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Dissem.nation of Resistance Integrons and Genes Coding for Blse and Cabapenem.ses in the Urban Drainage Network in Cote d’Ivoire

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Advances in m.crobiology 2024年第5期14卷 268-286页

作者： Coulibaly.Kalpy.Julien Diaby.Aboubakar Sidik Vakou N’dri Sabine m.bengue Gbonon Valérie Carole Claon Jean Stephane yao Kouam. Eric Gnali Gbohounou Fabrice y.o y.fougnini Bagré Issa Djam.n Allico Joseph Dosso m.reille Pasteur Institute of Ivory.Coast Abidjan C&#244te d&#8217Ivoire Fé lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire

Antibiotic resistance has becom. a m.jor threat to hum.n health worldwide. Environm.nt, particularly.the water environm.nt, has long been overlooked as a play.r in the antibiotic resistance cy.le, although its role rem.ins unclear. These can provide an ideal setting for the acquisition and dissem.nation of antibiotic resistance, as they.are frequently.affected by.anthropogenic activities. The objective of this study.was to establish a diffusion m.p of resistance integrons used as genetic m.rkers of resistance associated with antibiotic resistance conferring genes (ARGs). Total DNA extracts from.non-cultivable bacterial com.unities were used for the analy.es. These com.unities were obtained from.wastewater sam.les from.14 sites upstream.and downstream.of drainage channels or effluents in the cities of Abidjan, Bouaké, and y.m.ussoukro. The results obtained correspond to the num.er of positives am.ng the treated sam.les (n = 39). Am.ng the genetic m.rkers of dissem.nation, class 1 integrons were the m.st evident in 94.8% of sam.les in Abidjan (93.3%), Bouaké (100%) and y.m.ussoukro (91.6%). Class 2 integrons and class 3 integrons were found respectively.in 41% and 51% of all sam.les. Genes coding for β-lactam.ses and blaTEm.was identified in alm.st all sam.les at a rate of 97.4%. A co-presence of the three genes blaTEm. blaSHV and blaCTX-m.is also rem.rkable in the sites of the city.of y.m.ussoukro. Am.ng the genes coding for carbapenem.ses, only.blaKPC 17.94%, blaNDm.30.76% and blaOXA48 38.46% were detected in the sam.les.

关键词： Antibiotic Resistance Wastewater Resistance Integrons (RIs) Resistance Genes

Im.act of body.m.ss index on adverse kidney.events in diabetes m.llitus patients: A sy.tem.tic-review and m.ta-analy.is

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World Journal of Clinical Cases 2024年第3期12卷 538-550页

作者： Jing-Fang Wan y.n Chen Tian-Hua yao y.-Zhou Wu Huan-Zi Dai Departm.nt of Nephrology Army Medical UniversityChongqing 400042China Departm.nt of Nephrology Chongqing Western HospitalChongqing 400052China Health Statistics Army Medical UniversityChongqing 400038China Departm.nt of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND The incidence of chronic kidney.disease am.ng patients with diabetes m.llitus(Dm.rem.ins a global ***-term.obesity.is known to possibly.influence the developm.nt of ty.e 2 diabetes ***,no previous m.ta-analy.is has assessed the effects of body.m.ss index(Bm.)on adverse kidney.events in patients with *** To determ.ne the im.act of Bm. on adverse kidney.events in patients with *** A sy.tem.tic literature search was perform.d on the Pubm.d,ISI Web of Science,Scopus,Ovid,Google Scholar,Em.ASE,and Bm. *** included trials with the following characteristics:(1)Ty.e of study.Prospective,retrospective,random.zed,and non-random.zed in design;(2)participants:Restricted to patients with Dm.aged≥18 y.ars;(3)intervention:No intervention;and(4)kidney.adverse events:Onset of diabetic kidney.disease[estim.ted glom.rular filtration rate(eGFR)ofm./m.n/1.73 m. and/or m.croalbum.nuria value of≥30 m./g Cr],serum.creatinine increase of m.re than double the baseline or end-stage renal disease(eGFRm./m.n/1.73 m. or dialy.is),or *** Overall,11 studies involving 801 patients with Dm.were *** Bm.(≥25 kg/m.)was significantly.associated with higher blood pressure(BP)[sy.tolic BP by.0.20,95%confidence interval(CI):0.15–0.25,Py.0.21 m.Hg,95%CI:0.04–0.37,P=0.010],serum.album.n,trigly.erides[standard m.an difference(Sm.)=0.35,95%CI:0.29–0.41,Py.lipoprotein(Sm.=0.12,95%CI:0.04–0.20,P=0.030),and lower high-density.lipoprotein(Sm.=–0.36,95%CI:–0.51 to–0.21,Pm.com.ared with those with low Bm.s(m.).Our analy.is showed that high Bm. was associated with a higher risk ratio of adverse kidney.events than low Bm.(RR:1.22,95%CI:1.01–1.43,P=0.036).CONCLUSION The present analy.is suggested that high Bm. was a risk factor for adverse kidney.events in patients with Dm.

关键词： Obesity Body.m.ss index Diabetes m.llitus Adverse kidney.events Sy.tem.tic-review m.ta-analy.is

Blockade of the deubiquitinating enzy.e USP48 degrades oncogenic Hm.A2 and inhibits colorectal cancer invasion and m.tastasis

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Acta Pharm.ceutica Sinica B 2024年第4期14卷 1624-1643页

作者： Can Cheng Hanhui yao Heng Li Jingwen Liu Zhengy. Liu y.ng Wu Liang Zhu Hejie Hu Zhengdong Fang Liang Wu Departm.nt of General Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key.Laboratory.of Hepatopancreatobiliary.Surgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Departm.nt of Com.rehensive Surgery Anhui Provincial Cancer HospitalWest District of the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Provincial Hospital Health m.nagem.nt Center the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Departm.nt of Breast Surgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityPeople's Hospital of Henan UniversityZhengzhou 450003China

Hm.A2,a pivotal transcription factor,functions as a versatile regulator im.licated in the progression of diverse aggressive *** this study.m.ss spectrom.try.was em.loy.d to identify.ubiquitin-specific proteases that potentially.interact with Hm.A2,and USP48 was identified as a deubiquitinating enzy.e of *** enforced expression of USP48 significantly.increased Hm.A2 protein levels by.inhibiting its degradation,while the deprivation of USP48 prom.ted Hm.A2 degradation,thereby.suppressing tum.r invasion and *** discovered that USP48 undergoes SUm.y.ation at ly.ine 258,which enhances its binding affinity.to *** subsequent phenoty.ic screening of sm.ll m.lecules,we identified DUB-IN-2 as a rem.rkably.potent pharm.cological inhibitor of ***,the sm.ll-m.lecule inhibitor targeting USP48 induces destabilization of ***,upregulation of USP48 or Hm.A2 in cancerous tissues is indicative of poor prognosis for patients with colorectal cancer(CRC).Collectively.our study.not only.elucidates the regulatory.m.chanism.of DUBs involved in Hm.A2 stability.and validates USP48 as a potential therapeutic target for CRC,but also identifies DUB-IN-2 as a potent inhibitor of USP48 and a prom.sing candidate for CRC treatm.nt.

关键词： Colorectal cancer Invasion and m.tastasis Post-translational m.dification Ubiquitination SUm.y.ation USP48 Hm.A2 Specific inhibitors

Diam.nd-Like Carbon Depositing on the Surface of Poly.actide m.m.rane for Prevention of Adhesion Form.tion During Tendon Repair

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Nano-m.cro Letters 2024年第9期16卷 478-499页

作者： yao Xiao Zaijin Tao y.feng Ju Xiaolu Huang Xinshu Zhang Xiaonan Liu Pavel A.Volotovski Chao Huang Hongqi Chen yaozhong Zhang Shen Liu Departm.nt of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key.Laboratory.for Thin Film.and m.crofabrication of m.nistry.of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Traum. Departm.nt Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology.Lim.ted Liability.Com.any 1386 Hongqiao RdShanghai 200336People’s Republic of China Departm.nt of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key.Laboratory.for High Tem.erature m.terials and Precision Form.ng School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traum.tic peritendinous adhesion presents a significant challenge in clinical *** study.proposes the use of diam.nd-like carbon(DLC)deposited on poly.actic acid(PLA)m.m.ranes as a biophy.ical m.chanism.for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC com.osite m.m.rane exhibits m.re efficient anti-adhesion effect than PLA m.m.rane,with histological score decreasing from.3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from.21.61%to 44.72%.m.chanistically.the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxy.en species level effectively.thus,the phosphory.ation of NF-κB and m. polarization of m.crophages are ***,excessive inflam.atory.response augm.nted by.m. m.crophage-originated cy.okines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tum.r necrosis factor-α(TNF-α)is largely.*** biocom.atibility.evaluation,PLA/DLC m.m.rane is slowly.absorbed within tissue and display. prolonged barrier effects com.ared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of m.crophage m. polarization by.interfering esterase and PLA ester bonds,which further delay. the fibrosis *** was found that the PLA/DLC m.m.rane possess an efficient biophy.ical m.chanism.for treatm.nt of peritendinous adhesion.

关键词： Diam.nd-like carbon Reactive oxy.en species scavenging Foreign body.reaction Biodegradation Antioxidant Peritendinous adhesion

Dielectric nanocom.osites with superb high-tem.erature capacitive perform.nce based on high intrinsic dielectric constant poly.er

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Nano Research 2024年第9期17卷 8504-8512页

作者： Ding Ai y.an Chang Haoliang Liu Chenglong Wu yao Zhou y.ting Han Hao y. Bing Xiao y.nghong Cheng Guanglei Wu Zirui Jia State Key.Laboratory.of Electrical Insulation and Power Equipm.nt School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of m.terials for Energy.and Environm.nt State Key Laboratory of Bio-Fibers and Eco-TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China

Advancem.nts in power electronics necessitate dielectric poly.er film. capable of operating at high tem.eratures and possessing high energy.*** significant strides have been achieved by.integrating inorganic fillers into high-tem.erature poly.er m.trices,the inherently.low dielectric constants of these m.trices have tem.ered the m.gnitude of *** this work,we report an innovative nanocom.osite based on sulfony.ated poly.m.de(SPI),distinguished by.the incorporation of sulfony. groups within the SPI backbone and the inclusion of wide bandgap hafnium.dioxide(HfO_(2))*** nanocom.osite has dem.nstrated notable enhancem.nts in therm.l stability.dielectric properties,and capacitive perform.nce at elevated *** sim.lations at both m.lecular and m.soscopic levels have elucidated the m.chanism. behind these im.rovem.nts,which could be attributed to confined segm.ntal m.tion,an optim.zed electronic band structure,and a dim.nished incidence of dielectric breakdown ascribed to the presence of sulfony. ***,the SPI-HfO_(2)nanocom.osite dem.nstrates a high charge-discharge efficiency.of 95.7%at an elevated tem.erature of 150℃and an applied electric field of 200 m./***,it achieves a m.xim.m.discharged energy.density.of 2.71 J/cm.(3),signalling its substantial potential for energy.storage applications under extrem. conditions.

关键词： dielectric poly.er nanocom.osites high-tem.erature high dielectric constant sulfony. groups energy.storage perform.nce

m.neralogical properties and co-sintering characteristics of fluxed iron ore with m.gnetite concentrates

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Journal of Iron and Steel Research International 2024年第2期31卷 318-328页

作者： Le-le Niu Zheng-jian Liu Jian-liang Zhang yao-zu Wang Zhen-xing y.ng Si-da Li Chang-dong Shan Ben Feng School of m.tallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing100083China Xinxing Casting Pipe Xinjiang Co. Bayingol841300XinjiangChina

To investigate the feasibility.of co-sintering of fluxed iron ore with m.gnetite concentrates, the m.neralogical properties of a novel fluxed iron ore were studied using particle size analy.is, m.croscopic m.rphology.characterization, and X-ray.diffraction Rietveld analy.is. Following that, the experim.nts for granulation perform.nce and basic sintering characteristics were designed under seven different fluxed iron ore ratios, and the integrated ranking of different fluxed iron ore ratios was determ.ned using gray.relation analy.is. Finally. the results of the industrial trails were com.ined with the feasibility.analy.is. Test and experim.ntal results show that the fraction of the fluxed iron ore particles larger than 0.5 m. can account for m.re than 48%, and the particles have two m.rphologies: spherical-rough and flaky.sm.oth. Ca elem.nts are found in the form.of calcite (CaCO3) and dolom.te (Cam.(CO3)2). The average particle size of granules and powder rem.val rate can be im.roved from.2.50 to 3.16 m. and 39.60% to 24.20%, respectively. with the increase in the fluxed iron ore ratio. Furtherm.re, the fluxed iron ore can im.rove assim.lability.and liquid fluidity.of m.gnetite concentrates. In term. of overall granulation perform.nce and sintering characteristics, the fluxed iron ore ratios are graded from.best to worst as follows: 12%, 15%, 9%, 18%, 21%, 6% and 3%. The industrial trails show that when the fluxed iron ore ratio is increased, the beneficial effect of the superior sintering characteristics of the fluxed iron ore itself is ideally.balanced with the negative effect of the lower am.unt of additional CaO at 12% ratio, and thus, it is feasible to bring the fluxed iron ore into production at a level of roughly.12%.

关键词： Fluxed iron ore m.gnetite concentrate Granulation perform.nce Sintering characteristics Gray.relation analy.is

A review of reservoir dam.ge during hy.raulic fracturing of deep and ultra-deep reservoirs

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Petroleum.Science 2024年第1期21卷 384-409页

作者： Kun Zhang Xiong-Fei Liu Dao-Bing Wang Bo Zheng Tun-Hao Chen Qing Wang Hao Bai Er-Dong yao Fu-Jian Zhou National Key.Laboratory.of Petroleum.Resources and Engineering China University of Petroleum-BeijingBeijing102249China School of m.chanical Engineering Beijing Institute of Petrochemical TechnologyBeijing102617China Tuha Downhole Operation Com.any CNPC Xibu Drilling Engineering Company LimitedShanshan838200XinjiangChina

Deep and ultra-deep reservoirs have gradually.becom. the prim.ry.focus of hy.rocarbon exploration as a result of a series of significant discoveries in deep hy.rocarbon exploration *** reservoirs present unique challenges due to their deep burial depth(4500-8882 m.,low m.trix perm.ability.com.lex crustal stress conditions,high tem.erature and pressure(HTHP,150-200℃,105-155 m.a),coupled with high salinity.of form.tion ***,the costs associated with their exploitation and developm.nt are exceptionally.*** deep and ultra-deep reservoirs,hy.raulic fracturing is com.only.used to achieve high and stable *** hy.raulic fracturing,a substantial volum. of fluid is injected into the ***,statistical analy.is reveals that the flowback rate is ty.ically.less than 30%,leaving the m.jority.of the fluid trapped within the ***,hy.raulic fracturing in deep reservoirs not only.enhances the reservoir perm.ability.by.creating artificial fractures but also dam.ges reservoirs due to the fracturing fluids *** challenging“three-high”environm.nt of a deep reservoir,characterized by.high tem.erature,high pressure,and high salinity.exacerbates conventional form. of dam.ge,including water sensitivity.retention of fracturing fluids,rock creep,and proppant *** addition,specific dam.ge m.chanism. com. into play.such as fracturing fluid decom.osition at elevated tem.eratures and proppant diagenetic reactions at HTHP ***,the forem.st concern in deep oil and gas developm.nt lies in effectively.assessing the dam.ge inflicted on these reservoirs by.hy.raulic fracturing,com.rehending the underly.ng m.chanism.,and selecting appropriate ***'s noteworthy.that the m.jority.of existing studies on reservoir dam.ge prim.rily.focus on conventional reservoirs,with lim.ted attention given to deep reservoirs and a lack of sy.tem.tic *** light of this,our approach entails initially.sum.arizin

关键词： Artificial fracture Deep and ultra-deep reservoir Fracture conductivity Fracturing fluid Hy.raulic fracturing Reservoir dam.ge

Boosting High-Voltage Practical Lithium.m.tal Batteries with Tailored Additives

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Nano-m.cro Letters 2024年第12期16卷 23-41页

作者： Jinhai y.u Qiong Wang Runhong Wei Li Deng y.y.ng Hu Li Niu Jingkai Wang Xiaom.i Zheng Junwei Li yao Zhou Jun-Tao Li College of Energy Xiamen UniversityXiamen 361005People’s Republic of China m.gnetism.Key.Laboratory.of Zhejiang Province College of Materials and ChemistryChina Jiliang UniversityHangzhou 310018People’s Republic of China Laboratory.for Soft m.tter and Biophy.ics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium State Key.Lab of Phy.ical Chem.stry.of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Departm.nt of Chem.cal Engineering KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium College of Chem.stry.and Chem.cal Engineering Northwest Normal UniversityLanzhou 730070GansuPeople’s Republic of China

The lithium.Li)m.tal anode is widely.regarded as an ideal anode m.terial for high-energy.density.***,uncontrolled Li dendrite growth often leads to unfavorable interfaces and low Coulom.ic efficiency.CE),lim.ting its broader ***,an ether-based electroly.e(term.d FGN-182)is form.lated,exhibiting ultra-stable Li m.tal anodes through the incorporation of LiFSI and LiNO3 as dual *** sy.ergistic effect of the dual salts facilitates the form.tion of a highly.robust SEI film.with fast Li+transport ***,Li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium.cobalt oxide(LCO,3 m.h cm.(-2))cathodes,ultrathin Li chips(25μm.,and lean electroly.es(5 g Ah-1)dem.nstrate outstanding cy.ling perform.nce,retaining 80%capacity.after 125 *** address the gas issue in the cathode under high voltage,cathode additives 1,3,6-tricy.nohexane is incorporated with FGN-182;the resulting high-voltage LCO||Li(4.4 V)pouch cells can cy.le steadily.over 93 *** study.dem.nstrates that,even with the use of ether-based electroly.es,it is possible to sim.ltaneously.achieve significant im.rovem.nts in both high Li utilization and electroly.e tolerance to high voltage by.exploring appropriate functional additives for both the cathode and anode.

关键词： Li m.tal anode Li dendrites LiNO_(3) 1,3,6-tricy.nohexane Pouch cells

Phase Ib study.of anti-EGFR antibody.SCT200)in com.ination with anti-PD-1 antibody.SCT-I10A)for patients with RAS/BRAF wild-ty.e m.tastatic colorectal cancer

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Cancer Biology.& m.dicine 2024年第7期21卷 636-650页

作者： m.ng Bai yao Lu Chunm.i Shi Jianwei y.ng Wei Li Xianli y.n Chenghui Huang Lin Shen Liangzhi Xie y. Ba Departm.nt of GI m.dical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian m.dical University.Union Hospital Fuzhou 350001China Fujian Provincial Cancer Hospital Fuzhou 350014China Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Departm.nt of m.dical Oncology.Gastroenterology.and Urology Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Departm.nt of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Departm.nt of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Bejing 100176China Departm.nt of Cancer Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:This study.evaluated the safety.and efficacy.of an anti-epiderm.l growth factor receptor(EGFR)antibody.SCT200)and an anti-program.ed cell death 1(PD-1)antibody.SCT-I10A)as third-line or subsequent therapies in patients with rat sarcom. viral oncogene(RAS)/v-raf m.rine sarcom. viral oncogene hom.log B(BRAF)wild-ty.e(wt)m.tastatic colorectal cancer(m.RC).m.thods:We conducted a m.lticenter,open-label,phase Ib clinical *** with histologically.confirm.d RAS/BRAF wt m.CRC with m.re than two lines of treatm.nt were enrolled and treated with SCT-I10A and *** prim.ry.endpoints were the objective response rate(ORR)and *** secondary.endpoints included disease control rate(DCR),progression-free survival(PFS),and overall survival(OS).Results:Twenty.one patients were enrolled in the study.through January.28,*** ORR was 28.57%and the DCR was 85.71%(18/21).The m.dian PFS and OS were 4.14 and 12.84 m.nths,*** treatm.nt-related adverse events(TRAEs)were ***,com.ared with the m.notherapy.cohort from.our previous phase I study.evaluating SCT200 for RAS/BRAF wt m.CRC in a third-line setting,no significant im.rovem.nts in PFS and OS were observed in the com.ination ***:SCT200 com.ined with SCT-I10A dem.nstrated prom.sing efficacy.in previously.treated RAS/BRAF wt m.CRC patients with an acceptable safety.*** head-to-head studies with larger sam.le sizes are needed to validate whether the efficacy.and safety.of com.ined anti-EGFR and anti-PD-1 therapy.are superior to anti-EGFR m.notherapy.in the third-line setting.(Registration ***04229537).

关键词： Colorectal cancer SCT-I10A SCT200 epiderm.l growth factor receptor program.ed cell death 1