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Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis

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Genes & Diseases 2023年第4期10卷 1613-1625页

作者： Tingwei Zhang Ziqi Chen Mengyuan Zhu Xuan Jing Xiaohui Xu xulei yuan Mengjiao Zhou Yanan Zhang Miao Lu Duanjing Chen Shihan Xu Jinlin Song Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher Educationand Stomatological Hospital of Chongqing Medical UniversityChongqing 401147China

Extracellular vesicles(EVs)derived from mesenchymal stem cells(MSCs)have emerged as a new mode of intercellular crosstalk and are responsible for many of the thera-peutic effects of *** promote the application of MSC-EVs,recent studies have focused on the manipulation of MSCs to improve the production of EVs and EV-mediated *** current paper details an optimization method using non-invasive low-intensity pulsed ul-trasound(LIPUS)as the stimulation for improving oral MSC-EV production and *** cells from apical papilla(SCAP),a type of oral mesenchymal stem cell,displayed inten-sity-dependent pro-osteogenic and anti-inflammatory responses to LIPUS without significant cytotoxicity or *** stimuli increased the secretion of EVs by promoting the expres-sion of neutral sphingomyelinases in *** addition,EVs from LIPUS-induced SCAP exhibited stronger efficacy in promoting the osteogenic differentiation and anti-inflammation of peri-odontal ligament cells in vitro and alleviating oral inflammatory bone loss in *** addition,LIPUS stimulation affected the physical characteristics and miRNA cargo of *** investigations indicated that miR-935 is an important mediator of the pro-osteogenic and anti-inflammatory capabilities of LIPUS-induced *** together,these findings demonstrate that LIPUS is a simple and effective physical method to optimize SCAP-EV produc-tion and efficacy.

关键词： Extracellular vesicles Low-intensity pulsed ultrasound Oral bone loss Periodontitis Stem cells from apical papilla

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Systemic antibiotics increase microbiota pathogenicity and oral bone loss

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International Journal of Oral Science 2023年第1期15卷 99-112页

作者： xulei yuan Fuyuan Zhou He Wang Xinxin Xu Shihan Xu Chuangwei Zhang Yanan Zhang Miao Lu Yang Zhang Mengjiao Zhou Han Li Ximu Zhang Tingwei Zhang Jinlin Song Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical UniversityChongqingChina

Periodontitis is the most widespread oral disease and is closely related to the oral *** oral microbiota is adversely affected by some pharmacologic *** antibiotics are widely used for infectious diseases but can lead to gut dysbiosis,causing negative effects on the human *** systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been *** this research,mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone *** results demonstrated,for the first time,that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate ***,the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal *** microbiota transplantation with normal mice feces restored the gut microbiota and barrier,decreased the pathogenicity of the oral microbiota,reversed the Th17/Treg imbalance in periodontal tissue,and alleviated alveolar bone *** study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis.A Th17/Treg imbalance might be related to this ***,these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice.

关键词： Th17/Treg diseases reversed

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大学信息化架构探索

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实验技术与管理 2011年第5期28卷 7-11页

作者：蒋东兴袁徐磊刘启新袁芳付小龙清华大学计算机与信息管理中心北京100084

当前高校信息化已经进入基于顶层设计的校级统一信息系统建设阶段,在此阶段,建立与之相适应的高校信息化理论模型至关重要。根据对企业架构理论的研究和清华大学信息化建设经验的总结,提出了信息集成阶段高校建设统一信息系统的理论模... 详细信息

当前高校信息化已经进入基于顶层设计的校级统一信息系统建设阶段,在此阶段,建立与之相适应的高校信息化理论模型至关重要。根据对企业架构理论的研究和清华大学信息化建设经验的总结,提出了信息集成阶段高校建设统一信息系统的理论模型——大学架构。大学架构主要包括业务架构、信息系统架构和技术架构三部分,能为信息系统设计与开发提供全程统一的规划。

关键词：信息化企业架构大学架构业务架构信息系统架构技术架构

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供精人工授精周期妊娠率相关因素及妊娠结局分析

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实用妇产科杂志 2009年第11期25卷 678-680页

作者：王冰松孙绪磊袁水桥刘莹周玉言胡淑敏宋莹张桂华刘新宇沈阳204医院辽宁沈阳110043

目的:探讨影响供精人工授精周期妊娠率的相关因素及其妊娠结局。方法:对2005年11月至2007年10月在本中心治疗的594对不孕夫妇行1088个供精人工授精(AID)治疗周期。并分析不孕妇女的年龄、授精次数、治疗周期、促排卵等因素对AID治疗妊... 详细信息

目的:探讨影响供精人工授精周期妊娠率的相关因素及其妊娠结局。方法:对2005年11月至2007年10月在本中心治疗的594对不孕夫妇行1088个供精人工授精(AID)治疗周期。并分析不孕妇女的年龄、授精次数、治疗周期、促排卵等因素对AID治疗妊娠率的影响,并对AID治疗后妊娠结局进行统计分析。结果:①≥36岁组的周期妊娠率18.30%,与≤25岁组(30.37%)、26～30岁组(32.99%)、31～35岁组(27.10%)比较,差异有统计学意义(P0.05),但有随年龄增高的趋势。②促排卵组与自然周期组行AID治疗,其周期妊娠率比较差异无统计学意义(P>0.05)。③双次授精的周期妊娠率(34.34%)高于单次授精(20.05%)(P0.05)。结论:供精人工授精周期妊娠率与多种因素有关,其中不孕妇女的年龄是影响AID成功率的重要因素。同一周期行两次人工授精能更有效控制授精时机,有较高周期妊娠率。

关键词：供精人工授精周期妊娠率妊娠结局

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Concentrations of Heavy Metals in Suburban Horticultural Soils and Their Uptake by Artemisia selengensis

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Pedosphere 2015年第6期25卷 878-887页

作者： CUI Xu SUN xulei HU Pengjie yuan Cheng LUO Yongming WU Longhua Peter CHRISTIE Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of Sciences University of Chinese Academy of Sciences College of Resources and Environment Shanxi Agricultural University Key Laboratory of Coastal Zone Environmental Processes Yantai Institute of Coastal Zone ResearchChinese Academy of Sciences

A total of 222 surface soil samples and 40 plant samples were collected to investigate the spatial distribution and possible sources of soil heavy metals and to know the uptake and translocation of heavy metals from roots to different plant parts in a representative vegetable production area in the Baguazhou Island, a suburb of Nanjing City, East China. The arithmetic mean values of total Cd, Cr,Cu, Ni, Pb, and Zn concentrations in the soils were 0.314, 133, 41.0, 58.0, 31.8, and 114 mg kg-1, respectively. All of these values were above the topsoil background values in the Nanjing area. Multivariate and geostatistical analyses showed that soil Cd contamination was derived mainly from agricultural practices. In contrast, Cu and Zn were derived mainly from soil parent materials and Pb from atmospheric deposition from highway gasoline stations. Artemisia selengensis, a locally important specialty vegetable, accumulated heavy metals primarily in the edible leaves. The general distribution of heavy metal concentrations in this plant species showed that the highest occurred in the leaves, intermediate in the stems and lowest in the roots. Cd had the highest concentration factor(root-to-soil ratio) and may pose increased health risks in the future to the local population through the consumption of contaminated vegetables.

关键词： concentration factor plant uptake pollution source spatial distribution translocation factor vegetable

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Hepatic transcriptome signatures in mice and humans with nonalcoholic fatty liver disease

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Animal Models and Experimental Medicine 2023年第4期6卷 317-328页

作者： Yiming Ding xulei Dai Miaoye Bao yuanming Xing Junhui Liu Sihai Zhao Enqi Liu Zuyi yuan Liang Bai Department of Laboratory Animal Science School of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'anChina Department of Cardiology First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Institute of Cardiovascular Science Translational Medicine InstituteXi'an Jiaotong University Health Science CenterXi'anChina Department of Clinical Laboratory First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina

Background:Nonalcoholic fatty liver disease(NAFLD)is the main reason for cirrhosis and hepatocellular *** a starting point for NAFLD,the treatment of nonalcoholic fatty liver(NAFL)is receiving increasing *** fed a high-fat diet(HFD)and hereditary leptin deficiency(ob/ob)mice are important NAFL animal ***,the comparison of these mouse models with human NAFL is still ***:In this study,HFD-fed mice and ob/ob mice were used as NAFL animal *** histopathological characteristics were compared,and liver transcriptome from both mouse models was performed using RNA sequencing(RNA-seq).RNAseq data obtained from the livers of NAFL patients was downloaded from the GEO *** gene expression profiles in the livers were further analyzed using functional enrichment analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)***:Our results showed that the biochemical parameters of both mouse models and human NAFL were *** with HFD-fed mice,ob/ob mice were more similar in histologic appearance to NAFL *** liver transcriptome characteristics partly overlapped in mice and ***,in the NAFL pathway,most genes showed similar trends in mice and humans,thus demonstrating that both types of mice can be used as models for basic research on NAFL,considering the ***:Our findings show that HFD-fed mice and ob/ob mice can mimic human NAFL partly in pathophysiological *** comparative analysis of liver transcriptome profile in mouse models and human NAFL presented here provides insights into the molecular characteristics across these NAFL models.

关键词： animal model high-fat diet nonalcoholic fatty liver disease ob/ob mice transcriptomics

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Effects of second-order dispersion of ultrashort laser pulse on stimulated Raman scattering

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High Power Laser Science and Engineering 2022年第6期10卷 41-48页

作者： Yanqing Deng Dongning Yue Mufei Luo Xu Zhao Yaojun Li xulei Ge Feng Liu Suming Weng Min Chen Xiaohui yuan Jie Zhang Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina

The influence of second-order dispersion(SOD)on stimulated Raman scattering(SRS)in the interaction of an ultrashort intense laser with plasma was *** significant backward SRS was observed with the increase of the absolute value of SOD(|ψ2|).The integrated intensity of the scattered light is positively correlated to the driver laser pulse *** by the side SRS,filaments with different angles along the laser propagation direction were observed in the transverse shadowgraph.A model incorporating Landau damping and above-threshold ionization was developed to explain the SOD-dependent angular distribution of the filaments.

关键词： second-order dispersion stimulated Raman scattering ultrashort intense laser

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Pulse shape of ultrashort intense laser reflected from a plasma mirror

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Chinese Optics Letters 2018年第10期16卷 85-89页

作者： xulei Ge Xiaohui yuan yuan Fang Wenqing Uei Su Yang Feng Liu Min Chen Li Zhao Zhengming Sheng Jie Zhang State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Key Laboratory for Laser Plasmas(MoE)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240China SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom

The temporal profiles of high-power short-pulse lasers reflected from self-induced plasma mirrors(PMs)were measured with high temporal resolution in the sub-picosecond *** leading front shape of the laser pulse is found to depend sensitively on the laser fluence on the PM *** modulation plays a key role in pulse profile *** findings will extend our knowledge on properly using PMs.

关键词： Fused silica High power lasers Laser beams Pulse shaping Temporal resolution Ultrashort pulses

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碳酸盐岩缝洞储层地震反射波特征及其与油气的关系

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天然气工业 2014年第4期34卷 57-61页

作者：朱仕军唐绪磊朱鹏宇吴晓华路远西南石油大学中国石油川庆钻探工程公司地球物理勘探公司

碳酸盐岩复杂的成岩作用和储集空间的演化史,导致了其特有的、以缝洞体为主的储集空间在横向上有着较强的非均质性,使得钻探成功率降低,提高对碳酸盐岩缝洞体反射特征的认识,则可大大降低勘探风险。为此,采用弹性波动方程模拟了不同形... 详细信息

碳酸盐岩复杂的成岩作用和储集空间的演化史,导致了其特有的、以缝洞体为主的储集空间在横向上有着较强的非均质性,使得钻探成功率降低,提高对碳酸盐岩缝洞体反射特征的认识,则可大大降低勘探风险。为此,采用弹性波动方程模拟了不同形态碳酸盐岩溶洞储层模型的地震反射波特征,总结了溶洞在正演偏移剖面上最大波峰振幅与溶洞大小的关系,同时对波形做了相关分析,得到以下结论:①随着溶洞宽度的增加,溶洞对应的振幅是不断增大的;②振幅随溶洞宽度增加是有极限的,当溶洞宽度大于菲涅尔带半径时,其宽度对振幅几乎无影响;③溶洞在剖面上的一般表现特征为"串珠"状或"羊排"状,在宽度和高度固定的情况下,溶洞表面积越大,振幅越大;④最大波峰振幅曲线有助于识别溶洞。塔里木盆地TH油气藏的勘探实践证明了该方法的可靠性,也为类似油气藏的勘探提供了技术支撑。

关键词：地震勘探正演模拟地震属性储集层岩溶波动方程最大波峰振幅塔里木盆地

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基于拒绝采样法的BRDF模型散射光线追迹方法

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光学学报 2023年第6期43卷 210-217页

作者：伦旭磊朱丹高志山许宁晏乔文佑袁群南京理工大学电子工程与光电技术学院江苏南京210094

针对现有散射光线追迹概率模型方案受限于解析解难以获取的问题,提出利用拒绝采样法设计基于双向反射分布函数(BRDF)的散射光线追迹概率模型,通过设置检验条件规避了积分求解过程,进而筛选出有效角度坐标,实现散射光线追迹,该方案具有... 详细信息

针对现有散射光线追迹概率模型方案受限于解析解难以获取的问题,提出利用拒绝采样法设计基于双向反射分布函数(BRDF)的散射光线追迹概率模型,通过设置检验条件规避了积分求解过程,进而筛选出有效角度坐标,实现散射光线追迹,该方案具有适用范围广的优势。对于具有平移不变性的BRDF模型,进一步提出对称采样方案,通过将采样区域减半后再镜像提升速率。设置表面属性、入射角与追迹光线数量等仿真条件相同,编制了本文方案的仿真程序,对不同光机结构材料进行建模仿真后从重复性和精确度方面与LightTools软件运算结果作对比验证,基于拒绝采样法编制程序的仿真结果可以与软件模型结果相媲美。最后对软件中未包含的BRDF模型进行建模仿真以进一步验证上述方案的普适性。

关键词：测量双向反射分布函数光线追迹拒绝采样法蒙特卡罗法概率模型

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