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Long noncoding RNAs in innate immunity

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Cellular & Molecular Immunology 2016年第2期13卷 138-147页

作者： Yuan Zhang xuetao cao National Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical Sciences Chinese Academy of MedicalSciences Beijing 100005 China

Long noncoding RNAs （IncRNAs） have been shown to play important roles in immune cell development and immune responses through different mechanisms, such as dosage compensation, imprinting, enhancer function, and transcriptional regulation. Although the functions of most IncRNAs are unclear, some IncRNAs have been found to control transcriptional or post-transcriptional regulation of the innate and adaptive immune responses via new methods of protein-protein interactions or pairing with DNA and RNA. Interestingly, increasing evidence has elucidated the importance of IncRNAs in the interaction between hosts and pathogens. In this review, an overview of the IncRNAs modes of action, as well as the important and diversified roles of IncRNAs in immunity, are provided, and an emerging paradigm of IncRNAs in regulating innate immune responses is highlighted.

关键词： host-pathogen interaction innate immunity long noncoding RNA

Interleukin-17 and its expanding biological functions

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Cellular & Molecular Immunology 2010年第3期7卷 164-174页

作者： Sheng Xu xuetao cao National Key Laboratory of Medical Immunology&Institute of Immunology Second Military Medical UniversityShanghaiChina

Interleukin-17(IL-17)and IL-17-producing cells have been shown to play important roles in inflammation and the immune ***-17 is believed to be mainly produced by T helper 17(Th17)cells,a unique helper T-cell subset different from Th1 and Th2 *** subsets of T cells such as cdT and natural killer T(NKT)cells have also been found to produce IL-17 in response to innate ***-17 acts as a proinflammatory cytokine that can induce the release of certain chemokines,cytokines,matrix metalloproteinases(MMPs)and antimicrobial peptides from mesenchymal and myeloid *** leads to the expansion and accumulation of neutrophils in the innate immune system and links innate and adaptive immunity in ***,increasing evidence indicates that IL-17 and IL-17-producing cells are involved in the pathogenesis of various diseases such as allergies,autoimmune diseases,allograft transplantation and even *** may also play protective roles in host defense against infectious diseases and promote induction of cytotoxic T lymphocyte(CTL)responses against *** of the IL-17 axis is under investigation for the treatment of inflammatory disorders.

关键词： autoimmune disease immunity interleukin-17 neutrophil T cells

Reversing the mitochondrial stress-induced exhaustion of CD8^(+)T cells for improving cancer immunotherapy

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Cellular & Molecular Immunology 2021年第7期18卷 1634-1637页

作者： Cheng Qian xuetao cao National Key Laboratory of Medical Immunology Institute of ImmunologySecond Military Medical UniversityShanghaiChina Laboratory of Immunity and Inflammation College of Life SciencesNankai UniversityTianjinChina

Antigen-specific CD8+T cells that infiltrate tumor tissue have been considered the primary cytotoxic lymphocytes that exert antitumor effects,building a foundation for current immunotherapies against ***,in the face of continuous antigenic stimulation during chronic infections and cancer,T-cell differentiation leads to a state of incapacitation called T-cell exhaustion,which is a critical barrier to successful T-cell immunotherapy of *** explosive growth of malignant tumor cells accompanied by a dysfunctional vascular system and metabolite competition leads to a stressful tumor microenvironment characterized by low-oxygen tension,acidic interstitial pH,and insufficient *** evidence for the contribution of the tumor microenvironment to the metabolic reprogramming of exhausted CD8+T cells has been increasing,but the response of intratumoral T cells to metabolic stress signals is still not fully *** of a study by Scharping et al.,1 together with other recent evidence,have highlighted that the tumor microenvironment can influence the mitochondrial stress of T cells and drive the trajectory of T-cell differentiation toward *** findings add new perspectives on and insights into the molecular initiators of T-cell exhaustion and the combination of strategies that should be utilized to improve the efficacy of immunotherapy,and these perspectives are discussed in this review.

关键词： immunotherapy cancer stimulation

Fine-tuning MAVS- and STING-mediated antiviral innate immunity

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National Science Review 2015年第3期2卷 262-264页

作者： Xingguang Liu xuetao cao National Key Laboratory of Medical Immunology& Institute of Immunology Second Military Medical University National Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences

The pathogen-associated molecules or nucleic acids derived from the invading pathogens can initiate the production of type I interferons(IFNs)and IFN-inducible genes,resulting in the establishment of an efective antimicrobial *** case of viral infection,nucleic acids from viruses are detected by patern recognition receptors mainly including several endosomal members of

关键词： Fine-tuning MAVS and STING-mediated antiviral innate immunity IFN

The origin and function of tumor-associated macrophages

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Cellular & Molecular Immunology 2015年第1期12卷 1-4页

作者： Yang Liu xuetao cao National Key Laboratory of Medical MolecularBiology & Department of Immunology Instituteof Basic Medical Sciences Chinese Academy ofMedical Sciences Beijing China

Identifying the cellular and molecular suppressors of the immune response against tumors is a popular topic in the field of tumor immunology that will provide new targets for the cancer immunotherapy. Suppressing the suppressor is a very attractive approach to enhan- cing the anti-tumor immune response by reversing the immunosuppression or blocking immune escape in the late stages of cancer progression.

关键词： origin function tumor-associated

cGAS-STING pathway in senescence-related inflammation

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National Science Review 2018年第3期5卷 308-310页

作者： Kun Chen Juan Liu xuetao cao National Key Laboratory of Medical Molecular Biology Department of Immunology & Center for Immunotherapy Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University

Cellular senescence marked with persistent cell cycle arrest plays critical roles in orchestrating tissue remodeling and immune surveillance in response to multiple developmental and physiological ***,chronic or persistent cellular senescence can promote aberrant inflammatory responses,therefore is linked with variable pathogeneses such as fibrosis,cancer,autoimmune diseases,

关键词： GAS cGAS-STING pathway in senescence-related inflammation

Advances in innate immune signaling:new activators and regulators

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National Science Review 2016年第2期3卷 160-162页

作者： Juan Liu xuetao cao National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University National Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences

The innate immune system can detect the invading microbe components via three major pattern recognition receptorsToll-like receptors,RIG-I-like receptors and NOD-like receptors as well as a variety of cytoplasmic DNA or RNA *** innate receptors induce a series of intracellular downstream signaling pathways,leading to the efficient innate immune responses to eliminate pathogens(Fig.1).Meanwhile,

关键词： Advances in innate immune signaling IKK DNA TLR

Long noncoding RNAs in the metabolic control of inflammation and immune disorders

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Cellular & Molecular Immunology 2019年第1期16卷 1-5页

作者： Junfang Xu xuetao cao Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China Department of Immunology&Center for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100005China

The metabolic control of immune cell development and function has been shown to be critical for the maintenance of immune homeostasis and is also involved in the pathogenesis of immune *** infections or cancers may induce metabolic reprogramming through different pathways to meet the energy and metabolite demands for pathogen propagation or cancer *** addition,some deregulated metabolites could trigger or regulate immune responses,thus causing chronic inflammation or immune disorders,such as viral infection,cancer and ***,the methods through which metabolism is regulated and the role of metabolic regulation in inflammation and immunity attract much *** regulation of inflammation and immunity is an emerging *** noncoding RNAs(lncRNAs)have been well documented to play crucial roles in many biological processes through diverse mechanisms,including immune regulation and metabolic ***,we review the functions and mechanisms of lncRNAs in the metabolic regulation of inflammatory immune disorders,aiming to deepen our understanding of the epigenetic regulation of inflammation and immunity.

关键词： inflammation immunity disorders

The function and regulation of TET2 in innate immunity and inflammation

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Protein & Cell 2021年第3期12卷 165-173页

作者： Boyi Cong Qian Zhang xuetao cao Laboratory of Immunity and Inflammation College of Life SciencesNankai UniversityTianjin 300071China National Key Laboratory of Medical Immunology Institute of ImmunologyNavy Military Medical UniversityShanghai 200433China Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China

TET2,a member of ten-eleven translocation(TET)family as a-ketoglutarate-and Fe2+-dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine(5mC),has been widely recognized to be an important regulator for normal hematopoiesis especially *** and dysregulation of TET2 contribute to the development of multiple hematological *** studies reveal that TET2 also plays an important role in innate immune homeostasis by promoting DNA demethylation or independent of its enzymatic ***,we focus on the functions of TET2 in the initiation and resolution of inflammation through epigenetic regulation and signaling *** addition,we highlight regulation of TET2 at various molecular levels as well as the correlated inflammatory diseases,which will provide the insight to intervene in the pathological process caused by TET2 dysregulation.

关键词： TET2 innate immune response DNA demethylation inflammatory resolution inflammatory diseases

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