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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi Hua Mingzhuang Hou Lei Deng Nanning Lv Yong Xu xuesong zhu Huilin Yang Qin Shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

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3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

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The Innovation 2024年第2期5卷 88-97页

作者： Yijian Zhang Duo Li Yang Liu Liuqi Peng Dongdong Lu Pinpin Wang Dongxu Ke Huilin Yang xuesong zhu Changshun Ruan Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Novaprint Therapeutics Suzhou Co. Ltd.Room 605B1 BuildingBioBayNo.218 Xinghu StreetSuzhou Industrial ParkSuzhou 215000China

Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified *** revolutionary innovation of bioprinting provides a robust method for precise fabrication of tissue-engineered OCs with hierarchical structure;however,their spatial living cues for simultaneous fulfilment of osteogenesis and chondrogenesis to reconstruct the cartilage-bone interface of OC are ***,inspired by natural OC bilayer features,anisotropic bicellular living hydrogels(ABLHs)simultaneously embedding articular cartilage progenitor cells(ACPCs)and bone mesenchymal stem cells(BMSCs)in stratified layers were precisely fabricated via two-channel extrusion *** optimum formulation of the 7%GelMA/3%AlgMA hydrogel bioink was demonstrated,with excellent printability at room temperature and maintained high cell ***,the chondrogenic ability of ACPCs and the osteogenic ability of BMSCs were demonstrated in vitro,confirming the inherent differential spatial regulation of ABLHs.

关键词： printing stratified boost

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永磁同步电机宽转速的高阶滑模MRAS控制

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实验技术与管理 2024年第6期41卷 70-80页

作者：韩琨张长征袁雷朱雪松湖北工业大学太阳能高效利用及储能运行控制湖北省重点实验室湖北武汉430068

为抑制基于滑模控制的永磁同步电机系统的抖振现象,提出一种通过高阶滑模控制设计的MRAS无传感器控制策略。通过设置滑模积分环节达到了抑制抖振的目的,表明了高阶滑模控制过程中积分环节的重要性,阐述了非线性滑模控制参数设置思路,相... 详细信息

为抑制基于滑模控制的永磁同步电机系统的抖振现象,提出一种通过高阶滑模控制设计的MRAS无传感器控制策略。通过设置滑模积分环节达到了抑制抖振的目的,表明了高阶滑模控制过程中积分环节的重要性,阐述了非线性滑模控制参数设置思路,相较于MRAS与SMCMRAS提高了SPMSM在中低速的表现性能。最后,基于MATLAB/Simulink代码自动生成的电机算法测试平台,验证了所设计观测器的有效性。实验结果表明,SPMSM在低速的表现效果良好,零速启动表现良好,高阶滑模控制策略较一阶SMC有效降低了抖振,提高了PI控制的鲁棒性,实现了PMSM的宽速域控制。

关键词： MRAS 自动代码生成抖振高阶滑模控制低速控制

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基于熵权-TOPSIS法的货运航线网络设计研究

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中国民航飞行学院学报 2024年第1期35卷 5-8,24页

作者：朱学松陈肯中国民用航空飞行学院四川广汉618307

本文提出了一种轴辐式货运航线网络设计的方法。运用聚类分析(K-Means)进行枢纽机场选址,以枢纽机场间多重连接的方式,建立无机场容量限制的轴辐式货运航线网络优化模型,运用枚举法求解最终得到一个较为合理的货运航线网络。其中为提高... 详细信息

本文提出了一种轴辐式货运航线网络设计的方法。运用聚类分析(K-Means)进行枢纽机场选址,以枢纽机场间多重连接的方式,建立无机场容量限制的轴辐式货运航线网络优化模型,运用枚举法求解最终得到一个较为合理的货运航线网络。其中为提高聚类精度,引入熵权-TOPSIS法对数据进行处理,通过对TOPSIS评价数据进行聚类得到精度较高的聚类结果,实验表明基于熵权-TOPSIS的聚类分析较传统的聚类分析降低了运输成本。

关键词：交通运输工程航线网络设计熵权-TOPSIS K-Means聚类分析

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基于灰靶理论的竞争航线货运机队规划研究

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舰船电子工程 2024年第3期44卷 22-27页

作者：朱学松陈肯陈洪浩李梁昆中国民用航空飞行学院空中交通管理学院广汉618307

随着航空事业的发展,航空公司间的竞争关系不断加剧。为解决竞争环境下的航空公司的机队规划问题,建立了灰靶-PSO模型,并以航空公司货运航线机队规划为研究对象,验证模型的科学性。该模型引入灰靶理论,通过靶心度量化航空公司航线竞争力... 详细信息

随着航空事业的发展,航空公司间的竞争关系不断加剧。为解决竞争环境下的航空公司的机队规划问题,建立了灰靶-PSO模型,并以航空公司货运航线机队规划为研究对象,验证模型的科学性。该模型引入灰靶理论,通过靶心度量化航空公司航线竞争力,其中为降低主观因素对结果的影响,引入C-OWA算子赋权法计算指标权重,将量化后的竞争力转换为航空公司在货运航线上的初始市场份额,并基于初始市场份额,运用粒子群算法对模型进行求解。通过数据仿真实验表明:建立的灰靶-PSO模型对于解决竞争环境下航空公司机队规划问题具有一定的科学性,可为航空公司在进行航线运营和机队规划前期提供决策参考。

关键词：交通运输工程竞争环境运力分配灰靶理论粒子群算法

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High-resolution sea surface wind speeds of Super Typhoon Lekima (2019) retrieved by Gaofen-3 SAR

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Frontiers of Earth Science 2022年第1期16卷 90-98页

作者： He FANG William PERRIE Gaofeng FAN Zhengquan LI Juzhen CAI Yue HE Jingsong YANG Tao XIE xuesong zhu Zhejiang Climate Centre Hangzhou 310017China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Shanghai Typhoon Institute and Key Laboratory of Numerical Modeling for Tropical Cyclone of China Meteorological AdministrationShanghai 200030China Fisheries&Oceans Canada Bedford Institute of OceanographyDartmouth B2Y4A2Canada School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing 210044China

Gaofen-3(GF-3)is the first Chinese spaceborne multi-polarization synthetic aperture radar(SAR)instrument at C-band(5.43 GHz).In this paper,we use data collected from GF-3 to observe Super Typhoon Lekima(2019)in the East China *** a VH-polarized wide ScanSAR(WSC)image,ocean surface wind speeds at 100m horizontal resolution are obtained at 21:56:59 UTC on 8 August 2019,with the maximum wind speed,38.9 m·s^(-1).Validating the SAR-retrieved winds with buoymeasured wind speeds,we find that the root mean square error(RMSE)is 1.86 m·s^(-1),and correlation coefficient,*** suggests that wind speeds retrieved from GF-3 SAR are *** the European Centre for MediumRange Weather Forecasts(ECMWF)fine grid operational forecast products with spatial resolution,and China Global/Regional Assimilation and Prediction Enhance System(GRAPES)have good performances on surface wind prediction under weak wind speed condition(24m·s^(-1)).With respect to SAR-retrieved wind speeds,the RMSEs are 5.24 m·s^(–1) for ECMWF and 5.17 m·s^(–1) for GRAPES,with biases of 4.16 m·s^(–1) for ECMWF and 3.84 m·s^(-1)for GRAPES during Super Typhoon Lekima(2019).

关键词： synthetic aperture radar wind speed numerical weather predication(NWP) typhoon

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Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

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Journal of Materials Science & Technology 2023年第15期146卷 102-112页

作者： Mingzhuang Hou Yijian Zhang Yang Liu Xiaoyang Ge Xiayu Hu Zhijian Zhao Xin Tian Tao Liu Huilin Yang Xi Chen Fan He xuesong zhu Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007China Department of Pathology The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

Articular cartilage injury induced by collision or trauma is a common sports-related condition that may progress to pain,dysfunction,and secondary osteoarthritis(OA).Limited by self-renewal potential,cartilage regeneration faces a quandary while bio-inspired novel strategies are urgently *** this study,by a soft freezing method and surface modification technique,a multi-functional silk fibroin(SF)plus gelatin methacrylate(GelMA)scaffold laden with melatonin(MT)was ***-GelMA@MT scaffold demonstrated enhanced biomechanical characteristics and long-acting melatonin *** vitro treatment with SF-GelMA@MT induced the synthesis of cartilage extracellular matrix(ECM)***,sustained release of melatonin yielded robust chondroprotective effects via improving mitochondrial polarization and antioxidant ***-GelMA@MT implantation boosted cartilage renascence in a full-thickness cartilage defect model via mitochondria-associated sirtuins 1(SIRT1)-superoxide dismutase 2(SOD2)signaling pathway in *** summary,this research proposed a welldesigned bionic composite scaffold that promotes cartilage regeneration via mitochondrial function enhancement,which is of tremendous potential for cartilage tissue engineering.

关键词： Cartilage injury Silk fibroin Gelatin methacrylate Melatonin Mitochondri

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Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway

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Bioactive Materials 2020年第4期5卷 880-890页

作者： Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li xuesong zhu Qin Shi Department of Orthopedics The First Affiliated Hospital of Soochow UniversityOrthopedic InstituteMedical CollegeSoochow University188 Shizi RoadSuzhouJiangsu215006PR China Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology 199 Renai RoadSuzhou215123PR China

The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular ***,the mechanical characteristics of ECM affecting cell differentiation are still under ***,we aimed to study the effect of ECM substrate stiffness on macrophage *** prepared polyacrylamide hydrogels with different substrate stiffness,*** the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the *** simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the *** the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness *** addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in *** together,these findings demonstrated that substrate stiffness could affect macrophages *** substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB ***,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary.

关键词： Substrate stiffness Macrophage polarization NF-κB signaling pathway

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Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model

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Science China(Life Sciences) 2014年第2期57卷 232-240页

作者： SHI Qin GAO Wei HAN XingLong zhu xuesong SUN Jie XIE Fang HOU XiangLin YANG HuiLin DAI JianWu CHEN Liang Orthopedic Department the First Affiliated Hospital of Soochow University Orthopedic Department the Sixth People's Hospital of Hangzhou Division of Nanobiomedicine Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences Pathological Department Medical School of Soochow University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Nerve conduit is one of strategies for spine cord injury(SCI)***,studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury ***,the scaffold by itself was difficult to meet the need of SCI functional *** basic fibroblast growth factor(bFGF)administration significantly promotes functional recovery after organ ***,using a rat model of T9 hemisected SCI,we aimed at assessing the repair capacity of implantation of collagen scaffold(CS)modified by collagen binding bFGF(CBD-bFGF).The results showed that CS combined with CBD-bFGF treatment improved survival rates after the lateral hemisection *** CS/CBD-bFGF group showed more significant improvements in motor than the simply CS-implanted and untreated control group,when evaluated by the 21-point Basso-Beattie-Bresnahan(BBB)score and footprint *** hematoxylin and eosin(H&E)and immunohistochemical staining of neurofilament(NF)and glial fibrillary acidic protein(GFAP)demonstrated that fibers were guided to grow through the *** findings indicated that administration of CS modified with CBD-bFGF could promote spinal cord regeneration and functional recovery.

关键词： collagen scaffold basic fibroblast growth factor spinal cord injury nerve regeneration

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Selenium-modified bone cement promotes osteoporotic bone defect repair in ovariectomized rats by restoring GPx1-mediated mitochondrial antioxidant functions

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Regenerative Biomaterials 2023年第1期10卷 533-548页

作者： Quan Zhou Weikai Chen Chao Gu Hao Liu Xiayu Hu Lei Deng Wei He Yong Xu xuesong zhu Huilin Yang Xi Chen Fan He Tao Liu Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215007China Department of Orthopaedics Suzhou Dushu Lake HospitalSuzhou 215125China Department of Pathology The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

Over-accumulation of reactive oxygen species(ROS)causes mitochondrial dysfunction and impairs the osteogenic potential of bone marrow-derived mesenchymal stem cells(BMMSCs).Selenium(Se)protects BMMSCs from oxidative stress-induced damage;however,it is unknown whether Se supplementation can promote the repair of osteoporotic bone defects by rescuing the impaired osteogenic potential of osteoporotic BMMSCs(OP-BMMSCs).In vitro treatment with sodium selenite(Na2SeO3)successfully improved the osteogenic differentiation of OP-BMMSCs,as demonstrated by increased matrix mineralization and up-regulated osteogenic genes *** importantly,Na2SeO3 restored the impaired mitochondrial functions of OP-BMMSCs,significantly up-regulated glutathione peroxidase 1(GPx1)expression and attenuated the intracellular ROS and mitochondrial *** of Gpx1 completely abrogated the protective effects of Na2SeO3 on mitochondrial functions of OP-BMMSCs,suggesting the important role of GPx1 in protecting OP-BMMSCs from oxidative *** further fabricated Se-modified bone cement based on silk fibroin and calcium phosphate cement(SF/CPC).After 8 weeks of implantation,Se-modified bone cement significantly promoted bone defect repair,evidenced by the increased new bone tissue formation and enhanced GPx1 expression in ovariectomized *** findings revealed that Se supplementation rescued mitochondrial functions of OP-BMMSCs through activation of the GPx1-mediated antioxidant pathway,and more importantly,supplementation with Se in SF/CPC accelerated bone regeneration in ovariectomized rats,representing a novel strategy for treating osteoporotic bone fractures or defects.

关键词： sodium selenite osteoporosis GPx1 mitochondrial function bone cement

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