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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang Yang Liu cheng Yang xuyi chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

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Application of artificial hibernation technology in acute brain injury

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Neural Regeneration Research 2024年第9期19卷 1940-1946页

作者： Xiaoni Wang Shulian chen Xiaoyu Wang Zhen Song Ziqi Wang Xiaofei Niu Xiaochu chen xuyi chen Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina

Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain *** is currently a lack of effective treatment *** has the characteristics of low temperature,low metabolism,and hibernation rhythm,as well as protective effects on the nervous,cardiovascular,and motor *** hibernation technology is a new technology that can effectively treat acute brain injury by altering the body’s metabolism,lowering the body’s core temperature,and allowing the body to enter a state similar to *** review introduces artificial hibernation technology,including mild hypothermia treatment technology,central nervous system regulation technology,and artificial hibernation-inducer *** summarizing the relevant research on artificial hibernation technology in acute brain injury,the research results show that artificial hibernation technology has neuroprotective,anti-inflammatory,and oxidative stress-resistance effects,indicating that it has therapeutic significance in acute brain ***,artificial hibernation technology can alleviate the damage of ischemic stroke,traumatic brain injury,cerebral hemorrhage,cerebral infarction,and other diseases,providing new strategies for treating acute brain ***,artificial hibernation technology is currently in its infancy and has some complications,such as electrolyte imbalance and coagulation disorders,which limit its *** research is needed for its clinical application.

关键词： cute brain injury artificial hibernation hypothermia low metabolism mild hypothermia

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The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

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Neural Regeneration Research 2024年第1期19卷 22-28页

作者： Caiyun Liu Haixin Yu Zhengchao Li Shulian chen Xiaoyin Li xuyi chen Bo chen School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture Science Tianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina Binhai New Area Hospital of TCM TianjinChina Fourth Teaching Hospital of Tianjin University of TCM TianjinChina

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system *** present,no effective clinical treatment *** one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord ***,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord *** hibernation is a futureoriented disruptive technology for human life *** involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold ***,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia *** review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation *** summarizes the relevant research on hypothermia and hibernation for organ and nerve *** studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central *** also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine *** review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial *** present,artificial hibernation technology is not mature,and research fa ces various *** rtheless,the effort is wo rthwhi

关键词： artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

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Three-dimensional-printed collagen/chitosan/secretome derived from HUCMSCs scaffolds for efficient neural network reconstruction in canines with traumatic brain injury

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Regenerative Biomaterials 2022年第1期9卷 572-584页

作者： Xiaoyin Liu Guijun Zhang Pan Wei Lin Zhong Yaxing chen Jianyong Zhang xuyi chen Liangxue Zhou Department of Neurosurgery West China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041SichuanChina Department of Neurosurgery The First People’s Hospital Of Long Quan yi DistrictChengdu 610000SichuanChina Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of People’s Armed Police ForcesTianjin 300162China The First Affiliated Hospital of chengdu Medical College Chengdu 610500SichuanChina Department of General Surgery the Affiliated Hospital of Guizhou Medical UniversityGuiyang CN 540000P.R.GuizhouChina Institute of Medical Security for Maritime Rights Protection of Characteristic Medical Center of Chinese People’s Armed Police Force(PAP) Tianjin300162China

The secretome secreted by stem cells and bioactive material has emerged as a promising therapeutic choice for traumatic brain injury(TBI).We aimed to determine the effect of 3D-printed collagen/chitosan/secretome derived from human umbilical cord blood mesenchymal stem cells scaffolds(3D-CC-ST)on the injured tissue regeneration process.3D-CC-ST was performed using 3D printing technology at a low temperature(20C),and the physical properties and degeneration rate were *** utilization of low temperature contributed to a higher cytocompatibility of fabricating porous 3D architectures that provide a homogeneous distribution of *** after the establishment of the canine TBI model,3D-CC-ST and 3D-CC(3D-printed collagen/chitosan scaffolds)were implanted into the cavity of *** implantation of scaffolds,neurological examination and motor evoked potential detection were performed to analyze locomotor function *** and immunofluorescence staining were performed to evaluate *** group treated with 3D-CC-ST had good performance of behavior *** 3D-CC-ST significantly reduced the cavity area,facilitated the regeneration of nerve fibers and vessel reconstruction,and promoted endogenous neuronal differentiation and synapse formation after *** implantation of 3D-CC-ST also markedly reduced cell apoptosis and regulated the level of systemic inflammatory factors after TBI.

关键词： traumatic brain injury canines secretome low temperature extrusion 3D printing collagen chitosan

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Topic Model Optimization and Data Mining under the eTOM Framework

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通讯和计算机（中英文版） 2010年第6期7卷 19-24页

作者： Ning Zhou Jian He xuyi chen Research Center of lnformation Resources Wuhan University Wuhan 430072 China

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商务数据挖掘与可视化实现方法

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现代图书情报技术 2007年第11期 91-94页

作者：陈旭毅中国移动通信集团贵州有限公司贵阳550004

较全面地讨论商务数据挖掘的系统结构、方法与技术。为了直观、方便地利用商务数据挖掘结果,采用可视化方法是一种优选方案。从商务数据特征值的抽取、处理流程与算法到特征库的建立、降维映射,直至可视化结果的生成都进行详细探讨。

关键词：电子商务数据挖掘可视化方法

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新会计准则、会计错配与利润波动——基于寿险公司资产、负债计量方式影响利润波动的分析

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金融研究 2014年第12期 178-193页

作者：周桦陈旭毅中央财经大学保险学院/中国精算研究院北京100081 华泰财险精算部北京100033

本文在随机利率假设框架下,分析公允价值计量体系的引入对保险公司传统寿险业务利润波动的影响。根据我国保险会计改革的实际情况,本文细分了三种情况进行讨论:资产负债均为历史成本法计量;资产以公允价值方法计量,负债以历史成本法计量... 详细信息

本文在随机利率假设框架下,分析公允价值计量体系的引入对保险公司传统寿险业务利润波动的影响。根据我国保险会计改革的实际情况,本文细分了三种情况进行讨论:资产负债均为历史成本法计量;资产以公允价值方法计量,负债以历史成本法计量;资产负债均为公允价值计量。我们发现:第一种情况下利润释放无波动;第二种情况存在资产负债计量的会计错配,各年会计利润波动最大;最后一种情况的会计利润波动介于前二者之间,且真实反映了寿险公司经营结果。此外,本文还讨论了被保险人参保年龄及缴费期限的选择对利润波动的影响,随着参保年龄与缴费期限增大,会计利润释放的波动性逐渐减小。

关键词：新会计准则会计错配保险会计

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考虑参数随机特征的地源热泵换热器可靠性设计

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暖通空调 2010年第2期40卷 73-75,9页

作者：管昌生陈绪义武汉理工大学

分析了地源热泵换热器设计参数的随机影响因素。结合工程实例,在考虑总负荷及单位管长换热量变异系数的基础上,计算得到了具有一定系统可靠度的埋管管长,并讨论了设计参数变异性对管长计算结果的影响程度。

关键词：随机特征地源热泵换热器可靠性设计

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里弄微更新--一项以问题导向社会空间再生的建筑学教育实验

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建筑学报 2018年第1期 107-111页

作者：李彦伯陈珝怡同济大学建筑与城市规划学院上海200092

介绍和分析了同济大学建筑与城市规划学院基础教学"里弄微更新"课题的架构和教学成果,提出应将社会现实背景作为讨论建筑学教育的核心议题,鼓励从基础阶段开始建构"现场—问题—策略"的逻辑链,注重设计对现实条件的回应性,并基于此反思... 详细信息

介绍和分析了同济大学建筑与城市规划学院基础教学"里弄微更新"课题的架构和教学成果,提出应将社会现实背景作为讨论建筑学教育的核心议题,鼓励从基础阶段开始建构"现场—问题—策略"的逻辑链,注重设计对现实条件的回应性,并基于此反思建筑学教育的组织、导向与定位。

关键词：建筑学教育实验社会空间再生问题导向里弄研究回应性逻辑链

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中枢神经发育中的力学-生物学响应与网络形成

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医用生物力学 2018年第5期33卷 471-476页

作者：赵飞陈旭义张西正锦州医科大学研究生院辽宁锦州121000 武警后勤学院附属医院脑科中心、武警部队脑创伤与神经疾病研究所、天津市神经创伤修复重点实验室天津300162 军事医学科学院卫生装备研究所天津300162

中枢神经发育与成熟过程中,生物力学因素长期以来并未受高度重视。近年来大量研究显示,力学环境等物理因素对神经细胞定向迁移、分化和成熟以及细胞间相互作用具有重要的影响作用。力学因素对脑和脊髓结构和功能的实现具有举足轻重的作... 详细信息

中枢神经发育与成熟过程中,生物力学因素长期以来并未受高度重视。近年来大量研究显示,力学环境等物理因素对神经细胞定向迁移、分化和成熟以及细胞间相互作用具有重要的影响作用。力学因素对脑和脊髓结构和功能的实现具有举足轻重的作用。简要回顾中枢神经发育过程中,神经细胞感受、寻路、调控以及网络塑形中的生物力学作用,并扼要介绍静态和动态力学对神经细胞力学-生物学反应,为未来重建修复中枢神经提供思路。

关键词：神经细胞中枢神经系统细胞相互作用力学-生物学反应生物力学

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