Impact of body mass index on adverse kidney events in diabetes mellitus patients: A systematic-review and meta-analysis

作     者：Jing-Fang Wan Yan Chen Tian-Hua Yao Ya-Zhou Wu Huan-Zi Dai 

作者机构：Department of NephrologyArmy Medical UniversityChongqing 400042China Department of NephrologyChongqing Western HospitalChongqing 400052China Health StatisticsArmy Medical UniversityChongqing 400038China Department of NephrologyDaping HospitalArmy Medical UniversityChongqing 400042China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第3期

页      面：538-550页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by Special Project for Improving Science and Technology Innovation Ability of Army Medical University No.2022XLC09 

主　　题：Obesity Body mass index Diabetes mellitus Adverse kidney events Systematic-review Meta-analysis 

摘      要：BACKGROUND The incidence of chronic kidney disease among patients with diabetes mellitus(DM)remains a global ***-term obesity is known to possibly influence the development of type 2 diabetes ***,no previous meta-analysis has assessed the effects of body mass index(BMI)on adverse kidney events in patients with *** To determine the impact of BMI on adverse kidney events in patients with *** A systematic literature search was performed on the PubMed,ISI Web of Science,Scopus,Ovid,Google Scholar,EMBASE,and BMJ *** included trials with the following characteristics:(1)Type of study:Prospective,retrospective,randomized,and non-randomized in design;(2)participants:Restricted to patients with DM aged≥18 years;(3)intervention:No intervention;and(4)kidney adverse events:Onset of diabetic kidney disease[estimated glomerular filtration rate(eGFR)of60 mL/min/1.73 m2 and/or microalbuminuria value of≥30 mg/g Cr],serum creatinine increase of more than double the baseline or end-stage renal disease(eGFR15 mL/min/1.73 m2 or dialysis),or *** Overall,11 studies involving 801 patients with DM were *** BMI(≥25 kg/m2)was significantly associated with higher blood pressure(BP)[systolic BP by 0.20,95%confidence interval(CI):0.15–0.25,P0.00001;diastolic BP by 0.21 mmHg,95%CI:0.04–0.37,P=0.010],serum albumin,triglycerides[standard mean difference(SMD)=0.35,95%CI:0.29–0.41,P0.00001],low-density lipoprotein(SMD=0.12,95%CI:0.04–0.20,P=0.030),and lower high-density lipoprotein(SMD=–0.36,95%CI:–0.51 to–0.21,P0.00001)in patients with DM compared with those with low BMIs(25 kg/m2).Our analysis showed that high BMI was associated with a higher risk ratio of adverse kidney events than low BMI(RR:1.22,95%CI:1.01–1.43,P=0.036).CONCLUSION The present analysis suggested that high BMI was a risk factor for adverse kidney events in patients with DM.