检索结果-南通市图书馆

Chemical Research in Chinese Universities 2015年第6期31卷 942-951页

作者： WANG Yang LEI Fan LI Xiaolong HE Yi LI Jue QIU Rui wu xueying HAI Li wu Yong Department of Pathology The First Affiliate Hospital College of Medicine Zhejiang University Hangzhou 310003 P. R. China Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Siehuan University Chengdu 610041 P. R. China School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of new substituted phenyl-coupled heterocyclic ethylamide derivatives was designed and synthe- sized as anti-influenza agents. In vitro anti-influenza A（A/PR/8/34 H1N1 strain） activities of these compounds were investigated and compared to those of the commercial antiviral drugs（Arbidol and Ribavirin） against the influenza. Specifically, among these twelve compounds exhibiting moderate levels of antiviral activity against influenza A, compounds 30c and 30d are the most effective ones, and as efficacious as the positive control Ribavirin and much more effective than Ingavirin and Arbidol, indicating that they are prospective candidates for further exploration. These results are also consistent with the docking study results in terms of the design of compounds targeting in- fluenza A via viral nucleoprotein.

关键词： Influenza virus A Nucleoprotein inhibitor Ingavirin Nucleozin Biological evaluation

The mutational pattern of homologous recombination(HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer

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Cancer Biology & Medicine 2020年第4期17卷 1002-1013页

作者： Yue Fan Haifeng Ying xueying wu Huan Chen Ying Hu Henghui Zhang Lijia wu Ying Yang Beibei Mao Lan Zheng Department of integrated Traditional Chinese Medicine and Western Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Traditional Chinese Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025China Genecast Precision Medicine Technology Institute Beijing 100191China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective:Currently,there is an urgent need to identify immunotherapeutic biomarkers to increase the benefit of immune checkpoint inhibitors(ICIs)for patients with gastric cancer(GC).Homologous recombination deficiency(HRD)can modify the tumor immune microenvironment by increasing the presence of tumor-infiltrating lymphocytes and therefore might serve as a biomarker of immunotherapeutic *** aimed to analyze the mutational pattern of HR-associated genes in Chinese patients with GC and its relevance to the tumor immune profile and clinical immunotherapeutic ***:A panel of 543 cancer-associated genes was used to analyze genomic profiles in a cohort comprising 484 Chinese patients with *** between HR gene mutations and tumor immunity or clinical outcomes were identified via bioinformatic analysis using 2 GC genomic datasets(TCGA and MSK-IMPACT).Results:Fifty-one of the 484(10.54%)patients carried at least one somatic mutation in an HR gene;ATM(16/484,3.31%)was among the most frequently mutated HR genes in the Chinese *** in HR genes were associated with elevated tumor mutational burden,enhanced immune activity,and microsatellite instability *** the MSK-IMPACT cohort comprising 49 patients with stomach adenocarcinoma or gastroesophageal junction adenocarcinoma treated with ICIs,patients with HR-mut GC(n=12)had significantly better overall survival than those with HR-wt GC(n=37)(log-rank test,P<0.05).Conclusions:Our data suggest that detection of somatic mutations in HR genes might aid in identifying patients who might benefit from immune checkpoint blockade therapy.

关键词： Gastric cancer homologous recombination deficiency immunotherapy biomarker

A chiral spirofluorene-embedded multiple-resonance thermally activated delayed fluorescence emitter for efficient pure-green circularly polarized electroluminescence

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Aggregate 2024年第2期5卷 261-267页

作者： Xu-Feng Luo Shi-Quan Song xueying wu Ching-Fai Yip Songliang Cai You-Xuan Zheng State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingP.R.China GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals Guangzhou Key Laboratory of Analytical Chemistry for BiomedicineSchool of ChemistrySouth China Normal UniversityGuangzhouP.R.China

The simultaneous achievement of chiral multiple-resonance thermally activated delayed fluorescence(MR-TADF)emitters with narrowband and circularly polarized electroluminescence(CPEL)poses a ***,a MR-TADF emitter,Spiro-BNCz,embedding spirofluorene structure was developed and chiral separated,whose emission peaks at 528 nm in toluene with Commission Internationale de L’Eclairage coordinates of(0.26,0.69).The conjugation extension caused by embedding sulfur substituted spirofluorene on B/N framework shortens the singlettriplet energy gap and increases spin-orbital coupling matrix ***,a fast reverse intersystem crossing rate constant of 2.8×10^(6)s^(−1)and a high photoluminescence efficiency of 92%in film were *** organic light-emitting diode(OLED)exhibits a maximum external quantum efficiency of 32.3%.Particularly,the circularly polarized OLEDs based on Spiro-BNCz enantiomers show symmetric CPEL with dissymmetry factors(|gEL|)≈10^(−3).

关键词： circularly polarized electroluminescence CP-MR-TADF emitter organic light-emitting diode pure green sulfur substituted spirofluorene

High-visibility ghost imaging with phase-controlled discrete classical light sources

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Chinese Physics B 2024年第7期33卷 328-334页

作者：仵雪滢赵岳李利明 School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255049China

We take phase modulation to create discrete phase-controlled sources and realize the super-bunching effect by a phasecorrelated method. From theoretical and numerical simulations, we find the space translation invariance of the bunching effect is a key point for the ghost imaging realization. Experimentally, we create the orderly phase-correlated discrete sources which can realize high-visibility second-order ghost imaging than the result with chaotic sources. Moreover, some factors affecting the visibility of ghost image are discussed in detail.

关键词： ghost imaging high visibility space translation invariance

Research on the development of group buying website based on O2O model

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International English Education Research 2016年第2期 43-45页

作者： wu xueying YANG Fan Shanghai University Of Engineering Science China

This paper mainly analysis of group buying website based on O2O model. This new e-business model which has great development potential attracted many entrepreneurs. The related theories of network group-buying model were collected. The problems existed in this new e-business model were discussed and analyzed with professional management knowledge. Corresponding suggestions and measures were also given.

关键词： Electronic commerce O2O model Business model Group buying website Meituan

Storm of soluble immune checkpoints associated with disease severity of COVID-19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 881-883页

作者： Yaxian Kong Yu Wang xueying wu Junyan Han Guoli Li Mingxi Hua Kai Han Henghui Zhang Ang Li Hui Zeng Institute of Infectious Diseases Beijing Key Laboratory of Emerging Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Immupeutics Medicine Institute Beijing 100191China Department of Intensive Care Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Dear Editor,As the outbreak of coronavirus disease 2019(COVID-19)turns into a pandemic,it has literally caused a worldwide public health *** lymphopenia,especially in T cells,was a prominent clinical feature of severe COVID-19 in addition to dyspnea,hypoxemia,acute respiratory distress,and cytokine release syndrome.1 Recently,several studies revealed a correlation between T cell depletion and increased expression levels of several inhibitory checkpoint molecules on T cells in severe COVID-19 cases.2 Classically,inhibitory checkpoint molecules have been documented as key factors for regulating T cell exhaustion in a variety of chronic viral infections and *** studies further implied a pivotal role of inhibitory checkpoint molecules in the pathophysiology of acute viral infections,such as Ebola virus or hantavirus *** note,soluble isoforms of checkpoints can be produced by cleavage of membrane-bound proteins or by alternative splicing of mRNA and competitively regulate the functions of their membrane-bound counterparts.3 Thus it is of great interest to determine whether soluble checkpoint molecules are involved in immune regulation and severity of COVID-19.

关键词： severity acute distress

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自媒体时代图书馆网络投诉应对技能的探析

图书馆杂志 2015年第7期34卷 46-49页

作者：吴雪映温州市图书馆

自媒体被越来越多的读者所青睐,采取网络投诉渠道者也越来越多,图书馆面临着一定的挑战。本文分析了当代图书馆服务的网络信息环境,记述了多种类型的投诉及其对馆员的影响,梳理了图书馆提高网络投诉应对技能的对策。

关键词：自媒体图书馆网络投诉

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对图书馆志愿服务活动的再认识

图书馆杂志 2011年第8期30卷 36-39页

作者：吴雪映温州市图书馆温州325000

现今图书馆越来越多地引入了志愿者服务,给工作带来了不少帮助。然而,笔者认为,我们对图书馆志愿服务活动的认识还有所局限。要使志愿服务活动长久开展下去,我们可以拓宽思路,加深认识,以使志愿者这一资源得以更好的利用。

关键词：图书馆志愿服务

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努力做好党委办公室工作

中华医院管理杂志 1998年第11期14卷 666-667页

作者：吴雪莹北京天坛医院

医院党委办公室是协助党委和领导同志工作的职能部门。党委办公室工作重点从以下几方面做起：①做好“三服务”：一是深入基层，综合信息，为领导有针对性的开展思想政治工作服务；二是为党员和职工服务；三是为病人服务。②做到“二重... 详细信息

医院党委办公室是协助党委和领导同志工作的职能部门。党委办公室工作重点从以下几方面做起：①做好“三服务”：一是深入基层，综合信息，为领导有针对性的开展思想政治工作服务；二是为党员和职工服务；三是为病人服务。②做到“二重视”：一是重视接洽工作；二是重视协调工作的质量和效率。③抓规范服务，确保工作质量。④抓学习、重实践。

关键词：党委办公室管理医院管理

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六流道喷嘴涡流管流动与传热数值模拟

低温与超导 2017年第1期45卷 1-5页

作者：梁法春吴雪莹中国石油大学(华东)储运与建筑工程学院青岛266580

为了研究涡流管内部的能量分离机理,建立了六流道喷嘴涡流管的三维数值计算模型,采用Realizable k-ε模型对涡流管的速度和温度分布进行数值模拟,并将涡流管无量纲总温的径向分布与其他研究者的结果进行对比,验证了模拟结果的准确性。... 详细信息

为了研究涡流管内部的能量分离机理,建立了六流道喷嘴涡流管的三维数值计算模型,采用Realizable k-ε模型对涡流管的速度和温度分布进行数值模拟,并将涡流管无量纲总温的径向分布与其他研究者的结果进行对比,验证了模拟结果的准确性。结果表明:保持入口压力不变,涡流管的制冷效应随着冷流率的增大呈现先增大后减小的趋势,存在着一个最佳制冷效应;涡流管内存在着内旋流、外旋流和循环流,循环流的存在使内旋流的能量传递到外旋流中,使得涡流管内存在能量分离现象;能量分离主要发生在涡流室区域附近。

关键词：涡流管数值模拟流场温度分布