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Nomogram for predicting overall survival in Chinese triple-negative breast cancer patients after surgery

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World Journal of Clinical Cases 2022年第31期10卷 11338-11348页

作者： wei-xun Lin Yan-Na Xie Yao-Kun Chen Jie-Hui Cai Juan Zou Jie-Hua Zheng Yi-Yuan Liu Zhi-Yang Li Ye-Xi Chen Department of Thyroid Breast and Hernia SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND There are few nomograms for the prognosis of Chinese patients with triplenegative breast cancer(TNBC).AIM To construct and validate a nomogram for overall survival(OS)of Chinese TNBC patients after *** This study used the data of SEER*stat 8.3.5 and selected Chinese patients with TNBC operated on between 2010 and *** and multivariate Cox proportional hazard regression models were *** identified variables were integrated to form a predictive nomogram and risk stratification model;it was assessed with C-indexes and calibration *** The median and maximal OS of the 336 patients was 39 and 83 mo,*** multivariate analysis showed that age(P=0.043),marital status(P=0.040),tumor localization(P=0.030),grade(P=0.035),T classification(P=0.012),and N classification(P=0.002)were independent prognostic *** six variables were combined to construct a 1-,3-and 5-year OS *** C-indexes of the nomogram to predict OS were 0.766 and compared to the seventh edition staging system,which was higher(0.766 vs 0.707,P<0.001).In order to categorize patients into different prognostic groups,a risk stratification model was *** was a significant difference between the Kaplan–Meier curves of the entire cohort and each disease stage according to the *** The nomogram provided prognostic superiority over the traditional tumor,node and metastasis *** could help clinicians make individual OS or risk predictions for Chinese TNBC patients after surgery.

关键词： Triple-negative breast cancer Chinese nomogram Risk stratification Overall survival

Prognostic significance of epidermal growth factor-like domain 7 in pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 523-528页

作者： Li Zhou Jian Li Yu-Pei Zhao Jun-Chao Guo Quan-Cai Cui wei-xun Zhou Tai-Ping Zhang Wen-Ming Wu Lei You Hong Shu Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College

BACKGROUND： Recent studies have shown the clinical significance of epidermal growth factor-like domain 7（EGFL7）in a variety of cancers. However, the relationship between EGFL7 and the prognosis of pancreatic cancer（PC） remains unclear. The present study was undertaken to investigate the role of EGFL7 in the prognosis of ***： The expression of EGFL7 in nine PC cell lines was first determined by Western blotting analysis. Tissue microarray-based immunohistochemical staining was performed in paired formalin-fixed paraffin-embedded tumor and non-tumor samples from 83 patients with PC. Finally,correlations between EGFL7 expression and clinicopathological variables as well as overall survival were ***： EGFL7 was widely expressed in all PC cell lines ***7 expression in tumor tissues was significantly higher than that in non-tumor tissues（P0.040）. In addition, univariate analysis revealed that high EGFL7 expression in tumor tissues was significantly associated with poor overall survival,accompanied by several conventional clinicopathological variables, such as gender, histological grade and lymph node metastasis. In a multivariate Cox regression test, EGFL7 expression was identified as an independent marker for longterm outcome of ***： Our data showed that EGFL7 is extensively expressed in PC and that EGFL7 is associated with poor prognosis.

关键词： epidermal growth factor-like domain 7 pancreatic cancer prognosis Western blotting immunohistochemistry tissue microarray

Prospect of Hexagonal CsMg(I1-xBrx)3 Alloys for Deep-Ultraviolet Light Emission

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Chinese Physics Letters 2024年第9期41卷 52-56页

作者： Siyuan Xu Zheng Liu xun Xu Su-Huai wei Yuzheng Guo Xie Zhang School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Beijing Computational Science Research Center Beijing 100193China School of Materials Science and Engineering Northwestern Polytechnical UniversityXi’an 710072China

Materials for deep-ultraviolet(DUV)light emission are extremely rare,significantly limiting the development of efficient DUV light-emitting *** we report CsMg(I_(1−x)Br_(x))3 alloys as potential DUV light *** on rigorous first-principles hybrid functional calculations,we find that CsMgI3 has an indirect bandgap,while CsMgBr3 has a direct ***,we employ a band unfolding technique for alloy supercell calculations to investigate the critical Br concentration in CsMg(I_(1−x)Br_(x))3 associated with the crossover from an indirect to a direct bandgap,which is found to be∼***,CsMg(I_(1−x)Br_(x))3 alloys with 0.366≤6≤1 cover a wide range of direct bandgap(4.38–5.37 eV;284–231 nm),falling well into the DUV *** study will guide the development of efficient DUV light emitters.

关键词： alloys alloy Deep

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航空发动机约简遗传规划起动非线性动态模型

航空动力学报 2006年第4期21卷 759-766页

作者：尉询楷李应红空军工程大学工程学院陕西西安710038

提出了一种新的用于航空发动机最优化起动过程数据驱动动态建模的约简遗传规划(PGP)算法。这种模型采用遗传规划产生航空发动机辨识模型的输入输出非线性模型集,并以二叉树结构表征函数项,运用正交最小二乘算法(OLS)估计二叉树分支对于... 详细信息

提出了一种新的用于航空发动机最优化起动过程数据驱动动态建模的约简遗传规划(PGP)算法。这种模型采用遗传规划产生航空发动机辨识模型的输入输出非线性模型集,并以二叉树结构表征函数项,运用正交最小二乘算法(OLS)估计二叉树分支对于模型精度的贡献并据此去除复杂、冗余的函数项,从而加快遗传规划的收敛速度,最后通过GP进化可获得简单、可靠、准确的线参数非线性线参数动态模型。实际发动机起动过程建模应用案例证明,这种思路对于具有非线性输入输出关系特征的数据可以产生鲁棒性好、解析性强的线参数非线性模型。

关键词：航空航天推进系统航空发动机起动约简遗传规划正交最小二乘非线性动态模型

塔里木巴楚小海子正长岩杂岩体的岩石成因探讨

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岩石学报 2011年第10期27卷 2984-3004页

作者：位荀徐义刚中国科学院广州地球化学研究所同位素地球化学国家重点实验室广州510640 中国科学院研究生院北京100049

巴楚小海子正长岩杂岩体是二叠纪塔里木大火成岩省的重要组成部分。SIMS锆石U-Pb定年显示其形成于279.7±2.0Ma,与本区辉绿岩脉和石英正长斑岩岩脉近于同时侵位。根据矿物学特征,小海子正长岩体可分为铁橄榄石正长岩和角闪正长岩两类。... 详细信息

巴楚小海子正长岩杂岩体是二叠纪塔里木大火成岩省的重要组成部分。SIMS锆石U-Pb定年显示其形成于279.7±2.0Ma,与本区辉绿岩脉和石英正长斑岩岩脉近于同时侵位。根据矿物学特征,小海子正长岩体可分为铁橄榄石正长岩和角闪正长岩两类。前者主要由碱性长石、铁橄榄石、单斜辉石、角闪石和少量石英、斜长石组成,后者主要由碱性长石、角闪石、黑云母和少量的石英、斜长石组成。小海子正长岩体为铁质、碱性系列,轻稀土相对富集,重稀土亏损,具有明显的Eu正异常,无Nb、Ta负异常,相对低的(87Sr/86Sr)i(0.7033～0.7038)和正的εNd(t)值(+3.1～+3.8),暗示它们来自亏损的地幔源区,没有地壳物质的加入。主微量和同位素地球化学分析,暗示巴楚小海子正长岩的母岩浆为碱性的幔源玄武质岩浆经橄榄石、单斜辉石分离结晶后的残余熔体,并且含有堆晶的碱性长石。这种含有碱性长石堆晶的熔体,在相对还原的条件下结晶,形成铁橄榄石正长岩;在相对氧化的条件下结晶,并经过不同程度斜长石的分离结晶形成角闪正长岩。

关键词：正长杂岩体锆石定年碱性玄武质岩石分离结晶小海子巴楚塔里木大火成岩省

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无旁路300MW机组甩负荷试验

热力发电 2008年第1期37卷 95-96页

作者：熊巍西北电力建设调试施工研究所陕西西安710032

介绍了上海汽轮机厂(上汽)无旁路机组甩负荷试验情况,对试验过程进行了分析。并对无旁路300MW机组甩负荷试验过程中出现的汽轮机调速系统振荡、机组难以在短时间内维持空负荷运行、高压缸排汽温度上升较快等问题,提出了技术措施。

关键词： 300 MW机组旁路甩负荷转速调速系统

Effect of combination of extracts of ginseng and ginkgo biloba on acetylcholine in amyloid beta-protein-treated rats determined by an improved HPLC

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Acta Pharmacologica Sinica 2004年第9期 16-21页

作者： Jian-xun LIU, wei-hong CONG, Li XU, Jian-nong WANG Research Center, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China

AIM: To determine the concentration of acetylcholine (ACh) in amyloid beta-protein (Aβ) treated rats and offer a method determining ACh as well. METHODS: A 1-month combination of extrats of ginseng and ginkgo biloba (Naoweikang) ig administration to rats was performed daily after bilateral injection of Aβ1-40 (4 g/L, 1μL for each side) into hippocampus. After

关键词： ginseng ginkgo biloba acetylcholine high pressure liquid chromatography amyloid beta-protein

Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma

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World Journal of Gastroenterology 2014年第47期20卷 17883-17893页

作者： Xue Xu Lin Feng Yu Liu wei-xun Zhou Ying-Cai Ma Gui-Jun Fei Ning An Yuan Li Xi Wu Fang Yao Shu-Jun Cheng Xing-Hua Lu Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical College Graduate School of Peking Union Medical College and Chinese Academy of Medical Science State Key Laboratory of Molecular Oncology Cancer Institute HospitalPeking Union Medical CollegeChinese Academy of Medical Sciences Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical College Department of Gastroenterology Qinghai Provincial People’s Hospital

AIM: To investigate the differentiated whole genome expression profiling of gastric high- and low-grade intraepithelial neoplasia and early-stage adenocarcinoma.

关键词： Gastric early-stage adenocarcinoma High-and low-grade intraepithelial neoplasia G0/G1 switch 2 Whole genome expression microarray Quantitative real-time PCR Immunohistochemical staining

Heterostructural NiFeW disulfide and hydroxide dual‐trimetallic core‐shell nanosheets for synergistically effective water oxidatio

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Carbon Energy 2024年第8期6卷 192-204页

作者： Peng‐Fei Guo Yang Yang Bing Zhu Qian‐Nan Yang Yan Jia wei‐Tao Wang Zhao‐Tie Liu Shi‐Qiang Zhao xun Cui Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'anChina School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'anChina Key Laboratory of Carbon Materials of Zhejiang Province Wenzhou Key Lab of Advanced Energy Storage and ConversionZhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina

A stable and highly active core‐shell heterostructure electrocatalyst is essential for catalyzing oxygen evolution reaction(OER).Here,a dual‐trimetallic core‐shell heterostructure OER electrocatalyst that consists of a NiFeWS_(2)inner core and an amorphous NiFeW(OH)_(z)outer shell is designed and synthesized using in situ electrochemical *** electrochemical measurements of different as‐synthesized catalysts with a similar mass loading suggest that the core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)nanosheets exhibit the highest overall performance compared with that of other bimetallic reference catalysts for the ***,the nanosheet arrays were in situ grown on hydrophilic‐treated carbon paper to fabricate an integrated three‐dimensional electrode that affords a current density of 10 mA cm^(−2)at a small overpotential of 182 mV and a low Tafel slope of 35 mV decade^(−1)in basic *** Faradaic efficiency of core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)is as high as 99.5%for *** scanning electron microscope,transmission electron microscope,and X‐ray photoelectron spectroscopy analyses confirm that this electrode has excellent stability in morphology and elementary composition after long‐term electrochemical ***,density functional theory calculations further indicate that the core‐shell heterojunction increased the conductivity of the catalyst,optimized the adsorption energy of the OER intermediates,and improved the OER *** study provides a universal strategy for designing more active core‐shell structure electrocatalysts based on the rule of coordinated regulation between electronic transport and active sites.

关键词： amorphous NiFeW hydroxide core‐shell heterojunction in situ electrochemical tuning NiFeW disulfide oxygen evolution reaction