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Study.on Robust Active Guidance Controller for 1:5 Scaled Bogie with Independent Rotating Wheels

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Study on Robust Active Guidance Controller for 1:5 Scaled Bo...

副干酪乳酪杆菌PC-01复配剂量对发酵乳产品特性的影响

作者： Ju-yao WEI Ti XIAO Zheng-gang LU Gong-an TAO Zhe y.NG y.ng HE Institute of Rail Transit Tongji University CRRC Zhuzhou Locom.tive Co. Ltd

This paper presents a robust active guidance controller of 1:5 scaled bogie with independent rotating wheels（IRWs） based on the Iwnicki sim.larity.criterion in SIm.ACK and m.TLAB/Sim.link in order to im.rove the stability.of self-guidance and steering. Firstly. the dy.am.c m.del of bogie with IRWs is established. The active guidance steering control is realized by.torque difference between the left and right wheels in the sam. axle that generated by.four side m.tors. Considering the nonlinear characteristics of rail vehicles, the uncertainty.of structure param.ters and m.asurem.nt noise, the active guidance controller using the μ-sy.thesis m.thod is designed in m.TLAB/Sim.link by.taking wheel-rail force and prim.ry.suspension force as external disturbances. The co-sim.lation results show that com.ared with the passive case, the proposed control m.thod can significantly.im.rove the running perform.nce of bogie with IRWs and reduce the wheel-rail wear in both straight and curved tracks. The average wheel-rail wear num.er is reduced by.86% in straight track and 86.5%/99% in curved track with 5 m.10 m.radius, respectively.

关键词： Bogie with independent rotating wheels 1 scaled m.del Active guidance Robust control

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食品与发酵工业 2023年第18期49卷 89-96页

作者：张哲于学健李宏姚粟中国食品发酵工业研究院有限公司中国工业微生物菌种保藏管理中心北京100015 中国合格评定国家认可中心北京100062

副干酪乳酪杆菌PC-01是1株分离自我国拉萨地区自然发酵酸牦牛乳中,且具有益生特性的菌株。该试验以菌株PC-01为研究对象,探究了该菌株不同起始添加量对发酵乳发酵及贮藏期间产品特性的影响,探究该菌株是否适合复配于发酵乳中。结果表明,... 详细信息

副干酪乳酪杆菌PC-01是1株分离自我国拉萨地区自然发酵酸牦牛乳中,且具有益生特性的菌株。该试验以菌株PC-01为研究对象,探究了该菌株不同起始添加量对发酵乳发酵及贮藏期间产品特性的影响,探究该菌株是否适合复配于发酵乳中。结果表明,PC-01的添加不会加快产品到达发酵终点的时间。同时,PC-01的添加对发酵乳发酵及贮藏期间的pH值及滴定酸度无显著性影响(P>0.05),且保持活菌数持续上升。贮藏结束时,PC-01低、中、高剂量组活菌数分别由(6.27±0.022)、(6.74±0.027)、(7.008±0.004)lg CFU/m.上升到(7.84±0.010)、(8.13±0.013)、(8.22±0.004)lg CFU/m.。此外,PC-01的添加可以提高发酵乳的黏度,在贮藏14 d后添加PC-01组发酵乳黏度显著高于对照组(P<0.05)。菌株PC-01对发酵乳质构的影响与添加量有关,在添加中、低剂量时,产品与对照组的质构特征更为相近。综上,副干酪乳酪杆菌PC-01的添加在不改变发酵乳基本特性的同时,可以提高贮藏期间产品的稳定性,并保持有效的活菌数,适合应用于发酵乳中。该研究为该菌株发酵乳产品的开发提供依据,为实际应用奠定基础。

关键词：副干酪乳酪杆菌PC-01 发酵乳复配剂量流变学特性质构特性

Diazido m.xed-Am.ne Platinum.Ⅳ) Anticancer Com.lexes Activated by.Visible-Light Can Cause Guanine Oxidation

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Diazido Mixed-Amine Platinum(Ⅳ) Anticancer Complexes Activa...

The role of autophagy.in colitis-associated colorectal cancer

第八届全国化学生物学学术会议

作者： yao Zhao Nicola J.Farrer Jenny.Butler Peter J.Sadler Fuy. Wang Beijing National Laboratory.for m.lecular Sciences CAS Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences Departm.nt of Chem.stry University of Warwick

Platinum.diam.m.ine anticancer com.lexes,such as cisplatin,are successful in clinic, but suffer from.problem. of resistance and *** Ptprodrugs offer the potential of targeted drug release and new m.chanism. of *** report visible-light activated diazido com.lexes trans,trans,trans-[Pt(N)(OH)(Am.) (Am.)](Am. and Am.=am.nes)that are inert in the dark towards hy.roly.is and glutathione reduction,but undergo rapid photoreduction with UVA or blue light.

关键词： platinum antitum.r agents DNA binding guanine oxidation m.dicinal chem.stry

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Signal Transduction and Targeted Therapy 2018年第1期3卷 19-29页

作者： y.hui Wu Junlin yao Jiansheng Xie Zhen Liu y.bin Zhou Hongm.ng Pan Weidong Han Departm.nt of m.dical Oncology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou310016 ZhejiangChina Laboratory.of Cancer Biology Institute of Clinical ScienceSir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou310016 ZhejiangChina Center for Translational Cancer Research Institute of Biosciences and TechnologyTexas A&M University Health Science CenterHoustonTX 77030USA

Autophagy.is an evolutionarily.conserved catabolic process that elim.nates harm.ul com.onents through ly.osom.l *** addition to its role in m.intaining cellular hom.ostasis,autophagy.is critical to pathological processes,such as inflam.ation and ***-associated colorectal cancer(CAC)is a specific ty.e of colorectal cancer that develops from.long-standing colitis in inflam.atory.bowel disease(IBD)*** evidence indicates that autophagy.of m.croenvironm.ntal cells play. different but vital roles during tum.rigenesis and CAC ***,after sum.arizing the recent advances in understanding the role of autophagy.in regulating the tum.r m.croenvironm.nt during different CAC stages,we draw the following conclusions:autophagy.in intestinal epithelial cells inhibits colitis and CAC initiation but prom.tes CAC progression;autophagy.in m.crophages inhibits colitis,but its function on CAC is currently.unclear;autophagy.in neutrophils and cancer-associated fibroblasts(CAFs)prom.tes both colitis and CAC;autophagy.in dendritic cells(DCs)and T cells represses both colitis and CAC;autophagy.in natural killer cells(NKs)inhibits colitis,but prom.tes CAC;and autophagy.in endothelial cells play. a controversial role in colitis and *** the role of autophagy.in specific com.artm.nts of the tum.r m.croenvironm.nt during different stages of CAC m.y.provide insight into m.lignant transform.tion,tum.r progression,and com.ination therapy.strategies for CAC.

关键词： colitis colorectal hom.ostasis

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基于CBA-y.LO模型的煤矸石检测

工矿自动化 2022年第6期48卷 128-133页

作者：桂方俊李尧中国矿业大学(北京)机电与信息工程学院北京100083

煤矸石检测中存在样本间特征差异小、目标密集等问题,导致现有煤矸石检测方法精度不高且实时性较差。针对该问题,提出了一种基于CBA-y.LO模型的煤矸石检测方法。CBA-y.LO模型以速度较快、精度较高的y.LOv5m.基础模型,在y.LOv5m.Backb... 详细信息

煤矸石检测中存在样本间特征差异小、目标密集等问题,导致现有煤矸石检测方法精度不高且实时性较差。针对该问题,提出了一种基于CBA-y.LO模型的煤矸石检测方法。CBA-y.LO模型以速度较快、精度较高的y.LOv5m.基础模型,在y.LOv5m.Backbone中加入卷积块注意力模块(CBAm.,通过串联空间注意力模块和通道注意力模块,在聚焦特征差异的同时降低数据维度,提高煤矸石检测性能;在Neck部分采用双向特征金字塔网络(BiFPN)结构,通过融合不同尺度的特征提高模型计算效率,从而提升煤矸石检测速度;在Prediction部分采用Alpha-IoU函数作为损失函数,通过设置权重系数加速对高置信度目标的学习,进一步提高煤矸石检测精度。实验结果表明:CBA-y.LO模型对煤矸石的平均检测精度达98.2%,比y.LOv5模型提高了3.4%,检测速度提升了10%;CBA-y.LO模型的鲁棒性更强,可有效避免漏检、误检和重叠现象。

关键词：煤矸石检测 y.LOv5 CBA-y.LO 深度学习注意力机制双向特征金字塔网络损失函数

延胡索根际土壤细菌多样性与结构对毛竹林隙面积的响应

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生态学杂志 2019年第6期38卷 1716-1724页

作者：李伟成盛海燕杨慧敏刘姚姚张瑞国家林业局竹子研究开发中心/浙江省竹子高效加工重点实验室杭州310012 西南林业大学生命科学学院昆明650224 杭州环境保护科学研究院杭州310005

林下经济已成为增加林地产出和提升林业效益的重要途径。为揭示毛竹林隙中早春药用植物——延胡索根际土壤细菌多样性和群落结构的变化趋势,采集大林隙400m.2、中林隙100 m.2、小林隙25 m.2和郁闭林分4类样地的延胡索根际土样,基于高通... 详细信息

林下经济已成为增加林地产出和提升林业效益的重要途径。为揭示毛竹林隙中早春药用植物——延胡索根际土壤细菌多样性和群落结构的变化趋势,采集大林隙400m.2、中林隙100 m.2、小林隙25 m.2和郁闭林分4类样地的延胡索根际土样,基于高通量测序结合生境参数,分析其细菌群落多样性和结构变化。结果表明,4类样地的细菌类群达35门104纲195目321科532属,大林隙和中林隙的优势土壤细菌类群OTU所占百分比的次序虽有所不同,但基本表现为酸杆菌门和变形菌门占优,绿弯菌门和放线菌门其次;小林隙和郁闭林分则以变形菌门占绝对优势,其次是放线菌门和拟杆菌门,酸杆菌门成呈弱势。同时,随着林隙面积减小,相对光照强度从全光照直至全光照的10.7%~22.5%,细菌群落在总体数量上处于下降趋势,菌种丰富度和特异性、谱系多样性、菌群多样性和菌群均匀度均下降,郁闭林分优于小林隙。菌群在门和属分类水平的OTU百分比特征与相对光照强度、空气温度的梯度分布有显著相关关系,而与土壤水分含量、空气湿度的梯度趋势相反,未发现与林隙面积、海拔及边界立竹参数的梯度关联性。因此,大中型林隙有利于延胡索根际土壤细菌群落发育,而小林隙并不合适;林隙和郁闭林分可为某些特殊条件下进行更新的菌群提供生长机会,可用土壤微生物相关指标如特征菌群来反映林隙发育过程的变化;相对光照强度和空气温度对人工开辟林隙栽培延胡索的根际土壤菌群影响显著,在调控土壤细菌群落结构和促进土壤生态系统稳定具有重要参考价值。

关键词：林-药复合生态系统早春植物林隙生境边界立竹

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单相多电平电流源变流器混合调制与控制技术

电网技术 2018年第4期42卷 1300-1307页

作者：姚钢李俊刚周荔丹上海电力学院电气工程学院上海市杨浦区200090 上海交通大学电气工程系上海市闵行区200240

针对较低级联数的多电平电流源变流器,为减小开关损耗和降低谐波分量,引入一种基于低频与高频混合调制策略的单相多电平电流源变流器的拓扑。低频单元由共享直流电流源的m.H桥子模块级联,各子模块平均分配直流源能量,采用最近电平调制... 详细信息

针对较低级联数的多电平电流源变流器,为减小开关损耗和降低谐波分量,引入一种基于低频与高频混合调制策略的单相多电平电流源变流器的拓扑。低频单元由共享直流电流源的m.H桥子模块级联,各子模块平均分配直流源能量,采用最近电平调制;低频单元用来消除最近电平调制单元输出阶梯波中的谐波分量,采用脉宽调制;该方法综合了最近电平调制和脉宽调制的优点。对所提拓扑的工作原理、均流算法及混合调制策略进行了深入分析,并进行相应的仿真和实验验证。仿真和实验结果表明所引入拓扑能显著的降低谐波含量,同时减小开关损耗,由此验证了所提拓扑和控制方法的有效性和可行性。

关键词：多电平电流源变流器混合调制排序算法均流消谐波

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依托泊苷明胶微球的制备

中国现代应用药学 2005年第3期22卷 219-221页

作者：姚瑶陶昱斐丁燕飞杨芳中南大学药学院湖南长沙410078

目的制备难溶性药物依托泊苷(VP16)明胶微球,并对其形态学性质和载药特性进行研究。方法以PVP为分散介质,采用加液研磨法制得难溶性药物依托泊苷固体分散体,通过正交试验设计,筛选乳化缩聚法制备肺靶向依托泊苷明胶微球的最佳制备工艺... 详细信息

目的制备难溶性药物依托泊苷(VP16)明胶微球,并对其形态学性质和载药特性进行研究。方法以PVP为分散介质,采用加液研磨法制得难溶性药物依托泊苷固体分散体,通过正交试验设计,筛选乳化缩聚法制备肺靶向依托泊苷明胶微球的最佳制备工艺。结果微球平均粒径为17.21μm.其中10～30μm.占89.58%,载药量为(20.94±0.13)%,药物包封率为(86.27±0.65)%。结论以PVP为载体将药物制成固体分散体后再用乳化缩聚法制得的依托泊苷明胶微球外观均匀圆整,分散性良好,粒径分布符合肺靶向要求,载药量较高。

关键词：依托泊苷 PVP 明胶微球正交试验

FAST discovery.of an extrem.ly.radio-faint m.llisecond pulsar from.the Ferm.-LAT unassociated source 3FGL J0318.1+0252

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Science China(Phy.ics,m.chanics & Astronom.0} 2021年第12期64卷 10-17页

作者： Pei Wang Di Li Colin J.Clark Pablo m.Saz Parkinson Xian Hou Weiwei Zhu Lei Qian y.uling y.e Zhichen Pan Zhijie Liu Xuhong y. Shanping y.u Xiaoyao Xie Qijun Zhi Hui Zhang Jum.i yao Jun y.n Chengm.n Zhang Kwok Lung Fan Paul S.Ray.m.tthew Kerr David A.Sm.th Peter F.m.chelson Elizabeth C.Ferrara David J.Thom.son Zhiqiang Shen Na Wang FAST&Ferm.-LAT Collaboration CAS Key.Laboratory.of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University.of Chinese Academ.0}of Sciences Beijing 100049China Jodrell Bank Centre for Astrophy.ics Department of Physics and AstronomyUniversity of ManchesterManchester M139PLUK Departm.nt of Phy.ics and Laboratory.for Space Research University of Hong KongHong Kong 999077China Santa Cruz Institute for Particle Phy.ics University of CaliforniaSanta Cruz CA 95064USA y.nnan Observatories Chinese Academy of SciencesKunming 650216China Key.Laboratory.for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China School of Com.uter Science and Technology Key Laboratory of Information and Computing Guizhou ProvinceGuizhou Normal UniversityGuiyang 550001China School of Phy.ics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Phy.ics Departm.nt Stanford UniversityStanford CA 94305USA Um.P/CRESST/GSFC NASAGreenbeltMaryland MD 20771USA GSFC NASAGreenbeltMaryland MD 20771USA Centre d’´Etudes Nucl´eaires de Bordeaux Gradignan IN2P3/CNRSUniversit´e BordeauxGradignan 33175France Space Science Division U.S.Naval Research LaboratoryWashington DC 20375-5352USA Shanghai Astronom.cal Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronom.cal Observatory Urumqi 830011China Departm.nt of Phy.ics University of MarylandCollege Park MD 20742USA NAOC-UKZN Com.utational Astrophy.ics Centre University of KwaZulu-NatalDurban 4000South Africa 不详

High sensitivity.radio searches of unassociated γ-ray.sources have proven to be an effective way.of finding new pulsars. Using the Five-hundred-m.ter Aperture Spherical radio Telescope(FAST) during its com.issioning phase, we have carried out a num.er of targeted deep searches of Ferm. Large Area Telescope(LAT) γ-ray.sources. On February.27, 2018 we discovered an isolated m.llisecond pulsar(m.P), PSR J0318+0253, coincident with the unassociated γ-ray.source 3 FGL J0318.1+0252. PSR J0318+0253 has a spin period of 5.19 m., a dispersion m.asure(Dm. of 26 pc cm.3 corresponding to a Dm.distance of about 1.3 kpc, and a period-averaged flux density.of(~11±2) μJy.at L-band(1.05-1.45 GHz). Am.ng all high energy.m.Ps, PSR J0318+0253 is the faintest ever detected in radio bands, by.a factor of at least ~4 in term. of L-band fluxes. With the aid of the radio ephem.ris, an analy.is of 9.6 y.ars of Ferm.-LAT data revealed that PSR J0318+0253 also display. strong γ-ray.pulsations. Follow-up observations carried out by.both Arecibo and FAST suggest a likely.spectral turn-over around 350 m.z. This is the first result from.the collaboration between FAST and the Ferm.-LAT team. as well as the first confirm.d new m.P discovery.by.FAST, raising hopes for the detection of m.ny.m.re m.Ps. Such discoveries will m.ke a significant contribution to our understanding of the neutron star zoo while potentially.contributing to the future detection of gravitational waves, via pulsar tim.ng array.PTA) experim.nts.

关键词： FAST pulsar radio gam.a ray.