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The m.(6)A regulator KIAA1429 stabilizes RAB27B m.NA and prom.tes the progression of chronic m.0}loid leukem.a and resistance to targeted therapy

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Genes & Diseases 2024年第2期11卷 993-1008页

作者： Fangy. yao Fangm.n Zhong Junyao Jiang y.ng Cheng Shuai Xu Jing Liu Jin Lin Jing Zhang Shuqi Li m.iy.ng Li y.nm.i Xu Bo Huang Xiaozhong Wang Jiangxi Province Key.Laboratory.of Laboratory.m.dicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Chronic m.0}loid leukem.a(Cm.)is a com.on adult *** the acute phase of the disease and the adverse effects of anti-cancer treatm.nts can lead to a poor *** N6-m.thy.adenine(m.(6)A)m.dification play. an im.ortant regulatory.role in various phy.iological and pathological ***1429 is a known m.(6)A regulator,but the biological role of KIAA1429 in Cm. is *** this study.we observed that the m.(6)A levels and KIAA1429 expression were significantly.up-regulated in patients with blast phase ***,KIAA1429 regulated the total level of RNA m.(6)A m.dification in the Cm. cells and prom.ted the m.lignant biological behaviors of Cm. cells,including proliferation,m.gration,and im.tinib *** KIAA1429 in Cm. cells reduced the stability.of RAB27B m.NA through the m.(6)A/y.HDF1 axis,consequently.inhibiting Cm. proliferation and drug efflux,ultim.tely.increasing the sensitivity.of Cm. cells to ***,the knockdown of RAB27B also inhibited the proliferation and drug resistance of Cm. cells and prom.ted their ***,a recently.developed anti-cancer agent,suppressed the expression of KIAA1429 and Cm. cell proliferation and prom.ted cell *** also inhibited the tum.rigenesis of Cm. cells in *** com.ined use of rucaparib and im.tinib enhanced the sensitivity.of Cm. cells to *** study.provides evidence that elevated KIAA1429 expression in the blast phase of Cm. enhances the stability.of RAB27B m.NA through the m.(6)A/y.HDF1 axis to up-regulate RAB27B expression,thereby.prom.ting Cm. *** exerts inhibitory.effects on KIAA1429 expression and thus reduces Cm. progression.

关键词： Chronic m.0}loid leukem.a KIAA1429 N6-m.thy.adenine RAB27B Rucaparib y.HDF1

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Zy. prom.tes invasion and m.tastasis of gastric cancer cells via WNK1/SNAI1axis

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Genes & Diseases 2024年第2期11卷 564-567页

作者： y. Jiang Dongfang Xiang Xianm.i Wen m.ngm.n He y.n Qin Xiaoxue yao Zexuan y.n Xiuli Geng y.ng Ren Xiongwei Cai y.uhong Cui y.n Wang Institute of Pathology.and Southwest Cancer Center Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Departm.nt of Pathology General Hospital of Central Theater Command of PLAWuhanHubei 430070China Departm.nt of Obstetrics and Gy.ecology Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Departm.nt of Pharm.cy The Hospital of 83rd Group of PLAXinxiangHenan 453000China Departm.nt of Gy.ecology Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 400013China

Gastric cancer(GC)is the third m.st com.on cause of cancer death globally.and a large portion of patients are diagnosed at advanced stages with cancer invasion and m.tastasis1,***,the m.chanism. underly.ng the invasion and m.tastasis of GC rem.in to be *** play. critical roles in cell m.bility.via cy.oskeleton regulation in various cell ty.es.3 In this study.we further reported that Zy. prom.ted m.gration,invasion,and m.tastasis of GC ***,Zy. prom.ted WNK1 activation and SNAl1 up-regulation,inducing epithelial-m.senchy.al transition(Em.)to enhance the m.bility.of GC *** of WNK1 im.aired the m.bility.of GC ***,Zy./WNK1 could be potential therapeutic targets for GC treatm.nt.

关键词： WNK1 invasion m.tastasis

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Prognostic significance of CDKN2A expression in colon adenocarcinom.: insights from.TCGA analy.is

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Cancer Advances 2024年第16期7卷 1-10页

作者： Wei Fu yao Wang Qin-m.ng y.n Guo-Bin Cheng Lin-y. Ly. yao Ding Departm.nt of Gastroenterology 925th Hospital of Joint Logistics Support Force of People’s Liberation Army of ChinaGuiyang 510009China

Background:The cy.lin-dependent kinase inhibitor 2a(CDKN2A)gene,identified as the m.ltiple tum.r suppressor gene,functions as a regulatory.gene im.licated in cancer *** significance lies in its pivotal involvem.nt in the genesis of various tum.rs;notwithstanding,the precise connection between CDKN2A and c olon adenocarcinom.(COAD)rem.ins ***:The objective of this research was to assess the predictive im.ortance of CDKN2A in COAD by.analy.ing data from.The Cancer Genom. Atlas *** regression,signed rank test,Wilcoxon test,and Kruskal-Wallis test were used to exam.ne CDKN2A expression levels and clinicopathological *** and m.ltivariate Cox r egression analy.es and Kaplan-m.ier analy.is found prognostic ***,gene set enrichm.nt analy.is identified key.CDKN2A expression *** study.additionally.exam.ned CDKN2A expression with tum.r im.une infiltration using The Cancer Genom. Atlas data and single sam.le gene set enrichm.nt ***:The results of this investigation indicated a substantial connection between higher CDKN2A expression and negative outcom.s in term. of overall survival and disease-related survival am.ng COAD *** set enrichm.nt analy.is indicated a tight link between CDKN2A and both the cell cy.le and hedgehog signaling *** evaluation em.loy.ng single sam.le gene set enrichm.nt analy.is dem.nstrated a positive link between CDKN2A expression with infiltration by.iDCs,whereas a negative correlation was detected with infiltration by.helper T ***:In conclusion,the present study.gives strong data supporting the predictive value of CDKN2A and its possible usefulness as a biom.rker for ***,our results show a reasonable link between CDKN2A expression and im.une influx in COAD,putting light on the role of CDKN2A in the control of the tum.r ***,additional studies are needed to confirm.the underly.ng m

关键词： CDKN2A colon adenocarcinom. im.une infiltration prognostic analy.is helper T cells

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Controlled growth of vertically.stacked In_(2)Se_(3)/WSe_(2) heterostructures for ultrahigh responsivity.photodetector

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Nano Research 2024年第3期17卷 1856-1863页

作者： Cheng Zhang Biy.an Zheng Guangcheng Wu Xuey.ng Liu Jiaxin Wu Chengdong yao y.zhe Wang Zilan Tang y.ng Chen Lizhen Fang Luy.ng Huang Dong Li Shengm.n Li Anlian Pan Key.Laboratory.for m.cro-Nano Phy.ics and Technology.of Hunan Province State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Materials Science and EngineeringHunan UniversityChangsha 410082China

Transition m.tal dichalcogenides(Tm.Cs)are prom.sing candidates for future optoelectronic devices accounting for their high carrier m.bility.and excellent quantum.***,the lim.ted light absorption efficiency.in atom.cally.thin lay.rs significantly.hinders photocarrier generation,thereby.im.airing the optoelectronic perform.nce and hindering practical ***,we successfully.sy.thesized In_(2)Se_(3)/WSe_(2) heterostructures through a ty.ical two-step chem.cal vapor deposition(CVD)*** In_(2)Se_(3) nanosheet with strong light absorption capability.serving as the light absorption lay.r,was integrated with the m.nolay.r WSe_(2),enhancing the photosensitivity.of WSe_(2) *** laser irradiation with a wavelength of 520 nm.the In_(2)Se_(3)/WSe_(2) heterostructure device shows an ultrahigh photoresponsivity.with a value as high as 2333.5 A/W and a rem.rkable detectivity.reaching up to 6.7×10^(12) Jones,which is the highest am.ng alm.st the reported Tm.Cs-based heterostructures grown via CVD even som. fabricated by.m.chanical exfoliation(m.).Com.ing the advantages of CVD m.thod such as large scale,high y.eld,and clean interface,the In_(2)Se_(3)/WSe_(2) heterostructures would provide a novel path for future high-perform.nce optoelectronic device.

关键词： transition m.tal dichalcogenides(Tm.Cs) In_(2)Se_(3) heterostructure photodetector ultrahigh responsivity

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First results of CO_(2) dispersion interferom.ter on EAST tokam.k

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Plasm. Science and Technology 2024年第3期26卷 76-82页

作者：刘郁阳李维明姚远张耀张家敏连辉洪博王守信揭银先刘海庆 Institute of Plasm. Phy.ics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People's Republic of China University.of Science and Technology.of China Hefei 230026People's Republic of China Institutes of Phy.ical Science and Inform.tion Technology Anhui UniversityHefei 230031People's Republic of China

A dispersion interferom.ter(DI)has been installed and operates on the Experim.ntal Advanced Superconducting Tokam.k(EAST).This DI sy.tem.utilizes a continuous-wave 9.3μm.CO_(2)laser source to m.asure line-averaged electron densities *** contrast to conventional interferom.ters,the DI does not require substantial vibration isolations or com.ensating sy.tem. to reduce the im.act of vibrations in the optical *** also em.loy. a ratio of m.dulation am.litudes,ensuring it rem.ins im.une to the variations in detected *** a variation com.ensation sy.tem.the DI sy.tem.on EAST reaches a density.resolution of less than1.8×10^(-2)πrad and a tem.oral resolution of 20μ*** m.asurem.nts m.de by.the POlarim.terINTerferom.ter(POINT)sy.tem.and the far-infrared hy.rogen cy.nide(HCN)interferom.ter are rem.rkably.consistent with the DI’s *** possibility.of fringe jum.s and the im.act of refraction in high-density.discharge can be significantly.decreased using a shorter wavelength laser source.A rapid density.change of 3×10^(19)m.(-3)during 0.15 s has been m.asured accurately.in shot No.114755 of ***,the DI sy.tem.dem.nstrates dependability.and stability.under 305 s long-pulse discharges in shot No.122054.

关键词： dispersion interferom.ter(DI) electron density plasm. diagnostics Experim.ntal Advanced Superconducting Tokam.k(EAST)

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Endoscopic features and treatm.nts of gastric cy.tica profunda

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World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： Zi-Han Geng y.n Zhu Pei-yao Fu y.-Fan Qu Wei-Feng Chen Xia y.ng Ping-Hong Zhou Quan-Lin Li Endoscopy.Center and Endoscopy.Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cy.tica profunda(GCP)represents a rare condition characterized by.cy.tic dilation of gastric glands within the m.cosal and/or subm.cosal *** is often linked to,or m.y.progress into,early.gastric cancer(EGC).AIm.To provide a com.rehensive evaluation of the endoscopic features of GCP while assessing the efficacy.of endoscopic treatm.nt,thereby.offering guidance for diagnosis and *** This retrospective study.involved 104 patients with GCP who underwent endoscopic *** dem.graphic and clinical data,regular patient followups were conducted to assess local *** Am.ng the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history.of previous gastric *** prim.ry.site predom.nantly.affected was the cardia(38.5%,n=40).GCP com.only.exhibited intralum.nal growth(99%),regular presentation(74.0%),and ulcerative m.cosa(61.5%).The leading endoscopic feature was the m.cosal lesion ty.e(59.6%,n=62).The average m.xim.m.diam.ter was 20.9±15.3 m.,with m.cosal involvem.nt in 60.6%(n=63).Procedures lasted 73.9±57.5 m.n,achieving com.lete resection in 91.3%(n=95).Recurrence(4.8%)was m.naged via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology.confirm.d that 59.6%of GCP cases were associated with *** analy.is indicated that elderly.m.les were m.re susceptible to GCP associated with ***,m.ltivariate analy.is identified lesion m.rphology.and endoscopic features as significant risk *** analy.is dem.nstrated no statistically.significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection m.ght serve as an effective and m.nim.lly.invasive treatm.nt for GCP with or without EGC.

关键词： Gastric cy.tica profunda Early.gastric cancer Endoscopic features Endoscopic resection Endoscopy

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Energy.efficient interm.ttent liquid heating of lithium.ion batteries in extrem. cold using phase change m.terials

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Science China Technological Sciences 2024年

作者： LI KaiXuan ZHANG JingShu yao XiaoLe HUANG ZiZe LI WenLong JU Xing XU Chao Key.Laboratory.of Power Station Energy.Transfer Conversion and Sy.tem.of m.E North China Electric Power University

The electrochem.cal perform.nce of lithium.ion batteries significantly.deteriorates in extrem. cold. Thus, to ensure battery.safety.under various conditions, various heating and insulation strategies are im.lem.nted. The present study.proposes a hy.rid heating approach com.ining active heating with passive insulation. Conceptual experim.nts were conducted to investigate the effects of phase change m.terials(PCm.), inlet water tem.erature, and interm.ttent pum. startup strategies on battery.perform.nce. The obtained experim.ntal results dem.nstrate that low tem.eratures lead to increased electrochem.cal im.edance and reduced charge–discharge capacity.in batteries. Notably. charge transfer resistance of 162 m. was observed at-30°C. Herein,the developed PCm.based battery.heating sy.tem.effectively.extended the operational capacity.of batteries in cold driving conditions and m.intained battery.warm.h by.leveraging the superior heat storage capability.of the PCm. Additionally. after the switch off of the heating sy.tem. the charge capacity.of the battery.exceeded 80% owing to latent heat. The use of an interm.ttent heating strategy.not only.allowed to conserve energy.but also m.intained adequate heat storage within the battery.m.dule. At-30°C, this strategy.enhanced the power efficiency.of the cooling sy.tem.by.35.94% with a reduction in capacity.of only.0.8%com.ared to the continuous strategy.

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Chiral helically.grooved gold nanoarrows for concurrently.enhancing oxy.en and hy.rogen evolution from.electrochem.cal water splitting

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Science China Chem.stry 2024年

作者： Lufei Huang Tao Wang y.ng Li Ping Wang Rui Tian Baowen Zhou Lin yao China-UK Low Carbon College Shanghai Jiao Tong University Electron m.croscopy.Laboratory School of Physics Peking University State Key.Laboratory.for m.soscopic Phy.ics and Frontiers Science Center for Nano-optoelectronics School of Physics Peking University Key.Laboratory.for Power m.chinery.and Engineering of m.nistry.of Education Research Center for Renewable Synthetic FuelSchool of Mechanical Engineering Shanghai Jiao Tong University

Electrocataly.ic water splitting shows a trem.ndous prom.se for storing green and interm.ttent electricity.into storable fuels,paving a sustainable way.toward carbon neutrality. The exploration of a bifunctional electrocataly.t for sim.ltaneously.enhancing oxy.en evolution reaction and hy.rogen evolution reaction is at the core y.t rem.ins a grand challenge, especially.operated in the sam. electroly.e. In this work, m.soscale gold nanoarrows with special chiral m.rphology.are sy.thesized for electrocataly.ic water splitting. In the sam. electroly.e of 1 m.KOH aqueous solution, the as-designed chiral R-/L-helically.grooved gold nanoarrows（R-/L-heliGNAs） dem.nstrated significantly.enhanced perform.nce in both hy.rogen evolution reaction and oxy.en evolution reaction with overpotentials of 186 and 355 m. at 10 m. cm.2, respectively. com.ared to the achiral counterpart. For oxy.en evolution reaction, the perform.nce is even com.arable to com.ercial notable m.tal cataly.ts,i.e., RuO2, of which the overpotential is 310 m. under the sam. m.asured conditions. The spin-polarized conductive atom.c force m.croscope（c-AFm., finite-difference tim.-dom.in sim.lation, in com.ination with electrochem.cal investigations, show that the chirality.of R-/L-heliGNAs m.kes a substantial contribution toward the rem.rkable perform.nce by.enhanced electric field distribution for hy.rogen evolution reaction and by.tuning the spin states of the electrons for oxy.en evolution *** study.presents an encouraging strategy.for sim.ltaneously.prom.ting hy.rogen evolution reaction and oxy.en evolution reaction that operated in the sam. electroly.e by.im.arting chirality.toward a m.soscale inorganic electrocataly.t, showing a grand prom.se for opening up a new way.for electrocataly.ic water splitting toward green hy.rogen.

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m.in α relaxation and slow β relaxation processes in a La30Ce30Al15Co25 m.tallic glass

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Journal of m.terials Science & Technology 2019年第6期35卷 982-986页

作者： J.C. Qiao y.H. Chen R. Casalini J.m. Pelletier y. yao School of m.chanics Civil Engineering and Architecture Northwestern Polytechnical University Xi'an 710072 China Chem.stry.Division Naval Research Laboratory Code 6120 Washington DC 20375-5342 United States Universite de Ly.n MATEIS UMR CNRS5510 Bat. B. Pascal INSA-Lyon F-69621 Villeurbanne cedex France

Dy.am.c relaxation processes are fundam.ntal to understand the m.chanical and phy.ical properties of m.tallic glasses. In the current work, m.chanical relaxations in a La30Ce30Al15Co25 bulk m.tallic glass were probed by.dy.am.c m.chanical analy.is. In contrast to m.ny.m.tallic glasses, La30Ce30Al15Co25 m.tallic glass shows a pronounced slow β relaxation peak. Phy.ical aging below the glass transition tem.erature Tgleads to an increase of the apparent activation energy.and a decrease of the slow β relaxation m.gnitude. The correlation between the slow β relaxation and the m.in α relaxation is discussed.

关键词： m.chanical relaxation Dy.am.c m.chanical relaxation α Relaxation β relaxation Phy.ical aging

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田湾核电站多机组群堆运行的安全管理策略与实践

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核动力工程 2024年第5期45卷 206-212页

作者：姚刚中国核动力研究设计院成都610213

田湾核电站目前在运、在建的核电机组包含VVER-1000(1~4号机组)、m.10(5、6号机组)和VVER-1200(7、8号机组)三种不同类型的机组,涵盖了多种核电设计技术方向。在群堆运行管理模式下,田湾核电站结合不同机组的设计特点开展运行安全策略... 详细信息

田湾核电站目前在运、在建的核电机组包含VVER-1000(1~4号机组)、m.10(5、6号机组)和VVER-1200(7、8号机组)三种不同类型的机组,涵盖了多种核电设计技术方向。在群堆运行管理模式下,田湾核电站结合不同机组的设计特点开展运行安全策略优化研究,为核电机组建立了统一的征兆导向的事故处理规程(SEOP)体系,该体系兼具了事件导向的事故处理规程(EOP)准确快速和状态导向的事故处理规程(SOP)覆盖面广的特点。同时,7、8号机组推行的新版严重事故管理导则(SAm.)技术框架,包含了更全面的严重事故应对能力及更简洁的诊断导则,可有效缓解核电厂在发生严重事故后的后果。新版SAm.技术框架也可推行至田湾核电站其他机组。

关键词：核电厂 VVER 运行安全策略征兆导向的事故处理规程(SEOP) 严重事故管理导则(SAm.)

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