Fine-tuning MAVS- and STING-mediated antiviral innate immunity

作     者：Xingguang Liu Xuetao Cao 

作者机构：National Key Laboratory of Medical Immunology& Institute of Immunology Second Military Medical University National Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2015年第2卷第3期

页      面：262-264页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by Grants from the National Key Basic Research Program of China(2013CB530502,2013CB530603) the National Natural Science Foundation of China(31270943,81422021,31390431 and 81123006) 

主　　题：Fine-tuning MAVS and STING-mediated antiviral innate immunity IFN 

摘      要：The pathogen-associated molecules or nucleic acids derived from the invading pathogens can initiate the production of type I interferons(IFNs)and IFN-inducible genes,resulting in the establishment of an efective antimicrobial environment.In case of viral infection,nucleic acids from viruses are detected by patern recognition receptors mainly including several endosomal members of