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中国9个长寿地区65岁及以上老年人尿镉水平与体重指数及身体围度的关联研究

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中华预防医学杂志 2024年第2期58卷 227-234页

作者：章正吴兵曲英莉李阳徐岚静吕春贤陈晨王君薛锴魏源周锦辉郑栩琳裘一丹罗宇菲刘俊鑫吕跃斌施小明南京医科大学公共卫生学院全球健康中心南京211166 中国疾病预防控制中心环境与人群健康重点实验室、中国疾病预防控制中心环境与健康相关产品安全所北京100021 吉林大学公共卫生学院长春130012

目的研究我国9个长寿地区65岁及以上老年人尿镉与体重指数(BMI)及身体围度的关联。方法研究对象来自2017—2018年在我国9个长寿地区开展的“中国老年健康生物标志物队列研究”,共计1968名65岁及以上老年人被纳入本研究。通过问卷调查和... 详细信息

目的研究我国9个长寿地区65岁及以上老年人尿镉与体重指数(BMI)及身体围度的关联。方法研究对象来自2017—2018年在我国9个长寿地区开展的“中国老年健康生物标志物队列研究”,共计1968名65岁及以上老年人被纳入本研究。通过问卷调查和体格检查,收集调查对象的社会人口学特征、生活方式、膳食摄入和健康状态等信息,采集调查对象晨尿以检测尿镉和尿肌酐水平;身体围度包括腰围、臀围和小腿围。根据尿肌酐校正后尿镉水平三分位数将调查对象分为低水平组(<0.77μg/g·肌酐)、中水平组(0.77~1.69μg/g·肌酐)和高水平组(≥1.69μg/g·肌酐),采用多重线性回归模型分析尿肌酐校正后尿镉不同水平与BMI及身体围度的关联,采用限制性立方样条拟合多重线性回归模型分析尿肌酐校正后尿镉水平与BMI及身体围度的剂量-反应关系。结果1968名研究对象年龄为(83.34±11.14)岁,尿肌酐校正后尿镉水平的M(Q_(1),Q_(3))为1.13(0.63,2.09)μg/g·肌酐,BMI为(22.70±3.82)kg/m^(2),腰围为(85.42±10.68)cm,臀围为(92.67±8.90)cm,小腿围为(31.08±4.76)cm。多重线性回归模型分析结果显示,调整相关混杂因素后,尿肌酐校正后尿镉每增加1μg/g·肌酐,BMI、腰围、臀围和小腿围的变化水平β(95%CI)值分别为-0.28(-0.37,-0.19)kg/m^(2)、-0.74(-0.96,-0.52)cm、-0.78(-0.96,-0.61)cm和-0.20(-0.30,-0.11)cm;限制性立方样条模型结果显示,尿肌酐校正后尿镉水平与BMI呈负向非线性关联(P_(非线性)<0.001),与腰围、臀围和小腿围呈负向线性关联(均P线性<0.001)。结论中国9个长寿地区65岁及以上老年人尿肌酐校正后尿镉水平与BMI、腰围、臀围和小腿围呈负向关联。

关键词：体重指数老年人横断面研究尿镉身体围度

Admittance spectroscopy characterize graphite paste for back contact of CdTe thin film solar cells

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Science China(Technological Sciences) 2010年第9期53卷 2337-2341页

作者： HE xulin,ZHANG JingQuan,FENG LiangHuan,wu LiLi,LI Wei,ZENG GuangGen,LEI Zhi,LI Bing & ZHENG JiaGui College of Materials Science and Engineering,Sichuan University,Chengdu 610064,China College of Materials Science and Engineering Sichuan University

CdTe thin film solar cells with a doped-graphite paste back contact layer were studied using admittance spectroscopy *** positions and the capture cross sections of energy level in the forbidden band were calculated,which are the important parameters to affect solar cell *** results showed that there were three defects in the CdTe thin films solar cells with the doped-graphite paste back contact layer,whose positions in the forbidden band were close to 0.34,0.46 and 0.51 eV,respectively above the valence band,and capture cross sections were 2.23×10-16,2.41×10-14,4.38×10-13 cm2,respectively.

关键词： CdTe solar cells admittance spectroscopy deep-level defect

SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3055-3069页

作者： Pan Pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang Yu Zhen Luo xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo wu The First Affiliated Hospital of Jinan University 510632GuangzhouChina Foshan Institute of Medical Microbiology 528315FoshanChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan University510632GuangzhouChina State Key Laboratory of Virology College of Life SciencesWuhan University430072WuhanChina The First People’s Hospital of Foshan 528315FoshanChina

Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe ***,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus *** how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its ***,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N *** found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’*** study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and ***,N protein specifically interacted with anti-apoptotic protein MCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of MCL-1,which stabilized this protein and promoted it to hijack Bak in ***,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a MCL-1 specific inhibitor,***,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral *** may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other *** anticipate that abrogating the N/MCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses.

关键词： apo prevention promoted

Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial

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Chinese Journal of Cancer Research 2017年第2期29卷 144-148页

作者： Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao wu Jing Zhou Jun Zhang Gang Zhao xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji Department of Gastrointestinal Surgery the First Affiliated Hospital of Dalian Medical University Dalian 116011 China Deparunent of General Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Abdominal Surgery Zhejiang Cancer Hospital Hangzhou 310022 China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Center of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Beijing 100142 China Department of General Surgery Peking University First Hospital Beijing 100034 China Department of Gastrointestinal Surgery Peking University People's Hospital Beijing 100044 China Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of General Surgery Beijing Hospital Beijing 100730 China Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China Department of General Surgery Qilu Hospital of Shandong University Jinan 250012 China Department of General Surgery Nanjing General Hospital Nanjing 210002 China Department of Gastrointestinal Surgery the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China Department of Oncology Zhongnan Hospital of Wuhan University Wuhan 430071 China Department of Medical Oncology Zhejiang Cancer Hospital Hangzhou 310022 China Department of Medical Oncology the First Affiliated Hospital of Dalian Medical University Dalian 116011 China Department of Chemotherapy Qilu Hospital of Shandong University Jinan 250012 China

Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. Methods： We have commenced a randomized phase III trial in December 2016 to evaluate S-I plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer. A total of 564 patients will be accrued from 13 Chinese institutions in two years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are 5-year overall survival, proportion of patients who complete the postoperative chemotherapy and incidence of adverse events. Ethic and dissemination： The trial has been approved by the institutional review board of each participating institution and it was activated on December, 2016. The enrollment will be finished in December, 2018. Patient＇s follow-up will be ended until December, 2023. Trial registration： ***, identifier： NCT02867839. Registered on August 4, 2016.

关键词： Locally advanced gastric cancer S-1 plus oxaliplatin randomized phase HI trial

Declines in Blood Lead Levels Among General Population-China,2000–2018

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China CDC weekly 2022年第50期4卷 1117-1122,I0001-I0009页

作者： Yuebin Lyu Jing Chen Zheng Li Liang Ding Feng Zhao Yingli Qu xulin Zheng Zheng Zhang Xiaojian Hu Saisai Ji Yifu Lu Yawei Li Yuanduo Zhu Yanwei Yang Yidan Qiu Haocan Song Wenli Zhang Bing wu Jiayi Cai Miao Zhang Fangyu Li Ying Zhu Zhaojin Cao John Ji Xiaoyuan Yao Yuxin Zheng Xiaoming Shi China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Qingdao University School of Public Health Qingdao CityShandong ProvinceChina Vanke School of Public Health Tsinghua UniversityBeijingChina.

What is already known about this topic?Environmental and occupational lead exposure has generally declined in the past two ***,there is no large-scale monitoring of blood lead levels(BLLs)in the Chinese general *** is added by this report?This nationally representative study showed declines of BLLs in all ages of participants;for children aged 3–5 years,down from 78.1μg/L to 16.9μg/L,corresponding to 78.4%decrease in the past two decades(2000–2018).What are the implications for public health practice?Recommendations for elevated BLLs on screening children at high risk now need to be revisited and updated from 100μg/L to 50μg/L in guidelines to conform with the substantial declines in China.

关键词： Blood elevated Population

高渗盐复苏液对严重烫伤大鼠早期血钠及细胞因子的影响

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安徽医科大学学报 2012年第6期47卷 631-634页

作者：吴雪生孙业祥陈旭林安徽医科大学第一附属医院烧伤科合肥230022

目的探讨高渗盐复苏液对严重烫伤大鼠早期血钠及细胞因子的影响。方法 56只SD大鼠随机分成3组:对照组、乳酸钠林格液组(LR组)和高渗钠盐液组(HS组)。所有大鼠全部颈静脉置管,对LR组和HS组大鼠进行烫伤后复苏治疗,分别检测各组肺脏含水... 详细信息

目的探讨高渗盐复苏液对严重烫伤大鼠早期血钠及细胞因子的影响。方法 56只SD大鼠随机分成3组:对照组、乳酸钠林格液组(LR组)和高渗钠盐液组(HS组)。所有大鼠全部颈静脉置管,对LR组和HS组大鼠进行烫伤后复苏治疗,分别检测各组肺脏含水量、血钠、肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平,将所得数据进行统计学分析。结果 HS组复苏后各时间点的肺含水量明显低于LR组(P<0.05或P<0.01),两组明显低于对照组(P<0.05或P<0.01);HS组复苏后各时间点的血钠明显高于LR组(P<0.01),HS组与对照组比较,差异无统计学意义,LR组明显低于对照组(P<0.05或P<0.01);HS组复苏后各时间点TNF-α及IL-6与LR组的TNF-α及IL-6比较,差异均无统计学意义,两组均明显高于对照组的TNF-α及IL-6(P<0.05或P<0.01)。结论与乳酸钠林格液比较,早期使用高渗盐液进行液体复苏严重烫伤大鼠能明显减轻肺水肿与低钠血症。

关键词：烧伤液体复苏盐水,高渗血钠肿瘤坏死因子-α 白介素6

退火温度对5154A铝镁合金线组织与力学性能的影响

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热加工工艺 2022年第8期51卷 116-118页

作者：黄显吞吴顺意韦旭林百色学院材料科学与工程学院广西百色533000 广西平果博导铝镁线缆有限公司广西平果531400

针对5154A铝镁合金线随着冷压变形量的增加,其抗拉强度和屈服强度增加,但伸长率下降的问题,采取退火处理改善5154A铝镁合金线材的组织和力学性能。采用X射线衍射、扫描电镜及综合功能测试仪对不同处理态线材的组织和性能进行了研究。结... 详细信息

针对5154A铝镁合金线随着冷压变形量的增加,其抗拉强度和屈服强度增加,但伸长率下降的问题,采取退火处理改善5154A铝镁合金线材的组织和力学性能。采用X射线衍射、扫描电镜及综合功能测试仪对不同处理态线材的组织和性能进行了研究。结果表明:退火可以使线材的柱状晶减小并退化,使线材的晶粒得到了细化,且在退火温度为230℃时,5154A铝镁合金线材的综合力学性能最佳。

关键词：退火温度 5154A铝镁合金线组织力学性能

高渗钠盐溶液复苏对严重烫伤大鼠早期肝脏损伤的影响

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中华烧伤杂志 2017年第1期33卷 31-36页

作者：周季平高智孙业祥陈旭林吴雪生王飞安徽医科大学第一附属医院烧伤科合肥230022 安徽医科大学第一附属医院ICU 合肥230022 安徽医科大学第一附属医院急诊外科合肥230022

目的探讨高渗钠盐溶液复苏对严重烫伤大鼠早期肝脏损伤的影响。方法将56只SD大鼠按随机数字表法分为假伤组8只、乳酸钠林格液组24只与高渗钠盐组24只。假伤组大鼠模拟致假伤后不予补液，另2组大鼠致背部30%TBSA深Ⅱ～Ⅲ度烫伤。按Parkl... 详细信息

目的探讨高渗钠盐溶液复苏对严重烫伤大鼠早期肝脏损伤的影响。方法将56只SD大鼠按随机数字表法分为假伤组8只、乳酸钠林格液组24只与高渗钠盐组24只。假伤组大鼠模拟致假伤后不予补液，另2组大鼠致背部30%TBSA深Ⅱ～Ⅲ度烫伤。按Parkland公式补液，乳酸钠林格液组大鼠补充乳酸钠林格液，高渗钠盐组大鼠补充300 mmol/L钠离子溶液。假伤组于伤后即刻，另2组于伤后2、8、24 h，分别取8只大鼠，取腹主动脉血和肝脏。干湿质量法检测肝脏含水量，全自动生化分析仪测定血清中ALT、AST含量，ELISA法检测血清TNF－α、IL－1及高迁移率族蛋白B1（HMGB1）含量，紫外分光光度计检测肝脏丙二醛和SOD含量，HE染色观察肝脏病理变化。对数据行单因素方差分析和SNK检验。结果（1）伤后2、8、24 h，乳酸钠林格液组大鼠肝脏含水量均高于假伤组和高渗钠盐组（P〈0.05或P〈0.01）。（2）伤后2 h，3组大鼠血清ALT含量相近（P值均大于0.05）；伤后8、24 h，高渗钠盐组与乳酸钠林格液组大鼠血清ALT含量均高于假伤组（P〈0.05或P〈0.01），高渗钠盐组大鼠血清ALT含量低于乳酸钠林格液组（P值均小于0.01）。伤后2、8、24 h，高渗钠盐组与乳酸钠林格液组大鼠血清AST含量均高于假伤组（P值均小于0.01）；伤后2、8 h，高渗钠盐组大鼠血清AST含量低于乳酸钠林格液组（P〈0.05或P〈0.01）。（3）伤后2、8 h，乳酸钠林格液组大鼠血清TNF－α含量分别为（123±39）、（153±38）pg/mL，高于假伤组的（60±18）pg/mL和高渗钠盐组的（85±10）、（94±16）pg/mL（P值均小于0.01）；伤后8 h，高渗钠盐组大鼠血清TNF－α含量高于假伤组（P〈0.05）。伤后24 h，3组大鼠血清TNF－α的含量相近（P值均大于0.05）。伤后2、8、24 h，乳酸钠林格液组大鼠血清IL－1含量分别为（122±35）、（141±30）、（122±31）pg/mL，高渗钠盐组大鼠血清IL－1含量分别为（80±12）、（93±15）、（80±11）pg/mL，均高于假伤组的（40±17）pg/mL（P值均小于0.01）；高渗钠盐组大鼠血清IL－1含量均低于乳酸钠林格液组（P值均小于0.01）。伤后2 h，3组大鼠血清HMGB1的含量相近（P值均大于0.05）。伤后8、24 h，乳酸钠林格液组大鼠血清HMGB1含量分别为（0.386±0.146）、（0.590±0.188）ng/mL，高于假伤组的（0.050±0.027）ng/mL和高渗钠盐组的（0.143±0.038）、（0.309±0.095）ng/mL（P值均小于0.01）；伤后24 h，高渗钠盐组大鼠血清HMGB1含量高于假伤组（P〈0.01）。（4）伤后2、8、24 h，乳酸钠林格液组和高渗钠盐组大鼠肝脏丙二醛含量均高于假伤组，SOD含量均低于假伤组，P值均小于0.01；高渗钠盐组大鼠肝脏丙二醛含量均低于乳酸钠林格液组，SOD含量均高于乳酸钠林格液组，P值均小于0.01。（5）与假伤组比较，乳酸钠林格液组大鼠肝细胞伤后各时相点均可见大量脂肪样变，伤后8、24 h可见肝细胞水肿空泡；高渗钠盐组大鼠仅在伤后8、24 h出现少量肝细胞脂肪样变，且未见肝细胞水肿。结论与乳酸钠林格液相比，高渗钠盐溶液复苏可通过减少炎症介质产生，降低氧化应激程度等减轻严重烫伤大鼠早期的肝脏损伤。

关键词：烧伤复苏术盐水,高渗肝超氧化物歧化酶炎症介质

五种红树植物通气组织对人工非潮汐生境的响应

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生态学报 2010年第24期30卷 6927-6934页

作者：伍卡兰彭逸生郑康振李旭林陈桂珠中山大学环境科学与工程学院/广东省污染控制与修复技术重点实验室广州510275 深圳市宝安区水产科学研究所深圳518104 深圳市海上田园旅游发展有限公司深圳518104

红树植物自然条件下生长于河口、海岸潮间带。受潮汐作用影响,红树植物在生理、形态、结构上对渍水环境产生了相应的适应机制。其中红树植物通气组织的发达程度与其耐淹水的能力具有很高的相关性,是衡量红树植物耐淹浸能力的重要依据。... 详细信息

红树植物自然条件下生长于河口、海岸潮间带。受潮汐作用影响,红树植物在生理、形态、结构上对渍水环境产生了相应的适应机制。其中红树植物通气组织的发达程度与其耐淹水的能力具有很高的相关性,是衡量红树植物耐淹浸能力的重要依据。利用测定孔隙率和石蜡切片面积比两种方法揭示了华南地区5种红树植物优势种:白骨壤(Avicennia marina)、红海榄(Rhizophora stylosa)、木榄(Bruguiera gymnorrhiza)、秋茄(Kandelia candel)和桐花树(Aegiceras corniculatum)在自然条件和人工生境下根通气组织的发育规律,并用石蜡切片研究了茎和叶的通气组织发育状况。结果表明:两种方法测得根的通气组织发育程度的结果相关性显著(P白骨壤>秋茄>木榄>红海榄。红树植物对非潮汐淹浸条件的适应有利于在沿海地区开展人工生境下红树林的栽培与推广应用,研究结果对提高栽培成活率,更大限度地发挥红树林的生态服务价值,具有重大的实践意义。

关键词：红树植物通气组织非潮汐生境适应性