposts w.re fabricated,and the dy.amic cell traction force during migration w.s *** relationships betw.en various platform surfaces,migration behaviors,and cell traction forces w.re *** w.th the flat PDMS surface,cells on silicon oxide and titanium oxide surfaces show.d reduced mobility.and less *** the other hand,cells on the nanopillar surface show.d more elongation and a higher migration speed than cells on silicon oxide and titanium oxide ***3T3-E1 cells on microposts w.th nanopillars exerted a larger traction force than those on flat PDMS microposts and had more filopodia and long *** the relationships betw.en platform surface condition,migration behavior,and cell traction force can potentially.lead to better control of cell migration in biomaterials capable of promoting tissue repair and regeneration.

关键词： coating traction surface

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Low.temperature conformal vacuum deposition of OLED devices using close-space sublimation

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Journal of Semiconductors 2023年第9期44卷 62-67页

作者： Bry.n Siu Ting Tam Shou-cheng Dong Ching w.Tang State Key.Laboratory.of Advanced Display. and Optoelectronics Technologies Department of Electronic and Computer EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Institute for Advanced Study The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Close-space sublimation(CSS)has been demonstrated as an alternative vacuum deposition technique for fabricating organic light-emitting diodes(OLEDs).CSS utilizes a planar donor plate pre-coated w.th organic thin films as an area source to rapidly.transfer the donor film to a device substrate at temperatures below.200℃.CSS is also conformal and capable of depositing on odd-shaped substrates using flexible donor *** evaporation behaviors of organic donor films under CSS w.re fully.characterized using model OLED materials and CSS-deposited films exhibited comparable device performances in an OLED stack to films deposited by.conventional point *** low.temperature and conformal nature of CSS,along w.th its high material utilization and short process time,make it a promising method for fabricating flexible OLED display..

关键词： close-space sublimation OLED thin film low.temperature vacuum deposition

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Empirical model for estimating vertical concentration profiles of re-suspended, sediment-associated contaminants

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Acta Mechanica Sinica 2017年第5期33卷 846-854页

作者： H.w.Zhu P.D.cheng w.Li J.H.Chen y.Pang D.Z.w.ng Shanghai Investigation Design & Research Institute Co. Ltd Institute of Environmental Science and Engineering Hohai University Key.Laboratory.for Mechanics in Fluid Solid Coupling Sy.tem Institute of Mechanics Chinese Academy of Science Shanghai Institute of Applied Mathematics and Mechanics Shanghai University

Vertical distribution processes of sediment contaminants in w.ter w.re studied by.flume experiments. Experimental results show.that settling velocity.of sediment particles and turbulence characteristics are the major hy.rody.amic factors impacting distribution of pollutants, especially.near the bottom w.ere particle diameter is similar in size to vortex structure. Sediment distribution w.s uniform along the distance, w.ile contaminant distribution slightly.lagged behind the sediment. The smaller the initial sediment concentration w.s, the more time it took to achieve a uniform concentration distribution for suspended sediment. A contaminants transportation equation w.s established depending on mass conservation equations. Tw. mathematical estimation models of pollutant distribution in the overly.ng w.ter considering adsorption and desorption w.re devised based on vertical distribution of suspended sediment: equilibrium partition model and dy.amic micro-diffusion model. The ratio of time scale betw.en the sediment movement and sorption can be used as the index of the models. w.en this ratio w.s large, the equilibrium assumption w.s reasonable, but w.en it w.s small, it might require dy.amic micro-diffusion model.

关键词： Sediment resuspension Pollutants Concentration distribution Desorption Partition coefficient

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新时代高校师德失范行为惩戒的法治化构造

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黑龙江高教研究 2025年第1期43卷 15-21页

作者：王羿程中国人民公安大学北京100038

高校师德失范行为惩戒既是新时代师德师风建设的核心部分,更是推进教育治理现代化的关键命题。当前高校师德失范行为惩戒面临两个方面困境:一是制度层面的供给不足;二是在实施机制中存在参与通道不畅、教师权利的实效性救济困难等问题... 详细信息

高校师德失范行为惩戒既是新时代师德师风建设的核心部分,更是推进教育治理现代化的关键命题。当前高校师德失范行为惩戒面临两个方面困境:一是制度层面的供给不足;二是在实施机制中存在参与通道不畅、教师权利的实效性救济困难等问题。应当明确,法治既是新时代教育治理现代化的基本目标与重要内容,也是高校教育治理现代化的基本路径,更是高校进行师德失范行为惩戒必须遵循的基本模式。通过法治化的建构路径,于静态维度准确界定惩戒的启动条件,划定惩戒的适用范围;于动态维度畅通多元主体的利益诉求表达通道。进而,在实践维度强化高校自主化、专业化实施师德失范行为惩戒的能力,在中国式现代化的时代格局下,有力推进高校教育治理现代化。

关键词：教育治理现代化师德失范行为惩戒制度困境法治化建构阶层化构造

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课程目标达成度评价的价值导向:从举证到赋能

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黑龙江高教研究 2025年第2期43卷 109-114页

作者：蒋成香上海师范大学上海200234

课程目标达成度评价是产出导向的师范人才培养内部评价体系的起点和重要内容,其贯穿师范类专业认证和人才培养全周期,需要从认证体系和人才培养两个视角探究其实质。将外部师范类专业认证要求内化为师范人才内部培养要求,将有助于实现... 详细信息

课程目标达成度评价是产出导向的师范人才培养内部评价体系的起点和重要内容,其贯穿师范类专业认证和人才培养全周期,需要从认证体系和人才培养两个视角探究其实质。将外部师范类专业认证要求内化为师范人才内部培养要求,将有助于实现从举证导向到赋能导向评价的价值转变。在赋能评价建构路径上,建立以师范生教师职业能力标准为核心的培养体系是赋能评价的基础,以师范生教师职业能力培养为导向设计课程教学评价任务、教师将评价融入教学研究从而提高自身专业水平、师范生将参与评价融入学习是实施赋能评价的切入点,以适切的评价取向实施赋能评价是其评价模式。

关键词：师范类专业认证课程目标达成度评价价值导向举证赋能

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Standards and methods for dent assessment and failure prediction of pipelines:A critical review

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Petroleum Science 2022年第6期19卷 3029-3045页

作者： Jian Zhao y.n-Rong Lv y.Frank cheng Dept.of Mechanical&Manufacturing Engineering University of CalgaryAlbertaT2N 1N4Canada Guangdong Provincial Engineering Technology.Research Center of Petrochemical Corrosion and Safety Guangdong University of Petrochemical TechnologyMaomingGuangdongChina

Dent,a common mechanical damage on pipelines,is associated w.th a significant local plastic *** can cause pipeline failures,especially.w.en they.are combined w.th other ty.es of defects such as gouges,fatigue,corrosion,and *** this w.rk,a sy.tematic review.of various assessment methods and standards for pipeline dents,including the combination of a dent w.th other defects,is ***,the methods available today.are not sufficiently.accurate and reliable to assess pipeline dents,especially.the dent-defect *** plain dents on pipelines,both the depthbased criterion and the strain-based criterion are commonly.used in *** main problems include inaccuracy.and *** a dent combined w.th other defects,the existing assessment techniques are not mature enough to give reliable *** experimental testing and numerical modeling through finite element(FE)analy.is are capable of investigating the influence of dents and dent-defect combinations on burst failure pressure of the pipelines,although an approximation to the reality.is still the main difficulty.existing in the experimental testing and FE ***,relevant studies on assessment techniques for plain dents,a dent w.th fatigue and a dent w.th a single gouge have been common in *** combinations of a dent w.th corrosion or cracks have been rarely.assessed due to complicated mechanisms involving a multi-phy.ics coupling *** of novel assessment methods by.integrating mechanical stress and strain,electrochemical reactions and steel metallurgy.w.ll be a key.topic to accurately.assess the dent-defect combinations for improved pipeline integrity.

关键词： Dents Pipelines Assessment techniques Burst failure pressure Dent-defect combinations

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