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Recent Progress in AIE-active Poly.ers

Chinese Journal of Poly.er Science 2019年第4期37卷 289-301,I0004页

作者： y. bing hu Jacky.W.y.Lam Ben Zhong Tang HKUST-Shenzhen Research Institute Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology

The demand for highly.efficient solid-state luminophores is continuously.growing due to their potential applications in optoelectrical devices, chemosensors, and biological applications. The discovery.of luminogens with aggregation-induced emission(AIE)by.Tang et al. in 2001 provides a good reponse to this demand. Among the exploited AIE luminogens, AIE-active poly.ers possess many.advantages such as simple sy.thesis, convenient structrue modifications, and good processability. which offer an extensive platform for scientists and engineers. Herein, the design principles and latest sy.thetic advancement of AIE-active poly.ers are summarized, including click poly.erization and multicomponent poly.erization. Non-conjugated heteroatom-rich poly.ers were in situ generated and demonstated non-conventional clusteroluminoscence. Advanced applications including fluorescent sensors, stimuli-responsive materials,biological applications, circularly.polarized luminescence, and electroluminescence are then introduced in detail. AIE-active poly.ers display.the signal-amplification effect for sensitive and selective response to chemo/bioanaly.es or stimuli and enhanced photosensitization effect for cancer theranostics. Retrospecting the expansion of this field can further strengthen our belief that AIE-active poly.ers are promising for conceptual innovation and technological breakthroughs in the near future.

关键词： Aggregation-induced emission Poly.er sy.thesis High-tech application

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Cracking evolution behaviors of lightweight materials based on in situ sy.chrotron X-ray.tomography. A review

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Frontiers of Mechanical Engineering 2018年第4期13卷 461-481页

作者： y. Luo S. C. Wu y. N. hu y. N. Fu State Key.Laboratory.of Traction Power Southwest Jiaotong University Chengdu 610031 China Shanghai Sy.chrotron Radiation Facility Shanghai 201204 China

Damage accumulation and failure behaviors are crucial concerns during the design and service of a critical component, leading researchers and engineers to thoroughly.identify.ng the crack evolution. Third-generation sy.chrotron radiation X-ray.computed microtomo- graphy.can be used to detect the inner damage evolution of a large-density.material or component. This paper provides a brief review of study.ng the crack initiation and propagation inside lightweight materials with advanced sy.chrotron three-dimensional （3D） X-ray.imaging, such as aluminum materials. Various damage modes under both static and dy.amic loading are elucidated for pure aluminum, aluminum alloy.matrix, aluminum alloy.metal matrix composite, and aluminum alloy.welded joint. For aluminum alloy.matrix, metallurgical defects （porosity. void, inclusion, precipitate, etc.） or artificial defects （notch, scratch, pit, etc.） strongly.affect the crack initiation and propagation. For aluminum alloy.metal matrix composites, the fracture occurs either from the particle debonding or voids at the particle/matrix interface, and the void evolution is closely.related with fatigued cy.les. For the hy.rid laser welded aluminum alloy. fatigue cracks usually.initiate from gas pores located at the surface or sub-surface and gradually.propagate to a quarter ellipse or a ty.ical semi-ellipse profile.

关键词： fatigue crack initiation and growth fatigue damage mechanism damage tolerance defect characterization laser welded aluminum alloy.

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BIOPOLy.ER BASED NANO-DELIVERy.Sy.TEMS FOR ENHANCING BIOAVAILABILITy.OF NUTRACEUTICALS

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Chinese Journal of Poly.er Science 2013年第9期31卷 1190-1203页

作者： bing hu Qing-rong huang College of Food Science and Technology Nanjing Agricultural University Department of Food Science Rutgers University

Recently. there has been an increasing interest in the development of efficient food-grade oral nano-delivery.sy.tems for encapsulation, protection and target delivery.of nutraceuticals to enhance their bioavailability. fiarther to prevent disease and promote human health and well-being. Food proteins represent promising candidates for efficient nutraceutical nanocarriers due to their exceptional characteristics, namely.biodegradability. nonantigenicity. high nutritional value, abundant renewable sources and extraordinary.binding capacity.to various nutraceuticals. In addition, their biocompatibility. biodegradability. low toxicity. low cost, and non-starch poly.accharides possess many.favourable characteristics such as stability.in the harsh gastric environment, resistance to digestive enzy.es, and mucoadhesiveness to intestinal mucosal surface. This review describes the design and formation of nanoscaled delivery.sy.tems for nutraceuticals using food-grade proteins （including peptides）, poly.accharides and their associative complexes. The toxicity.and cellular uptake fate of the nanostructures, as well as their effects on the intestinal absorption of the encapsulated nutraceuticals were also discussed.

关键词： Food biopoly.er Nano-delivery.sy.tems Bioavailability Nutraceuticals.

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Suppression of grain boundary.migration at cry.genic temperature in an extremely.fine nanograined Ni-Mo alloy

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Journal of Materials Science & Technology 2020年第22期54卷 65-69页

作者： J.hu J.X.Li y.-N.Shi Sheny.ng National Laboratory.for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute of Advanced Materials East China JiaoTong UniversityNanchang 330013China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Microindentation creep tests on an electrodeposited extremely.fine(4.9 nm) nanograined(ng) Ni-14.2 at.% Mo(Ni-14.2 Mo) at both room temperature(RT) and liquid nitrogen temperature(LNT) demonstrated that lowering temperature retarded softening in the ng Ni-Mo alloy. The obtained strain rate sensitivity.at LNT was one order of magnitude lower than that at RT. Microstructural characterization revealed that mechanically.driven grain boundary.GB) migration was greatly.suppressed by.lowering temperature,which might be ascribed to the presence of solute Mo atoms that significantly.retarded coupled GB motion at LNT. Deformation was instead carried by.shear bands.

关键词： Extremely.fine nanograined metals Mechanically.driven grain boundary.migration Cry.genic temperature Shear bands Solute atoms

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EFFECTS OF METAL IONS ON THE CONFORMATIONAL CHANGES OF DNA

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Acta Metallurgica Sinica(English Letters) 2005年第5期18卷 659-663页

作者： G. Q. Liu y. y. Meng S.H. Liu y.H. hu Laser Life Science Institute South China Normal University Guangzhou 510631China Department of Medical Oncology Cancer Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

DNA takes on multi-different conformations such as A-, B-, C-, D- and Z-form. These conformations can transit to one another when DNA deposited in some metal ions solutions or when changing the concentrations of the same metal ions. Here, several major conformational transitions of DNA induced by.metal ions under different environment were introduced and the mechanism of the interaction of metal ions with DNA was discuss in detail.

关键词： DNA conformation transition mechanism condensation

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Experiment on building a real-time temperature field distribution model of the prostate using special data encry.tion multi-pole radiofrequency.ablation and a visualization phantom

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Chinese Science Bulletin 2011年第35期56卷 3845-3853页

作者： CHEN Lei hu bing hu Bin Department of Ultrasound Affiliated Sixth People ＂s Hospital Shanghai Jiaotong University Shanghai 200233 China

The aim of this study.was to explore the utility.of a visualization phantom for building a real-time temperature field distribution model of the prostate created by.the application of special data encry.tion(SDE) multi-pole radiofrequency.RF) *** prepared phantoms(phantom group) using acry.amide as the raw material and egg-white as a color developing *** prostate specimens of male adult dogs were fixed in this phantom to create a prostate phantom(prostate group).The SDE multi-pole RF electrode was inserted into the two groups for RF ablation,and the temperature changes at relevant points in space were *** set the x-axis as the left and right direction,the y.axis as the fore and aft direction,and the z-axis as the insertion direction of the RF *** this process,the effect of RF ablation on the appearance of each of the two groups was *** temperature measurements taken during the operation,a three-dimensional(3D) surface model of temperature was constructed by.drawing the boundary.areas of different temperatures on the maximum x-z plane of the two groups of ablation lesions,with y.equivalent to *** comparison of the temperature-time change curves of four space points were made by.setting y.equivalent to 0,z equivalent to 0.5,and x equivalent to 0,0.25,0.5 and *** solid lesions with a diameter of approximately.12 mm could be found in both groups after RF *** the ablation of the phantom group,the temperature ascended faster in a zone 1 cm from the needlepoint to the needle body.and 0.5 cm about the radiofrequency.*** time-property.result of the x-z plane with y.equivalent to 0 showed that the boundary.areas of the two groups were closer at 50 and 60°C,but the difference between the two groups at 70°C in the high temperature zone was relatively.*** 3D temperature surface model further proved that the 3D temperature outline at 60°C was in better concordance with the actual effect of RF abl

关键词：温度场分布射频消融前列腺癌数据加密分布模型临床试验可视化多极

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An Overview of Epigenetics in Chinese Medicine Researches

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Chinese Journal of Integrative Medicine 2017年第9期23卷 714-720页

作者： hu Xue-qing SU Shi-bing Research Center for Traditional Chinese Medicine Complexity.Sy.tem Shanghai University of Traditional Chinese MedicineShanghai201203China

Chinese medicine（CM） has contributed to human health care for several thousand y.ars and is still popular in Asian countries. But the mechanisms underly.ng CM remain obscure, and need to be clarified by.modern biological subjects and methods. Recently. CM researches on epigenetics have gained obvious improvement following rapidly.developed molecular technologies. In this review, we revealed mutual characteristics of epigenetics and CM, such as holism, y.n-y.ng dy.amic nature, reversibility.and balance, and visceral manifestation. Moreover, epigenetic modifications, including DNA methy.ation, histone post-transcriptional modifications, micro RNA interference, etc. may.help explore the molecular basis of CM sy.drome classification, and mechanisms of Chinese herbal medicine（CHM）, CHM compounds and Chinese herbal formulae activities. Meanwhile, CM and epigenetics might promote each other and jointly.develop following the continuous progress of epigenetics in CM researches.

关键词： Chinese medicine epigenetics methy.ation histone modification Chinese herbal medicine,Chinese herbal formula Chinese medicine sy.drome

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Regulation of T cell immunity.by.cellular metabolism

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Frontiers of Medicine 2018年第4期12卷 463-472页

作者： Zhilin hu Qiang Zou bing Su Shanghai Institute of Immunology Department of Immunology and Microbiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism play. a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly.controlled to mediate T cell immune responses, and alterations in T cell metabolism may.result in many.immunological disorders. In this review, we will summarize the main T cell metabolic pathway. and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.

关键词： T cell immunity metabolic pathway. nutrient uptake metabolic checkpoints

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Kruppel-like factors and vascular wall homeostasis

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Journal of Molecular Cell Biology 2017年第5期9卷 352-363页

作者： y.nbo Fan Haocheng Lu Weny.ng Liang Wenting hu Jifeng Zhang y. Eugene Chen Cardiovascular Center Department of Internal Medicine University of Michigan Medical Center Ann Arbor MI 48109 USA

Cardiovascular diseases （CVDs） are major causes of death worldwide. Identification of promising targets for prevention and treatment of CVDs is paramount in the cardiovascular field. Numerous transcription factors regulate cellular function through modulation of spe- cific genes and thereby.are involved in the phy.iological and pathophy.iologicai processes of CVDs. Although Kriippel-like factors （KLFs） have a similar protein structure with a conserved zinc finger domain, they.possess distinct tissue and cell distribution patterns as well as biological functions. In the vascular sy.tem, KLF activities are regulated at both transcriptional and posttranscriptional levels. Growing in vitro, in vivo, and genetic epidemiology.studies suggest that specific KLFs play.important roles in vascular walt biology. which further affect vascular diseases. KLFs regulate various functional aspects such as cell growth, differentiation, activa- tion, and development through controlling a whole cluster of functionally.related genes and modulating various signaling pathway. in response to pathological conditions. Therapeutic targeting of selective KLF family.members may.be desirable to achieve distinct treatment effects in the context of various vascular diseases. Further elucidation of the association of KLFs with human CVDs, their underly.ng molecular mechanisms, and precise protein structure studies will be essential to define KLFs as promising targets for therapeutic interventions in CVDs.

关键词： endothelial cells vascular smooth muscle cells inflammation shear stress atherosclerosis vascular injury drugdevelopment

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Automatic Bone Surface Restoration for Markerless Computer-Assisted Orthopaedic Surgery

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 85-90页

作者： Xue hu Ferdinando Rodriguez y.Baena Mechatronics in Medicine Laboratory Imperial College LondonLondonUK

An automatic markerless knee tracking and registration algorithm has been proposed in the literature to avoid the marker insertion required by.conventional computer-assisted knee surgery.resulting in a shorter and less invasive surgical ***,such an algorithm considers intact femur geometry.*** bone surface modification is inevitable due to intra-operative *** mismatched correspondences will degrade the reliability.of registered target *** solve this problem,this work proposed a supervised deep neural network to automatically.restore the surface of processed *** network was trained on a sy.thetic dataset that consists of real depth captures of a model leg and simulated realistic femur *** to the evaluation on both sy.thetic data and real-time captures,the registration quality.can be effectively.improved by.surface *** improvement in tracking accuracy.is only.evident over test data,indicating the need for future enhancement of the dataset and network.

关键词： Bone surface reconstruction Computer assisted orthopedic surgery Markerless femur tracking

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