Nomogram for predicting overall survival in Chinese triple-negative breast cancer patients after surgery
作者机构：Department of ThyroidBreast and Hernia SurgeryThe Second Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of Respiratory and Critical Care MedicineThe First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第31期
页 面：11338-11348页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the Special Fund Project of Guangdong Science and Technology,No.210728156901524,and No.210728156901519 Medical Scientific Research Foundation of Guangdong Province,China,No.A2021432,and No.B2021448 Shantou Medical Science and Technology Planning Project,No.210521236491457,and No.210625106490696
主 题：Triple-negative breast cancer Chinese nomogram Risk stratification Overall survival
摘 要：BACKGROUND There are few nomograms for the prognosis of Chinese patients with triplenegative breast cancer(TNBC).AIM To construct and validate a nomogram for overall survival(OS)of Chinese TNBC patients after *** This study used the data of SEER*stat 8.3.5 and selected Chinese patients with TNBC operated on between 2010 and *** and multivariate Cox proportional hazard regression models were *** identified variables were integrated to form a predictive nomogram and risk stratification model;it was assessed with C-indexes and calibration *** The median and maximal OS of the 336 patients was 39 and 83 mo,*** multivariate analysis showed that age(P=0.043),marital status(P=0.040),tumor localization(P=0.030),grade(P=0.035),T classification(P=0.012),and N classification(P=0.002)were independent prognostic *** six variables were combined to construct a 1-,3-and 5-year OS *** C-indexes of the nomogram to predict OS were 0.766 and compared to the seventh edition staging system,which was higher(0.766 vs 0.707,P0.001).In order to categorize patients into different prognostic groups,a risk stratification model was *** was a significant difference between the Kaplan–Meier curves of the entire cohort and each disease stage according to the *** The nomogram provided prognostic superiority over the traditional tumor,node and metastasis *** could help clinicians make individual OS or risk predictions for Chinese TNBC patients after surgery.
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